Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Ghoul]

Thank you for chiming, I was hoping you would. Much info I have got at this point was from you and I didn't want to depart from practices you shown drug company's recommended.

These compounds are by far the fastest, most effective weight loss drugs ever developed. They only require a small amount of patience as the body adjusts to a higher level of GLP, but it does, and by following the pharma protocol you're nearly guaranteed to be successful at getting to your ideal weight, and with a maintainance dose, staying there for a lifetime.

Right now, her digestive system is going from 100 to 30 miles per hour in an instant, so the side effects are potent. Everything else in her metabolic system needs a little time to catch up and reregulate, but it will. Future increases in dose will cause some mild effects, temporarily, but it'll never be as bad as it is now. Once she gets to her goal weight, she'll feel nothing. People in the long term studies take the same (maintainance) dose for years, and overwhelmingly don't experience any side effects.

That's the "promised land" she'll eventually reach. For most, it's around 6 months.

In a sense she's lucky to be such a good responder. Many, especially males, feel no effect until reaching 7.5mg or higher and don't lose as high of a percentage rate of overall weight. Thats a combination of males having more receptors requiring activation to regulate to a lower weight, and the person to person variation in GLP insufficiency and need more of the hormone to get to the ideal level.

Beyond all of this, GLPs are "putting money in the bank" for better long term health. Almost all organs show evidence of direct beneficial effects from GLP receptor activation. Systemic inflammation is reduced. It protects against the development. of everything from arthritis to alzheimer's and heart disease. The nervous system in particular seems to gain significantly, protecting against the ravages of oxidation and general degradation, preserving vision and cognition.

 

[benfrankparkway]

These compounds are by far the fastest, most effective weight loss drugs ever developed. They only require a small amount of patience as the body adjusts to a higher level of GLP, but it does, and by following the pharma protocol you're nearly guaranteed to be successful at getting to your ideal weight, and with a maintainance dose, staying there for a lifetime.

Right now, her digestive system is going from 100 to 30 miles per hour in an instant, so the side effects are potent. Everything else in her metabolic system needs a little time to catch up and reregulate, but it will. Future increases in dose will cause some mild effects, temporarily, but it'll never be as bad as it is now. Once she gets to her goal weight, she'll feel nothing. People in the long term studies take the same (maintainance) dose for years, and overwhelmingly don't experience any side effects.

That's the "promised land" she'll eventually reach. For most, it's around 6 months.

In a sense she's lucky to be such a good responder. Many, especially males, feel no effect until reaching 7.5mg or higher and don't lose as high of a percentage rate of overall weight. Thats a combination of males having more receptors requiring activation to regulate to a lower weight, and the person to person variation in GLP insufficiency and need more of the hormone to get to the ideal level.

Beyond all of this, GLPs are "putting money in the bank" for better long term health. Almost all organs show evidence of direct beneficial effects from GLP receptor activation. Systemic inflammation is reduced. It protects against the development. of everything from arthritis to alzheimer's and heart disease. The nervous system in particular seems to gain significantly, protecting against the ravages of oxidation and general degradation, preserving vision and cognition.

Sounds good and I will provide this as encouragement as I pass it along to here. In the meantime I have read of some things that could perhaps help, ginger chews, alka seltzer, and I believe I can get some anti nausea medication from a family member who is pregnant.

 

[Ghoul]

Sounds good and I will provide this as encouragement as I pass it along to here. In the meantime I have read of some things that could perhaps help, ginger chews, alka seltzer, and I believe I can get some anti nausea medication from a family member who is pregnant.

Whatever you do, don't start messing with the dose or timing.

And Metamucil. That'll help with the worst of the effects more than anything, in my opinion. It'll take a few days to start working, but for most who've tried it, they stick with that even if they stop taking GLPs. It's just natural fiber from the psyllium flower, but what it does for you in the bathroom is amazing. It corrects constipation and the opposite, making things much more pleasant while digestion is in turmoil.

 

[Avies48]

Sounds good and I will provide this as encouragement as I pass it along to here. In the meantime I have read of some things that could perhaps help, ginger chews, alka seltzer, and I believe I can get some anti nausea medication from a family member who is pregnant.

So there are pct sources where u can buy the anti nausea meds zofran : Ondansetron is what the scientific name is…

Also….

I respond well to meds and a lot of times i
cannnoottt take the starting dosage regardless of what the docs state the starting dosage should be… everyone is different… im trying to to talk my wife into starting lower than the recommended 2.5 mlg per week…. Because when she is dehydrated and has nausea… its bad to the point of non stop puking…, so i hope she takes this into account… it took how many years to pack on the weight yet everyone wants it magically gone in a few months? Sure… for some… and for others?? It could take longer… and if under the official dosage… may take a bit longer but shouldnt pose any real issues…imo

 

[Anat]

Can someone please clarify something about bac water? I’m using Pfizer. If I open a new vial and dilute my 20mg Tirz, which lasts me a month, can I still use the same bac water after that month? All online sources say it’s not recommended to use it after 28 days, but isn’t that more for hospitals where contamination risks are higher? Do you guys keep using it until the 30ml is finished? Thanks!

 

[Ghoul]

Can someone please clarify something about bac water? I’m using Pfizer. If I open a new vial and dilute my 20mg Tirz, which lasts me a month, can I still use the same bac water after that month? All online sources say it’s not recommended to use it after 28 days, but isn’t that more for hospitals where contamination risks are higher? Do you guys keep using it until the 30ml is finished? Thanks!

Provided you use sterile practices, wiping the stopper with an alcohol swab before use, and only going in with a clean needle (not back and forth to the peptide vial) it's fine to use until it's empty.

28 days is the FDA advised limit for all multi-dose vials, but really doesn't apply to BAC.

 

[Anat]

Provided you use sterile practices, wiping the stopper with an alcohol swab before use, and only going in with a clean needle (not back and forth to the peptide vial) it's fine to use until it's empty.

28 days is the FDA advised limit for all multi-dose vials, but really doesn't apply to BAC.

Thanks a lot! I always stick to sterile practices - fresh needles, alcohol swabs, and no cross-contamination. I really appreciate the explanation - it clears up my doubts completely!

 

[Ghoul]

Thanks a lot! I always stick to sterile practices - fresh needles, alcohol swabs, and no cross-contamination. I really appreciate the explanation - it clears up my doubts completely!

As it's extremely pure water and benzyl alcohol, there's nothing to spoil and bacterial growth is impossible within this environment, provided it's uncontaminated the only limiting factor is the integrity of the stopper.

Good choice going with pharma.

 

[Anat]

As it's extremely pure water and benzyl alcohol, there's nothing to spoil and bacterial growth is impossible within this environment, provided it's uncontaminated the only limiting factor is the integrity of the stopper.

Good choice going with pharma.

Your posts have completely changed my approach - from using vial adapters, filtered needles, and BD needles to properly administering Tirz and bac water. Plus, learning how GLP-1 is such an amazing medication, with weight loss being just a bonus, really shifted my perspective. Even if it costs more, it’s absolutely worth it. Thanks again!

 

[JG91]

Is there a problem if you switch between tirz and reta?

I was on tirz 5 mg and switched to Reta 3 mg because my supplier was actually selling reta very cheap. Now looking to make my first purchase of an actual kit and tirz is more affordable by a significant amount.

Is there anything to worry about switching between the two?

 

[Captainpotatohead]

What’s the highest tirz dose anyone here has taken? Currently on 20mg but was contemplating 30mg to try and completely nuke my appetite.

 

[Juiced_lizard]

What’s the highest tirz dose anyone here has taken? Currently on 20mg but was contemplating 30mg to try and completely nuke my appetite.

Curious how much weight you’ve lost and or are looking to lose total. 20mg seems like a lot when it seems online people from 2.5- 7.5mg/week get tons of results. Or any other reason to taking that much?

 

[Hardcoreboy]

What’s the highest tirz dose anyone here has taken? Currently on 20mg but was contemplating 30mg to try and completely nuke my appetite.

I take 15mg on Sundays and 10mg on Thursdays. The weight got stuck at 15mg and now it has started to drop well again. No noticeable side effects.

 

[Ghoul]

Is there a problem if you switch between tirz and reta?

I was on tirz 5 mg and switched to Reta 3 mg because my supplier was actually selling reta very cheap. Now looking to make my first purchase of an actual kit and tirz is more affordable by a significant amount.

Is there anything to worry about switching between the two?

Worry, likely not.

Establishing the correct Tirz dose will be complicated because, the rebound from stopping glucagon receptor agonism means an increase in appetite, glucose, and a drop in energy expenditure.

It'll take 4 weeks for these effects to fully manifest.

Even if you don't get the expected effect from Tirz, give it a few weeks to build up and the Reta to wash out. It may be a chaotic 4 weeks appetite wise until it settles down.

What’s the highest tirz dose anyone here has taken? Currently on 20mg but was contemplating 30mg to try and completely nuke my appetite.

I'm confident UGL tirz is not as strong as pharma, and 20-25mg is likely the equivalent of 15mg Zepbound.

But it's wise to use caution, since hypoglycemia is possible, and sometimes sides can take you by surprise, seemingly out of all proportion to the dose increase.

So try 25mg before going to 30. If you notice increased appetite suppression after a few days, keep in mind the next dose, even the same amount, will further increase suppression.

While there's a built in safety margin in the max dose established by pharma, I'd be hesitant to go beyond 30mg UGL, as that's really uncharted territory. (particularly with GIP, because that has far less long term safety data). In fact, instead of going beyond 25mg, consider adding .25mg Sema instead. I'm not a fan of mixing GLPs, but in this case, getting. as high as you have and still not getting sufficient response, boosting the GLP agonist without involving GIP seems more prudent.

And as always, once a week, and at least .5ml dilution for both Tirz and Sema (under 1.7mg dose).

 

[JG91]

Worry, likely not.

Establishing the correct Tirz dose will be complicated because, the rebound from stopping glucagon receptor agonism means an increase in appetite, glucose, and a drop in energy expenditure.

It'll take 4 weeks for these effects to fully manifest.

Even if you don't get the expected effect from Tirz, give it a few weeks to build up and the Reta to wash out. It may be a chairing 4 weeks appetite wise until it settles down.

Thanks Ghoul. I knew if I put my question out in the universe you would find me.

 

[Ghoul]

Thanks Ghoul. I knew if I put my question out in the universe you would find me.

"chairing" was supposed to be "chaotic", but I think you get the point.

Patience and consistence is the way to go with all GLP treatments.

Your decision to revert to Tirz is something I tell people starting on Reta, which is "if you stay.on it forever, is the cost of Reta 12mg/wk vs Tirz 15mg/wo something you're prepared to live with?"

We know there are health benefits from GIP, so Tirz is worth the premium over Sema in that sense, but Glucagon receptor agonism hasn't been clearly shown to do much for long term health so far.

 

[Sampei]

What’s the highest tirz dose anyone here has taken? Currently on 20mg but was contemplating 30mg to try and completely nuke my appetite.

Obese fatty spotted here

 

[Sampei]

"chairing" was supposed to be "chaotic", but I think you get the point.

Patience and consistence is the way to go with all GLP treatments.

Your decision to revert to Tirz is something I tell people starting on Reta, which is "if you stay.on it forever, is the cost of Reta 12mg/wk vs Tirz 15mg/wo something you're prepared to live with?"

We know there are health benefits from GIP, so Tirz is worth the premium over Sema in that sense, but Glucagon receptor agonism hasn't been clearly shown to do much for long term health so far.

You don't need to stay at max dosage tho for your life. Some ppl will never even reach it.

I can't even imagine being on 10mg of Tirzepatide for example, I would probably not eat for a week.

Reta doesn't give fatigue compared to TIRZ for example, that's why some ppl like it a lot more, it doesn't suppress appetite much either, another point of why.some ppl prefer it over tirz

 

[Ghoul]

Obese fatty spotted here

I'd actually be curious what the OPs previous use of GLPs looks like and percentage of bodyweight lost before he hit the wall.. I wonder of immunogenicity from prior use contributed to a loss of effectiveness.

 

[Captainpotatohead]

Worry, likely not.

Establishing the correct Tirz dose will be complicated because, the rebound from stopping glucagon receptor agonism means an increase in appetite, glucose, and a drop in energy expenditure.

It'll take 4 weeks for these effects to fully manifest.

Even if you don't get the expected effect from Tirz, give it a few weeks to build up and the Reta to wash out. It may be a chaotic 4 weeks appetite wise until it settles down.



I'm confident UGL tirz is not as strong as pharma, and 20-25mg is likely the equivalent of 15mg Zepbound.

But it's wise to use caution, since hypoglycemia is possible, and sometimes sides can take you by surprise, seemingly out of all proportion to the dose increase.

So try 25mg before going to 30. If you notice increased appetite suppression after a few days, keep in mind the next dose, even the same amount, will further increase suppression.

While there's a built in safety margin in the max dose established by pharma, I'd be hesitant to go beyond 30mg UGL, as that's really uncharted territory. (particularly with GIP, because that has far less long term safety data). In fact, instead of going beyond 25mg, consider adding .25mg Sema instead. I'm not a fan of mixing GLPs, but in this case, getting. as high as you have and still not getting sufficient response, boosting the GLP agonist without involving GIP seems more prudent.

And as always, once a week, and at least .5ml dilution for both Tirz and Sema (under 1.7mg dose).

Thanks for that ! Very helpful. Ill give 25mg a go for a few weeks and reassess before going any higher or adding sema in to the mix.

I’ve never understood how correctly dosed UGL tirz verified by HPLC testing wouldnt be the exact same as pharma? Isn’t it the same thing?