mudbutt22
Member
It would be pretty tough to stay in a defecit on mk677, at least for me. Shit made me absolutely ravenous. Like a painful hunger that I've never felt before
More importantly the negative feedback exerted by somatostatin will limit the efficacy of essentially any secretagogue.
So as a secretagogue increases GH secretion, it's followed by an increase somatostatin level which INHIBITS further GH elevation and prevents
one from reaching SUPRA-physiologic
GH levels!
Jim, it's believed that mk-677 works through multiple mechanisms and one of those mechanisms is possibly the suppression of somatostatin.
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And I suppose you have evidence of such an effect in-vivo HUMANS in particular. NOPE and if such an effect does exist it is not clinically relevant for the reasons I already mentioned.
No doubt that's a great means of increasing sales, as there are many who will "believe" almost anything that sounds good excepting the fact the highest level reached with MK is within PHYSIOLOGIC range AND that's THE PROBLEM, for those wanting to use this class of agents for anabolism.
If you can post any human data to the contrary, it's an open forum fella
Jim do some reading on "Anamorelin" you will find it interesting. It's another orally active secretagogue, only unlike mk-677 which was abandoned by its authors, Anamorelin has completed phase 3 trials and will soon be available as an RX. There's probably a lot more solid data available on Anamorelin than ibutamoren.
I concur. I had the same resulting hunger. It definitely works. I soon had the HGH side affects of sore joints and carpal tunnel which I had previously gotten on 4iu of HGH before. I'm 52 and very lean and muscular and most peptides don't work for someone my age. I tried MK-677 because it supposedly works for older people and it certainly does. It kept the fat off even though the hunger had me eating more. However, after about 2-3 weeks those results stopped and I started gaining the weight. The hunger just had me eating more calories than the HGH could keep from turning to fat.It would be pretty tough to stay in a defecit on mk677, at least for me. Shit made me absolutely ravenous. Like a painful hunger that I've never felt before
Control your diet and use some mild diuretics to remove the excess water if needed and the water retention will be mild. I stack it on top of GH for the hell of it. I can tell you it makes the sides worse though. I'm a glutton for punishment though.![]()
Same... Crazy abdominal bloating, hunger that makes strict diet difficult. Easily over eat. It's a great compound for a gaining phase but I'd never run it cutting. I eat too much on it. I have no idea why I get so much abdominal/gut bloat on this shit. It makes me paranoid that mk677 promotes intestinal growth (loaded with IGF receptors) moreso than gh but I think that's faulty logic as the igf conversion is done later in the liver and would be systematic in the blood, not localized in intestines from oral route.Control your diet and use some mild diuretics to remove the excess water if needed and the water retention will be mild. I stack it on top of GH for the hell of it. I can tell you it makes the sides worse though. I'm a glutton for punishment though.![]()
Same... Crazy abdominal bloating, hunger that makes strict diet difficult. Easily over eat. It's a great compound for a gaining phase but I'd never run it cutting. I eat too much on it. I have no idea why I get so much abdominal/gut bloat on this shit. It makes me paranoid that mk677 promotes intestinal growth (loaded with IGF receptors) moreso than gh but I think that's faulty logic as the igf conversion is done later in the liver and would be systematic in the blood, not localized in intestines from oral route.
I'm still not convinced increased gh/IGF leads to GI organ growth to substantial enough degree to increase abdominal distention. Although slin and ASSOCIATED VAT deposition may be...