Qingdao Sigma Chemicals
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Sildenafil 1 kilo bags available, $150/kg
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Ghoul
Member
Because the "idiots" in white coats involved in the multi-billion dollar research program that led to the development of this class of drugs figured out how to make a hormone that normally only lasts a few minutes before being destroyed last much longer and distribute widely through the body via Albumin binding. While bound the hormone is inactive, and slowly releases.
As a result, peak active levels are reached around 3 days after the once a week injection. When injected twice a week, there hasn't been enough time for the liver to restore Albumin levels to baseline concentration, so far less of the second dose is bound as intended, becoming immediately bioavailable, failing to properly distribute, causing an unintended, frequently side effect inducing spike in active levels of the drug, concentrated in regions near the injection site.
Either that or the Reddit geniuses know better than the guys who spent 30 years working on making long lasting GLPs.
Too many clowns out there giving advice who think these compounds work like stimulant based diet pills, instead of the carefully engineered metabolic regulation modifiers they are.
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I doubt that is the case. They use the once a week approach because most people don't like to inject stuff into their body, but people of this forum do.
Regular Joe
Member
the guys in the white lab coats also say to inject test c once every two weeks, sorry to question what big pharma says. so are you saying a weekly cycle of semiglutide levels rising and falling is needed for the drug to work properly?
Ghoul
Member
That makes sense.
Despite twice a week dosing having better clinical outcomes with fewer side effects, as Redditors discovered in their clinical trials. when Ozempic was introduced exclusively for diabetics 7 years ago. Novo Nordisk determined those patients would choose to stick with 7 to 21 weekly insulin injections, rather than 2 of semaglutide.
I didn’t say it is better or worse with twice weekly, I just doubted the albumin theory. And yes, most diabetics I know still don't like the needle.
Zebedee
Member
Post this in Jano’s thread or QSC’s testing thread & tag Janoshik to attract his attention & get his input. Plus doing it that way makes it easier for others to benefit from his response as posts in this thread get lost & buried really quickly.
Ghoul
Member
I'm saying when the first dose reaches peak bioavailability and peak side effects in 3 days, and the second reaches peak bioavailability almost immediately, you now have a potential peak of bioavailability higher than that reached by taking the same amount once week, when albumin blood concentrations are strong enough to quickly bind more of the drug at once.
This isn't like steroids you retards. Testosterone becomes bioavailable as the ester is broken off. You divide the dose to SLOW the rate of bioavailability in order to MINIMIZE PEAKS to minimize side effects like aromatization.
That's not how GLPs work. There is no ester to slow release. IT MUST BIND TO ALBUMIN, to slow its release over time. Three days after the first dose albumin concentration will be lower than it is at 7, leaving more of the hormone immediately available, CAUSING a spike, ironically, right at the time the first dose is peaking in bioavailability.
I used GLPs before you ever read a story about anyone in Hollywood using it, and I've seen countless people "top up" midweek thinking it wasn't strong enough, only to end up suffering sides worse than the cumulative dose would suggest. This is a case where for the purposes of peak level side effects, .50mg+.50mg in the same week didn't equal sides similar to 1mg once a week, but more like the effects you'd see going from .50mg to 2mg on a once a week schedule.
But just keep applying your "common sense" to this topic. Splitting the dose must reduce side effects, because that's how testosterone works right?
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Qingdao Sigma Chemicals
Subscriber
According to jano yes, something like 75-80iu.
More testing on different brands and batchs will confirm.
The few ones I saw from other sources tested lower than this for equivalent iu.
Zebedee
Member
No. He reacted to a comment I made in Sigma’s thread:
Sigma Audley Inc. - Your source for peptides, ancillaries, AAS, and more!
https://thinksteroids.com/community/threads/source-price-tracker-spreadsheet.134424082/ Can you get your apprentice/employee to update the price spreadsheet including the prices of raws in different weight increments, this will help customers compare prices among different vendors. @SigmaAudley...
thinksteroids.com
…. & then went 20 pages back to reply to a post I made a week ago in this thread.
& you think I’m the one who needs meds?
Like I said, he’s a pathetic, petty, thin-skinned, vindictive little keyboard warrior with a grossly inflated, yet incredibly fragile ego. Whilst this bears no relevance to the quality of the products he’s basically drop shipping for QSC, it does explain why he’s scammed & doxxed members in the past for “not respecting his authoritaaay”.
Ghoul
Member
So, how obese were you to be using this stuff for fucking ever? How long was this out in the public market now? 7 years? You mean you have been using it before that?
To be honest, take no offense now, since you are the number one vocal advocate of glp1 use can you show us your transformation pictures? Like they always say in the forum world, pics or it didn’t happen. Lucky you’re in Meso where we respect anonymity and entertain it, if this is Promuscle your ass would’ve been handed to you on the first week if you make claims without a picture to support credibility.
Regular Joe
Member
this is as deep as ive looked into this drug but what youre saying doesnt make sense, unless youre using up all of your albumin.
iris
New Member
U guys know there is that massive glp thread thing
@Qingdao Sigma Chemicals
Tracy,
I have sent several emails and can't get a reply. Can you help me please?
Order placed and confirmed payment received 8/7. No reply since.
Other here have already received their US Domestic orders.
Ive always had quick replies and shipping before but now getting no response.
Tracy,
I have sent several emails and can't get a reply. Can you help me please?
Order placed and confirmed payment received 8/7. No reply since.
Other here have already received their US Domestic orders.
Ive always had quick replies and shipping before but now getting no response.
Qingdao Sigma Chemicals
Subscriber
When there is a customer service issue, you can reach : tracy@sigmachemical.com.cn
Qingdao Sigma Chemicals
Subscriber
The Weight loss Kick-ass Promo !
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narta
Member
I definitely do thing you need meds if you suggest that the response you got was due to you saying in another vendors thread that you won't buy from this vendor and your few $k meant dick squat in relation to the 1000x he gets from other customers.
You (and me) are nothing in terms of revenue. If you think you mean something, you need meds.
Period
Thank you!
Also everyone, email reply received. Tracking sent.
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