Sema/Thriz/Reta choices

[Here2Learn]

Currently I’m on Sema, up to 1.25mg/week and have been losing an average of 1lb/week or less. I started at a medspa, just shifted to Skye and now researching China direct. My inflammation can vary widely so the scale jumps all over the place. Sema has helped with inflammation and I’m looking into running BPC/TB for. 6-8 week protocol to see if it helps more and than a series of Thymosin Alpha 1 after that.

My question is with the lower pricing of China direct Tirz/Reta is more affordable so it has become and option. Sema makes me SO tired and I feel like some weeks it works really well and other weeks not as much. If you were to change what would you choose? I’ve researched all of them pretty extensively so I know the pro/cons but looking for people who have switched and what they liked or don’t like.

 

[Ghoul]

I know what you mean lol horrible just horrible

So you get a skin sensitivity reaction that goes beyond the immediate injection site?

Classic biologic (peptide) drug immunogenicity response. Cytokine storm in the skin. This company sells patches of skin left over from surgeries, kept alive, so drug developers can test for it.

IM, or filtering may very well get rid of that problem.

"The subcutaneous (SC) route of administration for biologics offers distinct advantages such as enabling patient self-administration and reducing healthcare costs associated with hospital-administered treatments. However, this route also presents unique immunogenicity challenges compared to intravenous (IV) administration. These challenges arise from the first-pass interactions of the therapeutic proteins with resident immune cells at the SC injection site, notably skin-resident dendritic cells and monocyte-derived dendritic cells. Such interactions, along with the antigen presentation mechanisms in the skin, contribute to a potentially heightened immune response. Furthermore, the SC route facilitates frequent encounters with dynamic skin antigen-presenting cells, which can lead to a more efficient and effective host immune response, offering both benefits and complexities in vaccine and biologic therapy development."

 

[Sampei]

So you get a skin sensitivity reaction that goes beyond the immediate injection site?

Classic biologic (peptide) drug immunogenicity response. Cytokine storm in the skin. This company sells patches of skin left over from surgeries, kept alive, so drug developers can test for it.

IM, or filtering may very well get rid of that problem.

"The subcutaneous (SC) route of administration for biologics offers distinct advantages such as enabling patient self-administration and reducing healthcare costs associated with hospital-administered treatments. However, this route also presents unique immunogenicity challenges compared to intravenous (IV) administration. These challenges arise from the first-pass interactions of the therapeutic proteins with resident immune cells at the SC injection site, notably skin-resident dendritic cells and monocyte-derived dendritic cells. Such interactions, along with the antigen presentation mechanisms in the skin, contribute to a potentially heightened immune response. Furthermore, the SC route facilitates frequent encounters with dynamic skin antigen-presenting cells, which can lead to a more efficient and effective host immune response, offering both benefits and complexities in vaccine and biologic therapy development."

View attachment 316961

No filtering doesn't get rid of the problem and skin sensitivity is a side effect of reta.

7% of ppl get it from the trials

 

[sushak]

No filtering doesn't get rid of the problem and skin sensitivity is a side effect of reta.

7% of ppl get it from the trials

It's called "allodynia"

 

[Ghoul]

It's called "allodynia"

Just going to point out skin reactions for other GLPs are correlated with higher antibody levels, ie. stronger immune reactions.

They don't address whether the 7% who get that side are the ones with higher antibodies or not, but it would make sense.

Sure seems like more than 7% of UGL users are mentioning that symptom.

 

[SubparMarioBro]

Reta would awesome if not for the sensitive skin and bone chill cold

For the skin sensitivity issues, try a good quality zinc supplement. This was suggested in another community and multiple people have reported improvements.

 

[Sampei]

For the skin sensitivity issues, try a good quality zinc supplement. This was suggested in another community and multiple people have reported improvements.

Got multiple ppl reporting no change and they were already taking zinc supplement.

 

[Here2Learn]

Reta would awesome if not for the sensitive skin and bone chill cold

I get the bone chill cold on all of them but SS-31 took that to ice berg level.