Proviron

The dose was reasonable.

The animals either received gum arabic (GA) or the dihydrotestosterone (DHT) derivative, mesterolone (M) (2 mg/kg body weight) (Proviron trademark of Schering, Schering do Brasil, São Paulo, SP, Brazil) by orogastric tube during the last 3 weeks of the study (3d/wk: Monday, Wednesday, and Friday). Mesterolone (1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one) was chosen for two reasons: 1) it can be administered orally avoiding injection-induced wound formation and 2) as a non-17 alpha-alkylated derivative of testosterone it presents low hepatotoxicity.
 
Proviron is a must have in every cycle! Now if you are expecting it to give you tremendous gains you are in for a big shock. But what it does is give you this tremendous feeling of well being, extreme erections, and it seems to help with giving my muscles a smooth look. I run 25-50mgs a day....I will not blast without it ever again. I have seen some people run it up to 150mgs a day...I think that is overkill IMO...25-75mgs a day and you are in a grove!
 
one can certainly notice 25 or 50 mg... but 75 -100 mg is where you'll get good strength gains and libido will actually go up significantly.

it will also prevent bloat at the 75 mg+ dose.

but overall, masteron kicks it's ass.


now i just want injectable DHT.
 
one can certainly notice 25 or 50 mg... but 75 -100 mg is where you'll get good strength gains and libido will actually go up significantly.

it will also prevent bloat at the 75 mg+ dose.

but overall, masteron kicks it's ass.


now i just want injectable DHT.

I don't get the same libido kick from Mast as I do from proviron. I know everybody says mast just gives them extreme erections. They are nice but no where near proviron for me. But Mast kicks provirons ass as far as body composition affects.
 
Proviron a must have for "every cycle" I quite sure most mates on Meso would disagree with that sentiment.

It's anabolic activity is one of the lowest and considering it's the ONLY oral AAS without 17alpha methyl or alkylation, it's absorption is PATHETIC at LESS THAN ONE PERCENT.

Lastly it's ability to improve sexual drive because it does displace protein bound DHT is unproven and probably no more than an placebo effect, IMO
 
Proviron a must have for "every cycle" I quite sure most mates on Meso would disagree with that sentiment.

It's anabolic activity is one of the lowest and considering it's the ONLY oral AAS without 17alpha methyl or alkylation, it's absorption is PATHETIC at LESS THAN ONE PERCENT.

Lastly it's ability to improve sexual drive because it does displace protein bound DHT is unproven and probably no more than an placebo effect, IMO

IN YOUR OPINION vs IN MY EXPERIENCE. It definitely isn't placebo I can assure you this. My rod can tell the difference. [:o)] Notwithstanding any scientific angles but the stuff works for me. No doubt!
 
I still stick to my theory that people who don't like proviron are getting garbage.
I took a chance on some bayer proviron from an unknown source once and I was pleasantly surprised.
It came in an unlabeled Ziploc bag and the tiny white pills we're already starting to break apart. There was a lot of loose powder in the bottom of the bag.
despite believing it was most likely bunk I started taking 75mg ed.
3 or 4 days later I had plowed the old lady twice and punched the clown 3 more times that day.(not an exaggeration) So vigorously that my genitalia was literally throbbing sore. Had to back off just to give my little man a break.

No ugl proviron that I've ever tried can compare to farm grade.
50mg of farm grade would serve its purpose much better then 100mg ugl.

The only problem with proviron is it can sometimes be hard to find, expensive and there is never enough of it.
 
Well your experience is not consistent with the majority of Meso vets or the literature, but to each their own.

Perhaps if you were more well informed about Proviron you would understand my comments because I certainly understand yours. I've used Prov previously and was mush less than impressed.

Consequently I believe the "beneficial effect" on libido some experience when using this structural AAS (and that's about it) is because "bro lore"
says it works for that purpose and no one wants to be the outlier among a cadre of BB.

I mean think about it. This is an AAS whose absorption is no more than one percent.

Thus when 50mg are ingested only 0.5mg enters the circulation and is biologically active. There.is NO AAS that powerful and the dose then becomes "homeopathic".
 
Well your experience is not consistent with the majority of Meso vets or the literature, but to each their own.

Perhaps if you were more well informed about Proviron you would understand my comments because I certainly understand yours. I've used Prov previously and was mush less than impressed.

Consequently I believe the "beneficial effect" on libido some experience when using this structural AAS (and that's about it) is because "bro lore"
says it works for that purpose and no one wants to be the outlier among a cadre of BB.

I mean think about it. This is an AAS whose absorption is no more than one percent.

Thus when 50mg are ingested only 0.5mg enters the circulation and is biologically active. There.is NO AAS that powerful and the dose then becomes "homeopathic".

Doc I have no idea but I swear it does something and the tool is like a damn diamond tip drill.
 
Brancaleone V, Vellecco V, Matassa DS, et al. Crucial role of androgen receptor in vascular H2S biosynthesis induced by testosterone. British Journal of Pharmacology. http://onlinelibrary.wiley.com/doi/10.1111/bph.12740/abstract

Background and Purpose Hydrogen sulphide (H2S) is a gaseous mediator strongly involved in cardiovascular homeostasis, where it provokes vasodilatation. Having previously shown that H2S contributes to testosterone-induced vasorelaxation, here we aim to uncover the mechanisms underlying this effect.

Experimental Approach H2S biosynthesis was evaluated in rat isolated aortic rings following androgen receptor (NR3C4) stimulation. Co-immunoprecipitation and surface plasmon resonance analysis were performed to investigate mechanisms involved in NR3C4 activation.

Key Results Pretreatment with NR3C4 antagonist nilutamide prevented testosterone-induced increase in H2S and reduced its vasodilator effect. Androgen agonist mesterolone also increased H2S and induced vasodilatation; effects attenuated by the selective cystathionine-γ lyase (CSE) inhibitor propargylglycine.

The NR3C4-multicomplex-derived heat shock protein 90 (hsp90) was also involved in this effect; its specific inhibitor geldanamycin strongly reduced testosterone-induced H2S production. Neither progesterone nor 17-β-oestradiol induced H2S release.

Furthermore, we demonstrated that CSE, the main vascular H2S-synthesizing enzyme, is physically associated with the NR3C4/hsp90 complex and the generation of such a ternary system represents a key event leading to CSE activation.

Finally, H2S levels in human blood collected from male healthy volunteers were higher than those in female samples.

Conclusions and Implications We demonstrated that selective activation of the NR3C4 is essential for H2S biosynthesis within vascular tissue, and this event is based on the formation of a ternary complex between cystathionine-γ lyase, NR3C4and hsp90.

This novel molecular mechanism operating in the vasculature, corroborated by higher H2S levels in males, suggests that the L-cysteine/CSE/H2S pathway may be preferentially activated in males leading to gender-specific H2S biosynthesis.
 
I took proviron for years. In fact at one time before ai's it was my go to along with nolva for e2 sides management. My ultimate conclusion is it is essentially useless. It increases my libido for about 2 weeks, then even if I continue taking it that increase subsides and it does nothing. Nothing for gains, nothing for water retention, nothing for nothing. Some swear by it but for me it has ultimately proven a bust.
 
I ran prov for only a few weeks just to see what some of the hype was about and wow I could have fucked a hole in a wall. And this is my 2nd week running tren and the tren midnight blues hit last night. Think I slept 2 hours broken up. Don't know how long I can put up with that. May have to double dose melatonin
 
I ran prov for only a few weeks just to see what some of the hype was about and wow I could have fucked a hole in a wall. And this is my 2nd week running tren and the tren midnight blues hit last night. Think I slept 2 hours broken up. Don't know how long I can put up with that. May have to double dose melatonin
Try some NyQuil zzzzz that will help you to sleep all nite. I alway run 50 mgs of Proviron and that really work for me and help me a lot with my libido to keep my wife happy


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Try some NyQuil zzzzz that will help you to sleep all nite. I alway run 50 mgs of Proviron and that really work for me and help me a lot with my libido to keep my wife happy


Sent from my iPhone using Tapatalk
Last night was the first night it was bad, plus I was able to squeeze sweat out of my shirt after tracing this morning. I'm hoping I can sleep with the natural stuff cause I will be useless at work
 
Last night was the first night it was bad, plus I was able to squeeze sweat out of my shirt after tracing this morning. I'm hoping I can sleep with the natural stuff cause I will be useless at work
Yes that one of the side effect of tren, melatonin 5 mgs works but is not more effective than NyQuil just try it and you will see good result


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