Giant Semaglutide Thread (and other GLP-1 / GIP agonists)

[Doodle]

Wanted to create a thread where everyone can post their experiences with different sourced Semaglutide.

Who are you using?
Pharma vs non?
Dosage?
How long have you been taking it?
What are your thoughts?
Have you lost weight?
Side effects?
Oral vs injection?
Tests?

 

[Jesintn]

Are any of you guys getting in 350 grams protein in a very slight calorie surplus, with a standard recommended dose of any of the glps and are their any digestive issues ?

 

[Earthworm Jim]

.

Also, if someone has any tips to make preserving muscle easier while taking tirz/reta, I'm all ears. All I've read is taking test which I will do, and GH which I won't because I dislike the look it gives me. Any suggestion appreciated.

I got it in my head that I could do tirzepatide and recomp by having two protein shakes for breakfast, working out, and two more shakes afterwards. That's about 100g of protein so I would have to find a solid food source for another 100 grams at some point in the afternoon or evening. In reality what happened is my first protein shake sat in my stomach the entire day and I was miserable with indigestion, farts, heart burn, trouble sleeping. Now I understand why body builders either cut or bulk and I'm having to accept that my fat guy recomp phase is coming to a close

 

[Earthworm Jim]

I think anyone using Reta while on more than TRT level AAS should be certain they’ve got BP under perfect control on cycle, <120/80, to minimize LVH risk.

I took the telmisartan and cilnidipine you have written about and my BP was 110/90

 

[TheBeast1]

Did you do any labwork to see where you were sodium and other mineral-wise prior to supplementing? Just curious as I've had some hypotension as well, but my bloodwork is fine.

I've always been low on sodium per my regular tests but nothing to the point where it caused pots. Adding reta tipped the scale.

 

[Luke391]

Are any of you guys getting in 350 grams protein in a very slight calorie surplus, with a standard recommended dose of any of the glps and are their any digestive issues ?

I have had binge days where I had like 300 protein and 100+ grams of fiber and other than some bloating I was fine. My stomach is a black hole tho so can't speak for everybody

 

[Jesintn]

I have had binge days where I had like 300 protein and 100+ grams of fiber and other than some bloating I was fine. My stomach is a black hole tho so can't speak for everybody

When you say your stomach is a black hole what do you mean by that?

 

[Jesintn]

Now I understand why body builders either cut or bulk and I'm having to accept that my fat guy recomp phase is coming to a close

Currently Im under the impression for competing bodybuilders, that have difficulty with keeping their waist tight year round, and hunger, glps are best used in prep, and going though health phases where food can be lowered

Remember not everyone has struggled or figured out how to keep a certain degree of leanness year round where muscle really isn’t going to be increased much if at all

It’s a reality that maintaining and if need be for health or health prevention, if you choose that route Ive done is years competing in classic, that losing fullness, and muscle is okay

Again, blood labs are mandatory for a bodybuilder

There may be a slight calorie muscle phase where not much fat is gained, esp for bodybuilder s that dont want to use a high androgenic alike tren, that can minimize hunger while keeping their waist tight and still adding lbs of muscle in the desired places they attempt, where glps can be useful, obviously in the context of bodybuilders that struggle with hunger, keep waist tight

Best way is to try and see , either way

 

[Luke391]

When you say your stomach is a black hole what do you mean by that?

I just mean I have a massive appetite and can handle a ton of food with little to no issues (be it a good or bad thing)

 

[Liter O' Test]

I just mean I have a massive appetite and can handle a ton of food with little to no issues (be it a good or bad thing)

no you have body dysmorphia and your body is trying to stop you from dying

 

[The Answ3r]

HoWs the blood sugar so far?

Blood sugar’s looking pretty interesting so far. I’m on week 5 of Reta now, running it alongside a cycle of Test C 500 mg, Mast E 300 mg, and 2iu HGH every morning. My glucose came back at 74, insulin 6.4, and A1c actually dropped from 4.9 to 4.8 while eating around 160/65/350-400.

What really surprised me is the lipid profile. I’m not sure how much of that is Reta and how much is the combo of pita 4 mg and Bempesta EZ 10 mg, but everything came back perfect. Overall I’m really happy with the results so far, so I’m sticking with Reta and rolling forward.

 

[Ghoul]

Blood sugar’s looking pretty interesting so far. I’m on week 5 of Reta now, running it alongside a cycle of Test C 500 mg, Mast E 300 mg, and 2iu HGH every morning. My glucose came back at 74, insulin 6.4, and A1c actually dropped from 4.9 to 4.8 while eating around 160/65/350-400.

What really surprised me is the lipid profile. I’m not sure how much of that is Reta and how much is the combo of pita 4 mg and Bempesta EZ 10 mg, but everything came back perfect. Overall I’m really happy with the results so far, so I’m sticking with Reta and rolling forward.

View attachment 361345

Pita 4, Bemp Acid, Ezetimebe combo lowers LDL 72-75% after 12 weeks.

Reta’s liver fat clearance lowers LDL around 5-10 points.

Any additional, and the vast majority, of lipid lowering from Reta (or any GLP) comes from weight loss.

What was your LDL before?

I don’t known if you have a baseline HS-CRP, but Pitavastatin, Reta, and rHGH are all inflammation sledgehammers and I’ll bet it’s looking very good.

 

[The Answ3r]

Pita 4, Bemp Acid, Ezetimebe combo lowers LDL 72-75% after 12 weeks.

Reta’s liver fat clearance lowers LDL around 5-10 points.

Any additional, and the vast majority, of lipid lowering from Reta (or any GLP) comes from weight loss.

What was your LDL before?

I don’t known if you have a baseline HS-CRP, but Pitavastatin, Reta, and rHGH are all inflammation sledgehammers and I’ll bet it’s looking very good.

Here’s what things looked like in mid-September when I last ran labs. This was about one month after finishing a cycle where I ran Anavar at 50 mg every day for 8 weeks. My CRP at that time was 0.99.

 

[Ghoul]

Here’s what things looked like in mid-September when I last ran labs. This was about one month after finishing a cycle where I ran Anavar at 50 mg every day for 8 weeks. My CRP at that time was 0.99.

View attachment 361355
View attachment 361356

Wow Apo-I, don’t see that often. It’s an advanced lipid marker that indicates the quality of HDL “Efflux capacity”, ie how effective it is at removing plaque from arteries).

Surprised Lp(A) wasn’t in there too.

When did you start the lipid lowering meds then?

 

[The Answ3r]

Wow Apo-I, don’t see that often. It’s an advanced lipid marker that indicates the quality of HDL “Efflux capacity”, ie how effective it is at removing plaque from arteries).

Surprised Lp(A) wasn’t in there too.

When did you start the lipid lowering meds then?

I’d been running 5 mg rosu for about a year and a half, but at the end of August I switched to pita 4 mg and added Bempesta EZ. On just rosu my lipids were always a headache, both on cycle and on cruise, nothing dramatic, just consistently annoying numbers. But the pita + Bempesta EZ combo? That turned everything around fast. It’s like my lipid panel finally got the memo and decided to behave for once.

 

[Ghoul]

I’d been running 5 mg rosu for about a year and a half, but at the end of August I switched to pita 4 mg and added Bempesta EZ. On just rosu my lipids were always a headache, both on cycle and on cruise, nothing dramatic, just consistently annoying numbers. But the pita + Bempesta EZ combo? That turned everything around fast. It’s like my lipid panel finally got the memo and decided to behave for once.

With LDL @ 67 you’ve stopped accumulation. So off cycle HDL will increase, and LDL should drop <50 into regression territory, removing plaque.

 

[Luke391]

I've heard people say you have to use a certain acid substance for Cagrilintide the keep the ph low. is it true? if yes what was the name of the thing? it was like acid somethinf

 

[anon55]

Wow Apo-I, don’t see that often. It’s an advanced lipid marker that indicates the quality of HDL “Efflux capacity”, ie how effective it is at removing plaque from arteries).

Surprised Lp(A) wasn’t in there too.

When did you start the lipid lowering meds then?

You would be surprise in France nobody knows Lp(a).
I checked it last time and my lab didn't know they had to add it in the computer program and had it send in another lab lol

 

[HotPepper]

Does anyone here take sema, tirza or reta at high dosages and have noticed a change in their urination habits?
For example, a sudden urge to urinate?

 

[Luke391]

Does anyone here take sema, tirza or reta at high dosages and have noticed a change in their urination habits?
For example, a sudden urge to urinate?

I piss a lot but doesn't seem related to the Tirz.
Tho I maybe notice a difference in how it comes up? like instead of the slow buildin up of the urge to piss it just hits me out of nowhere

 

[Photon]

Does anyone here take sema, tirza or reta at high dosages and have noticed a change in their urination habits?
For example, a sudden urge to urinate?

No difference.
26mg/week reta.