realDevil1
New Member
10+ is where the saving are..$140
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10+ is where the saving are..$140
Right now, size and muscle.What are your goals?
Maybe, your ability to search pubmed is equal to my own. However, I anecdotally, as well as others I know, have yielded better results than one large bolus dose. My understanding is, you can only produce SO much IGF-1 at a time... So, at some point, larger doses will yield diminishing returns. Not only that, I would prefer to have a few spikes over one, personally.
When I have some time, I can see if I can dig up some studies/data on why spreading the dose may be better. It has, anecdotally, always worked better for ME.... For what that's worth.
Pharmacological aspects of growth hormone replacement therapy: route, frequency and timing of administration. - PubMed - NCBI
"The frequency of subcutaneous injections correlates positively with growth rate in animal studies. This is commonly ascribed to a closer resemblance to the endogenous pulsatile pattern. However, frequent subcutaneous injections do not induce a pulsatile pattern, but a pattern which is intermediary between continuous and true pulsatile administration. In a short-term patient study, we observed that pulsatile and continuous intravenous administration of GH generated identical increases in serum insulin-like growth factor I, which suggests that both pulsatory and constant, small elevations in serum GH are important for its actions. Concerning the time of administration, evening GH injections yield a more physiological pattern, and it has been shown that evening GH administration induces increased nitrogen retention and is more successful in normalizing circadian patterns of pertinent hormones and metabolites."
Well one factor I cater it around is the goal... If hypertophy is the goal, I structure my timing based on that. So, pre workout and pre bed I've found to be ideal. If fat loss is the goal, pre fasted AM cardio then pre bed appears to work best. I believe pre lifting w/ a carb surplus or exo. insulin is the MOST effective way to elicit the maximum amount of hypertrophy.... Steroids are also catered to the goal in mind, along with supplements etc.
I believe pre bed is the second best option, and pre workout is the most ideal. if you're splitting the dose, I would always have a pre bed shot and cater the other shot to either pre lifting or pre cardio.
Yeah, I've tried large bolus doses pre workout only, pre bed only and split doses... I liked the results I saw from the split doses and it just seemed to be the most logical method to me.
Nice, thanks. Will do a split type schedule for a bit.So it seems: For fat loss, better one dosage fasted pre cardio upon waking (if not very high like more than 5iu I think, don’t know, I used 3.3iu and was fine)
for bulk phase, split dosage pre Wo and pre bed, don’t know about suppression of endo night pulse
....... I bet my left ball your nutrition plan simply doesn’t existI want to get leaner... I have the Opti 120's. I have been taking 3iu a day for 3 months. Not getting much leaner. Should I up it to 4iu a day? Oh ya I do the whole 3iu an hour before bed.
....... I bet my left ball your nutrition plan simply doesn’t exist
Move the 3iu before fasted cardio...eat in a deficit....fatlossI want to get leaner... I have the Opti 120's. I have been taking 3iu a day for 3 months. Not getting much leaner. Should I up it to 4iu a day? Oh ya I do the whole 3iu an hour before bed.
Insulin pre bed is very dangerous since you couldn’t monitor your blood glucose level.. I read crazy stuff every day moreI’ve always done mine before bed with my insulin
If you run Lantus at morning it’s effect at night is highly diminished, just in case you get crazy and say Bro I use lantuzzzInsulin pre bed is very dangerous since you couldn’t monitor your blood glucose level.. I read crazy stuff every day more
If you run Lantus at morning it’s effect at night is highly diminished, just in case you get crazy and say Bro I use lantuzzz
Oh ok sorry bro... I m a total idiot haha, but you know, you read strange stories every day hereI take Triseba long acting insulin. I’m Diabetic. Blood sugar has never been better. Fasted blood sugar is 70-80 in the morning
My hands are still swollen af, and I'm down to 2.4 IU daily.Differences in the effects of 20 K- and 22 K-hGH on water retention in rats - PubMed
Opti please check if your HGH has those 15 amino acids responsible of Fuckin swelling because I have slightly swollen ankles...
If you find them so fuck them, we don’t wanna swollen ankles here
My hands are still swollen af, and I'm down to 2.4 IU daily.
Yeah, I noticed the same when I switched to the 120's from the 100's. Although I was also treating them as 12iu. Looks like some are more than that from the test I did. I'm the past when my hands swelled it took a long time for the swelling to go awayMy hands are still swollen af, and I'm down to 2.4 IU daily.