Sema/Thriz/Reta choices

[Here2Learn]

Currently I’m on Sema, up to 1.25mg/week and have been losing an average of 1lb/week or less. I started at a medspa, just shifted to Skye and now researching China direct. My inflammation can vary widely so the scale jumps all over the place. Sema has helped with inflammation and I’m looking into running BPC/TB for. 6-8 week protocol to see if it helps more and than a series of Thymosin Alpha 1 after that.

My question is with the lower pricing of China direct Tirz/Reta is more affordable so it has become and option. Sema makes me SO tired and I feel like some weeks it works really well and other weeks not as much. If you were to change what would you choose? I’ve researched all of them pretty extensively so I know the pro/cons but looking for people who have switched and what they liked or don’t like.

 

[Ghoul]

I’ve tried the microdosing ( I did injections every 3 days) and I swear the once every week does better. Also I messed with different amounts of bac water and @Ghoul is right. .50ml works best. I was just trying it more so as an experiment. Lot of talk about different ways of reinventing the wheel but I think if it works for someone then so be it.

I'm not gong to lie and suggest I'm out to save the world. I don't really care what some randos do to themselves. Presenting what I've learned and my hypothesis is primarily about me organizing my thoughts, and getting feedback from other intelligent people to revise my understanding with new info, other points of view, and the questions and challenges I'm presented with by participating in these discussions.

That said, it's a little sad that there are those who don't understand the risks of what they're doing. I think if they did, many would take a different approach, Injecting peptides is definitely not an area you want to be guided by via trends and fashion. Bad enough we're dealing with the risk of UGL produced stuff without embracing practices that needlessly increase risk.

 

[glpfun]

First, there are no formal studies of stacking or micro dosing GLPs.

Generally however, we know the following;

More frequent injections of proteins, called "exposure events", tends to increase the strength of immune response than less frequent injections. When immunogenicity is measured in the pharma trials, it's based on once weekly dosing. Splitting into daily doses could increase immunity development from "not clinically significant" to a problem.

That's why vaccines, essentially peptides/proteins engineered to maximize immunogenicity, are often split into multiple injections over weeks or months. Multiple exposure events "train" the immune system more effectively so there's a stronger destructive response to a similar looking (disease) protein it may encounter in the future vs a single larger dose,

Stacking could cause unknown issues, but in my opinion the biggest risk comes
from combining multiple peptides in one syringe or container, For various reasons, that's insane, and is an indicator the people doing this have no idea what they're dealing with or the risks they're exposing themselves to.

The other issue I'd ask is why? Did they follow the pharma protocol and not lose sufficient weight like 95%+ of participants trials did? Are these "miracle" drugs, providing weight loss so rapid muscle loss is an issue, not fast enough? What's the potential gain from turning yourself into a lab rat?

Peptide/protein therapeutics are nothing like AAS and other "small molecule" drugs, There are potential risks that can destroy you, and not develop for a decade or more. A large part of the reason protein based drugs cost billions to develop is the effort expended managing the unique risks these compounds present. 75% never make it past the first small scale clinical trials, frequently because of danger signals caught early on.

I think both ideas are fueled quite a bit in the peptide forums and chat rooms. They hit a pleateau and then ask people and the loudest voices in the crowd are always recommending stacking and/or micro dosing based on their own preferences. People aren’t even waiting out a plateau or adjusting other factors before changing the protocol. My personal experience with Tirz was there was a tipping point where I had to get my diet under control before I could lose anymore weight. Maybe another thing perpetuating it is the glp1plotter app which shows more stable levels with the microdosing route.

 

[Juiced_lizard]

I'm not gong to lie and suggest I'm out to save the world. I don't really care what some randos do to themselves. Presenting what I've learned and my hypothesis is primarily about me organizing my thoughts, and getting feedback from other intelligent people to revise my understanding with new info, other points of view, and the questions and challenges I'm presented with by participating in these discussions.

That said, it's a little sad that there are those who don't understand the risks of what they're doing. I think if they did, many would take a different approach, Injecting peptides is definitely not an area you want to be guided by via trends and fashion. Bad enough we're dealing with the risk of UGL produced stuff without embracing practices that needlessly increase risk.

I think it’s the mindset of anything - if xyz works why not try more so it’ll work faster and better? That mindset carries over to many facets of life.

In this aspect people don’t realize you didn’t become 350lbs of fat in a year, it took multiple years. You aren’t going to get down to 200lbs overnight. It takes months possibly years to undo all the bad doings up to this point.

 

[Ghoul]

I think both ideas are fueled quite a bit in the peptide forums and chat rooms. They hit a pleateau and then ask people and the loudest voices in the crowd are always recommending stacking and/or micro dosing based on their own preferences. People aren’t even waiting out a plateau or adjusting other factors before changing the protocol. My personal experience with Tirz was there was a tipping point where I had to get my diet under control before I could lose anymore weight. Maybe another thing perpetuating it is the glp1plotter app which shows more stable levels with the microdosing route.

And this is where I see a lack of understanding.

Why do they want more "stable" levels? There's nothing stable about natural GLP/GIP/Glucagon levels. Like most hormones, they're pulsatile.

This isn't a blood pressure medication, ibuprofen, or, what I see as the most common mindset, a fucking diet pill.

What if there's a benefit to blood levels dropping off before getting another dose? A chance for receptor activation to drop off before increasing again?

What if that initial "spike" provides its own benefits vs a constant level of a hormone we're never naturally exposed to at the same level on a continuous basis?

Again, I'm all for self sacrificial peptide Magellans, if it's done understanding they're exposing themselves to unknown risk, but those evangelizing these practices to others, don't know, and don't care enough to know.

 

[glpfun]

And this is where I see a lack of understanding.

Why do they want more "stable" levels? There's nothing stable about natural GLP/GIP/Glucagon levels. Like most hormones, they're pulsatile.

This isn't a blood pressure medication, ibuprofen, or, what I see as the most common mindset, a fucking diet pill.

What if there's a benefit to blood levels dropping off before getting another dose? A chance for receptor activation to drop off before increasing again?

What if that initial "spike" provides its own benefits vs a constant level of a hormone we're never naturally exposed to at the same level on a continuous basis?

Again, I'm all for self sacrificial peptide Magellans, if it's done understanding they're exposing themselves to unknown risk, but those evangelizing these practices to others, don't know, and don't care enough to know.

I think it may be influenced by practices in the aas community. When people are new to something or learning they collect a bunch of dogma which tends to be very black and white principles that aren’t exactly right but scaffolding for a mental framework to help them understand. As people learn more they hopefully start questioning the absoluteness of the dogma they carry and shed it off. Things like keeping stable levels and stacking anabolics is commonly discussed in an aas context and I suspect it was borrowed by the peptide community which is less mature and still figuring stuff out. Even though peptides have been around for a long time, from my perspective the peptide community didn’t really begin until the glp1 drugs. Could argue hgh too but hgh has always been in its own category imo and the communities around it were focused solely on gh and friends and not other peptides.

 

[Ghoul]

I think it may be influenced by practices in the aas community. When people are new to something or learning they collect a bunch of dogma which tends to be very black and white principles that aren’t exactly right but scaffolding for a mental framework to help them understand. As people learn more they hopefully start questioning the absoluteness of the dogma they carry and shed it off. Things like keeping stable levels and stacking anabolics is commonly discussed in an aas context and I suspect it was borrowed by the peptide community which is less mature and still figuring stuff out. Even though peptides have been around for a long time, from my perspective the peptide community didn’t really begin until the glp1 drugs. Could argue hgh too but hgh has always been in its own category imo and the communities around it were focused solely on gh and friends and not other peptides.

Agree completely,

I don't think "Harm reduction" even exists as a concept in the peptide groups. They're simply oblivious to health risk, vs AAS users for whom it's always been a factor to a lesser or greater degree.

MESO is the Ivy League of self administered (non-recreational) drugs by comparison,

There's also a level of seriousness about health among many members here that's largely absent in the peptide world.

When peptide users find their way to MESO, often men seeking TRT, since they've gotten over the "injection hump" with a GLP, you can see they're invariably upping their game here.

 

[Here2Learn]

I was just reviewing my original question in this thread and can’t believe how much I’ve been able to learn since coming here. Of course weight was a factor for me getting here but the healing process kind of took over. My focused has shifted and I feel better than I have in years. The weight is coming off slowly but having the energy to get back to lifting weights and doing all the things I haven’t had the energy to do has me so thankful I found this forum.

I know it is hard for me to go out to Reddit and read the advice that is given. Even before I knew better, and the why, much of what they are saying didn’t make sense. I’ve learned many of them have true fear or their own hunger, like it needs to be tamped down as much as possible and if that means mixing all the GLP’s with a cagri so be it. Don’t get me wrong, I really miss the better inflammatory control I got from Reta and would love to have a piece of that back. I am hoping once I get to goal I can maintain on a small dose of sema without sides just for the inflammation benefits.

 

[Sampei]

I was just reviewing my original question in this thread and can’t believe how much I’ve been able to learn since coming here. Of course weight was a factor for me getting here but the healing process kind of took over. My focused has shifted and I feel better than I have in years. The weight is coming off slowly but having the energy to get back to lifting weights and doing all the things I haven’t had the energy to do has me so thankful I found this forum.

I know it is hard for me to go out to Reddit and read the advice that is given. Even before I knew better, and the why, much of what they are saying didn’t make sense. I’ve learned many of them have true fear or their own hunger, like it needs to be tamped down as much as possible and if that means mixing all the GLP’s with a cagri so be it. Don’t get me wrong, I really miss the better inflammatory control I got from Reta and would love to have a piece of that back. I am hoping once I get to goal I can maintain on a small dose of sema without sides just for the inflammation benefits.

I don't understand your last paragraph did you have better inflammatory control with reta? If yes why do you hope to just maintain with sema?

Is that a typo?

 

[Middus]

Agree completely,

I don't think "Harm reduction" even exists as a concept in the peptide groups. They're simply oblivious to health risk, vs AAS users for whom it's always been a factor to a lesser or greater degree.

MESO is the Ivy League of self administered (non-recreational) drugs by comparison,

There's also a level of seriousness about health among many members here that's largely absent in the peptide world.

When peptide users find their way to MESO, often men seeking TRT, since they've gotten over the "injection hump" with a GLP, you can see they're invariably upping their game here.

LoL.. This is more 'high horse' than Reality. A lot of info abounds in AAS and peptide fora.

 

[Nested]

For those who have purchased Sema/Triz/Reta from both QSC and Sigma, did you find that one offers better quality than the other?

 

[Care2Play]

For those who have purchased Sema/Triz/Reta from both QSC and Sigma, did you find that one offers better quality than the other?

Retatrutide is an experimental drug and I would stay away from it and reconsider it after it is approved.


From research and dozens of experiances, Tirzepatide works better and (for most) with fewer side effects than Semaglutide. But it is more expensive.

 

[Nested]

Retatrutide is an experimental drug and I would stay away from it and reconsider it after it is approved.


From research and dozens of experiances, Tirzepatide works better and (for most) with fewer side effects than Semaglutide. But it is more expensive.

That did not answer my question.

 

[Sampei]

For those who have purchased Sema/Triz/Reta from both QSC and Sigma, did you find that one offers better quality than the other?

No don't feel any difference.

 

[BamaCrazy]

Retatrutide is an experimental drug and I would stay away from it and reconsider it after it is

lol. There’s no medical professional on the planet that would sign off on all the gear and peptides being stacked in this forum. Much less the FDA. There’s a reason all peptides come marked for research purposes only…

And Reta is the best for me. Easily my favorite after trying Sema and Tirz.

 

[Nested]

lol. There’s no medical professional on the planet that would sign off on all the gear and peptides being stacked in this forum. Much less the FDA. There’s a reason all peptides come marked for research purposes only…

And Reta is the best for me. Easily my favorite after trying Sema and Tirz.

Could you explain why you prefer Reta over Triz? Additionally, could you share the dosages you were using for each?

 

[glpfun]

lol. There’s no medical professional on the planet that would sign off on all the gear and peptides being stacked in this forum. Much less the FDA. There’s a reason all peptides come marked for research purposes only…

And Reta is the best for me. Easily my favorite after trying Sema and Tirz.

I think their statement is fair to some extent. Most of the steroids we take with maybe the exception of tren have been studied extensively for decades on human use even if the human populations were classes of sick people and not meso users. Reta is in phase 3 clinical trials and only 36% of drugs that get to phase 3 make it through. There’s still a decent chance something could surface with large scale testing although it seems unlikely and I don’t think we’ll know until 2026. As long as people are aware of the possible risks they’re taking I don’t really care but I think risks get downplayed a lot especially with peptides.

 

[BamaCrazy]

Could you explain why you prefer Reta over Triz? Additionally, could you share the dosages you were using for each?

So this is of course all anecdotal. And some members may comment that the “why” and my method doesn’t match what was seen or used in the trials. Sema had the best appetite suppression. Almost too good. It also comes with the most negative side effects for some. I really liked Tirz and lost the majority of my weight using Tirz. But I always felt lethargic and lacked motivation to do anything. I wouldn’t call it fatigue because once I started lifting or running I’d feel fine and had no problems completing my workout. So I initially stacked Reta with Tirz (7.5 Tirz, 4mg Reta). I immediately felt better on Reta. So I slowly lowered Tirz and increased Reta until I was no longer taking Tirz. I’m taking 8mg of Reta now as a maintenance dose after losing a total of 45 pounds. I like the way I feel on Reta. I’m hungrier on Reta compared to Tirz, but I still cannot overeat if that makes sense. It just feels more natural.

 

[Nested]

So this is of course all anecdotal. And some members may comment that the “why” and my method doesn’t match what was seen or used in the trials. Sema had the best appetite suppression. Almost too good. It also comes with the most negative side effects for some. I really liked Tirz and lost the majority of my weight using Tirz. But I always felt lethargic and lacked motivation to do anything. I wouldn’t call it fatigue because once I started lifting or running I’d feel fine and had no problems completing my workout. So I initially stacked Reta with Tirz (7.5 Tirz, 4mg Reta). I immediately felt better on Reta. So I slowly lowered Tirz and increased Reta until I was no longer taking Tirz. I’m taking 8mg of Reta now as a maintenance dose after losing a total of 45 pounds. I like the way I feel on Reta. I’m hungrier on Reta compared to Tirz, but I still cannot overeat if that makes sense. It just feels more natural.

That was a perfect answer. Thank you. I really value the of effects of Tirz. I'm currently taking 7 mg, which is ideal for appetite suppression, the main reason I use it. I'm considering switching to Reta because I've heard it helps burn more fat, but I don't want to lose the appetite suppression benefits. Of course, this is just based on your experience and not professional advice, but in a situation like this, would you suggest taking 5 mg of Reta and 5 mg of Tirz, or would you prefer increasing the dose of Reta to 10 mg to maintain equivalent appetite suppression?

 

[Nested]

So this is of course all anecdotal. And some members may comment that the “why” and my method doesn’t match what was seen or used in the trials. Sema had the best appetite suppression. Almost too good. It also comes with the most negative side effects for some. I really liked Tirz and lost the majority of my weight using Tirz. But I always felt lethargic and lacked motivation to do anything. I wouldn’t call it fatigue because once I started lifting or running I’d feel fine and had no problems completing my workout. So I initially stacked Reta with Tirz (7.5 Tirz, 4mg Reta). I immediately felt better on Reta. So I slowly lowered Tirz and increased Reta until I was no longer taking Tirz. I’m taking 8mg of Reta now as a maintenance dose after losing a total of 45 pounds. I like the way I feel on Reta. I’m hungrier on Reta compared to Tirz, but I still cannot overeat if that makes sense. It just feels more natural.

I forgot to mention that I follow a one meal a day (OMAD) schedule, which means it's essential for me to avoid feeling hungry throughout the day. Effective appetite suppression is very important to me, not just feeling full after eating.

 

[Ateam2023]

For those who have purchased Sema/Triz/Reta from both QSC and Sigma, did you find that one offers better quality than the other?