Grapefruit vs. Hematocrit

-Maui-

Member
Hello everyone!
Increased hematocrit is one of the most common issues associated with the use of AAS. It affects well-being, blood pressure, cognitive function, and can lead to the formation of blood clots.
The most effective way to lower hematocrit is to donate blood, but this temporary solution can cause iron deficiency, which reduces performance and quality of life in general.
Another way is to drink plenty of fluids and stay hydrated, but this only helps partially and only if you do it constantly, day after day.

Occasionally, various theories emerge claiming that some product or drug can reduce hematocrit. Are these theories genuine science or just bro-science? What is suitable and effective for athletes on AAS to use to control hematocrit?
In order to somehow sort this out, I gathered a dozen like-minded friends who were ready for experiments and periodic blood tests.
Each of them had a hematocrit above 50% and all of them have used AAS for a long time.

It was decided:
- the possible benefit of the experiment must exceed the possible harm;
- we will check the publicly available information.

First, we decided to check an article (PMID: 3243695) showing the effectiveness of grapefruit in reducing hematocrit.
Every day for 2 weeks we ate 1/2 or 1 grapefruit each day.
Tests were taken before the start and again on the 14-15th day of the protocol.

The first results were quite contradictory but interesting.
The effect was indeed observed; but, not for everyone and not always distinguishable from error.

2w.png
(change in hematocrit level after 2 weeks)

We decided to continue and figure things out as we went along.
It turned out that those who took antiplatelet agents or nootropics with this protocol had a weak effect.
In addition, the whole fruit gave a more noticeable result.
In the end, after another 2 weeks the results were already more significant and promising.

4w.png
(change in hematocrit level after 4 weeks)

Looks like it really works!
For a month we didn't notice any side effects, digestive problems, allergies, or anything else.

I decided to expand the group of subjects; we will recruit friends of our friends and generally everyone.
Therefore, if you are concerned about consistently high or increasing hematocrit, but are not ready to donate blood every 2-3 months, and you don’t mind eating plenty of grapefruits, you can join the experiment!

I would be glad to see blood tests before the start, impressions of the “treatment” of hematocrit, and analysis after a period of time consistently ingesting grapefruit.

Thank you for your attention! I hope this is useful and interesting to someone.
 
My H+H was always above range natural. When I got on TRT I started eating grapefruit and taking liquid grapefruit extract daily. My H+H has been lower while on high level TRT doing this. Hematocrit down 2 points with top range free t, total 1600. Could be coincidence, but I'm goin to stick with it.
 
Have you considered nattokinase and baby aspirin stack?

I've had some preliminary success with this combo. Naringin not really. Never was consistent with whole grapefruit trial.
 
Nice work. Always good to see some data. I’m assuming all the subjects ONLY change from the baseline was the addition of grapefruit?
 
I have seen several clients and myself consistently lower (still elevated but less so) using grapefruit.
Are we talking grapefruit or the the grapefruit seed extract on capsule or grapefruit liquid?

I am also having trouble finding a consistent protocol to control H and H, RBC. Even just after blood donation and proper hydration, my values are still slightly above range.
 
Are we talking grapefruit or the the grapefruit seed extract on capsule or grapefruit liquid?

I am also having trouble finding a consistent protocol to control H and H, RBC. Even just after blood donation and proper hydration, my values are still slightly above range.
I think actual grapefruit or a high quality grapefruit seed extract are what you want. I like the "Nutribiotic" liquid GSE. I buy grapefruit when I can but I can't always get decent quality grapefruit where I live. Good grapefruit is delicious but poor quality grapefruit tastes terrible.
 
Are we talking grapefruit or the the grapefruit seed extract on capsule or grapefruit liquid?

I am also having trouble finding a consistent protocol to control H and H, RBC. Even just after blood donation and proper hydration, my values are still slightly above range.
I use grapefruit juice as a carb source. Built in.

If you’re on prescription meds PLEASE check that it doesn’t interact with grapefruit; it reduces an enzyme that can result in certain drugs being more available. Especially worthy of note for people on drugs related to mental issues.
 
I use grapefruit juice as a carb source. Built in.

If you’re on prescription meds PLEASE check that it doesn’t interact with grapefruit; it reduces an enzyme that can result in certain drugs being more available. Especially worthy of note for people on drugs related to mental issues.
It inhibits the enzyme that breaks down a lot of different drugs. Sometimes that's really bad but sometimes it's good. Some drugs you can take a lower dose of and the duration of effect is longer.

List of common interactions: Online Appendix

Article on grapefruit and drugs: Grapefruit–medication interactions: Forbidden fruit or avoidable consequences?
 
Have you considered nattokinase and baby aspirin stack?

I've had some preliminary success with this combo. Naringin not really. Never was consistent with whole grapefruit trial.
Aspirin has no significant effect on hematocrit.
I did not test nattokinase separately. Maybe later ;)
 
Are we talking grapefruit or the the grapefruit seed extract on capsule or grapefruit liquid?

I am also having trouble finding a consistent protocol to control H and H, RBC. Even just after blood donation and proper hydration, my values are still slightly above range.
A slight overshoot during a cycle is not a big problem.
However grapefruit can help you. And we talk about grapefruit as a fruit.
 
Aspirin has no significant effect on hematocrit.
I did not test nattokinase separately. Maybe later ;)
Some arcane references below.

First study (rodents) indicates direct RBC effect but converting to human dose indicates very large daily dosing may be needed which is not workable.


Second ref shows other favorable effect for those running up against high HCT / elevated blood viscosity...


I'll find another thread for the nattokinase.
 
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