IGF-1 LR3.....WHAT WILL IT DO FOR ME ???

[Roco Bama]

The igf-1 lr3 or des aren't a recombinant human igf-1. The 70 amino acid igf-1 produced in our body has a long half life itself. Des or lr3 are a designer peptides. Human recombinant igf-1 actually requires large doses to elevate serum igf-1 level. We are taking about 8-15 mgs a day. And because it is used in children suffering from a rare condition, very few pharma companies in the world produce it.
The lr3 however does mimic igf-1 and improves vascularities and body composition from what I heard. How bout you give it a try and let keep us updated with your results.

 

[Dr JIM]

Have you used it?

Oh so that's the classic bro-science prerequisite and next in line did "you" use enough!

There's A LOT of evidence based research on the effects of IGF to
understand what it can or can not a achieve when used in isolation.

And the latter is the ONLY means
of KNOWING the effects of ONE drug on SKM metabolism, as the remainer is
anecdotal "everyone is different" bro-science!

Oh and surprise surprise I've never used IGF either and the same applies to heroin but I KNOW ITS ADDICTIVE "bro"!

 

[Leangains4life]

Oh so that's the classic bro-science prerequisite and next in line did "you" use enough!

There's A LOT of evidence based research on the effects of IGF to
understand what it can or can not a achieve when used in isolation.

And the latter is the ONLY means
of KNOWING the effects of ONE drug on SKM metabolism, as the remainer is
anecdotal "everyone is different" bro-science!

Oh and surprise surprise I've never used IGF either and the same applies to heroin but I KNOW ITS ADDICTIVE "bro"!

Haha.. I dont see anhthing wrong with plp doing stufd like that and having a life while some smoke 2 pak if smokes a day eat shit and drink pop 7 times a dayZ.. In the end those plp is what cause health system money.. Now highscool dont make fryed food cause if fatfucks..

 

[Roco Bama]

I would like to add for those people that are searching for igf-1lr3, take a look at mecasermin ( the complete human recombinant igf-1) Increlex Monograph for Professionals - Drugs.com
It doesn't have any added amino acids to its long chain of molecules whereas igf des has 67 and igf lr3 has 82 amino acids. It has a half life of 19.2h and bioavailability is 100% in healthy individuals. Daily doses is around 0.08-0.12/kg 2xper day in children. You guys can clearly see that lr3 or des can't be compared to mecasermin just like 192 HGH can't be compared to 191 amino acids HGH.
Then why don't china or rc companies produce human recombinant igf-1 ? I don't have the answer for it. If China is able to make 191 HGH then a 70 amino acid peptide will be easy and less costly for them to produce it. Ipsen pharma has a worldwide license to commercialize (increlex) mecasermin excluding Japan that have their own mecasermin (somazon) developed by astellas pharma. 1 more company in US called ismed inc also produce mecasermin but it's not FDA approved. I don't think there are any other companies besides the 3 listed above that makes mecasermin for human consumption.

 

[Dr JIM]

1) The igf-1 lr3 or des aren't a recombinant human igf-1.

2) The 70 amino acid igf-1 produced in our body has a long half life itself.

3) Des or lr3 are a designer peptides.

4) Human recombinant igf-1 actually requires large doses to elevate serum igf-1 level. We are taking about 8-15 mgs a day.

5) And because it is used in children suffering from a rare condition, very few pharma companies in the world produce it.

6) The lr3 however does mimic igf-1 and improves vascularities and body composition from what I heard. How bout you give it a try and let keep us updated with your results

.

1) DES and IGF-LR3 are IGF structural analogs produced by E-coli recombinant technology

2) about 10 hours and .....

3) they are one of SEVERAL POLY-peptide "IGF variants" developed in research labs to increase in-vitro CELL CULTURE GROWTH.

The application varies and could involve the study of; malignant cells, secretagogues, and perhaps some hormones

4) And what this statement is based upon

5) The current FDA
approved indication for IGF therapy is very narrow in scope
and so is the market for IGF, yet the MARKET for IGF variants is EVEN smaller, and to think some actually believe a VIAL of IGF-LR3 actually contains the genuine article ---- I'll bet ANYONE the cost of testing IT DOES NOT!

6) NOW THAT IS ALL BRO-science bc based on a Medline search I was unable to locate any CLINICAL TRIALS involving IGF variants

Yet this fact hasn't stopped an endless barrage of "bros" citing
cell culture or rat "potency" evidence these variants are perhaps even better than AAS!

Of course such details are irrelvant when those making such comments are also selling the product being touted.

Why some on this forum are SOOOOO
GULLIBLE!

 

[Dr JIM]

If China is able to make 191 HGH then a 70 amino acid peptide will be easy and less costly for them to produce it.

.

The LENGTH of a PolyPEP is only one of MANY factors involved in the cost of recombinant technology and IGF or its variants are no exception!

 

[Juced]

1) DES and IGF-LR3 are IGF structural analogs produced by E-coli recombinant technology

2) about 10 hours and .....

3) they are one of SEVERAL POLY-peptide "IGF variants" developed in research labs to increase in-vitro CELL CULTURE GROWTH.

The application varies and could involve the study of; malignant cells, secretagogues, and perhaps some hormones

4) And what this statement is based upon

5) The current FDA
approved indication for IGF therapy is very narrow in scope
and so is the market for IGF, yet the MARKET for IGF variants is EVEN smaller, and to think some actually believe a VIAL of IGF-LR3 actually contains the genuine article ---- I'll bet ANYONE the cost of testing IT DOES NOT!

6) NOW THAT IS ALL BRO-science bc based on a Medline search I was unable to locate any CLINICAL TRIALS involving IGF variants

Yet this fact hasn't stopped an endless barrage of "bros" citing
cell culture or rat "potency" evidence these variants are perhaps even better than AAS!

Of course such details are irrelvant when those making such comments are also selling the product being touted.

Why some on this forum are SOOOOO
GULLIBLE!

it can be made, it is made and it is used and I have noticed results.. you just stated #1 yet cant grasp places actually selling it? its not like its a guy building a flying saucer, its a freaking simple peptide...
yes i agree most is crap or out right fake, but not all and thats the same case for black market hgh....

Now we're going to hear about how RUI makes legitimate IGF-1 in 3, 2, 1, ...../

well I do feel they do and i liked it but I nve personally tested it in a lab, but it seems the case as with other stuff i have used from them in past.

The igf-1 lr3 or des aren't a recombinant human igf-1. The 70 amino acid igf-1 produced in our body has a long half life itself. Des or lr3 are a designer peptides. Human recombinant igf-1 actually requires large doses to elevate serum igf-1 level. We are taking about 8-15 mgs a day. And because it is used in children suffering from a rare condition, very few pharma companies in the world produce it.
The lr3 however does mimic igf-1 and improves vascularities and body composition from what I heard. How bout you give it a try and let keep us updated with your results.

you are wrong here on many points, DocD already set you straight here, I just wanted to second it.

 

[Juced]

I would like to add for those people that are searching for igf-1lr3, take a look at mecasermin ( the complete human recombinant igf-1) Increlex Monograph for Professionals - Drugs.com
It doesn't have any added amino acids to its long chain of molecules whereas igf des has 67 and igf lr3 has 82 amino acids. It has a half life of 19.2h and bioavailability is 100% in healthy individuals. Daily doses is around 0.08-0.12/kg 2xper day in children. You guys can clearly see that lr3 or des can't be compared to mecasermin just like 192 HGH can't be compared to 191 amino acids HGH.
Then why don't china or rc companies produce human recombinant igf-1 ? I don't have the answer for it. If China is able to make 191 HGH then a 70 amino acid peptide will be easy and less costly for them to produce it. Ipsen pharma has a worldwide license to commercialize (increlex) mecasermin excluding Japan that have their own mecasermin (somazon) developed by astellas pharma. 1 more company in US called ismed inc also produce mecasermin but it's not FDA approved. I don't think there are any other companies besides the 3 listed above that makes mecasermin for human consumption.

legally making it, there are copyrights and other red tape to some of these things, but off the books like in china it is made, like hgh.

 

[Docd187123]

There's the sales pitch I knew was coming.

 

[Juced]

There's the sales pitch I knew was coming.

its no sales pitch I could care less who buys from them or another place tbh... but as mentioned there are alot of shitty places and for me this place has been good so Iv mentioned it. could care less if people buy, if it helps someone looking for something half decent then I am happy..
plus i responded because of how you posted and what you clearly expect but i dont care.....
we are not on the same page when it comes to peps/igf1, thats fine.

for me i know i have liked it and continue to. others that dont can go use something else that works for them, or try a new place.
I have talked to more than one that called BS on igf1 then used something half decent (at like 4-5x the price of their first run) and had results and changed mind on it, atleast a bit anyways (yes you will get more out a simple teste cycle $ to $, but its a nice combo IMO). yes it can be genetic make up but i feel the wide gap of either loving or hating igf is mostly due to crappy quality or out right BS in a vial.
Iv noticed you either used it and loved it or havent and bash it or have but liekly of crappy quality and bash it.
I just dont get how soomany say its BS (not just you) yet i know it is not for myself and from some others...
anyways not here to argue i put my 2 cents in on this.

 

[Roco Bama]

legally making it, there are copyrights and other red tape to some of these things, but off the books like in china it is made, like hgh.

Even if you do get real igf lr3, you do know that lr3 and des are igf variants derivatives. Several IGF, IGF receptors and IGFBP are produced naturally in the body but igf-1 is the major growth factor in adults. Show me the rc that carry recombinant 70 amino acids IGF-1 ? There is a reason many pro bbs were disappointed in lr3 when it first came to market and those were pharma grade.

 

[Juced]

Even if you do get real igf lr3, you do know that lr3 and des are igf variants derivatives. Several IGF, IGF receptors and IGFBP are produced naturally in the body but igf-1 is the major growth factor in adults. Show me the rc that carry recombinant 70 amino acids IGF-1 ? There is a reason many pro bbs were disappointed in lr3 when it first came to market and those were pharma grade.

yes i know their structure differs and its not the same thing as say testp to teste. When it first came out the quality might have been worse than now due to limited product and knowledge, there is more crap places now, but also some more good. market drives production AND greed sadly.
I was happy anyways. yes i know what you mean, but there is a reason these RC places also dont sell HGH when they can have it made for them, avoiding red tape and heat etc. des and lr3 are a variation of natty igf1 (as you mentioned)

 

[Dr JIM]

Many have posted legitimate pro and con positions with respect to PEPS and there are several OBJECTIVE means of evaluating these compounds based on existing evidence IMO.

FIRST
What is the RISK of using the agents

- exclusive of the concern all PEPs are proteins, and proteins are fundamental components of MANY allergic reactions, overall the risk seems to be quite small

BENEFITS

- obviously this is an area where a huge void exists especially compared to conventional PEDS

- primarily bc almost all of the existing evidence involves the use of animal models, in which the assigned outcome measure/s differ considerably from that of traditional PEDS

For example some PEPs tend to focus on more focal SKM changes, while AAS research often quantifies hypertrophic alterations within the prostate and anal sphincter

- some PEPs or secretogogues use changes in IGF values as a basis of efficacy

- while some "sselective" PEPS ascertain alterations of inflammatory mediators to determine benefit

- of course such differences in a studies design, test subjects, and outcome measures, can not only have a HUGE impact on data interpretation but may also ensure objective comparisons or conclusions approach the impossible from an evidence based perspective

COST ANALYSIS!

- Based on my observations this seems to be the most frequently overlooked factor with respect to PEPs .

So ASSUMING a relatively low frequency of adverse effects, one might ask a fundamental question, WHICH IS I--
what benefit do these agents offer compared to conventional PEPs and at what cost?

Do single or combination PEP "therapy" increase IGF levels above that which is achieved from GH, at the SAME COST?

Do the anti inflammatory or "recovery" effects of "selective" PEPs compare, on a symptomatic basis, with the cost of NSAIDS?

- Are the "anabolic benefits" of
PEPs on level with a simplified run of a TT at $50 bucks a vial?


I only mention these factors bc MANY much less experienced PED
runners will experiment with just about anything and it's disconcerting to watch these kids use any number of PEPS, yet fail to draw precycle labs, overlook the importance of PCT, or commit a majority of their funds to a eating sound diet or attending a legitimate GYM.

Jim

 

[I Don't Lift]

Anyone have experience with Geo or Cem IGF?

 

[Juced]

Anyone have experience with Geo or Cem IGF?

Haven't used Geo so i cant say, but CEM is the other place I also use (suspect might be somehow related to other I use but not 100% sure) used the lr3 and des along with other peps (MT2 is pretty crazy if you havent used that and like a tan IMO) .
Ill leave it at that before I'm called a shill... :/ lol

where ever you go do alot of research and make sure the place has been around for a few years atleast, if not longer..

 

[whynottalk]

How did the run go ?

 

[Megadick3000]

For those it does work on..... Placebo is a hell of a drug man.

I OD'd on placebo once, spent three weeks in a non existent coma. My imaginary doctor was amazed i even survived such a fictitious event, let alone walked away with no permant damage.

 

[Dillon_21]

Honestly your money is better spent on gear or growth hormone peptides. Just my 2 cents.

 

[JayWaWa]

Your free IGF1-LR3 is rumored to cause liver tumors.
I'd just dose HGH/Slin at 1:2 IU ratio 5-6 times a day and you'll get the effect that youre looking for.

Hello fellow muscle enthusiasts......

Not sure if you can see my posting history, so I will brief you on my background story.

Im 40 years old, have been lifting for 25 years and cycling AAS for about 12 years. Im 5'11" and just weighed in at 244 pounds yesterday. In early May I had my right pec reattached as I blew it off the bone while warming up for the National Bench-Only record. My weight dipped to 225 by mid June, as I was just running a "light" sustanon/deca dosage to aid in a quality heal. Although im still leary to do much if any pectoral isolation exercises - I am back going very heavy on all other bodyparts and am currently running

1000mg Sustanon/wk
60 mg DBol/day
60 mg Anavar/day.

I am aware of the increased risk of liver harm from running 2 orals simultaneously - but ive run the DBol/Var combo in the past (6 weeks at a time) and it is an explosive combo for me. In 2 weeks when its time to come off the orals, I will be subbing in

Tren Enanthate 600mg/week
Equipoise 900mg/wk

in addition to the 1000mg/wk of Sustanon I am running.

Now, I was given 3x 1mg human-grade IGF-1 LR3 by a friend in the pharmaceutical business. I have no clue how to use this stuff (besides the 15-20 completely different dosing instructions ive seen on various websites).

My understanding now is that I want to inject a total of 50mcg into the muscle group I just finish training. So post shoulder workout for instance, 25mcg per delt. And that this should be run for no longer than 8 weeks.

My questions are as follows ;

1. Will this aid in the quality of heal from my pec reattachment surgery?

2. Am I correct in the dosing advice I have deciphered?

3. Since I lift 3-4 days per week - do I only inject on workout days, or also on off days? Where do I inject on off-days?

4. What kind of gains/results should I reasonably expect running this concurrently with the sustanon/tren/EQ cycle ive listed above?

I greatly appreciate any response/advice you guys can give me. As always, thanks in advance fellas.....

- KF

 

[tenor42]

This thread may be dead but I have to wonder if lack of clinical evidence alone warrants total dismissal of any of the many proclaimed benefits of IGF? It certainly is a major stike against those on the "pro" side of the debate. On the other hand if no one experienced benefit in any significant quantity one would think demand would wain fairly quickly and the interest in peptide use seems to be growing (purely an unscientific anecdotal observation....) But there are a lot of suckers out there. Finally I have to wonder what role individual biology might play in the both camps. Maybe the biology of the "pro" camp is simply more receptive to the peptide and the "con" camp feel like it's bunk because they get little or no benefit as an artifact of their biology? I tend to think in most arguments the truth is in the middle AND based on results or experience from a personal perspective that consist of individual variables of which no one is aware.

I also enjoy a good placebo now and again. Statistically aren't they usually the most effective?