Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[egruberman]

By that definition, sex should be banned if you're under 25 because brain doesn't stop developing until then.

My suggesting that it's gross is wholly different than creating laws or suggesting that something be banned. There's no perfect answer as to what should be allowed by law. It's all a compromise, thus the example of it being tricky legal ground for someone that's say 18-20 having sex with someone that's 16-18 which in most cases, people would consider reasonable.

I feel like you have made up your mind that it's a one-way street and some women don't seek grown-ass men, maybe it was the other way around? You don't need to make adults into victims if they're not.

I didn't make anyone into a victim. You're projecting here. I stated that it was gross, specifically, for someone whom I believe wrote that they were 46yo. Regardless of the age of the smashee, bragging about it on the Internet is also gross. A gentleman does not do such things if for no other reason than the fact that one won't be able to get the wildest, uninhibited performance out of their partner, if that partner is concerned about someone trying to get some fucking cred on the Internet by bragging about it.

Also, you're presuming it was a girl. I was guessing it was some kind of daddy/boy thing.

 

[Stamkos]

Awesome. You guys turned a very good thread into another totally off topic thread full of insults. I thought I was reading QSCs thread for a second. I had to double check.

 

[RekTest]

Is there any literature on why 12.5mg for Tirz is the max dose?

Or is that just where the studies stopped at

 

[narta]

just slammed an 18yo

The only 18yr old you slammed is your hand.

And even that was getting grossed out by your ugly mug

@RekTest I think it was 15mg

 

[eryximachus]

The only 18yr old you slammed is your hand.

And even that was getting grossed out by your ugly mug

@RekTest I think it was 15mg

Hey don't insult my dachshund you indolent twat!

 

[eryximachus]

My suggesting that it's gross is wholly different than creating laws or suggesting that something be banned. There's no perfect answer as to what should be allowed by law. It's all a compromise, thus the example of it being tricky legal ground for someone that's say 18-20 having sex with someone that's 16-18 which in most cases, people would consider reasonable.



I didn't make anyone into a victim. You're projecting here. I stated that it was gross, specifically, for someone whom I believe wrote that they were 46yo. Regardless of the age of the smashee, bragging about it on the Internet is also gross. A gentleman does not do such things if for no other reason than the fact that one won't be able to get the wildest, uninhibited performance out of their partner, if that partner is concerned about someone trying to get some fucking cred on the Internet by bragging about it.

Also, you're presuming it was a girl. I was guessing it was some kind of daddy/boy thing.

I'm so glad my fire is still smoldering here.

 

[Ghoul]

My suggesting that it's gross is wholly different than creating laws or suggesting that something be banned. There's no perfect answer as to what should be allowed by law. It's all a compromise, thus the example of it being tricky legal ground for someone that's say 18-20 having sex with someone that's 16-18 which in most cases, people would consider reasonable.



I didn't make anyone into a victim. You're projecting here. I stated that it was gross, specifically, for someone whom I believe wrote that they were 46yo. Regardless of the age of the smashee, bragging about it on the Internet is also gross. A gentleman does not do such things if for no other reason than the fact that one won't be able to get the wildest, uninhibited performance out of their partner, if that partner is concerned about someone trying to get some fucking cred on the Internet by bragging about it.

Also, you're presuming it was a girl. I was guessing it was some kind of daddy/boy thing.

FYI I suggest you dig deeper into the viral "brain isn't fully developed until 25" nonsense.

Attractive to those attempting to remove responsibility, the fact is the brain is fully developed from a biological perspective well before that, around the time maximum height is reached.

After that, the brain continues to change in response to stimuli, nutrition, and other factors throughout life. You won't find any more significant changes between 20-25 than you would between 35-40, or 55-60.

With a lifespan well under 30 for the overwhelming majority of human existence this claim was patently idiotic from the start, but survived for social and political reasons.

Those who cling to this notion should be fierce advocates against pot legalization for those under 25, because if you "believe the science" the likelihood of a permanent intellectual deficit increases with use beginning at an earlier age. We can see on scans, we can measure it on tests.

 

[egruberman]

FYI I suggest you dig deeper into the viral "brain isn't fully developed until 25" nonsense.

All I have is the science to go by:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621648/pdf/ndt-9-449.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475802/pdf/nihms56148.pdf

Which suggests to me that the prefrontal cortex isn't typically fully developed until around age 25. That doesn't account for individual variability or emotional maturity or whatever, but otherwise seems pretty straightforward to me.

Also, why are so many papers on this topic behind a damn paywall?

 

[Ghoul]

All I have is the science to go by:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621648/pdf/ndt-9-449.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475802/pdf/nihms56148.pdf

Which suggests to me that the prefrontal cortex isn't typically fully developed until around age 25. That doesn't account for individual variability or emotional maturity or whatever, but otherwise seems pretty straightforward to me.

Also, why are so many papers on this topic behind a damn paywall?

Those two are the most oft quoted papers by anti-death penalty advocates, and a host of other "let them off the hook" policy advocates.

Plenty of more substantive science has pushed back against these assertions in the decade+ since.

https://www.sciencefocus.com/comment/brain-myth-25-development

Does The Brain Really Mature At The Age Of 25?

The human brain is a lot more complex than many people think.

www.iflscience.com

We can actually watch the prefrontal cortex volume increase and decrease over the course of just a year, shrinking from heavy pot use, for instance, and increasing when someone takes on a new challenging hobby.

 

[iris]

Hey don't insult my dachshund you indolent twat!

Lol.
There is a chance the gentleman was talking about your face, not the dog's.

Anyway, is he/she wearing a bandana?
There's that look in the dachshund' s eyes that says "I may or may not have been possessed by evil spirits".
I might be wrong, but I am usually quite good at identifying beings that are in need of some form of exorcism.

 

[egruberman]

Plenty of more substantive science has pushed back against these assertions in the decade+ since.

I invite you to supply those citations. Really, anything other than an opinion piece. We can argue about the implications, but the science seems pretty straightforward. Chrononeurogenesis exists and is proven by multiple studies (not listed) using MRI observations. The fact that the prefrontal cortex is the last to develop also seems pretty well settled.

For the prefrontal cortex, cortical thinning seems to peak around age 25 which represents a period of neural pruning. From what I can tell, that is generally consider the end stage of development for a particular section of the brain. Certainly, the brain remains a degree of plasticity throughout life and that plasticity can be preserved by various means.

 

[iris]

Those two are the most oft quoted papers by anti-death penalty advocates, and a host of other "let them off the hook" policy advocates.

Plenty of more substantive science has pushed back against these assertions in the decade+ since.

https://www.sciencefocus.com/comment/brain-myth-25-development

Does The Brain Really Mature At The Age Of 25?

The human brain is a lot more complex than many people think.

www.iflscience.com

We can actually watch the prefrontal cortex volume increase and decrease over the course of just a year, shrinking from heavy pot use, for instance, and increasing when someone takes on a new challenging hobby.

I am just seeing this now.
What is this relating to?

 

[roofer22]

At what age are men supposed to stop finding girls in their early 20s attractive?

Screaming "paedophile" is just a loser's cope, knowing if they had to go back out there at 40+, they have so little to offer their only options would be other men's used up leftovers.

As a 50 yo man I couldn't be attracted to women the same age as my kids. It's just gross to me, but to each there own as long as it's legal and consensual I suppose.

 

[Ghoul]

As a 50 yo man I couldn't be attracted to women the same age as my kids. It's just gross to me, but to each there own as long as it's legal and consensual I suppose.

I don't have kids. If you were single again, what's the most attractive thing you'd find about the 50-60 year old women you'd pursue?

At what age are men supposed to stop finding women in their 20s attractive?

Typically hear this kind of backhanded judgement from men for whom a young, attractive partner wouldn't be an option anyway, not you of course. The "consensual" comment and what it suggests is pretty vile, but since such a relationship is so far out of your realm of possibility, it's not surprising you can only imagine it's some sort of coerced, non-consensual slavery.

 

[narta]

MesoRx is probably THE internet spot, were middle aged men are banging the most 20yr olds in the entire planet. We have some of the best looking, rich, 12" wrapped-around-my-leg-penis bearing men in here. Not to mention they are the most intelligent beings that came out of a vagina.

I am really proud of you. Bang away!

P.S. Don't forget the moisturizer and the tissues or your special shock, or mommy will be angry and will kick you off the basement this time.

 

[Ghoul]

I am just seeing this now.
What is this relating to?

Nearly two decades ago there were a couple of weak, deeply flawed studies that suggest human cognition and the ability to responsibly make decisions doesn't happen until 25.

That until 25, the brain wasn't "fully developed".

These studies were pounced on ideologies and politicians who sought to change many policies, particularly around the age of criminal responsibility (but not the voting age),

That level of selective enthusiasm for "science" that confirms pre-existing ideological positions alone should raise suspicions.

A large number of neuroscientists have since countered this "brain doesn't mature until 25" as patently false, if not outright deceptive.

Perhaps the most glaring flaw, the seminal study on this issue stopped looking at brain changes after 25 (hint: it continues to change at the same pace).

In other words, they chose an arbitrary age, 25, and stopped looking at whether changes continued beyond that age, the. declared at 25 the brain was "fully developed".

 

[Ghoul]

MesoRx is probably THE internet spot, were middle aged men are banging the most 20yr olds in the entire planet. We have some of the best looking, rich, 12" wrapped-around-my-leg-penis bearing men in here. Not to mention they are the most intelligent beings that came out of a vagina.

I am really proud of you. Bang away!

P.S. Don't forget the moisturizer and the tissues or your special shock, or mommy will be angry and will kick you off the basement this time.

My mother's been dead for 27 years, but it's nice to know moving into the basement of yours provides a backstop for whatever unsatisfying, low paying, dead end career you have that brings you closer, day by day, to a miserable few hours on your death bed, lamenting what an unfulfilling life you've had.

Spoiler

(and if those weren't the thoughts that would've occupied your mind in those last hours, they are now)

 

[narta]

My mother's been dead for 27 years, but it's nice to know moving into the basement of yours provides a backstop for whatever unsatisfying, low paying, dead end career you have that brings you closer, day by day, to a miserable few hours on your death bed, lamenting what an unfulfilling life you've had.

Spoiler

(and if those weren't the thoughts that would've occupied your mind in those last hours, they are now)

If you come to my basement, esse, you WILL shit your pants, before your soul leaves your body willingly.

 

[Ghoul]

If you come to my basement, esse, you WILL shit your pants, before your soul leaves your body willingly.

I have no doubt. Grossly unsanitary conditions have always turned my stomach.

Is this your MO now? To follow me into threads you have no interest in to harass me, unprovoked?

(PS, he's characterized GLP users as worthless, weak trash, lacking the superior willpower he exhibits.)

 

[narta]

Grossly unsanitary conditions have always turned my stomach.

You got a point there. But we do hose it down at the end of operations. Not squeaky clean, but good enough.

To follow me into threads you have no interest in to harass me, unprovoked?

I just happened to respond to a forum post. If you feel harassed, well... sue me.

(PS, he's characterized GLP users as worthless, weak trash, lacking the superior willpower he exhibits.)

Au contraire. I have stated multiple times that glps are tools that can be used and should be used to help a person better themselves.

But if a person, after 7+ years of using them, is still a fat fuck, like some unnamed pos in here, it shows the true strength of character he has, which is none. And that usually translates to all parts of life, including work ethic, dedication, etc.

I REALLY DOUBT such an individual is successful in other aspects of his life.