Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Avies48]

I noticed the "anti-compulsive behavior" effect years ago, and from casual observation to more detailed studies on specific addictions, there's an avalanche of evidence this is in fact the case. Whether it's chemical dependency, or something as abstract as compulsive shopping.

At the risk of straying too far to the edge of the kind of hypothesis most people can accept, I'm going to lay down a marker right here and say it even lessens the effects of certain aspects of the set of emotions we group together as "love". I'm not suggesting it kills off love for other people, but I think it changes the nature of it.

As was said at a major international Cardiology conference a week ago, "increasingly weight loss is going to be seen as a side effect of these drugs.".

Sooo IF i help a chick lose weight with this she will eventually, if she hasnt already, stop loving me… oh FFS… she can stay chunky then hahaha

Or it will allow me to move away and get down ta bidness… like a peeiuuump…P.I.M.P

 

[Ghoul]

Sooo IF i help a chick lose weight with this she will eventually, if she hasnt already, stop loving me… oh FFS… she can stay chunky then hahaha

Or it will allow me to move away and get down ta bidness… like a peeiuuump…P.I.M.P

Let me tell ya brother, help *any* chick look better and you can expect her to start exploring her options.

(same thing goes for a guy who suddenly becomes much more successful, ie, the woman left after supporting the loser through medical school is a classic)

There are more than a few stories of guys dragging new girlfriends to the gym and losing them shortly thereafter.

One of my business mentors came from the fashion industry and taught me enough of the basics that I've been able to help a few girls in my life significantly upgrade their look.

If you're gong to do that, you'd better carry yourself with massive self confidence, because if you don't behave like you're unquestionably her best option she's going to decide it's time to try her luck at an upgrade.

 

[explodingHeart]

Let me tell ya brother, help *any* chick look better and you can expect her to start exploring her options.

(same thing goes for a guy who suddenly becomes much more successful, ie, the woman left after supporting the loser through medical school is a classic)

There are more than a few stories of guys dragging new girlfriends to the gym and losing them shortly thereafter.

One of my business mentors came from the fashion industry and taught me enough of the basics that I've been able to help a few girls in my life significantly upgrade their look.

If you're gong to do that, you'd better carry yourself with massive self confidence, because if you don't behave like you're unquestionably her best option she's going to decide it's time to try her luck at an upgrade.

When a woman gets fat, it destroys her titties. Basically makes them stretch mark ridden which can be seen very visibly when she leans down. Then they'll look like two socks filled with loose change, stapled to her chest.

I don't think for women (and to a certain extent, men) you can really "get hot" after they've been fat.

 

[Ghoul]

When a woman gets fat, it destroys her titties. Basically makes them stretch mark ridden which can be seen very visibly when she leans down. Then they'll look like two socks filled with loose change, stapled to her chest.

I don't think for women (and to a certain extent, men) you can really "get hot" after they've been fat.

Yeah stretch marks are permanent, more or less, but when they're young enough and not sun fried skin is plenty elastic to snap back up to about 50lbs overweight. Besides I've got my own collection of scars from bacne, surgeries from various mishaps, even a small superficial shrapnel wound.

That's said my type are fit enough from the start. Stupid and excessive makeup and nearly no sense of style fundamentals is an epidemic though. Luckily, unlike putting your life at risk by suggesting they could lose a few pounds, no woman turns down the gift of a spa day, hair stylist, manicure and the offer to be taken clothes shopping.

 

[Avies48]

Let me tell ya brother, help *any* chick look better and you can expect her to start exploring her options.

(same thing goes for a guy who suddenly becomes much more successful, ie, the woman left after supporting the loser through medical school is a classic)

There are more than a few stories of guys dragging new girlfriends to the gym and losing them shortly thereafter.

One of my business mentors came from the fashion industry and taught me enough of the basics that I've been able to help a few girls in my life significantly upgrade their look.

If you're gong to do that, you'd better carry yourself with massive self confidence, because if you don't behave like you're unquestionably her best option she's going to decide it's time to try her luck at an upgrade.

I hope this dht cream reaaaly does the trick on there ol stick then hahaha

 

[egruberman]

It's clear the mechanisms underlying addiction are linked

If by clear, you mean that there is an observed effect with some theories about why, then sure.

no woman turns down the gift of a spa day, hair stylist, manicure and the offer to be taken clothes shopping.

My life would be improved if you never again on this forum mention your opinions about relationships and women.

 

[Ghoul]

If by clear, you mean that there is an observed effect with some theories about why, then sure.

No one here is presenting a thesis.

However, when a single compound has such widespread, common observations (in medical blogs, professional journals, not forums or reddit, etc) regarding impacts on compulsive behavior as disparate as food, gambling, and alcohol, and that the subset tested thus far in high quality studies are only further confirmed, that's good enough for me to characterize it as "clearly linked" in an informal forum. I don't need to wait for someone to establish the mechanism by which this is occurring at the atomic level.

My life would be improved if you never again on this forum mention your opinions about relationships and women.

I'm sure it would be. I'm not surprised it wouldn't be appreciated by what I strongly suspect is a Guardian reader's sensibilities.

I mean this respectfully, feel free to be your own moderator and ignore me. There's no chance I'm changing what I choose to post in response to negative feedback. If I was that susceptible to influence, I would've run from here long ago.

 

[GrumpyBandersnatch]

Is there any literature on how much drugs that agonize glucagon receptors raise metabolic rate? I have reta on the way because it seems to beat out the current big 3 so no doubt its substantial, just curious.

in your experience, if you were to eat the same amount of calories on and off survo while keeping protein high to spare muscle, how much weight would you lose in a week?

Just incase anyone else was interested in the thermogenic effects of GCgR agonism. Found a study on PubMed that states:

“In humans, acute infusion of glucagon (45 min to 210 min, 3-50 ng/kg/min) raises caloric expenditure on average by 200 kcal/day in lean and obese fasted subjects (51, 52, 68)” (Is Glucagon Receptor Activation the Thermogenic Solution for Treating Obesity?)

A 135kg person receiving 50ng/kg/min over the course of 210 minutes would be getting ~1.5mg of Glucagon.

Now this is actual glucagon administered acutely and not Reta or Survo, but seeing as the trials go up to 12mg of reta I feel like the numbers could be comparable though obviously I have no proof.

200 Calories a day is 1400 calories a week, which is 40% of a pound of fat (3500 calories). So clearly Gcgr receptor agonism alone is very potent. If reta/survo can cause similar numbers in addition to the GLP/GIP benefits that is very impressive (which of course is not news, the results speak for themselves just thought it might interest some others to see some related numbers and the study for further reading).

 

[egruberman]

However, when a single compound has such widespread, common observations (in medical blogs, professional journals, not forums or reddit, etc) regarding impacts on compulsive behavior as disparate as food, gambling, and alcohol, and that the subset tested thus far in high quality studies are only further confirmed, that's good enough for me to characterize it as "clearly linked" in an informal forum. I don't need to wait for someone to establish the mechanism by which this is occurring at the atomic level.

I'm wondering if you also have reading comprehension issues. It's clear there's an effect. That's undeniable. The original question was "How so?" and the answer to that is undetermined. There are various hypotheses, but nobody has done the research that I can tell.

I'm sure it would be. I'm not surprised it wouldn't be appreciated by what I strongly suspect is a Guardian reader's sensibilities.

You misunderstand my motivations. I have respect for your intellectual capacity and your reasoning, which is why I don't have you on ignore. Unfortunately, you've yet to mature both in emotion and in your reasoning. My life would be improved because I have only so much appetite for asinine bullshit.

There's no chance I'm changing what I choose to post in response to negative feedback.

Consider it constructive feedback. Not only would my life be improved, but yours would as well.

 

[HB_22]

200 Calories a day is 1400 calories a week, which is 40% of a pound of fat (3500 calories). So clearly Gcgr receptor agonism alone is very potent. If reta/survo can cause similar numbers in addition to the GLP/GIP benefits that is very impressive (which of course is not news, the results speak for themselves just thought it might interest some others to see some related numbers and the study for further reading).

Interesting! This would match the 0.5kg/week of bodyweight loss since I added survodutide.

 

[TheHaus88]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

- A Chinese vendor
- Non but I have a script for wegovy, my insurance shit the bed back in July and PA is denied for everyone now.
- 0.25mg
- 6 weeks then stopped
- Lost over 20 pounds
- Gastro paralysis
- Injection
- No bloods

Great appetite suppression

Stacked with Tirz also.

Took a break now back on Tirz only.

 

[Country Club Hero]

When a woman gets fat, it destroys her titties. Basically makes them stretch mark ridden which can be seen very visibly when she leans down. Then they'll look like two socks filled with loose change, stapled to her chest.

I don't think for women (and to a certain extent, men) you can really "get hot" after they've been fat.

Socks with loose change stapled to her chest lol. If you made that phrase up please post more

 

[Avies48]

- A Chinese vendor
- Non but I have a script for wegovy, my insurance shit the bed back in July and PA is denied for everyone now.
- 0.25mg
- 6 weeks then stopped
- Lost over 20 pounds
- Gastro paralysis
- Injection
- No bloods

Great appetite suppression

Stacked with Tirz also.

Took a break now back on Tirz only.

How was that gastro paralysis? How did it act? Just numbness or ibs type sides?

 

[TheHaus88]

How was that gastro paralysis? How did it act? Just numbness or ibs type sides?

I could literally feel the food wasn't moving and freaked me out to be honest.

First injection it was very uncomfortable. I may have taken too much because the peptide may not have been fully diluted before injection. Probably could have left it overnight but I was in a hurry.

I could feel the chemical creeping up in my brain over the course of an hour for the first time. I felt so full to the point of nausea for over 4 to 5 hours at a time after each injection after that first injection. It reminded me of M2 nausea.

I could barely eat anything but I knew I had to put food in my body, my brain kept telling me I need to eat when my body was saying no. I was on liquids and crackers for the first two weeks.

When I started to reintroduce regular food I couldn't. I could barely eat one meal a day and it was very small. I felt over full after eating the entire time no matter how small the meal was.

By day three or four of trying to eat normal meals and nothing was coming out. I tried force feeding a little just to get the food to come out. Drank lots of water but didn't seem to help flow movements. Food shouldn't be stuck in your body.

Tirz is something else. Food moves lol

I had IBS issues prior to GLP-1s. Sem and Tirz felt different than IBS.

 

[Hopemore]

When a woman gets fat, it destroys her titties. Basically makes them stretch mark ridden which can be seen very visibly when she leans down. Then they'll look like two socks filled with loose change, stapled to her chest.

I don't think for women (and to a certain extent, men) you can really "get hot" after they've been fat.

And I can very visibly see why your only interactions with boobs are when an unsuspecting woman has to bend over in your presence

 

[Clover 0080]

When a woman gets fat, it destroys her titties. Basically makes them stretch mark ridden which can be seen very visibly when she leans down. Then they'll look like two socks filled with loose change, stapled to her chest.

I don't think for women (and to a certain extent, men) you can really "get hot" after they've been fat.

its called get a breast reduction in the middle of losing weight so your still a little chunky and qualify for insurance paid reduction surgery. Then shred the rest of your weight. Boobies will still look fabulous because of the surgical lift that comes with a reduction. Even if you dont need a reduction do it for the paid lift alone. Drs will only take away as much fat as they think they should (which wouldnt be alot if your not that big to begin with.)

thats how i lost 98 pounds, went from a DDD to a C and they are just as perky as the day i grew them. but timing is crucial because once you lose too much weight your boobs will get smaller and you will no longer qualify for a paid reduction BUT if you do the reduction before significant weight loss they WILL get saggy even after the surgery.
I started at 236 and i went in for the consultation at 188 lbs. Once the insurance approved it i put the surgery off until i lost even more weight because they cant take back their decision. The surgeon will just adjust his plans on how much was taken off. Did the surgery at around 150ish and now im 138 and my girls dont look like chewed gum.

 

[eryximachus]

- Gastro paralysis

What is this exactly?

My botox place is offering sema for $600 per month and considering doing it. But this sounds scary af.

 

[HB_22]

What is this exactly?

My botox place is offering sema for $600 per month and considering doing it. But this sounds scary af.

Sema for 600$ a month? You know sema is dirt cheap, right? Like 5-20$ a month even at higher doses.

 

[eryximachus]

Sema for 600$ a month? You know sema is dirt cheap, right? Like 5-20$ a month even at higher doses.

I can afford $600. $20/mo sounds like black market. Which is fine, I'm just trying to stick to the straight and narrow while I get back into bodybuilding.

I'm just trying to figure out if sema is a good way to quickly lose excess bodyfat with minimal sides while you start to get back into the game.

Gastro paralysis sounds scary? Wtf does this mean? You can't shit?

 

[Ghoul]

What is this exactly?

My botox place is offering sema for $600 per month and considering doing it. But this sounds scary af.

True gastroparesis is a non-issue unless you're a diabetic.

GLP slows gastric emptying. In other words, the speed food is moved through your system for digestion, via contractions.

Because of this slowing, unless you stay sufficiently hydrated and get enough fiber, you can get severe constipation. This, along with food "backing up" causing acid reflux, leads some hysterics to think they have gastroparesis.

Especially when starting, or increasing the dose, this slowed digestion tends to kick in before appetite suppression, so if you're eating your "normal" quantity of food, the symptoms are made worse.

Simply stay well hydrated, and use a fiber supplement like a glass of Metamucil daily (before starting a GLP) will prevent this from happening, because it keeps things "moving" more easily.

True gastroparesis requires nerve damage that weakens the muscles used in digestion, or some other extremely rare cause like eating some object that causes a permanent blockage.

Diabetics often have some degree of neuropathy, and get gastroparesis fairly frequently. Because Ozempic was primarily used by this population, the slowing of gastric emptying combined with pre-existing nerve damage, was enough to push them into gastroparesis.

Don't let the fear mongers scare you off. You're more likely to suffer from the illnesses GLPs prevent by not using it than any life threatening side effect. Tens of millions of people have used these meds, with hundreds of millions of "patient years" of clinical experience, and there's only been ONE fatality of a non-diabetic associated with this class of meds.