Night sweats from HGH

[Sampei]

I think op mostly dislikes the increase in fragmented sleep, which is understandable and the sweating probably doesn't help with that. Otherwise basically I agree. I think it's the lack of experience of these new posters.

However, an immunogenic response is/was an interesting and seldom overlooked topic of discussion ...

Yeah but HGH is known for fragmented sleep especially when you add in the mix AAS + the personal response to it

You can give the same HGH to 10 different ppl and few will report great sleep, some other fragmented sleep and some other Will report no change in their sleep.

I remember getting crazy vivid dream from HGH years ago. It has been a long time I don't remember dreaming at all and I'm still doing HGH.

Things changes and there is not always a clear answer to it.

I was sweating like a mofo for 2 months last year and I had no idea what was what and maybe it wasn't one thing just multiple things all together.
It stopped after a while.

I'm all for trying to find an explanation for things but we need to remember we are srsly fucking with our body with different substances all together and sometime there isn't any explanation to it except: that's the cost you gotta pay.

I wouldn't go down the rabbit hole and start with crazy theories if it's not something that's impacting your health badly, so unless it's an health risk, sometime the best is to wait and see if it adjust itself or to stop the substance.

 

[Ghoul]

Yeah but HGH is known for fragmented sleep especially when you add in the mix AAS + the personal response to it

You can give the same HGH to 10 different ppl and few will report great sleep, some other fragmented sleep and some other Will report no change in their sleep.

I remember getting crazy vivid dream from HGH years ago. It has been a long time I don't remember dreaming at all and I'm still doing HGH.

Things changes and there is not always a clear answer to it.

I was sweating like a mofo for 2 months last year and I had no idea what was what and maybe it wasn't one thing just multiple things all together.
It stopped after a while.

I'm all for trying to find an explanation for things but we need to remember we are srsly fucking with our body with different substances all together and sometime there isn't any explanation to it except: that's the cost you gotta pay.

I wouldn't go down the rabbit hole and start with crazy theories if it's not something that's impacting your health badly, so unless it's an health risk, sometime the best is to wait and see if it adjust itself or to stop the substance.

There's nothing crazy about the fact that UGL HGH is a black box as far as our knowledge regarding the presence of contaminants, especially large aggregates that are carefully controlled in pharma formulations but not in UGL. On top of this, low quality vials are likely filled with particulates that act as "amplifiers" of the well known immune response to large protein aggregates.

One of the impacts of immunogenicity can be rapidly fluctuating hormone levels,

Virtually eliminating this possibility by filtering, enhancing safety as well as quality at nearly no cost seems perfectly reasonable.

 

[Jin23]

Thanks for the last point. I don't mean to imply it's likely the cause, just a possibility, even if remote.

There's enough evidence now that filtering does no harm, and, depending on the condition of the UGL rHGH, can improve its quality by removing contaminants that may be responsible for the variation in sides and potency widely observed between different formulations.

In other words, "can't hurt".

It can't hurt and mentioning a possible contaminant and the proposition of filtering your gear are imo valuable harm reduction ideas.

But as I've commented beforehand, these shouldn't be your first ideas (in this topic) and you'd do more good, if you'd mention them more as an afterthought, after you'd establish GH's dynamics and common side effects. Because if it wasn't for me that chimed in (maybe somebody else would eventually), op might have been chasing only your idea, which (probably) wouldn't have helped him ...

 

[Ghoul]

It can't hurt and mentioning a possible contaminant and the proposition of filtering your gear are imo valuable harm reduction ideas.

But as I've commented beforehand, these shouldn't be your first ideas (in this topic) and you'd do more good, if you'd mention them more as an afterthought, after you'd establish GH's dynamics and common side effects. Because if it wasn't for me that chimed in (maybe somebody else would eventually), op might have been chasing only your idea, which (probably) wouldn't have helped him ...

I was confident plenty of GH vets would step in with their experiences.

Still, considering the rHGH is the same in all these vials, pharma and UGL, but the overwhelming majority swear to different experiences between them, leaves the door open to the other factors that differentiate these compounds.

The fact there's overlap between immune responses and "normal" GH (like edema) only adds to the complexity of course, but as more users filter, perhaps some start to get GH antibody tests, or even just monitor CRP, and Jano starts measuring contaminants a clearer picture may emerge.

And definately a better than the "I pinned cloudy GH and it was fine" stuff we hear from certain members.

 

[Musmadar]

I can't do HGH before sleep because I won't get any sleep at all ... all I get is a wakefulness-vigilance state for the whole night.


I've only did QSC' s HGH so I don't know if it happens with any other HGH.

 

[Sampei]

There's nothing crazy about the fact that UGL HGH is a black box as far as our knowledge regarding the presence of contaminants, especially large aggregates that are carefully controlled in pharma formulations but not in UGL. On top of this, low quality vials are likely filled with particulates that act as "amplifiers" of the well known immune response to large protein aggregates.

One of the impacts of immunogenicity can be rapidly fluctuating hormone levels,

Virtually eliminating this possibility by filtering, enhancing safety as well as quality at nearly no cost seems perfectly reasonable.

If it was 100% like this we would see report of ppl left and right with issues something we don't see, and we didn't even see it when HGH quality was a lot worse than today but I do agree it doesn't cost much to do it

HOWEVER One thing you forget to mention is that removing those possible aggregates brings even more aggregates with time so if the vial is not used all in one go you could have after few days a solution that has even more aggregates than before, practically making it worse.

Btw pharma is happy with 4% of aggregates. Our UGL HGH has less than 0.0X% of aggregates not so sure our issue is in aggregates.

 

[Ghoul]

Another possibility is sleep apnea.

Something I recent stumbled on in some medical literature about daytime lethargy in GH treated patients.

HGH improves lung function. Unfortunately for those predisposed to developing sleep apnea, the deeper breathing can push someone into full blown apnea.

If you have a partner ask if they've noticed
you snoring.

 

[Ghoul]

If it was 100% like this we would see report of ppl left and right with issues something we don't see, and we didn't even see it when HGH quality was a lot worse than today but I do agree it doesn't cost much to do it

HOWEVER One thing you forget to mention is that removing those possible aggregates brings even more aggregates with time so if the vial is not used all in one go you could have after few days a solution that has even more aggregates than before, practically making it worse.

Btw pharma is happy with 4% of aggregates. Our UGL HGH has less than 0.0X% of aggregates not so sure our issue is in aggregates.

Filtering doesn't bring *more* aggregates. If your vial is completely saturated with aggregates because the formula is so bad a massive amount of aggregates have grown, then removing them creates room for them to be replaced. This is most likely because the PH is too low, a problem pharma never has, only trash UGL. Better to remove them than inject them, and use the HGH before they reform.

Don't confuse dimer and oligomer with large aggregates. This is nonsense spread by "Doctor" AlexDavis. Dimer and Oligomer, while technically the smallest possible aggregates, are byproducts of manufacturing, cannot be removed by any practical method, and do not cause immunogenicity. That's why pharma and the FDA is ok with them. In fact they continue to be partially bioactive. They are byproducts of NATURAL gh production as well, making up about 15% of circulating growth hormone. Since growth hormone antibodies are normally zero in a healthy person, that shows there's no immunogenic response to them.

The huge aggregates removed by .22um filtration are the types that induce immunogenicity, and pharma/FDA are VERY concerned about those. While for ethical reasons they can't be intentionally injected in humans, we know when they're injected into animals they induce immunogenicity.

 

[Sampei]

Filtering doesn't bring *more* aggregates. If your vial is completely saturated with aggregates because the formula is so bad a massive amount of aggregates have grown, then removing them creates room for them to be replaced. This is most likely because the PH is too low, a problem pharma never has, only trash UGL. Better to remove them than inject them, and use the HGH before they reform.

Don't confuse dimer and oligomer with large aggregates. This is nonsense spread by "Doctor" AlexDavis. Dimer and Oligomer, while technically the smallest possible aggregates, are byproducts of manufacturing, cannot be removed by any practical method, and do not cause immunogenicity. That's why pharma and the FDA is ok with them. In fact they continue to be partially bioactive. They are byproducts of NATURAL gh production as well, making up about 15% of circulating growth hormone. Since growth hormone antibodies are normally zero in a healthy person, that shows there's no immunogenic response to them.

The huge aggregates removed by .22um filtration are the types that induce immunogenicity, and pharma/FDA are VERY concerned about those. While for ethical reasons they can't be intentionally injected in humans, we know when they're injected into animals they induce immunogenicity.

Dimer test of Jano is not dimer and oligomers but includes a whole spectrum of things aggregates too
I believe @readalot was trying to explain it not so long ago, I could be wrong however.

Thing is you are assuming that all the UGL HGH is full of aggregates and shit.

Do we have any proof of that? Do we have any proof that the UGL population of users that is injecting UGL HGH is suffering for immunogenic response?

I like to base my conclusion on practical and real data not supposedly theories extrapolated, that can be 100% true not denying it, but are at the moment just theories.

Do we have any idea that the GH we are injecting doesn't have a PH buffer? Are we implying all UGL HGH is the same?

The room made removing aggregates create even more room for more aggregates formation. So if one didn't have much if any, there is now more room to have more. That has been stated around here plenty of times, one just need to make a search, are we now backpedaling that?
That's why you stated multiple time one should filter and inject straight away and not filter and leave the solution there for long.

It's clear the filtration is not always practical for everyone and possible, even so it's clearly a great tool at our disposal and should be understood and used properly, however is not the answer to all the problems, at the moment one could argue is the answer to almost nothing as we have no data to prove we have an issue with our GH or other peptides.

 

[Jin23]

I was confident plenty of GH vets would step in with their experiences.

Still, considering the rHGH is the same in all these vials, pharma and UGL, but the overwhelming majority swear to different experiences between them, leaves the door open to the other factors that differentiate these compounds.

The fact there's overlap between immune responses and "normal" GH (like edema) only adds to the complexity of course, but as more users filter, perhaps some start to get GH antibody tests, or even just monitor CRP, and Jano starts measuring contaminants a clearer picture may emerge.

And definately a better than the "I pinned cloudy GH and it was fine" stuff we hear from certain members.

The different experiences is down to a) intra-individual variability in pharmacodynamic response (referring to which is mostly not subject to immune issues) and b) again intra-individual variance but in subjects interoception - ie. some people wouldn't notice if you'd hit them on the head with a brick. Most people would show worse sleep, if you performed polysomnography while administering GH, some just don't notice it. Sleep on GH is usually potentially better only upon treatment initiation, when the initial sedative properties overshadow the excitatory response.

But the fact of the matter is that these drugs have a really, really wide mechanism of action and our bodies can also be quite different, some variance in response is to be expected, which is in reality still rather constrained (it's not like some people grow an extra leg and others just sweat more). And this variance is really pronounced when it comes to the body's energy system, which in a sense serves as the central integrator where all factors such as; mitochondrial function, hormonal regulation, metabolic state, nervous system activity, drug interactions (especially important for us), etc — coalesce to determine the final pharmacodynamic responses.

Immunity is a factor and as everything else, it varies, but it's most likely not by it self the biggest, nor a particularly meaningful variable, although you are making it a somewhat exclusive point of contention. It's just the level of energy you are putting in this argument has a somewhat "parents house basement nerd" type of feel to it. Your post count "maxing" and the "elite" avatar also aren't helping me in decoding your argumentation in a different way ...

How do you know about the state of qsc hgh? And have you ever used GH in general or even specifically qsc gh? How old are you?

 

[Kralteramon]

Another possibility is sleep apnea.

Something I recent stumbled on in some medical literature about daytime lethargy in GH treated patients.

HGH improves lung function. Unfortunately for those predisposed to developing sleep apnea, the deeper breathing can push someone into full blown apnea.

If you have a partner ask if they've noticed
you snoring.

I'm around the snoring threshold right now. My partner reports light snoring some nights but last/past week apparently she noticed none. My smart watch also isn't indicating a drop in breathing frequency outside of the expected range. when I get above 100kg it does become more of an issue normally (lethargy etc.), this is different.

 

[Kralteramon]

I appreciate the discussion guys.

 

[Jin23]

Another example of inappropriate advice (contamination), causing the OP to fixate on the wrong ideas and causing harm to him self yet again.

U

Thread 'Is 300mg test E going to be dangerous for me?'

Mar 9, 2025

I remember 2 months ago, I injected 300mg, the day before, then the whole week my bp went insanely high, 150-170 systolic and 90-100 diastolic, do you think it’s gonna be safe? because I want to start again. Thank you.

• upandcoming
• Replies: 56
• Forum: Steroid Forum

This is what I was referring to in my previous post. I don't have time to research, but is this kid/fella going all over meso and yelling contamination in every thread? Enlighten me ...

 

[Kralteramon]

Alright.. So I used a PES filter last night to rule out a reaction from >22 micron particles. I injected 3.5iu to make the effect more pronounced. Had very poor sleep last night (not according to my watch), kept waking up every 30 minutes or so and pretty heavy sweating again the first 4 hours of the night. My wife now reported worsened/louder snoring and frequent leg shakes (like when you stretch your legs upon waking). I measured blood glucose at the height of the sweats and it was 4.4mmol/L. I don't think it is a contamination causing the effects. I've snored before when I was heavier and that didn't give me any of the negative effects that I'm experiencing either. Next method I'm going to try is split dosing 1.5iu am and 1.5iu pm.

 

[Kralteramon]

By the way, I wanted to also report the following as it is quite puzzling to me. I lost 1kg bodyweight vs yesterday even though my calories remained the same (+500kcal surplus). Also my systolic dropped by 10 points, I measure it daily on multiple occasions and it stable in the mid 120s normally on this combination of AAS. This morning it was low 110s.

 

[Jin23]

Alright.. So I used a PES filter last night to rule out a reaction from >22 micron particles. I injected 3.5iu to make the effect more pronounced. Had very poor sleep last night (not according to my watch), kept waking up every 30 minutes or so and pretty heavy sweating again the first 4 hours of the night. My wife now reported worsened/louder snoring and frequent leg shakes (like when you stretch your legs upon waking). I measured blood glucose at the height of the sweats and it was 4.4mmol/L. I don't think it is a contamination causing the effects. I've snored before when I was heavier and that didn't give me any of the negative effects that I'm experiencing either. Next method I'm going to try is split dosing 1.5iu am and 1.5iu pm.

Stop injecting before sleep. Do only am. Even a smaller amount will mess up your sleep.

Apparently you either don't need tirz or you need to lower the dosage.

 

[Jin23]

By the way, I wanted to also report the following as it is quite puzzling to me. I lost 1kg bodyweight vs yesterday even though my calories remained the same (+500kcal surplus). Also my systolic dropped by 10 points, I measure it daily on multiple occasions and it stable in the mid 120s normally on this combination of AAS. This morning it was low 110s.

GH increases lipolysis and at the same time decreases adipogenesis (which is also decreased due to increased lipolysis).

However, if you lowered your gh intake, then the loss in bw is to be expected as it's a loss in water.

 

[Kralteramon]

Stop injecting before sleep. Do only am. Even a smaller amount will mess up your sleep.

Apparently you either don't need tirz or you need to lower the dosage.

That's also what I was thinking. Maybe the effects that I'm getting are due to the Tirz HGH combination. That might explain why my friend had a similar(ish) experience since he was also on Tirz. I will try 1,5am + 1,5iupm today and then tomorrow all AM for comparison. Keep you posted.

 

[Kralteramon]

GH increases lipolysis and at the same time decreases adipogenesis (which is also decreased due to increased lipolysis).

However, if you lowered your gh intake, then the loss in bw is to be expected as it's a loss in water.

Thanks. I increased the dose from 3iu to 3,5iu so it can't be water loss due to lower dose.

 

[Jin23]

That's also what I was thinking. Maybe the effects that I'm getting are due to the Tirz HGH combination. That might explain why my friend had a similar(ish) experience since he was also on Tirz. I will try 1,5am + 1,5iupm today and then tomorrow all AM for comparison. Keep you posted.

For sure, low bg can cause sweating and the increased adrenaline which releases when bg is low, increases fragmented sleep, can cause nightmares and vivid dreams. Increasing norepinephrine usually does this to sleep. It's partly why SNRI's and stuff like mirtazapine, cause vivid dreams.

Your response to tirz is rather strong so it is possible that this is the reason to your night sweats. And if you started tirz and GH at the same time, then you could have mistakenly attributed the effect to GH.

But maybe it's a combination of both. GH causing insulin resistance, without an immediate hyperglycemic response, lowering glucose availability, and tirz at the same time increasing insulin and decreasing hepatic glucose release ...