It can cause elevated liver enzymes in some people. One recent study showed 1.3% of those using high doses had elevated enzymes, but not high enough to require stopping treatment. Levels return to normal after stopping,
Many countries no longer require liver function tests for accutane use.
Roughly 20 million people have used accutane worldwide over the last 40 years and there isn't a single documented case of liver injury.
Official answer: No reports of permanent liver damage associated with Accutane (isotretinoin) could be found in the literature but...
www.drugs.com
(And incidentally
@iris, I know this not because I'm autistic or have ADHD, it's because I'm concerned enough about my long term health to invest the time to educate myself up front, rather than potentially pay a much heavier price later.)