Sema/Thriz/Reta choices

[Here2Learn]

Currently I’m on Sema, up to 1.25mg/week and have been losing an average of 1lb/week or less. I started at a medspa, just shifted to Skye and now researching China direct. My inflammation can vary widely so the scale jumps all over the place. Sema has helped with inflammation and I’m looking into running BPC/TB for. 6-8 week protocol to see if it helps more and than a series of Thymosin Alpha 1 after that.

My question is with the lower pricing of China direct Tirz/Reta is more affordable so it has become and option. Sema makes me SO tired and I feel like some weeks it works really well and other weeks not as much. If you were to change what would you choose? I’ve researched all of them pretty extensively so I know the pro/cons but looking for people who have switched and what they liked or don’t like.

 

[Ryobi]

Currently using sema from amplified amino. Started very low with 0.25mg sub q didn’t feel much bumped into to 0.5mg and felt the effects very strongly. Nausea was very bad first day and couldn’t even look at food. Second day the nausea has calmed down a bit after a couple cups of ginger tea and now foods super enzymes. I will stick with 1-2 injection a week at no more than 0.5mg. Appetite suppression is very good I had a big issue with binge eating and eating too many snacks throughout the day. Have ordered reta but reading this thread about the doses I don’t think the 5mg vial I got will last that long.

 

[Optovisc]

FWIW my personal experience with Tirz at 10mg was that it made me extremely tired. Switching over to Reta was night and day in terms of energy for me. I'm not exactly sure of the mechanism because the amount of calories I take in hasn't changed much on Reta.

 

[Ghoul]

FWIW my personal experience with Tirz at 10mg was that it made me extremely tired. Switching over to Reta was night and day in terms of energy for me. I'm not exactly sure of the mechanism because the amount of calories I take in hasn't changed much on Reta.

Fatigue is always worst at the sudden restricting of calories, metabolism adjusts. and fatigue lifts. I've never heard of someone going from Reta to Tirz complaining of fatigue, only when they switch to Reta after another GLP was used first,

If this benefit is so pronounced, why isn't Lily boasting about it? Why doesn't it show up in the clinical trials as a glaring difference vs Tirz? They carefully monitor and report every tiny side effect, but fatigue doesn't appear any different between the two, according to them.

 

[BamaCrazy]

Fatigue is always worst at the sudden restricting of calories, metabolism adjusts. and fatigue lifts. I've never heard of someone going from Reta to Tirz complaining of fatigue, only when they switch to Reta after another GLP was used first,

If this benefit is so pronounced, why isn't Lily boasting about it? Why doesn't it show up in the clinical trials as a glaring difference vs Tirz? They carefully monitor and report every tiny side effect, but fatigue doesn't appear any different between the two, according to them.

There is too much anecdotal evidence to discount people’s experiences switching from Tirz to Reta. I wouldn’t define what I felt on Tirz as fatigue, but I would describe it as anhedonia. Lack of motivation. Lack of interest. Once I started running, mountain biking, or lifting weights I felt fine. But getting started was challenging. But switching to Reta resolved that and quick. It had zero to do with my diet, caloric restriction or metabolism.

 

[Here2Learn]

There is too much anecdotal evidence to discount people’s experiences switching from Tirz to Reta. I wouldn’t define what I felt on Tirz as fatigue, but I would describe it as anhedonia. Lack of motivation. Lack of interest. Once I started running, mountain biking, or lifting weights I felt fine. But getting started was challenging. But switching to Reta resolved that and quick. It had zero to do with my diet, caloric restriction or metabolism.

On Sema I had extreme fatigue and anhedonia, Tirz I had less of both, I believe fatigue let up more than anhedonia. On Reta I have neither. I agree it is anecdotal with so many variables but that was my experience.

 

[Ryobi]

What about the nausea for those compounds how do they compare?

 

[BamaCrazy]

On Sema I had extreme fatigue and anhedonia, Tirz I had less of both, I believe fatigue let up more than anhedonia. On Reta I have neither. I agree it is anecdotal with so many variables but that was my experience.

And that’s the experience of a lot of people. In fact too many people to just ignore because Eli Lilly’s trials did not identify that as a side effect. It is night and day for me from one to the other.

 

[Here2Learn]

What about the nausea for those compounds how do they compare?

I never got too much nausea but have had some acid reflux and it goes the same as the fatigue. Sema the most sides and Reta the least with Tirz falling in the middle.

 

[BamaCrazy]

What about the nausea for those compounds how do they compare?

I don’t know the statistics but Sema hits most people the hardest. But there are plenty who report nausea as a constant side effect on Tirz also. I’ve tried all 3 and I handle them all pretty well.

 

[Ghoul]

There is too much anecdotal evidence to discount people’s experiences switching from Tirz to Reta. I wouldn’t define what I felt on Tirz as fatigue, but I would describe it as anhedonia. Lack of motivation. Lack of interest. Once I started running, mountain biking, or lifting weights I felt fine. But getting started was challenging. But switching to Reta resolved that and quick. It had zero to do with my diet, caloric restriction or metabolism.

I don't "discount" it.

However, should we "discount" the results of trials involving thousands of participants closely monitored by a small army of scientists?

Perhaps it's something unique to the "close but not quite" UGL knockoffs, or the haphazard way they're often used.

I think it's worth recognizing the worst fatigue accompanies the initial big drop in calories, which would be expected.

 

[BamaCrazy]

I don't "discount" it.

However, should we "discount" the results of trials involving thousands of participants closely monitored by a small army of scientists?

Perhaps it's something unique to the "close but not quite" UGL knockoffs, or the haphazard way they're often used.

Possibly. But I’ve used Pharma Ozempic and Zepbound and that’s when I experienced the anhedonia. Switching to compounded Tirz didn’t make a difference. Switching to Reta did. Anhedonia makes some people feel depressed, and depression can cause fatigue. I don’t believe I was depressed but I definitely lacked the drive and motivation I usually have.

 

[Ghoul]

Possibly. But I’ve used Pharma Ozempic and Zepbound and that’s when I experienced the anhedonia. Switching to compounded Tirz didn’t make a difference. Switching to Reta did. Anhedonia makes some people feel depressed, and depression can cause fatigue. I don’t believe I was depressed but I definitely lacked the drive and motivation I usually have.

I've also used pharma of both, and find UGL Tirz in particular to significantly differ from pharma in its effects. Shorter duration, different sides profile, less appetite suppression. Going from 20mg UGL back to 15mg Zepbound threw me for a loop, since it was significantly more intense.

I'm not suggesting this is necessarily the case, merely pointing out factors we don't consider may be responsible for widespread fatigue reported on UGL and conspicuously less with pharma.

T-cells are activated when injecting compounds that trigger immunogenic reactions, the result of impurities including aggregates.

Continuous stimulation of T-cells is known to be associated with chronic fatigue.

. Immune T cells become exhausted in chronic fatigue syndrome patients | Cornell Chronicle

As I've mentioned before, when the FDA checked immune responses to compounded GLPs they found them to be as much as 2000x higher than pharma.

 

[BrunoES]

@Ghoul do you know what the trials say about the delayed gastric emptying between Sema and Tirz? And if they say anything, do they mention if it tends to improve with time? This is my main concern with GLP-1's

 

[Ghoul]

@Ghoul do you know what the trials say about the delayed gastric emptying between Sema and Tirz? And if they say anything, do they mention if it tends to improve with time? This is my main concern with GLP-1's

TLDR: At any given dose, as weight is lost, gastric transport speeds up. If you somehow manage to gain weight, it'll slow further inducing more of the sides associated with it. If it's too much to deal with lower the dose, and give it a couple
of weeks.

 

[Sampei]

On Sema I had extreme fatigue and anhedonia, Tirz I had less of both, I believe fatigue let up more than anhedonia. On Reta I have neither. I agree it is anecdotal with so many variables but that was my experience.

Reta would awesome if not for the sensitive skin and bone chill cold

 

[BamaCrazy]

Reta would awesome if not for the sensitive skin and bone chill cold

I still get the sensitive skin issues but not as often as before. Nor as intense. At one time it was every second of every day. Even my scalp was sensitive.

 

[Sampei]

I still get the sensitive skin issues but not as often as before. Nor as intense. At one time it was every second of every day. Even my scalp was sensitive.

The thing with reta is that it's not as good as other glp1 (even sema is better imho) for blood glucose control, the glucagon part of reta makes the glucose control odd... It's not a steady decrease, it goes up and down

 

[Sampei]

I still get the sensitive skin issues but not as often as before. Nor as intense. At one time it was every second of every day. Even my scalp was sensitive.

I know what you mean lol horrible just horrible

 

[Sawisthelaw]

Implemented Reta this past week at 2 mg. Taking a break from Tirz. Hoping for the best.

 

[Juiced_lizard]

Implemented Reta this past week at 2 mg. Taking a break from Tirz. Hoping for the best.

What made you swap? What do you mean by “taking a break”?