MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
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egruberman
Member
Some evidence that semaglutide upregulates metabolism:
Sorry haven’t been online much.
Maz is amazing. I still haven’t increased my dose from 3mg. It gets stronger after 2 days which is pretty cool. I’ve lost a good 15 pounds so far. I’m rarely hungry. I feel great. I have zero side effects. I prefer it over tirze.
gainslol
New Member
Glad to hear, were you on a similar dose for the tirz?
TheHaus88
Member
If I didn't let you eat you would be mad too lol
playerdev2024
New Member
they're actually calming and seem to reduce anxiety.
HB_22
Well-known Member
Im using it for 4-5 weeks now. It's great, but with any glucagon receptor agonist you gotta make sure to have enough protein feedings, otherwise it will be very catabolic.
GrumpyBandersnatch
New Member
Anyone know if Cagri and its Amylin agonism would cancel out or weaken the effects of Reta Glucagon agonism?? I can’t remember if I heard it here or elsewhere that the two are not an ideal mix and that reta + Sema would be a more ideal stack.
GrumpyBandersnatch
New Member
Is there any literature on how much drugs that agonize glucagon receptors raise metabolic rate? I have reta on the way because it seems to beat out the current big 3 so no doubt its substantial, just curious.
in your experience, if you were to eat the same amount of calories on and off survo while keeping protein high to spare muscle, how much weight would you lose in a week?
I don’t think so. I might feel it early in the morning but that’s just because my insomnia meds make me groggy in the am. Then I take my prescribed adderall and im wide away and ready to go.
HB_22
Well-known Member
Not sure there is. There is only literature saying it raises EE, but not by how much. But see my answer below.
Well, I was on tirzepatide before. I went up to 7.5mg tirz a week, stalled, then slowly added survodutide with 1mg the first week, 2mg the 2nd week, went up to 3mg and stayed there. The first 2 weeks it increased my hunger by a lot. Like being ravenous hungry, I ate a lot more but kept my bodyweight the same. In week 3 I finally started to drop bodyweight.
So... I am eating more calories and started losing around 0.5kg per week in week 3 after adding survodutide.
egruberman
Member
Couple of new papers:
"Food noise" or the absence thereof and how it's dampened finally has some plauible scientific explanation:
pubmed.ncbi.nlm.nih.gov
They're calling lack of "food noise" preingestive satiation.
Apparently there are GIP receptors on fat cells and they've discovered that tirzepatide triggers the liberation of fatty acids from those fat cells. That is to say, it causes increased lipolysis:
"Food noise" or the absence thereof and how it's dampened finally has some plauible scientific explanation:
GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans - PubMed
Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective antiobesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to patients with obesity and observed a heightened sense of preingestive satiation. Analysis of human and...
pubmed.ncbi.nlm.nih.gov
They're calling lack of "food noise" preingestive satiation.
Apparently there are GIP receptors on fat cells and they've discovered that tirzepatide triggers the liberation of fatty acids from those fat cells. That is to say, it causes increased lipolysis:
egruberman
Member
Observed, but no real mechanism of action is identified:
Frontiers | Decreased Risk of Anxiety in Diabetic Patients Receiving Glucagon-like Peptide-1 Receptor Agonist: A Nationwide, Population-Based Cohort Study
Background: Previous findings on using Glucagon-like peptide-1 receptor agonist (GLP1-RA) as an antidepressant were conflicting, lacking large-scale studies....
www.frontiersin.org
Ghoul
Member
The same way any biologically rooted addiction that's satiated provides stress relief and lowers agitation. Nicotine patches for those trying to stop smoking, suboxone for opioid addicts, etc.
It's clear the mechanisms underlying addiction are linked, or perhaps "hijack" is more accurate, the brain's very potent and effective weight homeostasis mechanisms.
Clinical Trial on Semaglutide Shows Promise for Treatment of Alcohol Use Disorder, Warrants Further Trials | Newsroom
Christian Hendershot, PhD, associate professor of psychiatry and director of the Clinical and Translational Addiction Research Program at the UNC School of Medicine, presented early findings from the first completed randomized controlled trial of semaglutide for reducing alcohol consumption in...
news.unchealthcare.org
Ghoul
Member
I noticed the "anti-compulsive behavior" effect years ago, and from casual observation to more detailed studies on specific addictions, there's an avalanche of evidence this is in fact the case. Whether it's chemical dependency, or something as abstract as compulsive shopping.
At the risk of straying too far to the edge of the kind of hypothesis most people can accept, I'm going to lay down a marker right here and say it even lessens the effects of certain aspects of the set of emotions we group together as "love". I'm not suggesting it kills off love for other people, but I think it changes the nature of it.
As was said at a major international Cardiology conference a week ago, "increasingly weight loss is going to be seen as a side effect of these drugs.".
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