Gut Microbiome

[hardasnails1973]

The first thing which needs to be done is to look at past history as well as current symptoms. Metametrix gi effects is what I use for clinical evaluation. Some times things will not be caught or show on these tests. One can go on total symptoms and address the GI with enzymes, probiotics or antimicrobial herbd..

 

[Dalexand]

Thanks hardasnails
I think I am going to have look at a different option as I Live in Malaysia/Singapore and don't think I can acquire the test kits. I might ask the labs here locally if they
can perform the same tests.

 

[hardasnails1973]

In order to save clients $400 I will just do a full spectrum sweep with antibacterial and antimicrobial herbs along with gi mucosa restoration recommendations.

 

[Dalexand]

Great - Thanks much Hardasnails.

Happy Holidays.
Dom

 

[Michael Scally MD]

Overuse of Antibiotics Caused Infections by Bug [Clostridium difficile] That Killed 29,000 in 1 Year. http://www.nejm.org/doi/full/10.1056/NEJMoa1408913

The study by the U.S. Centers for Disease Control and Prevention focused on the Clostridium difficile bacterium, which can cause deadly diarrhea.

The findings highlight how overprescription of antibiotics has fueled a rise in bacteria that are resistant to treatment.

People who take antibiotics are most at risk of acquiring C. difficile because these medications also wipe out "good" bacteria that protect a healthy person against the infection.

 

[Michael Scally MD]

Shanahan F. Separating the microbiome from the hyperbolome. Genome Med. 2015;7(1):17. http://genomemedicine.com/content/7/1/17

Microbiome-based therapies are moving quickly towards the clinic, with successes including fecal microbial transplants for recurring Clostridium difficile, hints of new antibiotics to come, and possible new microbial biomarkers for common complex diseases. Can the microbiome live up to its hype?

 

[Michael Scally MD]

Pedersen HK, Gudmundsdottir V, Nielsen HBr, et al. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature;advance online publication. http://www.nature.com/nature/journal/vaop/ncurrent/full/nature18646.html

Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes.

Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals.

The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids.

Prevotella copri and Bacteroides vulgatus are identified as the main species driving the association between biosynthesis of BCAAs and insulin resistance, and in mice we demonstrate that P. copri can induce insulin resistance, aggravate glucose intolerance and augment circulating levels of BCAAs.

Our findings suggest that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.