Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Ghoul]

You got a point there. But we do hose it down at the end of operations. Not squeaky clean, but good enough.

I just happened to respond to a forum post. If you feel harassed, well... sue me.

Au contraire. I have stated multiple times that glps are tools that can be used and should be used to help a person better themselves.

But if a person, after 7+ years of using them, is still a fat fuck, like some unnamed pos in here, it shows the true strength of character he has, which is none. And that usually translates to all parts of life, including work ethic, dedication, etc.

I REALLY DOUBT such an individual is successful in other aspects of his life.

While the unsubstantiated opinion of a man with a posting history that exhibits deep thoughts and a range of experience so broad he's got to turn in his passport twice a year after running out of pages, stings, I just need to correct you on a couple of minor points.

GLP hormones correct a dysfunction, either insufficient production of, or insensitivity to natural GLP production. They're not "diet pills in a syringe", a simpleton's take on how the body's energy regulation system works.

So your question would be equally valid for a diabetic "when are you going to control your blood sugar through willpower, and stop using the crutch of this external insulin hormone?".

Or equally valid, "When is Narta going to exhibit the true natural product of his lack of willpower and the disappointing genetic legacy handed to him, and stop using extraneous androgenic hormones, simulating the biology of men who chose their parents much more carefully?"

 

[OilCarrier]

i am curious what all of your experiences with retatrutide are.
Most peptide shops charge crazy amounts for a vial however.

 

[narta]

While the unsubstantiated opinion of a man with a posting history that exhibits deep thoughts and a range of experience so broad he's got to turn in his passport twice a year after running out of pages

So having an opinion and knowledge through google-fu makes you a citizen of the world that needs to check his passport twice every year because he runs out of pages? What do you do, stamp a page, each time you visit a server outside sweet home Alabama? Get a grip boi...

GLP hormones correct a dysfunction, either insufficient production of, or insensitivity to natural GLP production.

Agreed. That's why I called them tools. You use a tool to fix a problem. After 7+ years of fixing said problem you should AT LEAST have some kind of control over said problem. That's what scientific literature says anyways, that over a period of a year, the majority of subjects that used glps for loosing weight had an average reduction of 15%. I suppose extrapolating over that data would yield, that after 7 FUCKING YEARS they should have hit their ideal weight. So if that unnamed lazy pos couldn't, it means that there is an underlying condition that prevents him to be the average glp user. I theorize it's his lack of discipline and he doesn't know how to put a zipper over his cornhole for a mouth.

So your question would be equally valid for a diabetic "when are you going to control your blood sugar through willpower, and stop using the crutch of this external insulin hormone?".

No, but my question would have been: when will you be able to have somewhat controlled blood sugar levels while using insulin? Cause the majority of diabetics that use insulin can do that, so you are missing something...

When is Narta going to exhibit the true natural product of his lack of willpower and the disappointing genetic legacy handed to him

Sorry to disappoint you, but I was 220lbs at 17yrs old at 6'2" with adequate strength to drag an old Fiat Mini cooper sideways by my bare hands. Exogenous hormones just help me maintain and even add a bit at 50yrs+

 

[narta]

i am curious what all of your experiences with retatrutide are.
Most peptide shops charge crazy amounts for a vial however.

On paper its superior to Tirz. IRL it skyrockets rhr for most people.

 

[Ghoul]

i am curious what all of your experiences with retatrutide are.
Most peptide shops charge crazy amounts for a vial however.

Consider you should plan to use this class of meds indefinitely. While Reta will come down eventually, per dose Sema is far cheaper and Tirz is pretty inexpensive as well. I would only use Reta if the other two can't get you where you want to be. Perhaps the only other factor might be that Tirz has a far gentler side effect profile and some additional non-weight loss health benefits over Sema, particularly when it comes to liver health.

 

[OilCarrier]

On paper its superior to Tirz. IRL it skyrockets rhr for most people.

thanks. I plan to take reta in a low dose, non appetite suppressing. I want it for the health benefits, not for the dry look. Rhr boost happens also in microdoses?

Consider you should plan to use this class of meds indefinitely. While Reta will come down eventually, per dose Sema is far cheaper and Tirz is pretty inexpensive as well. I would only use Reta if the other two can't get you where you want to be. Perhaps the only other factor might be that Tirz has a far gentler side effect profile and some additional non-weight loss health benefits over Sema, particularly when it comes to liver health.

You mean it is a must to remain on?

 

[Ghoul]

thanks. I plan to take reta in a low dose, non appetite suppressing. I want it for the health benefits, not for the dry look. Rhr boost happens also in microdoses?

You mean it is a must to remain on?

thanks. I plan to take reta in a low dose, non appetite suppressing. I want it for the health benefits, not for the dry look. Rhr boost happens also in microdoses?

You mean it is a must to remain on?

Nothing is a "must" remain on. However, for weight control purposes consider the way these drugs work. Your metabolism has a "weight thermostat". Above that setting appetite suppression increases, pushing weight down, below that setting, appetite increases pushing you back up.

GLP meds lower the setting of that "energy homeostasis thermostat". Once you reach goal weight, you stay on a "maintenance dose". You don't experience any appetite suppression at that dose unless you regain weight. Just like the natural weight regulation mechanism.

Stop using, and the setting will return to where it was before.

This is how the pharma instructions for these meds has always been.

Now that said, there are MANY health benefits to staying on long term, that have nothing to do with weight. GLP receptors are everywhere, and wherever they're activated they seem to provide health benefits. From reversing harmful changes to the heart, to reducing inflammation in the blood vessels, making them less "sticky" to plaque. They also reduce brain inflammation, slowing the long term damage associated with aging, protecting you from alzheimer's.

Finally, there is some evidence that after a long enough period, the "thermostat" stays lower for good, so you won't necessarily gain all the weight back, but with short term use, it's almost certain, other than the moderate loss you might keep from developing healthier eating habits many do once the pressure of a potent appetite is lowered.

 

[BuildABro]

GLPs don’t teach an individual how to eat properly, how to train, recovery, sleep hygiene, etc. etc.

A fatty on GLP drugs who does not make these type of important lifestyle changes to go along with it is destined to be a fatty again. Only a matter of time.

 

[Ghoul]

GLPs don’t teach an individual how to eat properly, how to train, recovery, sleep hygiene, etc. etc.

A fatty on GLP drugs who does not make these type of important lifestyle changes to go along with it is destined to be a fatty again. Only a matter of time.

Having the pressure of a powerful appetite taken off allows most people to focus on making better choices, including beginning to exercise and focusing on other aspects of their health. This is being widely observed across healthcare, food, and fitness industries.

Everyone experiences appetite pressures differently based on their biology.

Plenty of rail thin complete losers who aren't "full of willpower", they just have a lower drive to eat.

 

[OilCarrier]

GLPs don’t teach an individual how to eat properly, how to train, recovery, sleep hygiene, etc. etc.

A fatty on GLP drugs who does not make these type of important lifestyle changes to go along with it is destined to be a fatty again. Only a matter of time.

there is actually an argument to be made for the psychological effect these medicines can have in the sense that you are automatically opting more for nutrient/protein dense foods that digest easier, or are the 'right' choice for you. Which could be a nudge in the right direction.

Nothing is a "must" remain on. However, for weight control purposes consider the way these drugs work. Your metabolism has a "weight thermostat". Above that setting appetite suppression increases, pushing weight down, below that setting, appetite increases pushing you back up.

GLP meds lower the setting of that "energy homeostasis thermostat". Once you reach goal weight, you stay on a "maintenance dose". You don't experience any appetite suppression at that dose unless you regain weight. Just like the natural weight regulation mechanism.

Stop using, and the setting will return to where it was before.

This is how the pharma instructions for these meds has always been.

Now that said, there are MANY health benefits to staying on long term, that have nothing to do with weight. GLP receptors are everywhere, and wherever they're activated they seem to provide health benefits. From reversing harmful changes to the heart, to reducing inflammation in the blood vessels, making them less "sticky" to plaque. They also reduce brain inflammation, slowing the long term damage associated with aging, protecting you from alzheimer's.

I love this. These effects were exactly why my intention is to perhaps run reta year round in a low dose.

Finally, there is some evidence that after a long enough period, the "thermostat" stays lower for good, so you won't necessarily gain all the weight back, but with short term use, it's almost certain, other than the moderate loss you might keep from developing healthier eating habits many do once the pressure of a potent appetite is lowered.

Since i dont plan to take it for weight loss goals, but rather building muscle more healthily, would the above mean someone would be having trouble bulking in the future if they were to stay on for longer periods?

 

[Ghoul]

there is actually an argument to be made for the psychological effect these medicines can have in the sense that you are automatically opting more for nutrient dense foods that digest easier, or the 'right' choice. Which could be a nudge in the right direction.

These guys aren't interested in the science.

After spending a lifetime believing in their superiority being behind maintaining a certain weight, to be shown that factors outside of an individual's control play a large part (not ALL) is not what they want to hear.

You're a cheater, using external hormones to compensate for not producing sufficient amounts naturally to achieve the body you want. You don't deserve it.

Meanwhile, they inject life shortening illegal drugs to compensate for not producing enough androgenic hormones, and their unwillingness to make the sacrifices necessary to get to the body they want.

More chicken breast and plates, cheaters.

 

[Sampei]

there is actually an argument to be made for the psychological effect these medicines can have in the sense that you are automatically opting more for nutrient/protein dense foods that digest easier, or are the 'right' choice for you. Which could be a nudge in the right direction.



I love this. These effects were exactly why my intention is to perhaps run reta year round in a low dose.

Since i dont plan to take it for weight loss goals, but rather building muscle more healthily, would the above mean someone would be having trouble bulking in the future if they were to stay on for longer periods?

You can't bulk on GLP.

How I know? Because I tried it and I failed hard.

If you are bodybuilder the only way you gonna use a glp is when you cutting and want the fantastic help of nuking your appetite, end of story.

If you ain't a BB yeah I would use a GLP for the health benefits.

 

[DECLAN]

These guys aren't interested in the science.

After spending a lifetime believing in their superiority being behind maintaining a certain weight, to be shown that factors outside of an individual's control play a large part (not ALL) is not what they want to hear.

You're a cheater, using external hormones to compensate for not producing sufficient amounts naturally to achieve the body you want. You don't deserve it.

Meanwhile, they inject life shortening illegal drugs to compensate for not producing enough androgenic hormones, and their unwillingness to make the sacrifices necessary to get to the body they want.

More chicken breast and plates, cheaters.

There goes your arguments again, nobody is against using glps, they’re simply saying you need to make nutritional and lifestyle changes to see real progress.

Show us your progress just using glps, I would have stopped calling your bullshit if you have shown me a progress pic displaying your fatloss just using these drugs alone. But you can’t because you’re still obese even after almost a decade on these drugs.

You are not the best guy to call out other people because you failed in using this products.

@OilCarrier You are better off looking at the logs of Oakley7565, Dirthand and Scruff, they have pictures and data on their diets, lifestyle changes, exercise protocols and supplementations to change their body compositions.

Pictures paint a thousand different words, don’t listen to me either, but instead go peruse the logs and transformation process these successful individuals and mimic what can be applicable to you.

There is no magic pill or injectable yet, maybe they’re close but until then to progress you need consistency, dedication and hard work. Aside from the health risks from these drugs you need to be aware of wrong advices that give you false hope too.

Good luck.

 

[OilCarrier]

You can't bulk on GLP.

How I know? Because I tried it and I failed hard.

If you are bodybuilder the only way you gonna use a glp is when you cutting and want the fantastic help of nuking your appetite, end of story.

If you ain't a BB yeah I would use a GLP for the health benefits.

I meant: will users have problems bulking when off, due to the supposed long lasting lower thermostat effect after prolonged use of reta in low doses?

@OilCarrier You are better off looking at the logs of Oakley7565, Dirthand and Scruff, they have pictures and data on their diets, lifestyle changes, exercise protocols and supplementations to change their body compositions.

Pictures paint a thousand different words, don’t listen to me either, but instead go peruse the logs and transformation process these successful individuals and mimic what can be applicable to you.

There is no magic pill or injectable yet, maybe they’re close but until then to progress you need consistency, dedication and hard work. Aside from the health risks from these drugs you need to be aware of wrong advices that give you false hope too.

Good luck.

Thanks for the pointers, i will take everything into account. Note, i am already lean and muscular, but only interested in retatrutide for the health benefits it could give me which seem to be enormous.
So I don't really mind any body composition pretense that has or has not been given.

I will try to see how a dose of about 1mg a week, microdosed long term will improve my health, and if there is any effect at all.

 

[Sampei]

I meant: will users have problems bulking when off, due to the supposed long lasting lower thermostat effect after prolonged use of reta in low doses?

I don't really believe in any of that thermostat long term etc. but you ain't using the GLP for so long lol..I mean if you are a BB you are bulking or recomping most of the time and cutting just one or twice a year. So your question makes no sense as you ain't gonna get any permanent effect even if there were any

 

[DECLAN]

I meant: will users have problems bulking when off, due to the supposed long lasting lower thermostat effect after prolonged use of reta in low doses?

The main problem when using glps if your aim is to build muscle is gastric emptying and appetite suppression. How can you put on muscle if you can’t eat because you’re still full?

You need to be in caloric surplus to add muscle hence, glps are optimal in fat loss phase not on gain phasesz

 

[narta]

but only interested in retatrutide for the health benefits it could give me which seem to be enormous.

Opt for tirz. It has some science that backs up the health benefits on low dosages.1mg-3mg should be more than enough that will not cut into your appetite

 

[OilCarrier]

Opt for tirz. It has some science that backs up the health benefits on low dosages.1mg-3mg should be more than enough that will not cut into your appetite

thanks. so you would advise against reta? I had my mind set on that since the health benefits seem to be the most prevalent with that compound.

 

[Ghoul]

There goes your arguments again, nobody is against using glps, they’re simply saying you need to make nutritional and lifestyle changes to see real progress.

Show us your progress just using glps, I would have stopped calling your bullshit if you have shown me a progress pic displaying your fatloss just using these drugs alone. But you can’t because you’re still obese even after almost a decade on these drugs.

You are not the best guy to call out other people because you failed in using this products.

@OilCarrier You are better off looking at the logs of Oakley7565, Dirthand and Scruff, they have pictures and data on their diets, lifestyle changes, exercise protocols and supplementations to change their body compositions.

Pictures paint a thousand different words, don’t listen to me either, but instead go peruse the logs and transformation process these successful individuals and mimic what can be applicable to you.

There is no magic pill or injectable yet, maybe they’re close but until then to progress you need consistency, dedication and hard work. Aside from the health risks from these drugs you need to be aware of wrong advices that give you false hope too.

Good luck.

"Health risks". What we see is an avalanche of health benefits. We have 30 years of clinical experience, with tens of millions of users, and hundreds of millions of "use years" of GLPs, and outside of a few rare concerns, and "bros" lighting candles in the hope eyeballs will fall out, or cancer will sprout out of fatty dick, the overwhelming, undeniable result of literally thousands of studies, is this HORMONE, because that's what a GLP is, will do more to extend human life and reduce disease than any other medical advance since antibiotics.

You still smoking bro? That's good for 20 pounds of weight loss, but worse for your health than 100 extra.

I was thinking of your long term health when I saw this.

Association of Semaglutide With Tobacco Use Disorder in Patients With Type 2 Diabetes : Target Trial Emulation Using Real-World Data - PubMed

National Institutes of Health.

pubmed.ncbi.nlm.nih.gov

We know for certain that GLPs reduce alcoholism, opioid addiction, and now it's looking like this may help you beat "Tobacco use disorder" (aka lack of willpower to avoid sucking on a fag, as the Brits would say), and save your kids from the toxins reeking off the smoke soaked clothing you bring into the house.

It seems most addictions hijaak the same mechanisms that control appetite, that's why GLPs reduce their intensity. It's diabolical really. Almost like addictions are so tough to kick because they're using one of the most powerful biological influencers of conscious behavior...

 

[narta]

thanks. so you would advise against reta? I had my mind set on that since the health benefits seem to be the most prevalent with that compound.

Reta does boost metabolism but the rhr elevation is a concern, personally. Tirz on the other hand seems to be the most gentle in terms of sides and that is what we want for long ass term use