how to make transdermal testosterone?

[tesarpaul]

Do you suppose we really need so much isopropyl myristate? For scrotal applications, it literally burns off some skin of my scrotum and has severe pain. Alcohol by itself no issue.

It should increase the absorbtion.

"Gels containing 2% IPM exhibited 11 folds increase in flux compared to formulation devoid of IPM"

https://www.researchgate.net/publication/315501927_Effect_of_Isopropyl_Myristate_on_Transdermal_Permeation_of_Testosterone_From_Carbopol_Gel

 

[Jire]

Some of the best information I've found come from trans community

https://reddit.com/r/estrogel/wiki

They include information about using this method with androgens.

 

[Frostillicus]

If anyone is curious, I tried this with trenbolone base at 100 mg/ml. I tried various dosages from just a couple of drops twice a day to upwards of 100mg per day. Basically, all I got were side-effects but none of the usual tren magic. No muscle building as far as I could see and no nutrient partitioning/fat-loss. It made my gyno flare up almost immediately, gave me insomnia and negatively affected my breathing. It was the worst experience I've ever had with the tren breathing problems, to such a degree that I abandoned the experiment after 4 weeks of trying to tweak my dosing and figure it out.

Not really sure why it behaved this way transdermally but I 100% do not recommend.

 

[Deleted member 59947]

Do you suppose we really need so much isopropyl myristate? For scrotal applications, it literally burns off some skin of my scrotum and has severe pain. Alcohol by itself no issue.

You don't need as much, the study shows that when Isopropyl Myristate represents 2-3% of the total solution it increases the dermal flux of testosterone by 11 folds.

 

[Deleted member 59947]

If anyone is curious, I tried this with trenbolone base at 100 mg/ml. I tried various dosages from just a couple of drops twice a day to upwards of 100mg per day. Basically, all I got were side-effects but none of the usual tren magic. No muscle building as far as I could see and no nutrient partitioning/fat-loss. It made my gyno flare up almost immediately, gave me insomnia and negatively affected my breathing. It was the worst experience I've ever had with the tren breathing problems, to such a degree that I abandoned the experiment after 4 weeks of trying to tweak my dosing and figure it out.

Not really sure why it behaved this way transdermally but I 100% do not recommend.

I was actually very curious and had been wondering whether transdermal tren base would have any side of the injectable tren ace.
You perfectly answered my questions and made my only possibility to ever try tren go away.

Thank you, I feel lighter.

I still have the curisosity to make a transdermal MENT, but still too scared of gyno although I'm a very low aromatizer.

 

[Frostillicus]

I was actually very curious and had been wondering whether transdermal tren base would have any side of the injectable tren ace.
You perfectly answered my questions and made my only possibility to ever try tren go away.

Thank you, I feel lighter.

I still have the curisosity to make a transdermal MENT, but still too scared of gyno although I'm a very low aromatizer.

I actually tried transdermal trestolone back in the day when the prohormone companies used to sell it. I'm very gyno-prone so I learned very quickly that ment is a no-go for me. It sucks because it made me feel awesome and blew me the fuck up. But if youre a low aromatizer you may have a different experience if you keep dosing low. I know guys running 2-5 mg a day of trest ace intramuscularly with zero anti-estrogens who swear by it!

 

[Andrew Androgen]

Very eager to know what your blood results will be.

The absolute ideal would be that you apply only once a day the total daily dose (which should be enough if it's propionate), and then draw bloods 24h after.

If levels are elevated, that will be the absolute proof that the ester does make it past the dermis, which is currently debated.

Apart from being less expensive, in what ways do you think the prop TD formulation is better than dissolving test base powder in a bit of BA and then mixing it with Phlojel Ultra?

 

[Deleted member 59947]

Apart from being less expensive, in what ways do you think the prop TD formulation is better than dissolving test base powder in a bit of BA and then mixing it with Phlojel Ultra?

Ethanol is the alcohol the body breaks down and processes the best.
I was feeling off when using BA as a transdermal carrier, my pee smelled of BA, my head was spinning and I constantly had a sore throught.

Never tried Phlogel, but my carrier made of Ethanol + Isopropyl Myristate is dry after 30 seconds.

 

[Andrew Androgen]

You don't need as much, the study shows that when Isopropyl Myristate represents 2-3% of the total solution it increases the dermal flux of testosterone by 11 folds.

So at 2% isotropyl myristate, your formula would be :

3g test prop
25ml 96% vodka
0.6ml isotropy myristate.

Is that correct?

 

[Andrew Androgen]

So here are the results. It was after 26 hours from the last application. Honestly I thought that the test level will be a little bit higher.

So the free test is about 910 ng/dl.
Prolactin is about 9,4 ng/ml.
And estradiol is about 15 pg/ml which maybe too low because of the aromasin which Im using right now.

You can find the results attached.

@Goingstronger any thoughts?

I'm surprised your total testosterone is not higher too. Some guys have around that level on 1ml per day of a 50mg/ml test cream.
Can you try using test base instead of prop and do your blood work again?

 

[Deleted member 59947]

So at 2% isotropyl myristate, your formula would be :

3g test prop
25ml 96% vodka
0.6ml isotropy myristate.

Is that correct?

Yes

 

[Deleted member 59947]

Some guys have around that level on 1ml per day of a 50mg/ml test cream.

Not when measured 24h after application.
Most likely measured 5h after application as advised by some doctors, which is nonsense.

 

[Deleted member 59947]

Can you try using test base instead of prop and do your blood work again?

That's the plan him and I decided on, he is due for other bloods after a month of test base, as the propionate ester most likely doesn't make it past the dermis and is useless.

 

[tesarpaul]

That's the plan him and I decided on, he is due for other bloods after a month of test base, as the propionate ester most likely doesn't make it past the dermis and is useless.

Exactly, Im planning to re do the blood tests later this month. Currently doing the test base twice a day.

@Goingstronger Your blood test for test base were after 12 or 24 hour after the last application?

 

[Andrew Androgen]

Not when measured 24h after application.
Most likely measured 5h after application as advised by some doctors, which is nonsense.

When I used 0.5g of a 100mg/g compounded testosterone cream, I only applied it once a day in the morning. My total testosterone was at 27nmol/L 24hrs after application. I was also applying it to the inside of my forearms, which as you know, is inferior to scrotum application.

 

[Andrew Androgen]

Ethanol is the alcohol the body breaks down and processes the best.
I was feeling off when using BA as a transdermal carrier, my pee smelled of BA, my head was spinning and I constantly had a sore throught.

Never tried Phlogel, but my carrier made of Ethanol + Isopropyl Myristate is dry after 30 seconds.

Do you use 99% ethanol or 75%?

 

[Deleted member 59947]

Do you use 99% ethanol or 75%?

96%

 

[Deleted member 59947]

When I used 0.5g of a 100mg/g compounded testosterone cream, I only applied it once a day in the morning. My total testosterone was at 27nmol/L 24hrs after application. I was also applying it to the inside of my forearms, which as you know, is inferior to scrotum application.

Are you sure you washed thoroughly your forearms before the blood draw ?

 

[Deleted member 59947]

Exactly, Im planning to re do the blood tests later this month. Currently doing the test base twice a day.

@Goingstronger Your blood test for test base were after 12 or 24 hour after the last application?

12h.

Next time I will do 24h with a single test base application in the am.

 

[Deleted member 59947]

Exactly, Im planning to re do the blood tests later this month. Currently doing the test base twice a day.

@Goingstronger Your blood test for test base were after 12 or 24 hour after the last application?

12h.

Next time I will do 24h with a single test base application in the am.

It's crazy I feel my best mentally wise and libido wise on transdermal DHEA with no test, but I run into dry joints issues after 48h on DHEA only.