Have experimented with Primo myself, used it in different situations.
TRT + little Primo: Libido higher than just with TRT, having more endurance on regular days and feeling better even on days with bad sleep.
Test/Primo: 1:1 ratio cut my e2 by half. When Primo was higher than Test, my e2 was too low and my libido was fading away.
My lipids take a toll using Primo, my families baseline LDL is pretty "high" by nature, so is mine even before TRT and with everything checked being in place (solid nutrition, cardio etc etc) - However basically no cardio vascular events existing.
Regarding shedding, I am one of the lucky people who barely experience that. I think some more hairs fall out while on Primo (not the 50-100mg with the TRT tho, that does nothing), but it can be just the hairline remained literally the same.
Body hair growth became more, but I cannot tell if thats mostly the compound or the fact of me getting older. I guess it grows just a little faster than before.
Other negatives beside lipids: Sweating way more. Also during nights. If Test/Primo/E2 have a certain balance, my libido is terribly high.
As a person prone to back/shoulder acne during my teens (which went away slowly at the age of 20 upwards) I never had any issue at all.
Doses being used were considered "lower end". I would like to run it higher but as it did what it should do, I did not see the point of using more.
It is highly interesting how different peoples lipids change using gear. I have seen bloodwork ofa guy I knew a day after getting his pro card, he literally had perfect LDL levels.