MESO-Rx
Anabolic Steroids
www.ncbi.nlm.nih.gov
‘Induction of cancer in the skin’.. what the?? Haven't heard that before“Melanotan II has five melanocortin receptor subtypes (MC-R) which reveal different biological functions based on localization [9]. In the skin and adrenal cortex, MC1-R and MC2-R are melanocytic and adrenocortical receptors [10–13]. Melanotan II stimulate the melanocytes in the skin (by stimulation of MC1-R) to increase the production of eumelanin which result in sunless tanning of the skin [5, 14, 15]. MC3-R is mostly expressed in the brain and digestive tract [13, 16], MC4-R is located in the nervous system [12, 13] and MC5-R is found in endo and exocrine glands [10, 11, 13]. The reported adverse effects relate to the location of the receptors are thus wide ranging including nausea, abdominal pain, anxiety, flushing, dizziness, headaches, appetite suppression, stomach pain, cramping, severe constipation, spontaneous penile erections, muscle pain and induction of cancer in the skin. The effects of Melanotan II can result in an overstimulation of the sympathic nervous system [6].”
Melanotan II: a possible cause of renal infarction: review of the literature and case report
Renal infarction is an uncommon condition resulting from an acute disruption of renal blood flow and it is potentially life-threatening disease. The cause and outcome of renal infarction is not well established and is frequently misdiagnosed or diagnosed ...
Circa 2008-2014 I used to take 1mg nightly. Now I use 0.5mg when loading and occasionally 0.75mg right before going to beach.
Probably due to the increased melanin in moles. Also 1mg is a ton. I mentioned in Qingding dong’s thread that 100mcg to 250mcg per day is sufficient for me, and at that dose the only side I get is a bit of flushing.
I used go load it also daily injections until I got to about 20mg. Thats when I would get dark AF. Before mt2 in 2008 i never had a tan in my life. Id only burn
I use Peptide Sciences. Imo theyre the best in the biz for many years now
syringe measurements are literally meaningless for an unconstituted/dose variant product
I cant disagree with that... With these peptides, it's a guessing game sometimes. It just takes very little with MT2
pubmed.ncbi.nlm.nih.gov
You got good result with 150mcg of MT1?
Melanotan II injection resulting in systemic toxicity and rhabdomyolysis - PubMed
Melanotan II use resulted in systemic toxicity including apparent sympathomimetic symptoms, rhabdomyolysis, and renal dysfunction.
Here it is...
"
A 39 year-old Caucasian male injected subcutaneously 6 mg of Melanotan II purchased over the Internet in an attempt to darken his skin during wintertime. This dose was six times the recommended starting dose per the patient. In the emergency department two hours post injection, he complained of diffuse body aches, sweating, and a sensation of anxiety. Vital signs included BP 151/85 mmHg, HR 130 bpm that peaked at 146 bpm, and temperature of 97.8°F. Physical exam demonstrated a restless and anxious appearing male with mydriasis, diaphoresis, tachycardia, and diffuse muscle tremors. Pertinent laboratory values were creatinine 2.25 mg/dL, CPK 1760 IU/L, troponin 0.23 ng/mL, WBC 19.1 k/μL. Urinalysis demonstrated 3 + blood with red cell casts but 0-2 RBC/hpf. Qualitative urine drug screen was negative for metabolites of cocaine and amphetamines but positive for opiates. The patient received benzodiazepines for agitation and anxiety and had improvement in his symptoms. He was admitted to the ICU and during hospitalization his CPK elevated to 17773 IU/L 12 hours later. He continued to receive intravenous fluids with sodium bicarbonate for rhabdomyolysis and his CPK decreased to 2622 IU/L with improvement of creatinine to 1.23 mg/dL upon discharge from the ICU after 3 days. The substance, which he injected, was analyzed via mass spectrometry and was confirmed to be Melanotan II when compared with an industry purchased standard sample.
Discussion: Melanotan products are purchased via the Internet and have three main formulations (Melanotan I, Melanotan II, and bremelanotide). Melanotan I increases melanogenesis and eumelanin content to produce sunless tanning. Melanotan II also increases skin pigmentation but also produces spontaneous penile erections and sexual stimulation. Bremelanotide is a variation of Melanotan II that is specifically designed for sexual stimulation. This unique case highlights the potential of systemic toxicity with sympathomimetic excess, rhabdomyolysis, and renal dysfunction from Melanotan II use."
Lol the guy is obviously an idiot. I mean he didn't deserve to go through that but saying that is only 6 tines the recommended starting dose?? I've never heard of anyone taking 1 mg (1000 mcg ) of MT1 or MT2. I've seen 250mcg as a loading dose but that's it. Dude obviously ducked up bad.
Regardless, it makes me concerned that there could be deleterious but unnoticeable side effects to MT2. Especially those who experience the yawning and elections, etc. It just seems like it is such an unnecessary thing to take when you can just take MT1 and get the tan you want without any neurological side effects...
MT1 and MT2 are equal MG to MG for you? In terms of tanning
People in qingding dongs thread are taking 1mg/day. I told them the exact same thing as you, that 100-250mcg/day works fine for me.Melanotan II injection resulting in systemic toxicity and rhabdomyolysis - PubMed
Melanotan II use resulted in systemic toxicity including apparent sympathomimetic symptoms, rhabdomyolysis, and renal dysfunction.
Here it is...
"
A 39 year-old Caucasian male injected subcutaneously 6 mg of Melanotan II purchased over the Internet in an attempt to darken his skin during wintertime. This dose was six times the recommended starting dose per the patient. In the emergency department two hours post injection, he complained of diffuse body aches, sweating, and a sensation of anxiety. Vital signs included BP 151/85 mmHg, HR 130 bpm that peaked at 146 bpm, and temperature of 97.8°F. Physical exam demonstrated a restless and anxious appearing male with mydriasis, diaphoresis, tachycardia, and diffuse muscle tremors. Pertinent laboratory values were creatinine 2.25 mg/dL, CPK 1760 IU/L, troponin 0.23 ng/mL, WBC 19.1 k/μL. Urinalysis demonstrated 3 + blood with red cell casts but 0-2 RBC/hpf. Qualitative urine drug screen was negative for metabolites of cocaine and amphetamines but positive for opiates. The patient received benzodiazepines for agitation and anxiety and had improvement in his symptoms. He was admitted to the ICU and during hospitalization his CPK elevated to 17773 IU/L 12 hours later. He continued to receive intravenous fluids with sodium bicarbonate for rhabdomyolysis and his CPK decreased to 2622 IU/L with improvement of creatinine to 1.23 mg/dL upon discharge from the ICU after 3 days. The substance, which he injected, was analyzed via mass spectrometry and was confirmed to be Melanotan II when compared with an industry purchased standard sample.
Discussion: Melanotan products are purchased via the Internet and have three main formulations (Melanotan I, Melanotan II, and bremelanotide). Melanotan I increases melanogenesis and eumelanin content to produce sunless tanning. Melanotan II also increases skin pigmentation but also produces spontaneous penile erections and sexual stimulation. Bremelanotide is a variation of Melanotan II that is specifically designed for sexual stimulation. This unique case highlights the potential of systemic toxicity with sympathomimetic excess, rhabdomyolysis, and renal dysfunction from Melanotan II use."
Lol the guy is obviously an idiot. I mean he didn't deserve to go through that but saying that is only 6 tines the recommended starting dose?? I've never heard of anyone taking 1 mg (1000 mcg ) of MT1 or MT2. I've seen 250mcg as a loading dose but that's it. Dude obviously ducked up bad.
Regardless, it makes me concerned that there could be deleterious but unnoticeable side effects to MT2. Especially those who experience the yawning and elections, etc. It just seems like it is such an unnecessary thing to take when you can just take MT1 and get the tan you want without any neurological side effects...
Idk I have never taken MT2 because I am not keen on neurological/parasympathetic nervous system ide effects.
