HGH split dose because of half-life?

[amar7]

Hi,
does it make sense to split 4IU of HGH into to injections because of the short half life it has or for effectiveness and would it be better pre workout or pre-bedtime to mimic the natural release? Soon going to start my next cycle.

 

[tenpoundsleft]

Hi,
does it make sense to split 4IU of HGH into to injections because of the short half life it has or for effectiveness and would it be better pre workout or pre-bedtime to mimic the natural release? Soon going to start my next cycle.

2IU on waking and 2IU right before bed is optimal dosage schedule AFAIK.

 

[Jeffg353]

It has such a short Half-Life, about 15-20 min, that splitting the dose doesn't have much of an effect on stabilizing serum blood levels. Most people will split the dose to help manage the side effects like CTS. Some people will use it right before bed but some say this stunts your natural GH pulses that happen during the first few hours of sleep. As long as ur getting it in ur body at ur chosen dose I don't think it matters as much.

 

[gobigorgohome1218]

It has such a short Half-Life, about 15-20 min, that splitting the dose doesn't have much of an effect on stabilizing serum blood levels. Most people will split the dose to help manage the side effects like CTS. Some people will use it right before bed but some say this stunts your natural GH pulses that happen during the first few hours of sleep. As long as ur getting it in ur body at ur chosen dose I don't think it matters as much.

I agree completely. Another point is that it's actually IGF-1 that is primarily responsible for the growth promoting effects of Gh. This substance has a much longer half-life and thus is quite stable and is the main reason it is used to guide Gh therapy or supplementation

 

[amar7]

I agree completely. Another point is that it's actually IGF-1 that is primarily responsible for the growth promoting effects of Gh. This substance has a much longer half-life and thus is quite stable and is the main reason it is used to guide Gh therapy or supplementation

I remember I've read a text, that stated, the liver has the capacity to produce only this much HGH at a time and that's where splitting of GH comes into play. I know GH itself has a very short half life. The thing that I don't remember was, how much HGH is to be injected at a maximum dose to get the maximum IGF-1 conversion by the liver without wasting growth hormone.

 

[Wunderpus]

If pinning over 2iu per day, split the shots at least 4 hours apart. Pre workout and pre bed are useful IMO unless using pre fasted cardio in AM. Play around, I've seen certain combos work better for different people. However, I don't really ever shoot more than 2iu at a time....

 

[amar7]

If pinning over 2iu per day, split the shots at least 4 hours apart. Pre workout and pre bed are useful IMO unless using pre fasted cardio in AM. Play around, I've seen certain combos work better for different people. However, I don't really ever shoot more than 2iu at a time....

ok, are there studys that proof that splitting 4IU dosage is an improvement for it to work out better?

 

[Wunderpus]

ok, are there studys that proof that splitting 4IU dosage is an improvement for it to work out better?

Maybe, your ability to search pubmed is equal to my own. However, I anecdotally, as well as others I know, have yielded better results than one large bolus dose. My understanding is, you can only produce SO much IGF-1 at a time... So, at some point, larger doses will yield diminishing returns. Not only that, I would prefer to have a few spikes over one, personally.

When I have some time, I can see if I can dig up some studies/data on why spreading the dose may be better. It has, anecdotally, always worked better for ME.... For what that's worth.

 

[Wunderpus]

Pharmacological aspects of growth hormone replacement therapy: route, frequency and timing of administration. - PubMed - NCBI

"The frequency of subcutaneous injections correlates positively with growth rate in animal studies. This is commonly ascribed to a closer resemblance to the endogenous pulsatile pattern. However, frequent subcutaneous injections do not induce a pulsatile pattern, but a pattern which is intermediary between continuous and true pulsatile administration. In a short-term patient study, we observed that pulsatile and continuous intravenous administration of GH generated identical increases in serum insulin-like growth factor I, which suggests that both pulsatory and constant, small elevations in serum GH are important for its actions. Concerning the time of administration, evening GH injections yield a more physiological pattern, and it has been shown that evening GH administration induces increased nitrogen retention and is more successful in normalizing circadian patterns of pertinent hormones and metabolites."

 

[amar7]

you can only produce SO much igf-1 at a time... So, at some point, larger doses will yield diminishing returns

That is exactly where my question lays. At some point the liver just doesn't get triggered to produce enough IGF-1. The question is, where is this point? Is it 1IU, 2IU, 4IU or maybe even up to 6-8IU?

It has, anecdotally, always worked better for ME.... For what that's worth.

Ok, did you just change the splitting and no other maybe relevant factors like steroids, diet, training, supplements and you realized that you had much better results at the same dose?

I find anecdotes sometimes usefull aswell as as tudies.

 

[Wunderpus]

That is exactly where my question lays. At some point the liver just doesn't get triggered to produce enough IGF-1. The question is, where is this point? Is it 1IU, 2IU, 4IU or maybe even up to 6-8IU?


Ok, did you just change the splitting and no other maybe relevant factors like steroids, diet, training, supplements and you realized that you had much better results at the same dose?

I find anecdotes sometimes usefull aswell as as tudies.

Well one factor I cater it around is the goal... If hypertophy is the goal, I structure my timing based on that. So, pre workout and pre bed I've found to be ideal. If fat loss is the goal, pre fasted AM cardio then pre bed appears to work best. I believe pre lifting w/ a carb surplus or exo. insulin is the MOST effective way to elicit the maximum amount of hypertrophy.... Steroids are also catered to the goal in mind, along with supplements etc.

I believe pre bed is the second best option, and pre workout is the most ideal. if you're splitting the dose, I would always have a pre bed shot and cater the other shot to either pre lifting or pre cardio.

 

[amar7]

Sounds good, my question though was about the anecdotal experience you had, that split dose works much better for you.

Like did you change any factors in you non-split / split dose intake that could have changed the experienced result?

 

[Wunderpus]

Sounds good, my question though was about the anecdotal experience you had, that split dose works much better for you.

Like did you change any factors in you non-split / split dose intake that could have changed the experienced result?

Yeah, I've tried large bolus doses pre workout only, pre bed only and split doses... I liked the results I saw from the split doses and it just seemed to be the most logical method to me.

 

[amar7]

Alright then, cheers, I'm going to give it a shot. Have a good night man.