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Interesting results on daily vs E3.5 day testosterone injections

J

jtmarlin

Member
I've always been a 2x per week injector of long esters but wanted to try daily and see the results on bloods and I was pretty shocked. On daily injects of 25mg per day of test cyp = 175mg per week, my total test came back 1500+, free t 46, e2 38. When I was running my standard protocol of e3.5 days of 80mg = 160mg per week, my trough total test would come in 900ish on average, free t 30 and E2 30-35. I didn't test SHBG but it appears to be have risen and my E2 seemed to stay in check even given the higher free t levels. Many guys could probably get away with 15mg per day or 105mg per week of daily injections and still be at the upper end. I tried lower doses e3.5 days and came in with shitty through numbers. I didn't realized how fast levels can decline after peaking.
 
jtmarlin said:
I've always been a 2x per week injector of long esters but wanted to try daily and see the results on bloods and I was pretty shocked. On daily injects of 25mg per day of test cyp = 175mg per week, my total test came back 1500+, free t 46, e2 38. When I was running my standard protocol of e3.5 days of 80mg = 160mg per week, my trough total test would come in 900ish on average, free t 30 and E2 30-35. I didn't test SHBG but it appears to be have risen and my E2 seemed to stay in check even given the higher free t levels. Many guys could probably get away with 15mg per day or 105mg per week of daily injections and still be at the upper end. I tried lower doses e3.5 days and came in with shitty through numbers. I didn't realized how fast levels can decline after peaking.
Click to expand...
IM injection of test cyp has a mean elimination half life of ~4 to 4.5 days. Lots of other drivers but decent estimate. Thanks for sharing.
 
Another AI example in this thread.

When you pose this question to ChatGPT and get back 8 to 12 days, the next question you have to ask yourself is why? Do you know why or will you accept the answer?
 
jtmarlin said:
I've always been a 2x per week injector of long esters but wanted to try daily and see the results on bloods and I was pretty shocked. On daily injects of 25mg per day of test cyp = 175mg per week, my total test came back 1500+, free t 46, e2 38. When I was running my standard protocol of e3.5 days of 80mg = 160mg per week, my trough total test would come in 900ish on average, free t 30 and E2 30-35. I didn't test SHBG but it appears to be have risen and my E2 seemed to stay in check even given the higher free t levels. Many guys could probably get away with 15mg per day or 105mg per week of daily injections and still be at the upper end. I tried lower doses e3.5 days and came in with shitty through numbers. I didn't realized how fast levels can decline after peaking.
Click to expand...

How long after the daily injections were the blood tests? IIRC from the research, levels peak around 14ish hours after injection (same source as the 4.5 half-life figures). This being a capped test (I think?) means we can't tell exactly how high the peak was but I'm interested anyway.

Also, how far from injections were the blood tests taken when you did it every 3.5 days?
 
all anecodotal but I switched to daily injections with an insulin syringe and I get literally zero bloat and looked way better on the same dose. Lean bulking right now so my food intake has been pretty consistent aswell

I just like the insulin syringes over 23 or 25 guage. They seem like a hardpoon in comparison lol
 
Size of the bolus also has an effect on rate of absorption. Whilst I wouldn't expect it to be major in the case of TRT doses - because the difference here is small in absolute volumes - it's probably playing some part.

Oh and did you use the same injection sites, as they vary also in terms of absorption rate.
 
rexy said:
How long after the daily injections were the blood tests? IIRC from the research, levels peak around 14ish hours after injection (same source as the 4.5 half-life figures). This being a capped test (I think?) means we can't tell exactly how high the peak was but I'm interested anyway.

Also, how far from injections were the blood tests taken when you did it every 3.5 days?
Click to expand...

I shoot the daily shots around 7am. Bloodtest was 4 hours later. When doing e3.5 days I would try to get it within a few hours of my evening Thursday shot so it was nearly 3.5 days later minus a few hours.
 
rexy said:
Size of the bolus also has an effect on rate of absorption. Whilst I wouldn't expect it to be major in the case of TRT doses - because the difference here is small in absolute volumes - it's probably playing some part.

Oh and did you use the same injection sites, as they vary also in terms of absorption rate.
Click to expand...
On daily I rotate between Delt, quads, and glutes (not sure if I'm getting muscle on glutes or not there). When doing the e3.5days it was always IM either delt or quad.

Also this is all pharmacy testosterone cyp Actavis.
 
There isn’t a trough or a peak(at max 1-2%)when doing daily TC after a couple of weeks
Injecting 50+ esters per week plus overlapping
Doesn’t get anymore stable than that
 
readalot said:
IM injection of test cyp has a mean elimination half life of ~4 to 4.5 days. Lots of other drivers but decent estimate. Thanks for sharing.
Click to expand...
SteroidPlotter lists TC as t1/2 of 6.9 days, Cmax of 5.5, and Tmax of 4.5 days. Compared to TE having a t1/2 of 7.19 days, Cmax of 11.3, and Tmax of 1.3 days.

I'd understand why daily injections of TE would help keep levels stable due to the higher Cmax and shorter Tmax, but I don't see why daily injections of TC would be any different than EOD injections given the lower Cmax and longer Tmax. If you plot EOD or even E3D injections of TC on SteroidPlotter, you'll see the fluctuations in blood levels are minuscule.

@readalot any thoughts?
 
lift4lyfe said:
SteroidPlotter lists TC as t1/2 of 6.9 days, Cmax of 5.5, and Tmax of 4.5 days. Compared to TE having a t1/2 of 7.19 days, Cmax of 11.3, and Tmax of 1.3 days.

I'd understand why daily injections of TE would help keep levels stable due to the higher Cmax and shorter Tmax, but I don't see why daily injections of TC would be any different than EOD injections given the lower Cmax and longer Tmax. If you plot EOD or even E3D injections of TC on SteroidPlotter, you'll see the fluctuations in blood levels are minuscule.

@readalot any thoughts?
Click to expand...

Are you sure those numbers for test cyp and test e are correct? They shouldn't be as different as they are on the plotter.
 
lift4lyfe said:
SteroidPlotter lists TC as t1/2 of 6.9 days, Cmax of 5.5, and Tmax of 4.5 days. Compared to TE having a t1/2 of 7.19 days, Cmax of 11.3, and Tmax of 1.3 days
Click to expand...
These parameters are simply way off. The 7 day t1/2 from TC comes from Pfizer's flawed PK analysis of men who weren't shut down (hence they were still making endogenous T on top of the exogenous bolus).

Test C and Test E in same oil/BB/BA should be interchangeable PK wise.

Very nice study looking at PK and HPTA suppression:

Mean apparently elimination half life about 4 days. Apparent absorption half life about 8 hrs. Tmax 18 to 36 hours IIRC.
 
readalot said:
These parameters are simply way off. The 7 day t1/2 from TC comes from Pfizer's flawed PK analysis of men who weren't shut down (hence they were still making endogenous T on top of the exogenous bolus).

Test C and Test E in same oil/BB/BA should be interchangeable PK wise.

Very nice study looking at PK and HPTA suppression:

Mean apparently elimination half life about 4 days. Apparent absorption half life about 8 hrs. Tmax 18 to 36 hours IIRC.
Click to expand...
SteroidPlotter cites that study in reaching their PK numbers. They also cite these two studies:

 
readalot said:
These parameters are simply way off. The 7 day t1/2 from TC comes from Pfizer's flawed PK analysis of men who weren't shut down (hence they were still making endogenous T on top of the exogenous bolus).

Test C and Test E in same oil/BB/BA should be interchangeable PK wise.

Very nice study looking at PK and HPTA suppression:

Mean apparently elimination half life about 4 days. Apparent absorption half life about 8 hrs. Tmax 18 to 36 hours IIRC.
Click to expand...
Could any difference in PK between TE and TC be attributable to the ester structure? Even if they're only 1-carbon chain difference, they have different structures. TC has that cyclic structure of carbons compared to TE's linear structure. Could that result in more resistance to enzymatic hydrolysis?
 
lift4lyfe said:
Could any difference in PK between TE and TC be attributable to the ester structure? Even if they're only 1-carbon chain difference, they have different structures. TC has that cyclic structure of carbons compared to TE's linear structure. Could that result in more resistance to enzymatic hydrolysis?
Click to expand...
Theoretically, yes. In practice, not much...


Forgive me for not pulling this from original reference. Don't have that pdf handy at the moment. I am familiar with the figure though.
 
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