HGH sleep issues

[400degrees]

About a month in on ugl GH, 4iu every night before bed, 2hrs after dinner. First couple weeks it knocked me out all night. Past couple weeks I've been wide awake at 3am every night. Almost feels like a cortisol spike. Wondering if I should ride it out, switch to am, or if anyone has had the same experience or knows the possible science behind this regarding the gh interactions with prolactin, progesterone or adrenals.

 

[Ateam2023]

I ran a few kits of TP recently but now on QSC.

how do you like the qsc hgh ? or is it to early to tell ? im switching to qsc hgh and have a good supply of the 15 iu kits , im also going to send some to jano for test with dimer so i at least know what im going to be injecting for next 7 months

 

[AlexDavis43]

how do you like the qsc hgh ? or is it to early to tell ? im switching to qsc hgh and have a good supply of the 15 iu kits , im also going to send some to jano for test with dimer so i at least know what im going to be injecting for next 7 months

QSC works for me just as good as Genos and Cinna.

 

[Lord Commander]

Just yesterday i took 2IU in the morning and 2IU right before bed. I slept and dreamt a lot but had many awakenings where i was not sure whether i was sleeping or not. If time my second dose around 5-6pm i don't have any awakenings through the night and slightly less dreaming and slightly less vivid too. Maybe its better for me to dose earlier...

 

[Lord Commander]

Night time bolus 4 iu dosing completly wrecks my sleep. I dose around three pm now, problem completly solved.

When I was doing 4 iu split am pm my sleep was also good. It's the night time bolus that causes issues for me.

Do you recover well from training even though there is no dose right before bed?

 

[hghlover]

Do you recover well from training even though there is no dose right before bed?

I do, my recovery is very very good. I can push my training pretty hard. I'm also sleeping nine hours tho and getting enough calories.

Lately tho I've been experimenting with dosing a bit later, around 17-18 pm, and my sleep has been fine. We are 100% meant to utilize HGH during sleep, so a timing like the above is ideal if possible.

 

[Lord Commander]

I do, my recovery is very very good. I can push my training pretty hard. I'm also sleeping nine hours tho and getting enough calories.

Lately tho I've been experimenting with dosing a bit later, around 17-18 pm, and my sleep has been fine. We are 100% meant to utilize HGH during sleep, so a timing like the above is ideal if possible.

Im doing the same split and it works for me. Before bed shot still messes up the sleep...

 

[Benf15harp]

I do, my recovery is very very good. I can push my training pretty hard. I'm also sleeping nine hours tho and getting enough calories.

Lately tho I've been experimenting with dosing a bit later, around 17-18 pm, and my sleep has been fine. We are 100% meant to utilize HGH during sleep, so a timing like the above is ideal if possible.

How do you figure that timing is ideal to utilize nighttime hgh when you’ve eliminated 1.5 of those 2ius by 11pm or 2300?

 

[malfeasance]

The effect of GH on nighttime awakenings (currently) and lethargy (initially) has, in the former case, to do with direct GH effects on stage 3/4 sleep; and in the latter one, with effects on 11β-HSD1, decreasing it (thereby ↓conversion of inactive cortisone ⇒ active cortisol).

Yes, exactly as I've alluded too previously in this thread. I gotta start using me these \ | ≠ < ↑→, to get more likes! : D

We also forgot to mention the ↑fT3 due to rhGH ↓TBG which = ↑↑metabolic activity (increased BMR, cardiac output, etc.) alongside with heightened mood (due to ↑neurotransmitters, most notably increased excitatory neurotransmission) which feels particularly adrenergic, presumably due to T3's effects on increasing the expression of beta receptors, or in other words ↑β1/β2 expression, to be more clear.

So how do we make all of this information actionable?

I can read it, nod my head, pretend to understand, mutter, "Cortisol," oh, and "beta receptors," and pretend like I am keeping up in the conversation, but what do I then do about my hgh administration?

 

[hghlover]

How do you figure that timing is ideal to utilize nighttime hgh when you’ve eliminated 1.5 of those 2ius by 11pm or 2300?

You're gonna have to expand on that bro, what 1.5 iu out of 2 are you talking about? I'm dosing 4 iu bolus ed.

Anyyyyway, seeing as rHGH takes four hour to reach peak levels, with a very slow and steady decline, dosing approx four hours before bed hits it right in the bullseye. I sleep at 10 pm.

Same protocol an endocro I talked to uses.

You can dose right before bed too, but you're not gonna be peaking before halfway into the night. Altho I'm sure its fine tbh. As i said, even dosing early in the day, I get amazing recovery.

 

[Benf15harp]

You're gonna have to expand on that bro, what 1.5 iu out of 2 are you talking about? I'm dosing 4 iu bolus ed.

Anyyyyway, seeing as rHGH takes four hour to reach peak levels, with a very slow and steady decline, dosing approx four hours before bed hits it right in the bullseye. I sleep at 10 pm.

Same protocol an endocro I talked to uses.

You can dose right before bed too, but you're not gonna be peaking before halfway into the night. Altho I'm sure its fine tbh. As i said, even dosing early in the day, I get amazing recovery.

Your second to last comment said you split doses bc 4 was too much. Half life is 3 hours.

 

[hghlover]

Your second to last comment said you split doses bc 4 was too much. Half life is 3 hours.

That wasn't me?

 

[Benf15harp]

That wasn't me?

lol. I think you are all over the place. Half life is 3 hours so if you’re taking it 3 hours or more before bed then half of it is gone before you are asleep.

 

[hghlover]

lol. I think you are all over the place. Half life is 3 hours so if you’re taking it 3 hours or more before bed then half of it is gone before you are asleep.

Buddy, you do you.

 

[deadbeef]

lol. I think you are all over the place. Half life is 3 hours so if you’re taking it 3 hours or more before bed then half of it is gone before you are asleep.

Unless he's doing an IV injection, this is not how it works.

 

[Benf15harp]

Buddy, you do you.

Done

 

[Benf15harp]

Unless he's doing an IV injection, this is not how it works.

Half life of iV is 20-30 mins so, if taken 3 hours before bed it would all be eliminated before he fell asleep

 

[songsofpyramids]

Unless he's doing an IV injection, this is not how it works.

As can easily be seen in the graph that was posted that Ben just chose to ignore lol

 

[hghlover]

As can easily be seen in the graph that was posted that Ben just chose to ignore lol

There's something off with this ben guy lol, no offence

 

[deadbeef]

As can easily be seen in the graph that was posted that Ben just chose to ignore lol

Ol' Ben here ain't too sharp.

 

[Type-IIx]

So how do we make all of this information actionable?

I can read it, nod my head, pretend to understand, mutter, "Cortisol," oh, and "beta receptors," and pretend like I am keeping up in the conversation, but what do I then do about my hgh administration?

The effect of GH on nighttime awakenings (currently) and lethargy (initially) has, in the former case, to do with direct GH effects on stage 3/4 sleep; and in the latter one, with effects on 11β-HSD1, decreasing it (thereby ↓conversion of inactive cortisone ⇒ active cortisol).

About a month in on ugl GH, 4iu every night before bed, 2hrs after dinner. First couple weeks it knocked me out all night. Past couple weeks I've been wide awake at 3am every night. Almost feels like a cortisol spike. Wondering if I should ride it out, switch to am, or if anyone has had the same experience or knows the possible science behind this regarding the gh interactions with prolactin, progesterone or adrenals.

@Jin23 @malfeasance