Is HGH decreasing the effects of Tirz and Sema?

[bigtom343]

I use WebMD to check my meds and gear for interactions. The interaction that I’m most interested in is my 3-4 IU/ day HGH and 10mgTriz 0.6 mg Cagri weekly regimen.

WebMD states that HGH reduces the effectiveness of Triz and Sema. I’ve been on GLP’s for weight loss for over a year and managed to drop 50lbs. I’m now at a weight where I can consistently incorporate long distance running into my fitness regimen.

I started getting in on the QSC GB’s and their Discord this year. Their marketing was very catchy and had a lot of consumer enthusiasm around their products. It got me interested in doing HRT and TRT to help me reduce my physical pain from heavy exercise at age 40 as well as the anti-aging/biohacking benefits.

I’ve been doing the 2-4 IU HGH for about 6 weeks and I have noticed some benefits such as less knee pain and better rest at night.

I’ve been holding at the 10mg Tirz for 3months while slowly adding the Cagri to maintain the appetite suppression. My concern is that the HGH might interfere with the peptide regimen for weight loss. I’m starting to eat a little more everyday and took my son to a Korean bbq hotpot tonight

I’m concerned I’m about to break thru the hunger threshold on the Tirz. In the winter I broke thru the hunger threshold on 3-4 mg Semaglutide and switched over to Tirz. 10mg Tirz with the Cargi seemed like a good cruising maintenance dose for not gaining weight untill just now.

The question I’m asking myself is which direction do I need to go? Do I stop the low dose HGH? Do up the Tirz to 15mg & 2.4 mg Cargi? Add some Metformin? Go even harder (I wish) on the exercise? Switch to Reta?

If possible I’d like to wait till winter to switch to Reta because I’ve heard it helps you stay warm.
The discord bros insist that HGH and Triz and TRT together are the perfect combo for a lean physique. I’m not convinced and I’d like to get some more input.

Thanks

 

[primojuju]

They "interact" because GH is prescribed for weight gain in AIDS patients and height increase in kids. GLPs are prescribed for weight loss in diabetics. Web md doesn't know you are trying to use both as a healthy adult, webmd is just going off what the drugs are written for clinically .

Here's some info relevant to you

https://ampouletude.com/article/6

 

[mochul]

They "interact" because GH is prescribed for weight gain in AIDS patients and height increase in kids. GLPs are prescribed for weight loss in diabetics. Web md doesn't know you are trying to use both as a healthy adult, webmd is just going off what the drugs are written for clinically .

Here's some info relevant to you

https://ampouletude.com/article/6

Also hgh causes insuline resistance while glp-1 makes it better. Hgh doesn’t effects the appetite suppressant but other benefits of glp-1.

 

[Ghoul]

HGH has nothing to do with the appetite regulation effects of GLPs, but glucose control. If you're not treating diabetes it's irrelevant.

The internet is unfortunately awash in a sea of idiots who have no idea how GLPs work; and every time their appetite increases a little they're convinced it's stopped working.

It's very simple. GLP supplementation lowers your body's "set weight" on a dose dependent basis, and the natural regulatory processes that drive humans to consume more or less calories simply does its thing to maintain that weight.

Like a thermostat. As you approach the weight "setting" appetite suppression eases, then stops. Once over that weight, appetite suppression returns to push you back down. A higher dose will, after several weeks, result in a lower "target".

What you don't see, with these impatient morons, is staying on a dose where they lost, say, 50 lbs, regaining 50 lbs. They achieve whatever loss at a certain maintainance dose, and may regain 3-5 lbs, then drop back down, hovering around the target weight.

Instead they switch compounds, or add new substances because they don't "feel" appetite suppression any more. Or worse, stop using it because it's "ineffective" (increasing the odds it WILL be less effective when they go back on).

That's how it's supposed to work once you've hit whatever weight that dose has set your "thermostat" for. Try putting. on another 10lbs while staying on that dose and you'll quickly experience a return of nausea, acid reflux, and a disinterest in food.

 

[MrTexas2]

It seems to me that GH in tirz/semi go very well together.

 

[niqTM]

HGH has nothing to do with the appetite regulation effects of GLPs, but glucose control. If you're not treating diabetes it's irrelevant.

The internet is unfortunately awash in a sea of idiots who have no idea how GLPs work; and every time their appetite increases a little they're convinced it's stopped working.

It's very simple. GLP supplementation lowers your body's "set weight" on a dose dependent basis, and the natural regulatory processes that drive humans to consume more or less calories simply does its thing to maintain that weight.

Like a thermostat. As you approach the weight "setting" appetite suppression eases, then stops. Once over that weight, appetite suppression returns to push you back down. A higher dose will, after several weeks, result in a lower "target".

What you don't see, with these impatient morons, is staying on a dose where they lost, say, 50 lbs, regaining 50 lbs. They achieve whatever loss at a certain maintainance dose, and may regain 3-5 lbs, then drop back down, hovering around the target weight.

Instead they switch compounds, or add new substances because they don't "feel" appetite suppression any more. Or worse, stop using it because it's "ineffective" (increasing the odds it WILL be less effective when they go back on).

That's how it's supposed to work once you've hit whatever weight that dose has set your "thermostat" for. Try putting. on another 10lbs while staying on that dose and you'll quickly experience a return of nausea, acid reflux, and a disinterest in food.

That is interesting. I never heard it explained like that. That is probably why people who are taking max dose stop losing weight. Happened to a few people I know. I'll have to bring this up to them.

 

[Ghoul]

That is interesting. I never heard it explained like that. That is probably why people who are taking max dose stop losing weight. Happened to a few people I know. I'll have to bring this up to them.

Take a look at the 3 and 4 year Sema and Tirz "extended clinical trial phase" studies.

Thousands of people on the same dose for years. If it became "ineffective" over time you'd see weight gain, but you don't. It's stable, with weight loss maintained over that time. If they want to lose more. bump the dose up slightly. I find UGL to be somewhat less effective than pharma. 20mg UGL Tirz is closer to a 15mg Zepbound pen, and that 15mg max dose is conservative, not fully taking into account individual differences in response.

Sema is proving safe up to a whopping 7.2mg in phase 3 trials, so bumping that up, to "turn the thermostat down" further if needed can also be safely done.

But I strongly advise not stopping entirely, or switching compounds unless you're committed to the new compound for the long term.

 

[niqTM]

Take a look at the 3 and 4 year Sema and Tirz "extended clinical trial phase" studies.

Thousands of people on the same dose for years. If it became "ineffective" over time you'd see weight gain, but you don't. It's stable, with weight loss maintained over that time. If they want to lose more. bump the dose up slightly. I find UGL to be somewhat less effective than pharma. 20mg UGL Tirz is closer to a 15mg Zepbound pen, and that 15mg max dose is conservative, not fully taking into account individual differences in response.

Sema is proving safe up to a whopping 7.2mg in phase 3 trials, so bumping that up, to "turn the thermostat down" further if needed can also be safely done.

But I strongly advise not stopping entirely, or switching compounds unless you're committed to the new compound for the long term.

I totally stopped Sema after 3 months. I just felt like garbage the whole time. Lethargic, low-level depression. Decided to try Tirz and liked it way more. Appetite suppression was there without all of the nasty sides.

Got off of Tirz and tried Reta for the last 4 weeks or so. No appetite suppression at all and started to gain a little weight.

After what you said, I might switch back to Tirz and keep that as my regular for a while since it seemed to work well.

 

[Ghoul]

I totally stopped Sema after 3 months. I just felt like garbage the whole time. Lethargic, low-level depression. Decided to try Tirz and liked it way more. Appetite suppression was there without all of the nasty sides.

Got off of Tirz and tried Reta for the last 4 weeks or so. No appetite suppression at all and started to gain a little weight.

After what you said, I might switch back to Tirz and keep that as my regular for a while since it seemed to work well.

Tirz is cheap, effective, widely available, and although Reta is probobly safe, Tirz has been in use much longer with millions of patient years of clinical experience. We know what happens with GLP and GIP manipulation, but Glucagon is a wildcard.

Once you get to goal weight and stay on a stable maintainance dose, you feel nothing. So try to get to that point, the same way millions of people using pharma have done, with a 95%.+ success rate.

The way the Reddit Institute has people jumping from compound to compound, stacking, and wild protocols based on feels rather than proven in extensive clinical trials, you'd think none of them work.

 

[niqTM]

Well, the way you explained it earlier makes sense. I wanted to stay on the minimum dose forever because I heard the bad effects of GLPs are because we are being overdosed. I didn't want to over-do it.

 

[Ghoul]

Well, the way you explained it earlier makes sense. I wanted to stay on the minimum dose forever because I heard the bad effects of GLPs are because we are being overdosed. I didn't want to over-do it.

GLP side effects are temporary. Within the clinical doses, there are literally no known negative health impacts from GLP(and GIP) hormone supplementation, quite the opposite. (I'm not talking about indirect effects from poor diet and the resulting malnutrition, dehydration, etc)

In fact, if your maintainance dose, the one at which you're at your ideal weight, is low, you're at somewhat of a disadvantage, because most of the (long list of) other lesser known benefits are more pronounced at higher doses.