Pharmaceutical vs Generic

[Cumminstech]

I should first add there are some slight exceptions to generic 191aa GH, but those still aren’t made from E. coli using recumbent DNA technology with the modified gene to make it bio similar to GH secreted by your pituitary.

 

[Silentlemon1011]

they are different because pharma is 191aa which is an exact copy of the growth hormone that your body naturally produces, where generics are 192aa and are not an exact copy so your body has to break them down and turn them into growth hormone it recognizes.

there’s a reason all FDA approved growth hormone is 191aa. Your body uses it better and doesn’t build immunity to it as fast. A growth hormone being pharmacuetical in China doesn’t mean shit because their regulations fucking suck and they let generics be pharmacuetical grade. The FDA is much more picky.

China doesn’t have the technology to make 191aa growth hormone because it’s a much more difficult folding process so it creates 192aa growth hormone which is sold black market here as generics. If they were able to make a 191aa generic they would be selling it on pharmacy shelves and making millions, but they aren’t doing that because they aren’t capable of doing so...

191aa > 192aa growth hormone

Pharma = 191aa
Generic = 192aa

Generics aren’t actually growth hormone, they are just a close match. Pharma Somatropin is bio similar to the growth hormone your body produces.

I want to say that's old tech
That Pharma is using solid state now
Ecoli method is pretty old school, considering we can just rearrange the Amino acid chains at pretty much our command now.

So, maybe 15 or 20 years ago, I'd say you're 100% correct.

BUT, I will say im not 100% sure TBH

I'll just tag @Human_backhoe here, who has extensive knowledge and experience in peptide synthesis methods.

He can call me out if I'm mistaken.

 

[Human_backhoe]

@Cumminstech @Silentlemon1011

The only studies done( that I am aware of) show that in both the 191 and 192 0.4 percent of patients develop a immunological response to protein itself. 26,000 patients who have been treated with 192 amino acid residues , 0.02 percent of patients have had growth deceleration associated with binding capacities. No evidence exists to indicate that the methionine on the N-terminus of 192 amino acid residues causes antibodies to growth hormone.

THAT BEING SAID! Most studies are performed on people with GHD, they already have a very high anti-body level to HGH...Another problem is that most antibodies that were measured in those studies is based on antibodies to Escherichia coli proteins and not the antibodies to met-HGH!

Most long term problems with 192 come from dirty Chinese products! Ecoli is now a dated method that they still can't get right in China

Also based on some industry experience..... Modified solid state synthesis is what pharma appears to be doing now.....that's a whole other ballgame!

 

[SUGARBEAR]

Have run a few brands (serostim, genotropin) always with distinct positive effects (soft tissue healing, skin quality) and occasional sides (carpal tunnel, numb fingers) . Hgh serum test came back positive the one time I tested.
Have also run a few brands generic (the provider, opti...) and never seem to be able to distinguish either the positive or negative gh sides. Have also never run a serum test on them, that's on me.
With a general understanding (work in a bio lab) of the process by which recombinant hgh is synthesized (genetically modified bacteria), I have to wonder if the generics are REAL hgh or just peptides? Where does an average Joe get a mutant strain of e.coli that pumps out hgh and how the hell do they retrieve it?

I feel the same way. Windex vs. supermarket window cleaner. I believe a lot of manufacturers of generic also do brand. Steroids are definitely that way.

 

[rfan2020]

@Cumminstech @Silentlemon1011

The only studies done( that I am aware of) show that in both the 191 and 192 0.4 percent of patients develop a immunological response to protein itself. 26,000 patients who have been treated with 192 amino acid residues , 0.02 percent of patients have had growth deceleration associated with binding capacities. No evidence exists to indicate that the methionine on the N-terminus of 192 amino acid residues causes antibodies to growth hormone.

THAT BEING SAID! Most studies are performed on people with GHD, they already have a very high anti-body level to HGH...Another problem is that most antibodies that were measured in those studies is based on antibodies to Escherichia coli proteins and not the antibodies to met-HGH!

Most long term problems with 192 come from dirty Chinese products! Ecoli is now a dated method that they still can't get right in China

Also based on some industry experience..... Modified solid state synthesis is what pharma appears to be doing now.....that's a whole other ballgame!

Based on your knowledge of the process, do you feel the Chinese made gh (generics) is a cost effective alternative to pharmaceutical gh?

 

[Human_backhoe]

Based on your knowledge of the process, do you feel the Chinese made gh (generics) is a cost effective alternative to pharmaceutical gh?

I would personally only run Chinese pharma. As @Cumminstech pointed out their pharma is really our generic lol. Is you choose Chinese "generic " this is a UGL in all reality. Zero quality control that means anything in the West. I have personally run them and got the dreaded painful welts. A grand or more of useless GH sitting around. The ugl's are using older still technology that is not really safe anymore in my opinion. The buy dated machines and "refurbish" them. There is one supplier here on Meso controlling his process with a $100 refurbished PC lol. I have switched to a domestic source of generic in North America and having great results!

But hey you might be different and not build up the antibodies to the ecoli like I did.

 

[rfan2020]

I wasn't even aware there were generics for GH in North America, I know we have UG labs for gear but I always thought Gh was either Pharma, or chinese generic? One reason why im trying to do my research before I start using lol

 

[Silentlemon1011]

I wasn't even aware there were generics for GH in North America, I know we have UG labs for gear but I always thought Gh was either Pharma, or chinese generic? One reason why im trying to do my research before I start using lol

For the most part North Americsn domestics are Chinese made.
HOWEVER
I know that some Chinese pharma companies do distribute to the "black market"
You used to be able to get Ansomnes that were "Generics" back in the day.. that were actually produced by Anke Biotech.
(Pretty sure it was TPs original Greytops)

Shit shit changes so often though.
Its fucking hard to keep track

 

[hghlover]

For the most part North Americsn domestics are Chinese made.
HOWEVER
I know that some Chinese pharma companies do distribute to the "black market"
You used to be able to get Ansomnes that were "Generics" back in the day.. that were actually produced by Anke Biotech.
(Pretty sure it was TPs original Greytops)

Shit shit changes so often though.
Its fucking hard to keep track

Would you say TP's newer greys are still better than meditropes?

 

[Frankdoz]

What about test et?