Overall, 5α-inhibitors are well-tolerated [14]. Nevertheless, sexual dysfunction and psychiatric side effects have been reported. While no causal link had been established, anecdotal evidence of mood changes and small studies reporting depressive symptoms relating to finasteride use have led to depression being added as an adverse reaction to the product labeling of the drug in 2011 [14]. Either way, this does suggest this side effect is quite rare. Erectile dysfunction seems to be more common. A 2010 meta-analysis suggests that, compared to a placebo, 1 in 80 will experience erectile dysfunction as a result of finasteride use [15]. However, no significant difference compared to a placebo was found in decreased libido or ejaculation dysfunction. A 2013 Similarly, around 1 in 80 also can get gynecomastia from its use compared to placebo [16]. Side effects usually resolve after discontinuation of the compound, although they are suggested to persist in some cases. This is also called the post-finasteride syndrome and is described as a “constellation of sexual, physical, and psychological symptoms that develop during and/or after finasteride exposure and persist after drug discontinuation” [17]. Considerable debate exists in the literature about whether or not post-finasteride syndrome even exists [17, 18, 19]. One paper went as far as suggesting it may represent a delusional disorder, stating: “We present the first case of PFS [post-finasteride syndrome] in our 20-year prescription practice of oral finasteride for treatment of male pattern baldness, with circumstantial evidence that PFS may represent a delusional disorder of the somatic type, possibly on a background of a histrionic personality disorder, and with the potential of a mass psychogenic illness due to its media coverage.” [19] Regardless, while it’s obviously hard to get solid evidence for a causal link, the lack of sufficient data to establish this doesn’t mean it’s not real. As such, it seems prudent to support further research in order to paint a clearer picture of its causal link with finasteride use, incidence and pathophysiology, while also maintaining a cautionary stance and informing the public of this rare possible side effect.