Nasal administration

[666bym]

natesto, yes good for sex and workouts... its TNE in castor oil with micro cellulose thickener.. its more like hemroid gel/cream and not a spray.

prob just as easy to make troche/candy prob need a bit more than nasal though.

one idea may be a coco cocoa butter with test as that is thick and applied measured amounts via syringe.. or just a drop or 2 of oil and rub inside of your nose the idea is not to snort it but use like tobacco snuff.

Appreciate your reply. So with the troche you would put it under your upper lip (sublabial) like a nicotine pouch or did I get that wrong?

I am considering multiple routes to go with TNE for rapid onset and peak pre-workout/ sex. As you seem to be educated on the subject which route do you think is best?
a) Intranasal (like Natesto)
b) Test cream applied to Scrotum
c) Rectal administration
d) Sublingual/ sublabial

Only thing I want to avoid with this is injection bc I want to be able to use this on the go. Also, I will be using it alongside my regular TRT injections as an on demand booster.

 

[clearheaded]

scrotum wouldn't be smart for sex as would transfer to the lady.

but ya could make suppositories thats not a bad idea with cocoa butter easy to do.

 

[AlexDavis43]

Kinda off-topic but I have a client on Natesto monotherapy for TRT and his wife just got pregnant. So it's possibly true that this might be one of the least fertility-suppressive form of testosterone application for TRT (no HMG hCG or enclomiphene).

 

[baxter0312]

a dht nasal spray would be like a horse kicking you in the face. I’d like to make one.

 

[clearheaded]

Kinda off-topic but I have a client on Natesto monotherapy for TRT and his wife just got pregnant. So it's possibly true that this might be one of the least fertility-suppressive form of testosterone application for TRT (no HMG hCG or enclomiphene).

how long has he been on it? full 3x a day I imagine? or do u know... wonder if he was actually hypogonadal prior to starting as imagine makes a big difference what ur starting point is.

cheers

 

[AlexDavis43]

how long has he been on it? full 3x a day I imagine? or do u know... wonder if he was actually hypogonadal prior to starting as imagine makes a big difference what ur starting point is.

cheers

He was hypogonadal before TRT, then 3x/d Natesto, conceived after about a year.

 

[666bym]

I succesfully made a Test 2% nasal spray (the compound manual is 1%)
It actually doesn't burn too badly, reasonably usable.

1 gram testosterone
75% ethanol 13ml
propylene glycol 20ml
benzyl alcohol 3 ml
distilled water to make 50ml
Do not heat, it will evaporate the ethanol
Filter into a glass spray bottle

adding much more water will crash it

Hey Baxter, two questions/ suggestions for this recipe.
Could we add a buffer to adjust the pH to more closely match the pH of the mucus membrane? Maybe this will help with the burning.
Second, maybe it would be possible to add a soothing agent like aloe vera or hyaluronic acid to help with irritation and burning.

What do you think? Possible or not?

 

[micro2000]

Hey Baxter, two questions/ suggestions for this recipe.
Could we add a buffer to adjust the pH to more closely match the pH of the mucus membrane? Maybe this will help with the burning.
Second, maybe it would be possible to add a soothing agent like aloe vera or hyaluronic acid to help with irritation and burning.

What do you think? Possible or not?

Some possibilities:

1. Substitute the propylene glycol with PEG400. PEGs are less irritating than PG.

2. Substitute the PG with dimethyl isosorbide. DMI is a good solvent for steroids and less irritating.

 

[666bym]

Some possibilities:

1. Substitute the propylene glycol with PEG400. PEGs are less irritating than PG.

2. Substitute the PG with dimethyl isosorbide. DMI is a good solvent for steroids and less irritating.

Thanks, just ordered some PEG400m and will try!

 

[baxter0312]

Hey Baxter, two questions/ suggestions for this recipe.
Could we add a buffer to adjust the pH to more closely match the pH of the mucus membrane? Maybe this will help with the burning.
Second, maybe it would be possible to add a soothing agent like aloe vera or hyaluronic acid to help with irritation and burning.

What do you think? Possible or not?

The problem with the recipe is the aqueous component. It should work but it doesn't. if someone could solve this.

 

[666bym]

The problem with the recipe is the aqueous component. It should work but it doesn't. if someone could solve this.

What about using saline then instead of distilled water and then adding a buffer to match the pH of the nose?
When you prepare Semax/ Selank nasal spray you also use Saline to prevent nasal burning.

 

[clearheaded]

miscibility doesn't change with saline vs distilled. saline will irritate less which perhaps ur idea?

either gel/cream like suspension or oil/glycerin/pg based is the way.