Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[forearms]

Domestic Aus order arrived a couple days after shipping which was such an amazing experience in contrast to the 2 months international orders take lol!!

Domestic hgh? Why are some guys waiting 7 + days and others get theirs like yourself in a couple of days

 

[5thGen]

correct

$20/bottle
$15/bottle for +10 bottles
$10/bottle for +20 bottles

except turinabol and primo acetate
turi $39
primo ace $90

Primo ace is $90 a bottle?

 

[Captainpotatohead]

Domestic hgh? Why are some guys waiting 7 + days and others get theirs like yourself in a couple of days

Not sure, maybe a question for @Qingdao Sigma Chemicals

 

[Qingdao Sigma Chemicals]

Primo ace is $90 a bottle?

Yes

 

[Qingdao Sigma Chemicals]

Domestic hgh? Why are some guys waiting 7 + days and others get theirs like yourself in a couple of days

Australian post

 

[BT1747]

Mi

Australian post

Mine come with a courier and still took time

 

[krasnoyarsk]

Can you please check PMs. Thanks.

 

[Qingdao Sigma Chemicals]

Can you please check PMs. Thanks.

Yes I will reply to all yesterday emails and PMs in the next hours, thank you for your patience.

 

[krasnoyarsk]

Thanks!

 

[Qingdao Sigma Chemicals]

@Qingdao Sigma Chemicals

With the constant changing of inventory availability, can you post Latest inventory (available) list?

Attached the price list

If you can't upload it, send me an email to get it by email.

qingdao.rep@protonmail.com

 

[Qingdao Sigma Chemicals]

Some products never advertised in my list, few kits in stock:

BPC157 2 mg：$30/kit (3 kits left)
Sermorelin 5mg: $78/kit (1 kit left)
Humanin 2mg：$118/kit (3 kits left)
Mots-C 25mg: $220/kit (1 kit left)
CJC no Dac 5mg: $80/kit (8 kits left)
TB500 2mg: $45/kit (10 kits left)

Benefits Of Humanin​

1. Improves Mitochondrial Function​

Humaninin (HN) directly inhibits oxidative stress on the mitochondrial membrane, thus protecting mitochondria from dying. R

HN inhibits Cytochrome C release from mitochondria and can increase their production of energy (ATP).

HN improves mitochondrial levels of Glutathione (GSH) as well. R

HN can also prevent Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) by directly increasing cellular ATP levels in lymphocytes.

Humanin also induces Mitochondrial Biogenesis (growth of new mitochondria).

2. Protects Cells From Dying​

HN can also protect cells from oxidative stress.

HN improves cell survival by binding to and inhibiting by Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) and Bcl2-Associated X protein (Bax).

HN can also promote cell survival by binding to and deactivating proapoptotic BH3 proteins Truncated Form of Bid (tBid) and Extra Long Isoform of Bim (BimEL).

3. May Enhance Longevity​

Growth Hormone (GH) negatively regulates HN levels. R

For example, mice that were unable to produce adequate amounts of GH had higher amounts of HN and lived longer than normal mice. R

Children of centenarians have 3x higher levels of HN than controls. R

HN can act as a Calorie-Restriction Mimetic (CRM) by suppressing Insulin-Like Growth Factor 1 (IGF-1) levels. R

HN has very similar actions to IGF-1 (see section above): R

• Activate ERK1/2
• Activate JAK2-STAT3
• Activate PI3K/Akt (helps with stroke)
• Cardioprotective
• Controls cell death, metabolism, and transcription
• Degrading Atherosclerotic Plaques
• Enhance Brain Aβ Clearance
• Enhancing Insulin Sensitivity
• Found in Mitochondria, plasma, cells, skeletal muscle, liver, fat, and hypothalamus
• Lowering Inflammation
• Inhibiting Cell death
• Suppressing Hypoxia

Although, HN and IGF-1 do have opposite effects on longevity and cancer growth, and both show a decline in expression with aging. R

For example, HN protects against cell senescence (biological aging of a cell). R

4. Ameliorates Alzehiemer's Disease And Improves Short-Term Memory​

HN can protect brain cells against Amyloid-Beta (AB)-induced cell death and increase clearance AB levels, a common pathology seen Alzheimer's Disease (AD). R R R

HN can also protect the brain against Tau Hyperphosphorylation (a pathology of AD). R

For example, HN can protect against Okadaic Acid (OA), a toxin extracted from marine life that causes tau hyperphosphorylation. R

HN may improve memory.

For example, HN can also reverse Long-Term Potentiation (LTP) loss from AB, in important mechanism used to form memory. R

HN can also prevent memory loss from other Anticholinergic drugs. R

For example, scopolamine, a Muscarinic Acetylcholine Receptor (mAChR) antagonist, can cause short-term memory loss and is a standard in testing AD animal models. R

A modified version of HN called Humanin G (HNG) can reverse the short-term memory loss from scopolamine. R

This modification (HNG) has shown to increase the neuroprotective effects of HN by 1000-fold. R

HNG taken intranasally can reduces AB accumulation and ameliorates memory deficit in AD animal models. R

HN may protect against Insulin Resistance (IR) in the brain, a main pathology of Type 3 Alzheimer's/Diabetes. R R

For example, by stimulating STAT3 and inhibiting IGFBP3 in the hypothalamus, HN is a powerful insulin sensitizer and may help with IR in AD. R R R

In the hippocampus, HNG can improve Autophagy by regulating IRS-1/mTOR signaling. R

HN also provides neuroprotection against some Familial Alzheimer's Disease (FAD) genes including presenilin 1, presenilin 2, and mutated Amyloid Precursor Protein (APP). R R

HN also binds to the receptor for Ciliary Neurotrophic Factor (CNTF), which is an important for neurodegenerative diseases, spinal cord injuries, retinal degeneration, autoimmune neuroinflammation and obesity-related metabolic diseases. R

5. Combats Proteopathy, Neuroinflammation, And Excitotoxicity​

In the Endoplasmic Reticulum (ER), ROS causes a calcium efflux leading to Proteopathy (toxic unfolded/misfolded protein aggregates). R

HN protects against proteopathy in 2 ways:

1. HN can inhibit ROS formation R
2. HN can inhibit calcium release in the ER R

For example, HN can protect against prion-proteopathy. R

HN also protects against Lipopolysaccharide-induced (Endotoxemia) neuroinflammation. R

HN also protects against excitotoxicity (both via action on NMDARs and independently). R

For example, HN can prevent Reactive Oxygen Species (ROS) and Nitric Oxide (NO) induced excitotoxicity caused by the overactivation of the NMDA receptors. R

HN can also reduce Lactate-Dehydrogenase (LDH) in the brain. R

6. Protects Against Insulin Resistance​

HN can inhibit pancreatic beta-cell death and improve Glucose tolerance in non-obese diabetic (NOD) animal models. R

This may be beneficial for both Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D). R R

By acting on the hypothalamus, HN can also increase Insulin sensitivity in the liver and stabilize blood glucose levels. R

HN may be a good biomarker for fasting glucose-related oxidative stress. R

HNG acutely increases Triglyceride (TG) secretion from the liver. R

7. Combats Obesity And Weight Gain​

HN can prevent weight gain by increasing glucose stimulated insulin release and decreasing body Weight Gain and visceral fat. R R

8. Protects The Eyes​

Age-related Macular Degeneration (AMD) is caused degeneration of the retina from oxidative stress resulting in irreversible vision loss. R

The ER of mitochondria play a huge role in protecting the Retinal Pigment Epithelium (RPE) in AMD. R

HN and HNG both prevent AMD as it can protect against oxidative stress and cell death of the RPE and ER by increasing mitochondrial GSH levels and reducing ROS, Caspase 3 and Caspase 4 levels. R R

9. May Fight Spinocerebellar Ataxia And Huntington's Disease​

Spinocerebellar Ataxia (SA) and Huntington's Disease (HD) are characterized by Polyglutamine (PolyQ) toxicity. R

HN can prevent PolyQ-induced mitochondrial dysfunction. R

10. May Help With Amyotrophic Lateral Sclerosis​

HN may help Familial Amyotrophic Lateral Sclerosis (ALS).

For example, animal models with mutations in G93A-SOD1, HN dose-dependently improved motor performance and prolonged survival of ALS mice. R

11. May Protect Against Sunburn​

HN can protect against Ultraviolet (UV)-induced cell death. R

12. Protects The Vascular System​

HN levels have been shown to be high in patients with atherosclerotic plaques and may protect against atherosclerosis. R

For example, in animal models that were unable to express APOE (an important protein for cholesterol metabolism), HNG was able to improve cardiovascular function from a high cholesterol diet (reducing plaque ~90%). R

HN can protect HN cells from cells from oxidative stress induced by Oxidized LDL (oxLDL). R R

By increasing AMPK and eNOS, during a heart attack HNG can protect against damage induced by left coronary occlusion, reducing infarct size and oxidative stress. R

13. Protects Against Hypoxia And Ischemia​

HN can attenuate the stresses caused by hypoxia and ischemia.

By activating PI3K/Akt and Jak2/Stat3, HNG is neuroprotective during hypoxia. R R

For example, HN can protect against cellular hypoxia induced by Compound Cobalt Chloride (CoCl₂). R

Cuprizone (CPZ), a copper chelator, provokes demyelination and schizophrenia-like symptoms. R

HN can suppress neuroinflammation and cognitive deficits from CPZ use. R

HN has shown to induce axonal remyelination in hypoxic brains. R

A major problem from ischemia is loss of blood flow which results in the reduction of growth factors, and thus cell death.

HN can prevent cell death from ischemia and improve hypoxic cell's ability to create energy (ATP). R R

HN may also be beneficial in a Traumatic Brain Injury (TBI), as HN can protect against ischemic and hemorrhagic stroke-induced damage. R R

For example, in animal models, HNG was able to reduce infarct volume size by 50%. R

One reason why HNG may protect against TBI is by upregulation of Suppressor Of Cytokine Signaling 3 (SOCS3). R

14. Protects The Colon​

In experimental models of Ulcerative Colitis (UC), HNG can protect against inflammation in the colon and ameliorate weight loss. R

15. Protects The Kidneys From Inflammation​

HN can protect the kidneys from inflammation. R

For example, in APOE deficient mice, HN was able to protect against the development of kidney disease. R

16. Protects Male Reproductive System​

HN is present at all stages of testicle development. R

HN can protect against testicular and sperm cells from death. R R

 

[Canuck83]

Some products never advertised in my list, few kits in stock:

BPC157 2 mg：$30/kit (3 kits left)
Sermorelin 5mg: $78/kit (1 kit left)
Humanin 2mg：$118/kit (3 kits left)
Mots-C 25mg: $220/kit (1 kit left)
CJC no Dac 5mg: $80/kit (8 kits left)
TB500 2mg: $45/kit (10 kits left)

Benefits Of Humanin​

1. Improves Mitochondrial Function​

Humaninin (HN) directly inhibits oxidative stress on the mitochondrial membrane, thus protecting mitochondria from dying. R

HN inhibits Cytochrome C release from mitochondria and can increase their production of energy (ATP).

HN improves mitochondrial levels of Glutathione (GSH) as well. R

HN can also prevent Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) by directly increasing cellular ATP levels in lymphocytes.

Humanin also induces Mitochondrial Biogenesis (growth of new mitochondria).

2. Protects Cells From Dying​

HN can also protect cells from oxidative stress.

HN improves cell survival by binding to and inhibiting by Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) and Bcl2-Associated X protein (Bax).

HN can also promote cell survival by binding to and deactivating proapoptotic BH3 proteins Truncated Form of Bid (tBid) and Extra Long Isoform of Bim (BimEL).

3. May Enhance Longevity​

View attachment 251325

Growth Hormone (GH) negatively regulates HN levels. R

For example, mice that were unable to produce adequate amounts of GH had higher amounts of HN and lived longer than normal mice. R

Children of centenarians have 3x higher levels of HN than controls. R

HN can act as a Calorie-Restriction Mimetic (CRM) by suppressing Insulin-Like Growth Factor 1 (IGF-1) levels. R

HN has very similar actions to IGF-1 (see section above): R

• Activate ERK1/2
• Activate JAK2-STAT3
• Activate PI3K/Akt (helps with stroke)
• Cardioprotective
• Controls cell death, metabolism, and transcription
• Degrading Atherosclerotic Plaques
• Enhance Brain Aβ Clearance
• Enhancing Insulin Sensitivity
• Found in Mitochondria, plasma, cells, skeletal muscle, liver, fat, and hypothalamus
• Lowering Inflammation
• Inhibiting Cell death
• Suppressing Hypoxia

Although, HN and IGF-1 do have opposite effects on longevity and cancer growth, and both show a decline in expression with aging. R

For example, HN protects against cell senescence (biological aging of a cell). R

4. Ameliorates Alzehiemer's Disease And Improves Short-Term Memory​

HN can protect brain cells against Amyloid-Beta (AB)-induced cell death and increase clearance AB levels, a common pathology seen Alzheimer's Disease (AD). R R R

HN can also protect the brain against Tau Hyperphosphorylation (a pathology of AD). R

For example, HN can protect against Okadaic Acid (OA), a toxin extracted from marine life that causes tau hyperphosphorylation. R

HN may improve memory.

For example, HN can also reverse Long-Term Potentiation (LTP) loss from AB, in important mechanism used to form memory. R

HN can also prevent memory loss from other Anticholinergic drugs. R

For example, scopolamine, a Muscarinic Acetylcholine Receptor (mAChR) antagonist, can cause short-term memory loss and is a standard in testing AD animal models. R

A modified version of HN called Humanin G (HNG) can reverse the short-term memory loss from scopolamine. R

This modification (HNG) has shown to increase the neuroprotective effects of HN by 1000-fold. R

HNG taken intranasally can reduces AB accumulation and ameliorates memory deficit in AD animal models. R

HN may protect against Insulin Resistance (IR) in the brain, a main pathology of Type 3 Alzheimer's/Diabetes. R R

For example, by stimulating STAT3 and inhibiting IGFBP3 in the hypothalamus, HN is a powerful insulin sensitizer and may help with IR in AD. R R R

In the hippocampus, HNG can improve Autophagy by regulating IRS-1/mTOR signaling. R

HN also provides neuroprotection against some Familial Alzheimer's Disease (FAD) genes including presenilin 1, presenilin 2, and mutated Amyloid Precursor Protein (APP). R R

HN also binds to the receptor for Ciliary Neurotrophic Factor (CNTF), which is an important for neurodegenerative diseases, spinal cord injuries, retinal degeneration, autoimmune neuroinflammation and obesity-related metabolic diseases. R

5. Combats Proteopathy, Neuroinflammation, And Excitotoxicity​

In the Endoplasmic Reticulum (ER), ROS causes a calcium efflux leading to Proteopathy (toxic unfolded/misfolded protein aggregates). R

HN protects against proteopathy in 2 ways:

1. HN can inhibit ROS formation R
2. HN can inhibit calcium release in the ER R

For example, HN can protect against prion-proteopathy. R

HN also protects against Lipopolysaccharide-induced (Endotoxemia) neuroinflammation. R

HN also protects against excitotoxicity (both via action on NMDARs and independently). R

For example, HN can prevent Reactive Oxygen Species (ROS) and Nitric Oxide (NO) induced excitotoxicity caused by the overactivation of the NMDA receptors. R

HN can also reduce Lactate-Dehydrogenase (LDH) in the brain. R

6. Protects Against Insulin Resistance​

HN can inhibit pancreatic beta-cell death and improve Glucose tolerance in non-obese diabetic (NOD) animal models. R

This may be beneficial for both Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D). R R

By acting on the hypothalamus, HN can also increase Insulin sensitivity in the liver and stabilize blood glucose levels. R

HN may be a good biomarker for fasting glucose-related oxidative stress. R

HNG acutely increases Triglyceride (TG) secretion from the liver. R

7. Combats Obesity And Weight Gain​

HN can prevent weight gain by increasing glucose stimulated insulin release and decreasing body Weight Gain and visceral fat. R R

8. Protects The Eyes​

Age-related Macular Degeneration (AMD) is caused degeneration of the retina from oxidative stress resulting in irreversible vision loss. R

The ER of mitochondria play a huge role in protecting the Retinal Pigment Epithelium (RPE) in AMD. R

HN and HNG both prevent AMD as it can protect against oxidative stress and cell death of the RPE and ER by increasing mitochondrial GSH levels and reducing ROS, Caspase 3 and Caspase 4 levels. R R

9. May Fight Spinocerebellar Ataxia And Huntington's Disease​

Spinocerebellar Ataxia (SA) and Huntington's Disease (HD) are characterized by Polyglutamine (PolyQ) toxicity. R

HN can prevent PolyQ-induced mitochondrial dysfunction. R

10. May Help With Amyotrophic Lateral Sclerosis​

HN may help Familial Amyotrophic Lateral Sclerosis (ALS).

For example, animal models with mutations in G93A-SOD1, HN dose-dependently improved motor performance and prolonged survival of ALS mice. R

11. May Protect Against Sunburn​

HN can protect against Ultraviolet (UV)-induced cell death. R

12. Protects The Vascular System​

HN levels have been shown to be high in patients with atherosclerotic plaques and may protect against atherosclerosis. R

For example, in animal models that were unable to express APOE (an important protein for cholesterol metabolism), HNG was able to improve cardiovascular function from a high cholesterol diet (reducing plaque ~90%). R

HN can protect HN cells from cells from oxidative stress induced by Oxidized LDL (oxLDL). R R

By increasing AMPK and eNOS, during a heart attack HNG can protect against damage induced by left coronary occlusion, reducing infarct size and oxidative stress. R

13. Protects Against Hypoxia And Ischemia​

HN can attenuate the stresses caused by hypoxia and ischemia.

By activating PI3K/Akt and Jak2/Stat3, HNG is neuroprotective during hypoxia. R R

For example, HN can protect against cellular hypoxia induced by Compound Cobalt Chloride (CoCl₂). R

Cuprizone (CPZ), a copper chelator, provokes demyelination and schizophrenia-like symptoms. R

HN can suppress neuroinflammation and cognitive deficits from CPZ use. R

HN has shown to induce axonal remyelination in hypoxic brains. R

A major problem from ischemia is loss of blood flow which results in the reduction of growth factors, and thus cell death.

HN can prevent cell death from ischemia and improve hypoxic cell's ability to create energy (ATP). R R

HN may also be beneficial in a Traumatic Brain Injury (TBI), as HN can protect against ischemic and hemorrhagic stroke-induced damage. R R

For example, in animal models, HNG was able to reduce infarct volume size by 50%. R

One reason why HNG may protect against TBI is by upregulation of Suppressor Of Cytokine Signaling 3 (SOCS3). R

14. Protects The Colon​

In experimental models of Ulcerative Colitis (UC), HNG can protect against inflammation in the colon and ameliorate weight loss. R

15. Protects The Kidneys From Inflammation​

HN can protect the kidneys from inflammation. R

For example, in APOE deficient mice, HN was able to protect against the development of kidney disease. R

16. Protects Male Reproductive System​

HN is present at all stages of testicle development. R

HN can protect against testicular and sperm cells from death. R R

Any side effects, seems to good to be true lol

 

[mvangor]

How are you guys taking your powders? Tesofensine dose is tiny and my mg scoops are even too big for it. Has anyone tried diluting it into a solution and taking it that way?

 

[M@NU]

any plans to get your hands on Retatrutide ?

 

[Steve0815]

How are you guys taking your powders? Tesofensine dose is tiny and my mg scoops are even too big for it. Has anyone tried diluting it into a solution and taking it that way?

Try 100mg in 100ml dmso.
1ml/1mg

 

[MrLoop]

Some products never advertised in my list, few kits in stock:

BPC157 2 mg：$30/kit (3 kits left)
Sermorelin 5mg: $78/kit (1 kit left)
Humanin 2mg：$118/kit (3 kits left)
Mots-C 25mg: $220/kit (1 kit left)
CJC no Dac 5mg: $80/kit (8 kits left)
TB500 2mg: $45/kit (10 kits left)

Benefits Of Humanin​

1. Improves Mitochondrial Function​

Humaninin (HN) directly inhibits oxidative stress on the mitochondrial membrane, thus protecting mitochondria from dying. R

HN inhibits Cytochrome C release from mitochondria and can increase their production of energy (ATP).

HN improves mitochondrial levels of Glutathione (GSH) as well. R

HN can also prevent Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) by directly increasing cellular ATP levels in lymphocytes.

Humanin also induces Mitochondrial Biogenesis (growth of new mitochondria).

2. Protects Cells From Dying​

HN can also protect cells from oxidative stress.

HN improves cell survival by binding to and inhibiting by Insulin-Like Growth Factor Binding Protein-3 (IGFBP-3) and Bcl2-Associated X protein (Bax).

HN can also promote cell survival by binding to and deactivating proapoptotic BH3 proteins Truncated Form of Bid (tBid) and Extra Long Isoform of Bim (BimEL).

3. May Enhance Longevity​

View attachment 251325

Growth Hormone (GH) negatively regulates HN levels. R

For example, mice that were unable to produce adequate amounts of GH had higher amounts of HN and lived longer than normal mice. R

Children of centenarians have 3x higher levels of HN than controls. R

HN can act as a Calorie-Restriction Mimetic (CRM) by suppressing Insulin-Like Growth Factor 1 (IGF-1) levels. R

HN has very similar actions to IGF-1 (see section above): R

• Activate ERK1/2
• Activate JAK2-STAT3
• Activate PI3K/Akt (helps with stroke)
• Cardioprotective
• Controls cell death, metabolism, and transcription
• Degrading Atherosclerotic Plaques
• Enhance Brain Aβ Clearance
• Enhancing Insulin Sensitivity
• Found in Mitochondria, plasma, cells, skeletal muscle, liver, fat, and hypothalamus
• Lowering Inflammation
• Inhibiting Cell death
• Suppressing Hypoxia

Although, HN and IGF-1 do have opposite effects on longevity and cancer growth, and both show a decline in expression with aging. R

For example, HN protects against cell senescence (biological aging of a cell). R

4. Ameliorates Alzehiemer's Disease And Improves Short-Term Memory​

HN can protect brain cells against Amyloid-Beta (AB)-induced cell death and increase clearance AB levels, a common pathology seen Alzheimer's Disease (AD). R R R

HN can also protect the brain against Tau Hyperphosphorylation (a pathology of AD). R

For example, HN can protect against Okadaic Acid (OA), a toxin extracted from marine life that causes tau hyperphosphorylation. R

HN may improve memory.

For example, HN can also reverse Long-Term Potentiation (LTP) loss from AB, in important mechanism used to form memory. R

HN can also prevent memory loss from other Anticholinergic drugs. R

For example, scopolamine, a Muscarinic Acetylcholine Receptor (mAChR) antagonist, can cause short-term memory loss and is a standard in testing AD animal models. R

A modified version of HN called Humanin G (HNG) can reverse the short-term memory loss from scopolamine. R

This modification (HNG) has shown to increase the neuroprotective effects of HN by 1000-fold. R

HNG taken intranasally can reduces AB accumulation and ameliorates memory deficit in AD animal models. R

HN may protect against Insulin Resistance (IR) in the brain, a main pathology of Type 3 Alzheimer's/Diabetes. R R

For example, by stimulating STAT3 and inhibiting IGFBP3 in the hypothalamus, HN is a powerful insulin sensitizer and may help with IR in AD. R R R

In the hippocampus, HNG can improve Autophagy by regulating IRS-1/mTOR signaling. R

HN also provides neuroprotection against some Familial Alzheimer's Disease (FAD) genes including presenilin 1, presenilin 2, and mutated Amyloid Precursor Protein (APP). R R

HN also binds to the receptor for Ciliary Neurotrophic Factor (CNTF), which is an important for neurodegenerative diseases, spinal cord injuries, retinal degeneration, autoimmune neuroinflammation and obesity-related metabolic diseases. R

5. Combats Proteopathy, Neuroinflammation, And Excitotoxicity​

In the Endoplasmic Reticulum (ER), ROS causes a calcium efflux leading to Proteopathy (toxic unfolded/misfolded protein aggregates). R

HN protects against proteopathy in 2 ways:

1. HN can inhibit ROS formation R
2. HN can inhibit calcium release in the ER R

For example, HN can protect against prion-proteopathy. R

HN also protects against Lipopolysaccharide-induced (Endotoxemia) neuroinflammation. R

HN also protects against excitotoxicity (both via action on NMDARs and independently). R

For example, HN can prevent Reactive Oxygen Species (ROS) and Nitric Oxide (NO) induced excitotoxicity caused by the overactivation of the NMDA receptors. R

HN can also reduce Lactate-Dehydrogenase (LDH) in the brain. R

6. Protects Against Insulin Resistance​

HN can inhibit pancreatic beta-cell death and improve Glucose tolerance in non-obese diabetic (NOD) animal models. R

This may be beneficial for both Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D). R R

By acting on the hypothalamus, HN can also increase Insulin sensitivity in the liver and stabilize blood glucose levels. R

HN may be a good biomarker for fasting glucose-related oxidative stress. R

HNG acutely increases Triglyceride (TG) secretion from the liver. R

7. Combats Obesity And Weight Gain​

HN can prevent weight gain by increasing glucose stimulated insulin release and decreasing body Weight Gain and visceral fat. R R

8. Protects The Eyes​

Age-related Macular Degeneration (AMD) is caused degeneration of the retina from oxidative stress resulting in irreversible vision loss. R

The ER of mitochondria play a huge role in protecting the Retinal Pigment Epithelium (RPE) in AMD. R

HN and HNG both prevent AMD as it can protect against oxidative stress and cell death of the RPE and ER by increasing mitochondrial GSH levels and reducing ROS, Caspase 3 and Caspase 4 levels. R R

9. May Fight Spinocerebellar Ataxia And Huntington's Disease​

Spinocerebellar Ataxia (SA) and Huntington's Disease (HD) are characterized by Polyglutamine (PolyQ) toxicity. R

HN can prevent PolyQ-induced mitochondrial dysfunction. R

10. May Help With Amyotrophic Lateral Sclerosis​

HN may help Familial Amyotrophic Lateral Sclerosis (ALS).

For example, animal models with mutations in G93A-SOD1, HN dose-dependently improved motor performance and prolonged survival of ALS mice. R

11. May Protect Against Sunburn​

HN can protect against Ultraviolet (UV)-induced cell death. R

12. Protects The Vascular System​

HN levels have been shown to be high in patients with atherosclerotic plaques and may protect against atherosclerosis. R

For example, in animal models that were unable to express APOE (an important protein for cholesterol metabolism), HNG was able to improve cardiovascular function from a high cholesterol diet (reducing plaque ~90%). R

HN can protect HN cells from cells from oxidative stress induced by Oxidized LDL (oxLDL). R R

By increasing AMPK and eNOS, during a heart attack HNG can protect against damage induced by left coronary occlusion, reducing infarct size and oxidative stress. R

13. Protects Against Hypoxia And Ischemia​

HN can attenuate the stresses caused by hypoxia and ischemia.

By activating PI3K/Akt and Jak2/Stat3, HNG is neuroprotective during hypoxia. R R

For example, HN can protect against cellular hypoxia induced by Compound Cobalt Chloride (CoCl₂). R

Cuprizone (CPZ), a copper chelator, provokes demyelination and schizophrenia-like symptoms. R

HN can suppress neuroinflammation and cognitive deficits from CPZ use. R

HN has shown to induce axonal remyelination in hypoxic brains. R

A major problem from ischemia is loss of blood flow which results in the reduction of growth factors, and thus cell death.

HN can prevent cell death from ischemia and improve hypoxic cell's ability to create energy (ATP). R R

HN may also be beneficial in a Traumatic Brain Injury (TBI), as HN can protect against ischemic and hemorrhagic stroke-induced damage. R R

For example, in animal models, HNG was able to reduce infarct volume size by 50%. R

One reason why HNG may protect against TBI is by upregulation of Suppressor Of Cytokine Signaling 3 (SOCS3). R

14. Protects The Colon​

In experimental models of Ulcerative Colitis (UC), HNG can protect against inflammation in the colon and ameliorate weight loss. R

15. Protects The Kidneys From Inflammation​

HN can protect the kidneys from inflammation. R

For example, in APOE deficient mice, HN was able to protect against the development of kidney disease. R

16. Protects Male Reproductive System​

HN is present at all stages of testicle development. R

HN can protect against testicular and sperm cells from death. R R

Its nice .
Whats the dosage for humanin ?
I dont find anything about humanin

 

[Noah9666]

Has anyone testen QSC Primo at janoshik? Its half as cheap as from other sources

 

[Laxbro88]

Has anyone testen QSC Primo at janoshik? Its half as cheap as from other sources

It has been tested many many many times, raws and finished oils

 

[Qingdao Sigma Chemicals]

Has anyone testen QSC Primo at janoshik? Its half as cheap as from other sources

All blind tests, done by meso members, all can be found in the lab testing section

 

[Resurgence]

Its nice .
Whats the dosage for humanin ?
I dont find anything about humanin

Hard to say because there haven't been any human trials/clinical studies. "Internet" dosages range from 100mcg/day to 3mg/day, 3-5mg a week, it's all over the place because nobody knows. Rat dosages are published but obviously there's a difference there. Apparently the clinical rat dosages was 250mcg/kg up to 4mg/kg. Closest thing I've seen online to a regular dosage is .04mg/kg for humans based on math from rats, which on a 90KG human would equate to 3.6mg per day.
Humanin peptides halflife is 30 minutes. So you'd probably be splitting that dosage into multiple times a day. Not sure how some people using it twice a week would notice any benefits from it other than that day.

Some things to consider, Humanin (HN) has been shown in breast cancer studies to actually increase it. So there's a toss up on if it's a positive thing if you may already have some form of cancer OR hereditary cancers.

HN has very similar actions to IGF-1

• Activate ERK1/2
• Activate JAK2-STAT3
• Activate PI3K/Akt (helps with stroke)
• Cardioprotective
• Controls cell death, metabolism, and transcription
• Degrading Atherosclerotic Plaques
• Enhance Brain Aβ Clearance
• Enhancing Insulin Sensitivity
• Found in Mitochondria, plasma, cells, skeletal muscle, liver, fat, and hypothalamus
• Lowering Inflammation
• Inhibiting Cell death
• Suppressing Hypoxia

Lifestyle/Diet:
Exercise - Resistance training increases HN in skeletal muscle
Fasting - Suppresses IGF1 and increases HN
Hyperbaric Chamber - Hyperoxia increases HN
Supplements:
B Vitamins - Increase HN levels, especially in those with higher homocysteine
Zinc - binds to HN

These reduce HN levels:

• Aging - reduces HN in the hypothalamus and muscles
• GH or IGF1 - HN is reduced in mice and humans treated with GH or IGF-1
• H2O2 - reduces Rattin, a rat homolog of HN
• TRIM11
• VSTM2L

Cancer​

HN has both positive and negatives in cancer.

HNG can enhance chemotherapy-induced suppression of cancer metastases.

HN may contribute to cancers such as:

• Bladder Cancer
• Pituitary Cancer
• Prostate Cancer

Lowering HN expression may be beneficial in some cancers.

There's more than one type of Humanin also. HNG is a modified HN.