Sema/Thriz/Reta choices

[Here2Learn]

Currently I’m on Sema, up to 1.25mg/week and have been losing an average of 1lb/week or less. I started at a medspa, just shifted to Skye and now researching China direct. My inflammation can vary widely so the scale jumps all over the place. Sema has helped with inflammation and I’m looking into running BPC/TB for. 6-8 week protocol to see if it helps more and than a series of Thymosin Alpha 1 after that.

My question is with the lower pricing of China direct Tirz/Reta is more affordable so it has become and option. Sema makes me SO tired and I feel like some weeks it works really well and other weeks not as much. If you were to change what would you choose? I’ve researched all of them pretty extensively so I know the pro/cons but looking for people who have switched and what they liked or don’t like.

 

[Nested]

View attachment 313603

I can't tell if you're trying to help or if this is a confrontation.

 

[glpfun]

I can't tell if you're trying to help or if this is a confrontation.

Both. People don’t like answering questions about vendor comparisons. Just look at their recent tests in their analytical testing threads and come to your own conclusion.

 

[Nested]

Both. People don’t like answering questions about vendor comparisons. Just look at their recent tests in their analytical testing threads and come to your own conclusion.

Thank you for clarifying. I understand.

 

[BamaCrazy]

That was a perfect answer. Thank you. I really value the of effects of Tirz. I'm currently taking 7 mg, which is ideal for appetite suppression, the main reason I use it. I'm considering switching to Reta because I've heard it helps burn more fat, but I don't want to lose the appetite suppression benefits. Of course, this is just based on your experience and not professional advice, but in a situation like this, would you suggest taking 5 mg of Reta and 5 mg of Tirz, or would you prefer increasing the dose of Reta to 10 mg to maintain equivalent appetite suppression?

That is a tough call. Stacking has to be a decision made based on your own level of risk tolerance. There is no research that I know of that has evaluated the risks and/or benefits of stacking GLPs. I get hungry on Reta. Not ravenous but what I consider normal hunger. On one meal a day Reta would not be my choice of GLP. But then again I wouldn’t subject myself to any diet that only allowed one meal a day. If I had very little risk tolerance I’d just increase Tirz to 8-10mg a week and see where that leads you. I feel like Tirz alone is definitely capable of helping you meet your goals without adding another GLP. The trials indicate this also.

 

[Nested]

That is a tough call. Stacking has to be a decision made based on your own level of risk tolerance. There is no research that I know of that has evaluated the risks and/or benefits of stacking GLPs. I get hungry on Reta. Not ravenous but what I consider normal hunger. On one meal a day Reta would not be my choice of GLP. But then again I wouldn’t subject myself to any diet that only allowed one meal a day. If I had very little risk tolerance I’d just increase Tirz to 8-10mg a week and see where that leads you. I feel like Tirz alone is definitely capable of helping you meet your goals without adding another GLP. The trials indicate this also.

I think your approach is solid. I’ve just ordered 10 vials of Reta, so I’m planning to try it on its own and see how it goes. Worst case, I can always go back to Tirz. I’d prefer not to stack them myself, so I’ll give Reta a try first. Appreciate your advice.

 

[Here2Learn]

I don't understand your last paragraph did you have better inflammatory control with reta? If yes why do you hope to just maintain with sema?

Is that a typo?

Yep total mistype, Sema gave me the best inflammation control.

 

[Here2Learn]

My experience with Reta has been the similar to @BamaCrazy. I started on Sema but it had too many sides and the hunger suppression was too much. Tirz I didn’t feel motivated to do anything, once I would get started I would be fine though. Still had the exhaustion and hunger suppression but not as much as Sema. I didn’t lose much of anything though. Reta has been the best for me (least inflammatory impact though) as I feel hungry and want to eat but also want to do things. I have great energy and just overall feel really good.

My personal annoyance is when people are constantly trying to avoid their hunger and want this major suppression. I think they are missing out on a wonderful opportunity to create better life long habits by still feeling hungry but not having cravings or overeating. Reta is just different in how it works, but I think it is superior for life long success. So many cover up where I truly think Reta shines by stacking with cagri or another GLP. As I said previously, I would love to stack sema just for inflammation but the hunger suppression is just too much for me. That isn’t even addressing potential safety issues of stacking. This is my opinion only and just my perspective.

 

[glpfun]

It will be interesting to see what Reta is ultimately marketed as, I don’t think they are going to market it as a weight loss drug but probably depends on outcome of current head to head trials with tirz. My money is on reducing fat from fatty liver disease and reducing liver inflammation. The glucagon receptor activation specifically removes liver fat.

 

[Ghoul]

My experience with Reta has been the similar to @BamaCrazy. I started on Sema but it had too many sides and the hunger suppression was too much. Tirz I didn’t feel motivated to do anything, once I would get started I would be fine though. Still had the exhaustion and hunger suppression but not as much as Sema. I didn’t lose much of anything though. Reta has been the best for me (least inflammatory impact though) as I feel hungry and want to eat but also want to do things. I have great energy and just overall feel really good.

My personal annoyance is when people are constantly trying to avoid their hunger and want this major suppression. I think they are missing out on a wonderful opportunity to create better life long habits by still feeling hungry but not having cravings or overeating. Reta is just different in how it works, but I think it is superior for life long success. So many cover up where I truly think Reta shines by stacking with cagri or another GLP. As I said previously, I would love to stack sema just for inflammation but the hunger suppression is just too much for me. That isn’t even addressing potential safety issues of stacking. This is my opinion only and just my perspective.

GLP appetite suppression is dependent on weight and dose. It's not a diet pill that induces endless appetite suppression.

People on maintenance doses don't continue to experience appetite suppression or lose weight, or those in the 4 year extended trials would be underweight anorexics by that point, rather than stabilizing.

 

[Here2Learn]

GLP appetite suppression is dependent on weight and dose. It's not a diet pill that induces endless appetite suppression.

People on maintenance doses don't continue to experience appetite suppression or lose weight, or those in the 4 year extended trials would be underweight anorexics by that point, rather than stabilizing.

Yes, but that is what people are wanting. They speak in terms of fear of their appetite and constantly scramble to add doses or other peps to avoid it.

 

[Nested]

Yes, but that is what people are wanting. They speak in terms of fear of their appetite and constantly scramble to add doses or other peps to avoid it.

First of all, who are you to judge? Not everyone needs to follow your perspective. Personally, I enjoy eating once a day, not because I fear appetite, but because it brings me mental clarity and allows me to savor my meals fully. It’s like foreplay for me. I understand your comment wasn’t directed at me, but please adopt a broader outlook, there’s no one-size-fits-all approach.

 

[Ghoul]

Yes, but that is what people are wanting. They speak in terms of fear of their appetite and constantly scramble to add doses or other peps to avoid it.

The pharma protocol is so simple and for the overwhelming majority effective.

X dose of GLP drug "sets" your biological target weight ("energy homeostasis") to a certain level. Once you reach that point, appetite suppression drops off. Increase the dose and that "setting" goes down, and appetite suppression returns, Keep titrating up until you reach goal weight, and if appetite suppression continues back off the dose slightly.

At maintainance dose you feel nothing. No appetite suppression, no sides, unless weight increases,

This only becomes a problem if you've reached maximum dose and it's still insufficient to get you to goal weight. At that point, going beyond pharma dose levels, switching compounds or considering stacking may make sense,

 

[Here2Learn]

First of all, who are you to judge? Not everyone needs to follow your perspective. Personally, I enjoy eating once a day, not because I fear appetite, but because it brings me mental clarity and allows me to savor my meals fully. It’s like foreplay for me. I understand your comment wasn’t directed at me, but please adopt a broader outlook, there’s no one-size-fits-all approach.

Yes but I wasn’t even talking to you as you just stated you aren’t doing it out of fear. I can say what my opinion is, and you can disagree that doesn’t mean either of us is right or wrong.

 

[Nested]

Yes but I wasn’t even talking to you as you just stated you aren’t doing it out of fear. I can say what my opinion is, and you can disagree that doesn’t mean either of us is right or wrong.

Absolutely, neither of us needs to be right or wrong. However, I did find your tone condescending, which is why I addressed it.

 

[Middus]

I think your approach is solid. I’ve just ordered 10 vials of Reta, so I’m planning to try it on its own and see how it goes. Worst case, I can always go back to Tirz. I’d prefer not to stack them myself, so I’ll give Reta a try first. Appreciate your advice.

There my not be significant benefits to appetite curbing in i creasing reta from 8mg to 10mg. However you will still likely get the benefit of satiety and also increased energy expenditure that comes with reta. It's the fear of reduced appetite suppression that makes some people augment their Reta intake with a dash of Sema and stuff like that..

 

[Nested]

There my not be significant benefits to appetite curbing in i creasing reta from 8mg to 10mg. However you will still likely get the benefit of satiety and also increased energy expenditure that comes with reta. It's the fear of reduced appetite suppression that makes people augment their Reta intake with a dash of Sema and stuff like that..

Of course, everyone is different and this is just a hypothetical question, but what would be considered a low dose for appetite suppression using Sema? I have experience with Tirz, so I’d like to understand what a small dose of Sema has to offer.

 

[Middus]

Of course, everyone is different and this is just a hypothetical question, but what would be considered a low dose for appetite suppression using Sema? I have experience with Tirz, so I’d like to understand what a small dose of Sema has to offer.

Sema for many people offers strong appetite suppression. "appetite suppression" may also be a vague term. Some people talk about GLPS reducing food noise. Unfortunately for me, it's never been a thing. GLP1s have never been able to match the initial 'food noise suppression I had after my gastric sleeve.
Some people have strong reactions to doses as small as 250-500mcg of Sema.
What GLPs do for me is the other aspect of appetite, which is satiety. So while I may always be thinking about Steak or Chicken, when it lands on my plate, I'm full after a few nibbles. Of course if one is a grazer it won't help. But the satiety is enough to curb bad habits.

 

[Nested]

Sema for many people offers strong appetite suppression. "appetite suppression" may also be a vague term. Some people talk about GLPS reducing food noise. Unfortunately for me, it's never been a thing. GLP1s have never been able to match the initial 'food noise suppression I had after my gastric sleeve.
Some people have strong reactions to doses as small as 250-500mcg of Sema.
What GLPs do for me is the other aspect of appetite, which is satiety. So while I may always be thinking about Steak or Chicken, when it lands on my plate, I'm full after a few nibbles. Of course if one is a grazer it won't help. But the satiety is enough to curb bad habits.

it seems that GLP-1s affect everyone differently. For me, Tirz completely suppresses my appetite, which is fantastic as someone who practices OMAD (one meal a day). It's wonderful not having to think about food until my final meal. However, since I'm only eating one meal a day, there are times when I find it challenging to maintain this schedule consistently. So, being able to manage my appetite so effectively has been a blessing.

 

[Middus]

it seems that GLP-1s affect everyone differently. For me, Tirz completely suppresses my appetite, which is fantastic as someone who practices OMAD (one meal a day). It's wonderful not having to think about food until my final meal. However, since I'm only eating one meal a day, there are times when I find it challenging to maintain this schedule consistently. So, being able to manage my appetite so effectively has been a blessing.

Tirz works just as well for many people. The general gist i get is that Sema is strongest per sides and appetite. I started with Sema. To be honest I had no idea whether it was working or not as I didn't fell any of the sides folks complained about. I only noticed the slight heart rate increase, lack of interest in alcohol and strangest side effect as anorgasmia . I switched to Tirz based solely on research results showing that it resulted in greater weight loss than Sema.

 

[Here2Learn]

Tirz works just as well for many people. The general gist i get is that Sema is strongest per sides and appetite. I started with Sema. To be honest I had no idea whether it was working or not as I didn't fell any of the sides folks complained about. I only noticed the slight heart rate increase, lack of interest in alcohol and strangest side effect as anorgasmia . I switched to Tirz based solely on research results showing that it resulted in greater weight loss than Sema.

One of my bff’s has great success on Sema with no sides. It is such a roll of the dice as to which one works best for your body. Someday they will know exactly what it is your body is missing to align with the proper med but I think we are a bit away from that still.