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Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
6FootFatty
Member
I have a friend in China and he swears by Mazdutide. It is new, and trials have been done already in China. I think one of the Pharma companies actually submitted an application already for Mazdutide.
Like you, he said he didn't experience any side effects. He was trying Sema before and said he would never try it again given how he's reacted to Mazdutide.
So another promising GLP-1 on the horizon.
I believe it’s with Eli Lilly and innovent. The research seems to favor higher doses between 9-10mg. With that trial either just beginning or about to start. It’s got a long way to go but I’m glad to experiment in the meantime.
Edit: I’m feeling a huge energy change. Kind of like I drank a bunch of caffeine. I’ve been caffeine free for probably a year now so I might just be super sensitive.
intensedrive
New Member
How long does semaglutide last after reconstituted? I can't seem to find much information on this topic. Anyone have personal experience using a reconstituted vial after 30 days vs 60 days etc..
Thanks
Thanks
day 3 on mazdutide.
Pros- I’m really really not hungry. I’m drinking tons of water and feel so full. I feel like the hunger control is stronger than tirze 10-15mg.
Cons- I feel like I might be sick. I can’t tell if it was because I worked my ass off loading furniture in the sun yesterday or if it’s maz. I feel very tired and slightly nauseous. In this case, (if it is the maz), these are side effects I didn’t have on both sema and tirze. It’s not the worst thing ever.
Pros- I’m really really not hungry. I’m drinking tons of water and feel so full. I feel like the hunger control is stronger than tirze 10-15mg.
Cons- I feel like I might be sick. I can’t tell if it was because I worked my ass off loading furniture in the sun yesterday or if it’s maz. I feel very tired and slightly nauseous. In this case, (if it is the maz), these are side effects I didn’t have on both sema and tirze. It’s not the worst thing ever.
1 week Maz 3mg
Appetite suppression is awesome. I really think it’s better than tirze in that aspect.
I am very fatigued. I’m so tired. Adderall seems like it can’t cut through that energy barrier right now.
I feel slightly nauseated. Not so much that I need to throw up. Just a tiny bit uncomfortable.
The fatigue is not what I expected. It’s difficult to pack up for my move. I’ve got so much to go through and box up. Furniture to haul to the pod. Today is shot day and I don’t really want to do it. It’s still really strong. I’m thinking I’ll hold off and see if the fatigue changes. I don’t mind playing around with it.
Appetite suppression is awesome. I really think it’s better than tirze in that aspect.
I am very fatigued. I’m so tired. Adderall seems like it can’t cut through that energy barrier right now.
I feel slightly nauseated. Not so much that I need to throw up. Just a tiny bit uncomfortable.
The fatigue is not what I expected. It’s difficult to pack up for my move. I’ve got so much to go through and box up. Furniture to haul to the pod. Today is shot day and I don’t really want to do it. It’s still really strong. I’m thinking I’ll hold off and see if the fatigue changes. I don’t mind playing around with it.
mok4315
New Member
The fatigue is strong with all of them for me, even reta. I barely got my run and workout in this morning, now I’m just sitting here trying not to fall asleep. Good luck with the packing brother. I do not envy you.
roofer22
Well-known Member
Have you tried splitting the dose? Like 1mg M/W/F. I've done it with other drugs to minimize sides.
I might do this next week.
The fatigue is really strong. It’s almost like it’s getting more “potent” versus wearing off. I’m burping constantly. My stomach has been a little upset. I’m still nauseated. It’s not unbearable but I didn’t have any of these symptoms on sema and tirze.
I’m not constipated or have diarrhea but I’m having the gurgles in my intestines I think.
I’m going to weigh myself on Monday.
How has the experiment been thus far? I'm quite curious about the glucagon agonism aspect of the drug.
Oh and what dosing guidelines are you using? I cannot find the dosing schedule that available for all the other glp-1's.
Finished week 2 maz
I don’t think it was the maz that made me feel so sick last week. I had been accidentally skipping one of my rx medicines and I was in withdrawal. As soon as I refilled it and took it I felt instant relief. So this whole last week was much better. No side effects. I feel good. Fatigue is gone but I think that was my withdrawal.
I don’t have too much weight to lose but I’m down 7 pounds so far. Which is fine by me.
Appetite suppression is actually really good still towards the end of that week. I feel it’s getting stronger. This is not how I felt on sema or tirze.
This is turning out to be pretty neat. I’m continuing with 3mg for as long as I feel this way and it’s working.
I don’t think it was the maz that made me feel so sick last week. I had been accidentally skipping one of my rx medicines and I was in withdrawal. As soon as I refilled it and took it I felt instant relief. So this whole last week was much better. No side effects. I feel good. Fatigue is gone but I think that was my withdrawal.
I don’t have too much weight to lose but I’m down 7 pounds so far. Which is fine by me.
Appetite suppression is actually really good still towards the end of that week. I feel it’s getting stronger. This is not how I felt on sema or tirze.
This is turning out to be pretty neat. I’m continuing with 3mg for as long as I feel this way and it’s working.
mok4315
New Member
In what way do you mean it’s different from tirz? Just stronger appetite suppression and more energy?
mok4315
New Member
I felt it almost immediately. Started with a weird taste in my mouth, then several hours later noticed that I couldn’t eat lunch. That’s different now though. I’m generally ravenous for the first 24-48 hours after the injection (which works out for me because my goal is not to lose weight). Also if you started at 2.5mg, you might not notice anything until you jump to 5mg or the higher doses, especially if you’re male.
I will say Sema had no impact on me, even up to the 1mg dose, so I think it’s very individual.
Yes. Much stronger. The longevity is a good example. With tirze, I felt it wear off before the next injection. And it kept getting shorter and shorter. Tirze also had to be upped in dosage a lot. I still feel the energy and suppression is amazing. I feel it actually getting stronger. I am able to continue on a low dose past the week. It’s really hard to explain I think. It’s a different feeling but better
How is your experience going?
What other glp have you tried before?
HB_22
Well-known Member
Im wondering what the ratio of GLP-1 to GIP to Glucagon for most of these twincretin and triplecretin drugs is. I am mostly interested in glucagon and GIP, with just a little glp-1.
I did a long search but it seems even pharma doesnt know.
So far I liked semaglutide the least. It's strong no doubt but energy level is kinda low, sex drive is low and the acid reflux is annoying. Tirzepatide is a lot better by far! I havent tried Retatrutide yet.
I did a long search but it seems even pharma doesnt know.
So far I liked semaglutide the least. It's strong no doubt but energy level is kinda low, sex drive is low and the acid reflux is annoying. Tirzepatide is a lot better by far! I havent tried Retatrutide yet.
any thoughts on this?
pubmed.ncbi.nlm.nih.gov
Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide
Risk of Nonarteritic Anterior Ischemic Optic Neuropathy in Patients Prescribed Semaglutide - PubMed
This study's findings suggest an association between semaglutide and NAION. As this was an observational study, future study is required to assess causality.
pubmed.ncbi.nlm.nih.gov
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