MESO-Rx Sponsor OPTITROPIN HGH - PRIME PHARMA - UNIQUE PHARMA - EU DOMESTIC

[Creative04]

I placed my order on Monday and received my delivery today, fast as always. Unfortunately, I got Telmisartan instead of Modafinil. I’ve contacted them now; let’s see what they reply.

 

[frank282]

Your issue is not primarily a GLP-1 receptor problem. Its a combination of elevated evening cortisol, disrupted circadian rhythm, poor sleep architecture, and compulsive nighttime feeding behavior.
RETA reduces daytime appetite well, but people with: chronic insomnia, evening cortisol rebound, night-eating syndrome usually do not respond with appetite suppression in the evening, even at higher doses. Because this is not "hunger". It is a neurobiological soothing mechanism driven by dopamine + cortisol + low evening serotonin

What actually works:
Micro dose SEMA in the evening (0.125-0.25 mg twice weekly). Best for evening appetite suppression.
AND / OR
Bupropion: 75-150 mg. TOP "supplement" for compulsive nighttime eating

thx for your reply, Is Bupropion a prescription drug?

 

[es1989]

thx for your reply, Is Bupropion a prescription drug?

Yes, bupropion is officially a prescription medication (at least in the EU).
However, in reality it is fairly easy to get it "off-label" through private sources....

 

[juicebro]

What you’re describing, at nearly twice the max dose used in trials, suggests either something’s wrong with your batch, or if it’s different batches, immunogenicity has developed and your immune system is quickly neutralizing the Reta protein.

It very much sounds like the latter.

Cross immunogenicity isn’t common, so you might get a “fresh start” with Tirz.

The Sema 7.2mg trials demonstrated there really aren’t “non-responders” (at least on the GLP receptor) if the dose is high enough. At 20mg Reta, feeling nothing, that’s strongly suggestive you’re immune to Reta now.

That would mean I'm not getting any of the other benefits either?

I also tried taking a 2 week break and went from daily dosing to dosing it once a week. No difference.

The reta I use is g2g because my partner uses it too and it works well for her at 4mg a week. It's from SSA.

Someone mentioned Bupropion. I'm on that too lol. Works great for motivation and drive but hasn't had any effect on my appetite.

 

[es1989]

That would mean I'm not getting any of the other benefits either?

I also tried taking a 2 week break and went from daily dosing to dosing it once a week. No difference.

The reta I use is g2g because my partner uses it too and it works well for her at 4mg a week. It's from SSA.

Someone mentioned Bupropion. I'm on that too lol. Works great for motivation and drive but hasn't had any effect on my appetite.

That's actually pretty common. Bupropion can help reduce cravings for some people, but it does not reliably prevent overeating and for many it simply has no effect on appetite. Everyone reacts differently.

There is one FDA-approved medication in the US specifically for binge eating disorder: lisdexamfetamine better known by the brand name VYANSE. It's been shown to reduce the number of binge episodes in people with moderate to severe binge eating.

Bupropion is often well tolerated together with medications like SEMA or RETA.
In my work with clients who already use these medications under medical supervision, Ive found this combination helpful because: bupropion supports motivation, energy, overall drive, and in some cases slightly reduces compulsive overeating, while RETA/SEMA strongly reduce appetite, food cravings, and the total amount of food consumed.

Together, they target different mechanisms: one influences brain reward and behavior, while the other acts on physical appetite and satiety

 

[explodingHeart]

What you’re describing, at nearly twice the max dose used in trials, suggests either something’s wrong with your batch, or if it’s different batches, immunogenicity has developed and your immune system is quickly neutralizing the Reta protein.

It very much sounds like the latter.

Cross immunogenicity isn’t common, so you might get a “fresh start” with Tirz.

The Sema 7.2mg trials demonstrated there really aren’t “non-responders” (at least on the GLP receptor) if the dose is high enough. At 20mg Reta, feeling nothing, that’s strongly suggestive you’re immune to Reta now.

For what it's worth, at my leanest, when my glutes were finally starting to get dimples / striations, I was using 15mg or so chinese sema per week. After a month of bulking and back at 10%, I only needed very low doses. And I've been injecting sema for over 2 years now.

I originally started out at around 13% BF and needed a lot to get leaner. Maybe I lowered my set point (in my 40s), lol. Who knows.