Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Fat]

Yes
Sema only mimick GLP-1 (Glucagon-like peptide 1)(read: is an agonist).
Tirz mimick both GIP (Glucose-dependent insulinotropic polypeptide) and GLP-1 (in a ration of 9:1). (contains two agonists).

GIP actually release more Glucagon as a sideeffect; but it releases even more insulin, so tirz still works.

Glucagon is a bit complicated (it does several things) but its basically the opposite of insulin (insulin lowers blood glucose and Glucagon raises it).

So in Reta they added a glucagon antagonist to the mix, that works by blocking the action of glucagon at its receptor. This means it prevents glucagon from binding to its receptor and exerting its effects, which lead to a decrease in blood sugar levels compared to tirz.

All of this is theory obviously.

There is thing things regarding it that I can’t seem to fit with peoples real life experiences.

@DanishPanther Is glucagon antagonist beneficial for muscle hypertrophy? I know insulin is very anabolic for growing muscles.

 

[mochul]

@DanishPanther Is glucagon antagonist beneficial for muscle hypertrophy? I know insulin is very anabolic for growing muscles.

Glucagon does not cause muscle loss if not in a hypoglycemic state and even in that state it first uses glycogen storage. So no blocking glucagon receptor would not be beneficial and can actually hurt since it's necessary to keep blood glucose stable during exercise.

 

[Fat]

I have stayed at 2.5 for 6 months with slow and steady weight loss. I did not see a reason the up my dose as long as I was losing. Others need tof ollow the pharma sked. Everyone is different. I am at my goal weight and trying to figure out a good maintenance dose.

@slpanico Did you figure out a good maintenance dose?

 

[Fat]

Glucagon does not cause muscle loss if not in a hypoglycemic state and even in that state it first uses glycogen storage. So no blocking glucagon receptor would not be beneficial and can actually hurt since it's necessary to keep blood glucose stable during exercise.

Thank you @mochul

Tirzepatide increases GIP which increases Glucagon.

Would this be a problem for building muscle?

 

[mochul]

Thank you @mochul

Tirzepatide increases GIP which increases Glucagon.

Would this be a problem for building muscle?

No since it's not significant

 

[Fat]

Would you guys say this works out in the real world? 5mg Tirzepatide is superior than 2mg Semaglutide.

 

[DECLAN]

Thank you @mochul

Tirzepatide increases GIP which increases Glucagon.

Would this be a problem for building muscle?

I think you should worry more on the gastric emptying and appetite suppression when it comes to muscle growth.

I don’t think you can grow if you can’t eat, something to ponder on.

 

[Fat]

Semaglutid does for me. Tirzepatide is a lot better in this regards. Energy level is better on tirz as well.

@HB_22 What dosage did Semaglutide effect your sex drive? What about Tirz? Please let us know

 

[HB_22]

@HB_22 What dosage did Semaglutide effect your sex drive? What about Tirz? Please let us know

At any dosage sadly. Even at 0.25mg a week it was kinda affected, but of course not as much as with 1mg/wk.

 

[Fat]

At any dosage sadly. Even at 0.25mg a week it was kinda affected, but of course not as much as with 1mg/wk.

What about Tirzepatide? You're the first person I have heard this from

 

[HB_22]

What about Tirzepatide? You're the first person I have heard this from

Well but it's not just me, others felt it too. Its a lot better with tirz, but from what I have found the ratio of GIP:GLP-1 is 9:1 with tirz (if that ratio is true) which could be the cause of it being better and semaglutide being worse as it only hits the glp-1 receptor with more intensity.

Some quotes from this thread:

so interesting thing.. my libido shot up after stopping semaglutide..... I think my libido in general is sensitive to particular chemicals...

Huh does this affect libido? I've had a decrease the last couple weeks but hasn't considered this might be responsible

along with a total removal of her always healthy libido

Semaglutide Killed my libido.

I didn't get that issue on tirzepatide.

 

[Fat]

Well but it's not just me, others felt it too. Its a lot better with tirz, but from what I have found the ratio of GIP:GLP-1 is 9:1 with tirz (if that ratio is true) which could be the cause of it being better and semaglutide being worse as it only hits the glp-1 receptor with more intensity.

Some quotes from this thread:

Thank you. Do you think 5mg/week Tirzepatide will be low enough not to impact libido?

Apparently there is research stating it is GIP:GLP-1 is 5:1 so 0.5mg Semaglutide is equivalent to 2.5mg Tirzepatide when it comes to GLP

So 1mg Semaglutide = 5 mg Tirzepatide
2mg Semglutide = 10mg Tirzepatide

 

[HotPepper]

I have take 1mg Semaglutid and 3mg Tirzepatid per week.
Since 4 weeks I have eliminated the Tirzepatid and just take the Sema.
Since 2 weeks I feel horrible weak and tired. It's like you would have stop taking crack or having the biggest depressions. Nearly can't work and even workouts are not possible.

Does anyone even notice the same sides?
How long will this keep going on?

 

[HB_22]

I have take 1mg Semaglutid and 3mg Tirzepatid per week.
Since 4 weeks I have eliminated the Tirzepatid and just take the Sema.
Since 2 weeks I feel horrible weak and tired. It's like you would have stop taking crack or having the biggest depressions. Nearly can't work and even workouts are not possible.

Does anyone even notice the same sides?
How long will this keep going on?

Its the semaglutid. Low energy is what I feel like too when taking it.

Thank you. Do you think 5mg/week Tirzepatide will be low enough not to impact libido?

Apparently there is research stating it is GIP:GLP-1 is 5:1 so 0.5mg Semaglutide is equivalent to 2.5mg Tirzepatide when it comes to GLP

So 1mg Semaglutide = 5 mg Tirzepatide
2mg Semglutide = 10mg Tirzepatide

On tirzepatide I feel a lot better. I don't know what the underlying mechanism is but from my research I can tell the higher I go with semaglutide the less energy and sex drive (libido) I have. It could be that activating GIP with GLP-1 is giving a synergistic effect, but that is just a theory.

 

[Fat]

What Tirzepatide dosage do you use? @HB_22

Yes I was correct the ratio was 5

“Tirzepatide was discovered by engineering GLP-1 activity into the GIP sequence. It is an imbalanced dual agonist in favor of GIPR over GLP-1R activity as the molecule shows equal affinity for the GIPR compared with native GIP but binds the GLP-1R with approximately 5-fold weaker affinity than native GLP-1."

thanks

 

[RoidZ]

Have tried both semaglutide and now 3 days into Retatrutide. Reta feels infinitely "cleaner" if thats the word. Hardly any sides and still good appetite suppression with some energy to boot.

 

[HB_22]

Interestingly retatrutide seems to be the only glucagon receptor agonist causing cardiac arrhythmia. At least from phase 2 studies I couldnt find any arrhythmias being reported for either survodutide nor mazdutide. So for people with pre existing afib or history of afib/cardiac arrhythmia it may be safer to take mazdutide or survodutide, if the person is looking for the glucagon effect?

 

[cmK9s33]

Interestingly retatrutide seems to be the only glucagon receptor agonist causing cardiac arrhythmia. At least from phase 2 studies I couldnt find any arrhythmias being reported for either survodutide nor mazdutide. So for people with pre existing afib or history of afib/cardiac arrhythmia it may be safer to take mazdutide or survodutide, if the person is looking for the glucagon effect?

Is there any data comparing the magnitude of glucagon agonism of the 3 drugs?

 

[Hopemore]

Hi, I think I accidentally took a little more than 15mg of tirzepatide this week, and the appetite suppression and delayed gastrjc emptying effects are back. I think I saw they are testing doses of up to 25mg. When might I be able to go up?

I started in May 23 (sw 228) and been at 15 since May of this year when I got down to 163. I think I’m probably back up to 170 now. I guess I need to start working out, which I have always hated. I take two antipsychotics and been on them for 15 years so my metabolism is wrecked.

I skip breakfast and lunch easily, but lately I have been snacking after dinner. I tried sema but i got very depressed, which I don’t know if it caused it or if it was a coincidence. But I’m scared to use it now. And I don’t want to try Reta if it’s causing heart problems. What else could I try if I can’t increase the tirz? Here’s a progress pic for reference..
View: https://imgur.com/a/ykT0iYc

 

[mochul]

Hi, I think I accidentally took a little more than 15mg of tirzepatide this week, and the appetite suppression and delayed gastrjc emptying effects are back. I think I saw they are testing doses of up to 25mg. When might I be able to go up?

I started in May 23 (sw 228) and been at 15 since May of this year when I got down to 163. I think I’m probably back up to 170 now. I guess I need to start working out, which I have always hated. I take two antipsychotics and been on them for 15 years so my metabolism is wrecked.

I skip breakfast and lunch easily, but lately I have been snacking after dinner. I tried sema but i got very depressed, which I don’t know if it caused it or if it was a coincidence. But I’m scared to use it now. And I don’t want to try Reta if it’s causing heart problems. What else could I try if I can’t increase the tirz? Here’s a progress pic for reference..
View: https://imgur.com/a/ykT0iYc

Maybe not a good idea to share your face on yhe forum.
You can try cagri, but start working out and it will certainly help