Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[y777]

So IGF 1 of 343 from 2iu GH daily? If so, that's a crazy good response!

I did IGF bloods in the spring. Was taking 2ius daily then for three days prior to bloods (ordered by doc ) I ran only 1 IU. Got 186ng/mL. Would this still be from the 2ius or after 3-4 days of single unit it would come down already ?

Thanks.

 

[Benf15harp]

I did IGF bloods in the spring. Was taking 2ius daily then for three days prior to bloods (ordered by doc ) I ran only 1 IU. Got 186ng/mL. Would this still be from the 2ius or after 3-4 days of single unit it would come down already ?

Thanks.

Definitely the latter

 

[Heatheopia]

@Qingdao Sigma Chemicals did I understand you correctly. Your sildenafil is equal to 200mg “viagra”

 

[Middus]

QSC, my bad. Fixed it above.

Apologies, was trying to make a cheeky joke at your expense

 

[Ghoul]

Qui

Are you saying that there is absolutely 100% no possible way that a fine tuned “stack”of peptides could have a positive effect?

Well I mean if it's "fine tuned" that's a whole different matter and none of those issues apply. I recommend adding a little heat so those molecules melt together, it makes the effects smoother. Tune away brother...

Might want to add this bad boy to that killer stack:

WARNING: AVOID AMINOS RESEARCH AT ALL COSTS!!! DANGER!!!

So the nut job that runs AR just tried peddling a "new" peptide he claims to have invented. No papers published, no peer reviews, no rodent testing, no FDA filings, just "hey I invented this new GLP-1/GIP peptide and you should shoot yourself up with it!". This kind of dangerous behavior is...

glp1forum.com

 

[Middus]

Qui

Are you saying that there is absolutely 100% no possible way that a fine tuned “stack”of peptides could have a positive effect?

I will hazard a guess and say that most people who stack do it because of effects/Side effects. Some Find that reta works well in burning fat, but are worried about lack of apetite suppression so they shift Sema is added.
Some find that the Tirz they need to lose weight is on the lower end, but since Tirz has a rather weaker GLP-1 effect, they opt to add a tiny amount of Sema (which is too strong for them normally).
People in pharma will tell you these stacks are wasteful. Myself finds a Reta + Tirz stack a fancy way of wasting money. IMO Only Sema is worth stacking with anything else, essentially because of the appetite effect. This is a very personal opinion. The jury is out on stacking. Anecdotally it works for many. Then again monotherapy also works for many. Peeps will be peeps. There are no studies out there for this and there isn't any reason for companies to study stacking for now. Everyone is busy finetuning their repertoire of weight loss meds, why would they test whether a rival's meds works well with theirs?

For sake of harm reduction (financial harm inclusive) Stacking Glps not really worth the hassle. The more cavalier can try stacking sema with other things or stack a GLP with an amylin analogue. In the future GLP-1s will most likely be stacked with some lean mass increasing med (For the sake of middle aged and elderly fatties who will most likely be unable to 'gym' hard enough to retain lean mass). For now though, Stacking 2 glp-1s is 'short-cutty' and is not sustainable long term (financially and discipline wise). I would assume once people reach goal weight they mostly just stick to one med

 

[Middus]

Well I mean if it's "fine tuned" that's a whole different matter and none of those issues apply. I recommend adding a little heat so those molecules melt together, it makes the effects smoother. Tune away brother...

Might want to add this bad boy to that killer stack:

WARNING: AVOID AMINOS RESEARCH AT ALL COSTS!!! DANGER!!!

So the nut job that runs AR just tried peddling a "new" peptide he claims to have invented. No papers published, no peer reviews, no rodent testing, no FDA filings, just "hey I invented this new GLP-1/GIP peptide and you should shoot yourself up with it!". This kind of dangerous behavior is...

glp1forum.com

This wasn't a stack by the way. It was some Dude (with 2 firstnames ) That claimed to have invented a new peptide. Whether it was a gimmick or something, it was reckless and dumb. No form of study whatsoever. It wasn't even a blend. Just an invention. Like someone playing with crispr and coming up with some peptide.

 

[Middus]

Well I mean if it's "fine tuned" that's a whole different matter and none of those issues apply. I recommend adding a little heat so those molecules melt together, it makes the effects smoother. Tune away brother...

Might want to add this bad boy to that killer stack:

WARNING: AVOID AMINOS RESEARCH AT ALL COSTS!!! DANGER!!!

So the nut job that runs AR just tried peddling a "new" peptide he claims to have invented. No papers published, no peer reviews, no rodent testing, no FDA filings, just "hey I invented this new GLP-1/GIP peptide and you should shoot yourself up with it!". This kind of dangerous behavior is...

glp1forum.com

You might wanna look up what Viking is doing. They are conjuring up a quadruple action Peptide. Something like a Reta Cagri stack, however, unlike reta, their peptide is a GIP antagonist

 

[Ghoul]

I will hazard a guess and say that most people who stack do it because of effects/Side effects. Some Find that reta works well in burning fat, but are worried about lack of apetite suppression so they shift Sema is added.
Some find that the Tirz they need to lose weight is on the lower end, but since Tirz has a rather weaker GLP-1 effect, they opt to add a tiny amount of Sema (which is too strong for them normally).
People in pharma will tell you these stacks are wasteful. Myself finds a Reta + Tirz stack a fancy way of wasting money. IMO Only Sema is worth stacking with anything else, essentially because of the appetite effect. This is a very personal opinion. The jury is out on stacking. Anecdotally it works for many. Then again monotherapy also works for many. Peeps will be peeps. There are no studies out there for this and there isn't any reason for companies to study stacking for now. Everyone is busy finetuning their repertoire of weight loss meds, why would they test whether a rival's meds works well with theirs?

For sake of harm reduction (financial harm inclusive) Stacking Glps not really worth the hassle. The more cavalier can try stacking sema with other things or stack a GLP with an amylin analogue. In the future GLP-1s will most likely be stacked with some lean mass increasing med (For the sake of middle aged and elderly fatties who will most likely be unable to 'gym' hard enough to retain lean mass). For now though, Stacking 2 glp-1s is 'short-cutty' and is not sustainable long term (financially and discipline wise). I would assume once people reach goal weight they mostly just stick to one med

"Maintenance dose" is an alien concept to the vast majority of those using UGL GLPs. They have no idea how these drugs work, that they're hormones, similar to what insulin is to diabetes, or TRT is to hypogonadism.

They're a "crutch", a "diet pill" in a syringe, and long term use is a failure to muster the necessary willpower and get rid of the training wheels.

That's not my cynicism, there are hundreds of posts in this thread expressing exactly that sentiment.

I also don't see any "stacker", microdoser, intermittent user plan on any kind of "maintainance dose", with the exception of a handful of bodybuilders who've embraced the health protective aspects of GLPs and stay on non appetite suppressive doses of, generally, Tirz. But that's really recent.

Most normal users of pharma GLPs are on a maintainance dose by 6-12 months.

 

[GearUnit]

I started on branded zepbound at 2.5 and was decently sick the first couple weeks. Not bad, but zero appetite. I was also like 370 lbs then too so that contributed I’m sure.

For the added benefits, my suspicion is you get them at lower doses too, so if you aren’t targeting weight loss, start low and see where it goes. The inflammation change was drastic and noticeable within a couple weeks I’d say.

My dad started at 2.5 and felt nothing. Each month he’s moved up and now is on 10 and finally getting appetite control and losing weight. So maybe it’s all very individual based. But I’d say start slow imo.

Some people don't feel it here you can use cagillintide as a try to add this and see how that works

 

[HUGE McBIGLARGE]

How soon after them confirming they got the money do they send shipping confirmation? It’s been 60 hours and I’m wondering if this is normal.

 

[Middus]

"Maintenance dose" is an alien concept to the vast majority of those using UGL GLPs. They have no idea how these drugs work, that they're hormones, similar to what insulin is to diabetes, or TRT is to hypogonadism.

They're a "crutch", a "diet pill" in a syringe, and long term use is a failure to muster the necessary willpower and get rid of the training wheels.

That's not my cynicism, there are hundreds of posts in this thread expressing exactly that sentiment.

I also don't see any "stacker", microdoser, intermittent user plan on any kind of "maintainance dose", with the exception of a handful of bodybuilders who've embraced the health protective aspects of GLPs and stay on non appetite suppressive doses of, generally, Tirz. But that's really recent.

Most normal users of pharma GLPs are on a maintainance dose by 6-12 months.

You're spending too much time on gym bro forums then. There are so many folks out there that have lost weight after a lot of experimentation with glp-1s... and are now on maintenance doses. Many do not concern themselves with glp on glp stacks again, but rather are looking to gain lean mass or look better. "The weight loss universe" is filled with all sorts of people from all works of life. They've done everything known under the . Stacked, washed out, quit cold turkey. Some others just starting out, are midway or are on maintenance doses...e.t.c The more you immerse yourself the more frequent you will run into the people I'm talking about.. and you'll see that there is a vast amount of information that can be garnered from people (even if it's all anecdotal).
I mean, even the dude that was called out some days back. He was an early adopter of reta, stacked it, lost weight, dropped reta and picked up tren..

 

[Ghoul]

You're spending too much time on gym bro forums then. There are so many folks out there that have lost weight after a lot of experimentation with glp-1s... and are now on maintenance doses. Many do not concern themselves with glp on glp stacks again, but rather are looking to gain lean mass or look better. "The weight loss universe" is filled with all sorts of people from all works of life. They've done everything known under the . Stacked, washed out, quit cold turkey. Some others just starting out, are midway or are on maintenance doses...e.t.c The more you immerse yourself the more frequent you will run into the people I'm talking about.. and you'll see that there is a vast amount of information that can be garnered from people (even if it's all anecdotal).
I mean, even the dude that was called out some days back. He was an early adopter of reta, stacked it, lost weight, dropped reta and picked up tren..

I am on the other forums. They're filled with pseudo science bullshit, and the idea that that scene is filled with "success stories" of these chaotic, desperately impatient people who've jumped from compound to compound, miraculously stumble on a successful unconventional formula, reached goal weight, and then settled down to a single compound is a crock of shit. The vast majority hit brick walls, try something else, take a break, come back for the latest bullshit, and bounce up and down showing little durable progress over any significant period of time, Or course there are exceptions, and even those require a suspension of disbelief.

At least here you have a core of members who have a basic understanding of pharmacology, hormones, and physiology. 99% of the type in GLP forums hadn't touched a syringe until a year ago,

 

[thejumpingsheep]

I did IGF bloods in the spring. Was taking 2ius daily then for three days prior to bloods (ordered by doc ) I ran only 1 IU. Got 186ng/mL. Would this still be from the 2ius or after 3-4 days of single unit it would come down already ?

Thanks.

So dont take my word for it, but as I understand it, IGF-1 is a lagging indicator which is also why its useful because it takes into account a longer window of time. How much of a window im not sure. Some of the resident experts can probably tell you but I do know that I was on 2iu per day for about 2 months before the blood test.

Also based on my prior inquiries, IGF-1 isnt exclusively HGH. It includes other things as well. Again not an expert on the subject.

 

[Trenbolonetax]

@Qingdao Sigma Chemicals

Y’all get my emails for promos?

 

[Sampei]

You're misrepresenting what's being offered here.

First of all, this is about best practice, for those who care. There's no panic. Some here don't believe sterility matters, unless it manifests as a lost ass cheek. Do whatever you're comfortable with.

But don't suggest to anyone, that it's "understood", with a wink and a nod, that this is a meaningless issue. After effectiveness, it's the next most important area of focus for peptide drug development, and the FDA.

The presence of anti-drug and neutralizing antibodies have no clinically meaningful effect on, for instance Tirz or HGH? Are you sure you don't mean they have no effect at the levels of antibodies that developed in the pharma trials, using the pharma protocol, with pharma formulations?

Or are you saying that regardless of how high the levels of those antibodies become, there still won't be an impact?

Because isn't that the point of the trials? To demonstrate levels don't rise to the point they become an issue?

Isn't that why, if pharma proposes changing the dose, or the frequency, or change manufacturing techniques, or even the pen it's supplied in, they have to demonstrate all over again to the FDA that those antibodies don't go higher, where they might become "meaningful"?

That's how seriously this is taken.

And what makes them higher?

-Increased frequency of administration.

-Higher concentrations.

-Higher levels of aggregates.

-Impurities.

So are you going to confidently assert that because the trials, using the strict pharma protocol, don't cause an immunogenic issue, the low grade product we use, at whatever random concentration, reconstituted with Amazon or UGL sourced tap water and rubbing alcohol 'BAC', microdosed on a daily basis, isn't, perhaps, going to result in just a slightly stronger immune reaction and maybe just a few more antibodies?

Because to me, we couldn't really design a better "worst case scenario" for immunogenicity than what's being widely practiced now,

How often does it seem some peptides just "don't work" or "stopped working" or induce very unpleasant or odd side effects?

The sterility equivalent of our approach to immunogenicity would be dipping your vial in a clogged hospital toilet before wiping it off on a dog's ass, and I'm pretty sure even the knuckle draggers understand that's not a good idea.

Nobody even pays attention to how they dilute these compounds, are you going to argue that's fine, and only a "bubble boy" would suggest that low hanging fruit might be a good, easy target to start reducing a little potential harm?

Btw yesterday filtered for the first time my HGH and BPC and TB500. Ghoul are you weak as fuck or you have some dirty shit or I can't explain your post about being hard to push and filter 3ml.

I believe I did it in less than 15 seconds. Didn't even have to push hard. A toddler could have probably do it.

 

[egruberman]

So dont take my word for it, but as I understand it, IGF-1 is a lagging indicator which is also why its useful because it takes into account a longer window of time. How much of a window im not sure. Some of the resident experts can probably tell you but I do know that I was on 2iu per day for about 2 months before the blood test.

Serum IGF-1 levels begin to rise ~12 hours or so after administration of exogenous HGH and peak somewhere between 1-2 days after. As such, daily administration would cause one to have stable levels of serum IGF-1.