MESO-Rx
Anabolic Steroids
Low Dose Sublingual Anavar most effective and safe?
- Thread starter MaxGainz
- Start date
Theworm
Well-known Member
I don’t trust that guy nor do I have the patience to listen to that knucklehead for 32 minutes repeating the same thing 30 different ways. He may have some good points but he can sum it all up in under 2 minutes. I know on YouTube the longer the vid the more money you can make.
Theworm
Well-known Member
Btw, some hrt clinics have oxandrolone troches, but I found them no different than the capsules…
I've tried sublingual and oral and personally I couldn't tell a damn bit of difference. Maybe a troche or some other form designed specifically for sublingual use might change things. I was putting a crushed tablet under my tongue for 15 minutes. I went back to just swallowing them.
borkies
Member
Just boof your anavar like Daddy Pappo intended. Or as serial leg day skipper Derek would say, "deploy to the ass".
29trt
Well-known Member
the difference with sublingual adm. should be lower liver enzymes compared to normal oral administration if you are one that anavar raises said enzymes...
readalot
Member
Most definitive thread on this topic I am aware of for those who read.
forums.t-nation.com
Sorry for members only firewall. I can't even view my own threads over there since I got banned and not making another profile. F IT.
The correct answer is to use the troche buccally not via sublingual route. It takes discipline. You want to minimize swallowing. I know that is the opposite of what you usually tell a partner.
Using a troche buccally will minimize first pass effect and may have small improvement on LFTs.
Why don't pharma companies formulate oxandrolone like this? In US they don't make oxandrolone at all now. See recent FDA ruling. Remains to be seen what happens with compounded options in US. Looks like all Rx oxandrolone going away in US.
professionals.optumrx.com
I know it makes no difference to you UGL dudes but what a perversion of science and what we know about safety of oxandrolone. You can go find my huge review of literature over last 25 years over at ExcelMale. Complete hit job on oxandrolone.
Sorry Admin if I am linking alot of posts. I have 10k painstakingly made posts between EM and TNation and don't want to retype it all. Took a lot of time the first time.
@MESO-Rx Administrator I see this post got flagged? Any ideas? Thought I was following the rules to come up to speed quickly on here. I sure don't want to go through same BS I did at TNation and EM. If you have any tips let me know please. I ain't your typical new member asking if stacking AAS and SARMs is gtg.
Oxandrolone Troche Experience: Potential Atherosclerosis Marker WMD
I’d be interested in hearing others experience using oxandrolone troches instead of oral delivery (capsules) to bypass first-pass metabolism and reduce liver toxicity and lower minimum effective dose . Since oxandrolone has excellent oral bioavailability (97-98%) and is actually metabolized...
forums.t-nation.com
Sorry for members only firewall. I can't even view my own threads over there since I got banned and not making another profile. F IT.
The correct answer is to use the troche buccally not via sublingual route. It takes discipline. You want to minimize swallowing. I know that is the opposite of what you usually tell a partner.
Using a troche buccally will minimize first pass effect and may have small improvement on LFTs.
Why don't pharma companies formulate oxandrolone like this? In US they don't make oxandrolone at all now. See recent FDA ruling. Remains to be seen what happens with compounded options in US. Looks like all Rx oxandrolone going away in US.
FDA announces decision to withdraw Oxandrin® (oxandrolone)
June 28, 2023 - The FDA announced the final decision to withdraw approval of brand and generic Oxandrin (oxandrolone). The FDA believes a potential problem associated with oxandrolone tablets is sufficiently serious that the drug products should be removed from the market.
I know it makes no difference to you UGL dudes but what a perversion of science and what we know about safety of oxandrolone. You can go find my huge review of literature over last 25 years over at ExcelMale. Complete hit job on oxandrolone.
Sorry Admin if I am linking alot of posts. I have 10k painstakingly made posts between EM and TNation and don't want to retype it all. Took a lot of time the first time.
@MESO-Rx Administrator I see this post got flagged? Any ideas? Thought I was following the rules to come up to speed quickly on here. I sure don't want to go through same BS I did at TNation and EM. If you have any tips let me know please. I ain't your typical new member asking if stacking AAS and SARMs is gtg.
Last edited:
Theworm
Well-known Member
Probably easier and cheaper making a tablet or capsule. Plus a lot of people are stupid and won’t even know what sublingual means…
Snakum
Member
I guess I don't remember my college chemistry and patho .... so, the buccal route bypasses the gut, which affects the liver less?
Back in the old days I was always told Var wasn't too bad on the liver already. Think there's really something to be gained by SL admin?
Back in the old days I was always told Var wasn't too bad on the liver already. Think there's really something to be gained by SL admin?
Snakum
Member
Reason I ask is Var seems to be in stock a lot more places lately and my wife-unit wants to try it.
readalot
Member
Made a comprehensive response on all this but says it is awaiting mod approval. Maybe it goes through eventually. Are we not allowed to link to other forums? See nothing in the rules about that. Can't link to my prior posts on "competitor" forum threads? Good to know.
Snakum
Member
If you got some good info can you cut and paste for us? I'm really kinda interested in this.
readalot
Member
Yeah it is currently sitting up above in lala land purgatory. Did somebody flag it? Weird.
https://thinksteroids.com/community/threads/low-dose-sublingual-anavar-most-effective-and-safe.134418809/post-3171779
Last edited:
readalot
Member
While the other posts awaits moderation (geez is it really this difficult here?)...I made a new account at TNation to get my posts back. Hilarious.
More big words to address the question and concept above:
forums.t-nation.com
Nice demonstration of the measurements and procedure you’d leverage clinically to study this with oral vs sublingual / rectal ( @zeek1414
) approaches:
https://jpharmsci.org/article/S0022-3549(15)50414-0/pdf
Call me overly cautious, but every little bit of additional protection is useful when it comes to your precious liver and kidneys.
More big words to address the question and concept above:
Oxandrolone Troche Experience: Potential Atherosclerosis Marker WMD
Aha, I will correct myself. If you can get drug into systemic circulation (while avoiding first pass) where it presents at reduced systemic serum concentration (vs concentration upon introduction into portal vein) and metabolic clearance typically first order function of serum concentration, I...
forums.t-nation.com
Aha, I will correct myself. If you can get drug into systemic circulation (while avoiding first pass) where it presents at reduced systemic serum concentration (vs concentration upon introduction into portal vein) and metabolic clearance typically first order function of serum concentration, I can see where this concept has legs although effect may be quite minimal with highly bioavailable oxandrolone. Especially if most of the metabolic clearance is done in kidneys anyway. In short, dilution may be the solution.
Nice demonstration of the measurements and procedure you’d leverage clinically to study this with oral vs sublingual / rectal ( @zeek1414
https://jpharmsci.org/article/S0022-3549(15)50414-0/pdf
Call me overly cautious, but every little bit of additional protection is useful when it comes to your precious liver and kidneys.
Last edited:
RiceNKimchi
Well-known Member
Physiological and Pharmaceutical Considerations for Rectal Drug Formulations - PMC
Although the oral route is the most convenient route for drug administration, there are a number of circumstances where this is not possible from either a clinical or pharmaceutical perspective. In these cases, the rectal route may represent a ...
www.ncbi.nlm.nih.gov
Make a log too... it'll be interesting. Ha log.
readalot
Member
Nice.Physiological and Pharmaceutical Considerations for Rectal Drug Formulations - PMC
Although the oral route is the most convenient route for drug administration, there are a number of circumstances where this is not possible from either a clinical or pharmaceutical perspective. In these cases, the rectal route may represent a ...
Make a log too... it'll be interesting. Ha log.
And see here for folks interested. Hilarious my initial post here on all this still flagged for moderation.
Oxandrolone Troche Experience: Potential Atherosclerosis Marker WMD
None particular to AAS but some of these examples would partition similarly to 17-AA oral AAS. This is a nice review with examples. You have to give credit to @zeek1414 who already raised this possibility earlier in the thread. This was all tongue in cheek though. DRUG ABSORPTION BY...
forums.t-nation.com
Maybe I missed it but if someone is going to try the sublingual route does it need to be in a specifically prepared sublingual formula or would crushed tablets,capsules or raws be sufficient? I only tried it a handful of times with crushed tabs and never got blood work to check liver enzymes. I will say that I felt like the appetite suppression and lethargy I got from 50mg seemed a little less on the sublingual days but maybe it was just in my head.
This is my question as well. I thought I remember hearing someone credible say that the drug needs to be compounded specifically for sublingual administration--something about the molecules being too large to pass into the bloodstream through sublingually if it's not compounded correctly.
Definitely could be talking out of my ass here, but at least someone else has the same question.
Similar threads
