Processing Raw Powder: Tablet vs. Solution Methods

[kencho]

What is the best and safest method for processing raw powder into a solution or tablets?

I have the following options and would like advice on which is most effective and safest:

1. Tablet Pressing: Use a small blender to mix the binder and active ingredient, manually mix periodically, then grind the mixture in a mortar and pestle. Finally, use a hand press (e.g: this one ) to form tablets. Is this press suitable? tdp-0 press machines are expensive.
2. Capsule Filling: Mix the ingredients as above, but use a capsule mold to fill capsules instead.
3. Oral Solution: Dissolve the powder in a mix of deionized water and ethanol using a magnetic mixer.

Which method is best considering safety, effectiveness, and ease of use?

 

[crtx]

accuracy option 3
easy but inaccurate to do option 2
run your own lab option 1

there is nothing safe. effective yes.

 

[kencho]

accuracy option 3
easy but inaccurate to do option 2
run your own lab option 1

there is nothing safe. effective yes.

tablets are the one i want the most. do you think the tablet press from the link is any good? it’ll be slow but worthy if it works

 

[crtx]

tablets are the one i want the most. do you think the tablet press from the link is any good? it’ll be slow but worthy if it works

no idea bro tablet press would be the last thing i'd ever be ordering online.

talk about safety first.

 

[sushak]

There's another option and that is oral suspension becAuse not always will the solution mechanism be available. I am currently learning a nasty lesson about that ATM will post separately once confirmed and I am through it (possible telmisartan overdosing due to high concentration at the end of a batch)

 

[kencho]

wouldn’t oral suspension cause undissolved particles to flow down since they’re heavy? in terms of dosing oral solution seems the safest, but man do i want to produce some pills

 

[Ghoul]

wouldn’t oral suspension cause undissolved particles to flow down since they’re heavy? in terms of dosing oral solution seems the safest, but man do i want to produce some pills

Why? So you can play the "What random dose will I be getting today?" game?

 

[kencho]

Why? So you can play the "What random dose will I be getting today?" game?

it’s an interesting process and on a small, manual scale i think margin of error would be 2-3mg. i just need to mix it well and long enough

 

[Ghoul]

it’s an interesting process and on a small, manual scale i think margin of error would be 2-3mg. i just need to mix it well and long enough

That's a great thing to think, with no basis in reality. Just picking the proper excipients to prevent clumping at the molecular level, unique for each active ingredient, is a science unto itself.

Homebrewers think pharma manufacturers just mix active ingredients with "pill powder" in the correct proportions, thoroughly enough. and get uniformly dosed pills, and it's nothing like that.

Don't forget the crucial grinding stage, to ensure all ingredient particles are reduced to the same size, and figure out how to eliminate "fines", the smaller ones that can concentrate more of the active ingredient than you intended in a dose.

Brewing oils is child's play compared to properly making orals.

 

[kencho]

That's a great thing to think, with no basis in reality. Just picking the proper excipients to prevent clumping at the molecular level, unique for each active ingredient, is a science unto itself.

Homebrewers think pharma manufacturers just mix active ingredients with "pill powder" in the correct proportions, thoroughly enough. and get uniformly dosed pills, and it's nothing like that.

Don't forget the crucial grinding stage, to ensure all ingredient particles are reduced to the same size, and figure out how to eliminate "fines", the smaller ones that can concentrate more of the active ingredient than you intended in a dose.

Brewing oils is child's play compared to properly making orals.

i already said i’d use a mortar and a pestle along with a blender. on a small scale like this it’ll be easier to granulate. i don’t think big pharma companies do it so simple. they have huge industrial machines, but they produce on a huge scale. will the solution be the most accurate?

 

[notanothersnake]

Mortar and pestle isn't good for much past grinding raws into smaller pieces, which isn't required for many raws.

Excipient mixes (good ones) usually have a mix of size of granules to promote flow and deter caking. No sense in disturbing that. And yes, there are extras to add to improve flow further (and tab density) but usually only needed when running under power (tdp 1.5, tdp 5 or better).

Capsules is fine for personal use. But if your not good w math and ratios, dnt bother

 

[kencho]

Mortar and pestle isn't good for much past grinding raws into smaller pieces, which isn't required for many raws.

Excipient mixes (good ones) usually have a mix of size of granules to promote flow and deter caking. No sense in disturbing that. And yes, there are extras to add to improve flow further (and tab density) but usually only needed when running under power (tdp 1.5, tdp 5 or better).

Capsules is fine for personal use. But if your not good w math and ratios, dnt bother

so it comes down to capsule vs solution. do you handle raws? if so, how?

 

[narta]

Brewing oils is child's play compared to properly making orals.

Depends on the mg/pill-capsule. 1mg/cap and below is stupid difficult to achieve, 200mg/cap is easy peasy

 

[notanothersnake]

Capsule has a better shelf life... I've seen manual tab makers online and I've seen tabs w inconsistent thicknesses, I think that's how

 

[narta]

Mortar and pestle isn't good for much past grinding raws into smaller pieces

Decades of compounding pharmacy disagree with you

 

[Ghoul]

Depends on the mg/pill-capsule. 1mg/cap and below is stupid difficult to achieve, 200mg/cap is easy peasy

True, true. Large margin of error in high dose meds makes it more practical. Even pharma allows for +\- 5%

 

[Liter O' Test]

That's a great thing to think, with no basis in reality. Just picking the proper excipients to prevent clumping at the molecular level, unique for each active ingredient, is a science unto itself.

Homebrewers think pharma manufacturers just mix active ingredients with "pill powder" in the correct proportions, thoroughly enough. and get uniformly dosed pills, and it's nothing like that.

Don't forget the crucial grinding stage, to ensure all ingredient particles are reduced to the same size, and figure out how to eliminate "fines", the smaller ones that can concentrate more of the active ingredient than you intended in a dose.

Brewing oils is child's play compared to properly making orals.

thank you, meanwhile everytime someone wants to dose raws, I get flamed for saying to weigh the powder out on the scale and take it as is. They say its inaccurate.
Meanwhile they recommend half ass mixing up raws and whatever binder they have on hand, in a mixing bowl 7 times and shake it around and think its magically even and accurate because they copied some random repost from 1995, and they would have absolutely no way to tell what each dose is without laboratory testing.

yeah just dump 10g of anavar into 100g of creatine, mix it around good and split it up, thats way more accurate than measuring 50mg on a jewerly scale.

they think they can dump any powder into a liquid and its magically even all the time aswell lol, maybe shake it once or twice and its magically instnatly completely perfect

 

[Deskoze38192]

That's a great thing to think, with no basis in reality. Just picking the proper excipients to prevent clumping at the molecular level, unique for each active ingredient, is a science unto itself.

Homebrewers think pharma manufacturers just mix active ingredients with "pill powder" in the correct proportions, thoroughly enough. and get uniformly dosed pills, and it's nothing like that.

Don't forget the crucial grinding stage, to ensure all ingredient particles are reduced to the same size, and figure out how to eliminate "fines", the smaller ones that can concentrate more of the active ingredient than you intended in a dose.

Brewing oils is child's play compared to properly making orals.

Homebrewers that are knowledgeable know that the process of geometric dilution is the only proper way to evenly mix a raw and filler to be capsulated

 

[Deskoze38192]

thank you, meanwhile everytime someone wants to dose raws, I get flamed for saying to weigh the powder out on the scale and take it as is. They say its inaccurate.
Meanwhile they recommend half ass mixing up raws and whatever binder they have on hand, in a mixing bowl 7 times and shake it around and think its magically even and accurate because they copied some random repost from 1995, and they would have absolutely no way to tell what each dose is without laboratory testing.

yeah just dump 10g of anavar into 100g of creatine, mix it around good and split it up, thats way more accurate than measuring 50mg on a jewerly scale.

they think they can dump any powder into a liquid and its magically even all the time aswell lol, maybe shake it once or twice and its magically instnatly completely perfect

The pharmaceutical industry feels that liquid suspensions are a satisfactory way of accurately dosing insoluble raws

@Ghoul doesn’t though lol