Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Sampei]

Im wondering what the ratio of GLP-1 to GIP to Glucagon for most of these twincretin and triplecretin drugs is. I am mostly interested in glucagon and GIP, with just a little glp-1.

I did a long search but it seems even pharma doesnt know.

So far I liked semaglutide the least. It's strong no doubt but energy level is kinda low, sex drive is low and the acid reflux is annoying. Tirzepatide is a lot better by far! I havent tried Retatrutide yet.

does glp-1 affect sex drive as well?

 

[Country Club Hero]

does glp-1 affect sex drive as well?

Not for me. I’ve used Semaglutide and Tirzepatide and much prefer Tirzepatide.

Zero issues affecting sex drive.

 

[Sampei]

Not for me. I’ve used Semaglutide and Tirzepatide and much prefer Tirzepatide.

Zero issues affecting sex drive.

why do you prefer the latter?

 

[HB_22]

any thoughts on this?

Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide​

Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide - PubMed

This study's findings suggest an association between semaglutide and NAION. As this was an observational study, future study is required to assess causality.

pubmed.ncbi.nlm.nih.gov

This is only temporary if I get that right?

 

[Sampei]

This is only temporary if I get that right?

Nope, when it happens it's permanent. No cure, nothing at all. You are literally fucked.

 

[Sampei]

any thoughts on this?

Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide​

Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide - PubMed

This study's findings suggest an association between semaglutide and NAION. As this was an observational study, future study is required to assess causality.

pubmed.ncbi.nlm.nih.gov

@Type-IIx can we have your opinion about this.

 

[JayDog]

great info on Semaglutide thanks..

 

[Type-IIx]

@Type-IIx can we have your opinion about this.

Diabetes causes neuropathy and retinopathy; the association was very weak in the nondiabetes cohort (1.8%); and this was epidemiological meaning incapable of assessing causation vs. tertiary factor cause.

I wouldn’t bother keeping one eye open about this.

 

[Doodle]

Week 3 maz 3mg done. Stuff is awesome. Still feels very strong. Lost another 4 pounds. No side effects.

 

[mochul]

Week 3 maz 3mg done. Stuff is awesome. Still feels very strong. Lost another 4 pounds. No side effects.

Is this your first glp-1 or have you used others?

 

[HB_22]

does glp-1 affect sex drive as well?

Semaglutid does for me. Tirzepatide is a lot better in this regards. Energy level is better on tirz as well.

 

[HB_22]

Im interested in testing survodutide. Mostly due to its action on glucagon. I hope its a weak glp-1 receptor agonist.

 

[mochul]

Im interested in testing survodutide. Mostly due to its action on glucagon. I hope its a weak glp-1 receptor agonist.

You don't want too much glucagon activation since it increases blood sugar and could cause muscle break down.

 

[Doodle]

Started week 5 today. Down another 5 pounds. I haven’t needed to increase my small dose of 3mg. No side effects still. It feels even stronger now. I’m assuming that it builds up in the system because it’s been stronger the more I used. I still put this way above tirze.

 

[HB_22]

You don't want too much glucagon activation since it increases blood sugar and could cause muscle break down.

Well, this is true but there are a couple more things that are of interest, especially in combination with glp-1.

During fasting euglycemia, administration of glucagon caused blood glucose to rise due to increased EGP, with a delayed increase of insulin secretion. When given during experimental hyperglycemia, glucagon caused a rapid, threefold increase in insulin secretion, as well as a more gradual increase in EGP. Under both conditions, insulin clearance was decreased in response to glucagon infusion. The insulinotropic action of glucagon, which is proportional to the degree of blood glucose elevation, suggests distinct physiologic roles in the fasting and prandial states.

Interestingly, coinfusion of both glucagon and GLP-1 provides a synergistic effect on insulin secretion in humans

, which supports evidence that glucagon can increase energy expenditure

Finally, glucagon has well-documented actions for lipid metabolism (25,82), providing additional benefit for targeting hepatic steatosis. Interestingly, the ability for glucagon to promote lipid catabolism over storage may intersect with the actions of glucagon to drive ketogenesis

 

[Captainpotatohead]

I’m curious to understand why so many people report better appetite suppression on sema over tirz ? I was under the impression tirz being a dual agonist should have a greater impact ?

 

[JG91]

Week 3 of Tirz. Using 3 mg divided into 1.5 mg twice a week. Not necessarily appetite suppression but delayed hunger, and I get full way faster. Lost about 2.5 lbs per. Honestly can't recommend it enough.

 

[HB_22]

I’m curious to understand why so many people report better appetite suppression on sema over tirz ? I was under the impression tirz being a dual agonist should have a greater impact ?

I don't know about other but I feel like appetite is less with tirzepatide. Overall tirz seems stronger and I feel better on it.

 

[SpicyMeatball]

I’m curious to understand why so many people report better appetite suppression on sema over tirz ? I was under the impression tirz being a dual agonist should have a greater impact ?

Sema hammers GLP receptors and calls it a day. Tirz hammers GIP receptors and just tickles GLP. So if you’re getting appetite suppression from the GLP action you’re going to get more of it from sema.

 

[HB_22]

Interesting what I found on Bloomberg. As it seems glp-1 combined with glucagon is very strong.