My Visit with HAN and Dr. Overbeck

[m_ob]

Do tests exist for leptin resistance?

Yes, it's called Serum Leptin..and if you're extremely over weight, you almost certainly have some form of it.
What is leptin resistance?
Chief Wellness Officer,
Cleveland Clinic
POSTED BY Dr. Michael Roizen
The hormone leptin, a protein secreted by stored fat that signals satiety and stimulates you to burn more calories, doesn't always work the way it's supposed to.

In some research, when leptin was given to mice, their appetites decreased just as expected. When it was given to people, they initially got thin--but then something strange happened: They overcame the surge of leptin and stopped losing weight. That indicates that our bodies have the ability to override leptin's message tha… Read More » What is leptin resistance? | Ask Dr. Oz

 

[Ignitionnet]

Do tests exist for leptin resistance?

Yep.

(Holtorf Medical Group, Inc - Torrance, CA) Leptin / Weight Loss seems a reasonable explanation.

 

[nickatnite]

The leptin thing is interesting. Based on my stomach I have 100% leptin resistance. Ha, but in all seriousness I wonder if I should get my Leptin measured.

 

[hardasnails1973]

We have ability to check leptin its a simple blood test from quest.

 

[chemman]

Calling m_ob... calling m_ob

 

[m_ob]

haha..if he only knew how thoroughly I have studied Leptin. I can tell you you are not going to find anything out by testing it other than what you know by your body fat %. Leptin is parralled by body fat, meaning more body fat=more leptin with some acception for energy flux. If you were morbidly obese and went on a 800 calorie diet, your leptin levels would drop even though you are fat. The only way to become non-resistant is to exercise, lose some weight, and go from there.

 

[gettingold]

Byetta and Symlin (sp?) are used to help restore Leptin sensitivity.

It's an off label useage.

 

[m_ob]

Byetta and Symlin (sp?) are used to help restore Leptin sensitivity.

It's an off label useage.

as are Amylin and Amgen, both pharmaceutical companies in which one even produces human Leptin..but it is still infant in studies and noone knows how they really change the body yet.

 

[BigFreak]

the biggest problem with HAN's approach is that, unlike all those politically correct, big pharma approved, by the book, diploma-filled, anally-plugged out there, he is suggesting a treatment that might actually help Nick a lot. On top of that, he uses bio-identical hormones and everything he is doing has very little chances of backfiring for a long time.

We already know stuff about most of the strategies they're looking into, but it's interesting to view things put together in a specific example. HAN, please give as much info about what you guys are looking at/doing that nick is confortable with.

The alternative is Nick writing everything himself, but I would rather it comes from both of you

 

[nickatnite]

It's now been almost 4 weeks since starting the DHEA cream. I have lost about 5lbs. I was 207lbs before starting and now I am 202. Pretty exciting. So far so good. I still feel energetic and my libido still exists. I think it went down a little last week because I was stressing over some stuff, but I'm back. I will continue applying the DHEA cream and see what happens within another month. We also may test for estrogen metabolites to see where things are heading and possibly start some Adrenal Rebuilders since I'm adrenally fatigued. Hopefully the combo of the cream and rebuilders brings me back to homeostasis.

 

[nickatnite]

**Quick note, I just read that the drug FINASTRIDE is sim. to Accutane. I don't know if that has anything to do with my hormonal issues, but hearing about the two and their similarities is quite interesting. The other thing is I haven't taken Accutane since like 1999 so I'm not sure if that would still affect me today.

 

[BigFreak]

Nick due to your past history of cancer lets check 2/16 pathway as sometimes estrogen domainace can be not just estrodial but other esrogen metabolites as well that can bind to the receptors.

that's very interesting. I know estrogen dominance runs in my genes. I've also found out i got a CYP1B1 polymorphism (4-hydroxylation of estrogen). DIM appears like an obvious choice, but I dont know how to decide how much is enough. I'm wondering what else can be done. calcium d glucarate? myomin? I've already cleaned up with environment.

I would be concerned with altered methylation which need to be taken into consideration as well..

thats what kept me so far away from DIM. If I cant methylate enough, I guess I should fix that first. I did a bunch of tests, partly to see if my methylation appears fine, but i dont know if any of them are actually relevant. None of them looked at blood SAMe levels, is this not easily tested? What do you guys find the most efficient to find information on the methylation efficiency?

 

[hardasnails1973]

that's very interesting. I know estrogen dominance runs in my genes. I've also found out i got a CYP1B1 polymorphism (4-hydroxylation of estrogen). DIM appears like an obvious choice, but I dont know how to decide how much is enough. I'm wondering what else can be done. calcium d glucarate? myomin? I've already cleaned up with environment.



thats what kept me so far away from DIM. If I cant methylate enough, I guess I should fix that first. I did a bunch of tests, partly to see if my methylation appears fine, but i dont know if any of them are actually relevant. None of them looked at blood SAMe levels, is this not easily tested? What do you guys find the most efficient to find information on the methylation efficiency?

Instead of dim you can use iodoral does not stress methylation as much start low then gradually increase make sure you are taking celtic sea salt for bromide reaction if there is one.

4 hydroxlation - use reservatrol 250 mgs 100% trans.
Methylation can be a bitch some need magnesium , folinic acid, TMG, oand methyl b-12 others needs sam-e
calcium d is more for intestial dybiosis and cancer prevention I d 1000 mgs a day help s keep estrogen in check and if my flora is messed up it helps over ride it for prevention of cancer.

Myomin is no suggested because it can cause other things to happen mechanism by how it works is un known
I had a guy on it for a week nearly crippled him. That is one thing I stay away from 10 foot pole seem to much unknown information more questions then answers.

 

[BigFreak]

Instead of dim you can use iodoral does not stress methylation as much start low then gradually increase make sure you are taking celtic sea salt for bromide reaction if there is one.

4 hydroxlation - use reservatrol 250 mgs 100% trans.
.

Thats a lot to digest right there. My polymorphism give me a greater induction capacity of CYP1B1, which is a problem if your body cant deal with the products (for example 4-hydroxyestrogens/quinone).You're suggesting that instead of redirecting my estrogen metabolism away from 4-hydroxylation using DIM, I should use iodine/iodide + the great antioxidants in reservatrol to neutralize/excrete those products more efficiently?

 

[Jayho]

Jesus fucking christ.... You people are talking about some wacky shit.

With the little, questionable, borderline, grey area you are playing with.... using all that Ferngully Root and such.... why not just take anti depresants? it's mostly in your head how you "feel".

Given a reasonably proper level of androgens... achieved not through Poppin/rubbin Ferngully roots... but through ACTUAL TRT... using Testosterone itself.... ( *omg* scary shit! i know! they are DANGEROUS "steroids" unlike SAFE Ferngully DHEA root")

If you're going to keep trying to find food allergies etc, you might as well run a test to see if you were ever poisioned by ManBearPig as a child.

 

[m_ob]

Jesus fucking christ.... You people are talking about some wacky shit.

With the little, questionable, borderline, grey area you are playing with.... using all that Ferngully Root and such.... why not just take anti depresants? it's mostly in your head how you "feel".

Given a reasonably proper level of androgens... achieved not through Poppin/rubbin Ferngully roots... but through ACTUAL TRT... using Testosterone itself.... ( *omg* scary shit! i know! they are DANGEROUS "steroids" unlike SAFE Ferngully DHEA root")

If you're going to keep trying to find food allergies etc, you might as well run a test to see if you were ever poisioned by ManBearPig as a child.

haha! I'm seriously liking the South Park usage in there, but it's the truth guys. Stop worrying about every little damn thing and quit overeaching for these mystery miracle cures and fixations. You sound more hypochondriac than allergic, deficient, or sick at all. All I hear is "quack quack quack." Some sort of a line needs to be drawn.

 

[BigFreak]

I know it's hard to believe but some people are deeply impressed by all the capabilities of the human body. Some of them even think that given the proper conditions their body is even able to produce all the testosterone they need! Isnt it totally crazy?

 

[m_ob]

I know it's hard to believe but some people are deeply impressed by all the capabilities of the human body. Some of them even think that given the proper conditions their body is even able to produce all the testosterone they need! Isnt it totally crazy?

I sense sarcasm, but true, you don't need fancy protocols in most cases though..The body is extremely resilient in trying to maintain equilibreum. You have to almost try to mess that it up.

 

[BigFreak]

I sense sarcasm, but true, you don't need fancy protocols in most cases though..The body is extremely resilient in trying to maintain equilibreum. You have to almost try to mess that it up.

you mean try as in being exposed to thousands of chemicals it doesnt recognize, try as in feed your body a diet of processed, polluted food, as in feed it grains, alcohol, sugar, try as in try to recover from all sorts of abuse including bodybuilding "supplements" that contained god-knowns what?

Just as an example, CYP1B1 is not a problem to those not exposed to xenobiotics and xenoestrogens

 

[CenDS]

Yes, it's called Serum Leptin..and if you're extremely over weight, you almost certainly have some form of it.
What is leptin resistance?
Chief Wellness Officer,
Cleveland Clinic
POSTED BY Dr. Michael Roizen
The hormone leptin, a protein secreted by stored fat that signals satiety and stimulates you to burn more calories, doesn't always work the way it's supposed to.

In some research, when leptin was given to mice, their appetites decreased just as expected. When it was given to people, they initially got thin--but then something strange happened: They overcame the surge of leptin and stopped losing weight. That indicates that our bodies have the ability to override leptin's message tha… Read More » What is leptin resistance? | Ask Dr. Oz

reverset3 is one and only so far......leptin levels tell you nothing about resistance.