Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Rippidy Dippidy]

Why would you expect a hormone, and that's what GLP is, an energy homeostasis regulating hormone, to have the same impact on everyone?

It's not a diet pill.

Would you expect 200mg/week Test to have the same impact on someone who's 800 natural vs some hypogonadal guy at 300?

You don't need a GLP. You make enough. You're not insensitive to it. So even a small dose is having a major impact. The people on "megadoses" have a deficit of GLP, which is why they aren't puking their guts out all day on 10x the dose you take. That's the reason responses are all over the map. Hyper responders are the ones who need it the least.

Do you know how bariatric surgery induces weight loss? A smaller stomach pushes food into the intestine faster, Intestinal hypertrophy releases....wait for it...GLP. It reduces appetite of course, and often puts diabetes into remission.

Now that guys who struggle to put on weight are using GLPs to make cutting even easier, it makes the question of who the real lazy fucks in this scenario are a lot more interesting.

For all the crybabies without the "willpower" to eat enough on a bulk, read on. Despite not being able to muster the strength to just open their mouths, put the food in, and chew, there's hope for you weak willed pussies:

View attachment 307090

Avexitide

The cheat in a syringe your mother's wish they had when they couldn't get your scrawny assess to eat anything.

It's an anti-GLP.

It blocks GLP receptors.

The perfect antidote for the guys above who just can't manage to eat another bite without puking because their biology...er, I mean abundant "willpower" won't allow it.

It's intended for those who bariatric surgery was too successful. And now the abundance of naturally produced GLP is a problem, causing hypoglycemia. and even too low of an appetite.

Amylyx Pharmaceuticals Announces Pivotal Phase 3 LUCIDITY Trial Design for GLP-1 Receptor Antagonist (Avexitide) in Post-Bariatric Hypoglycemia

- Pivotal Phase 3 LUCIDITY trial will evaluate FDA-agreed upon primary outcome of reduction in hypoglycemia events and designed to align as closely as possible with previous Phase 2 trial designs - Amylyx expects first study participant dosed in LUCIDITY in Q1 2025 and topline results in 2026 -...

www.amylyx.com

It's time to let it go. You haven't been thin your entire life because you were born with some innate moral superiority. The 120 pound stringbean in dirty jeans at the gas station isn't skinny in a world of abundant food because he's overflowing with willpower and self control. He just has a high level of GLP. for whatever reason, just like you. And now we have a way to increase, and decrease that hormone at will.

Sorry, your natural state of low appetite being won't make you special any more. You'll have to find another way to distinguish yourself.

No one here was talking about having issues with bulking.
Why are you posting random things from 2017-2020 referring to people who have problems with bulking when no one here even mention it?

 

[Jeffholio5]

Why would you expect a hormone, and that's what GLP is, an energy homeostasis regulating hormone, to have the same impact on everyone?

It's not a diet pill.

Would you expect 200mg/week Test to have the same impact on someone who's 800 natural vs some hypogonadal guy at 300?

You don't need a GLP. You make enough. You're not insensitive to it. So even a small dose is having a major impact. The people on "megadoses" have a deficit of GLP, which is why they aren't puking their guts out all day on 10x the dose you take. That's the reason responses are all over the map. Hyper responders are the ones who need it the least.

Do you know how bariatric surgery induces weight loss? A smaller stomach pushes food into the intestine faster, Intestinal hypertrophy releases....wait for it...GLP. It reduces appetite of course, and often puts diabetes into remission.

Now that guys who struggle to put on weight are using GLPs to make cutting even easier, it makes the question of who the real lazy fucks in this scenario are a lot more interesting.

For all the crybabies without the "willpower" to eat enough on a bulk, read on. Despite not being able to muster the strength to just open their mouths, put the food in, and chew, there's hope for you weak willed pussies:

View attachment 307092
View attachment 307090

Avexitide

The cheat in a syringe your mother's wish they had when they couldn't get your scrawny assess to eat anything.

It's an anti-GLP.

It blocks GLP receptors.

The perfect antidote for the guys above who just can't manage to eat another bite without puking because their biology...er, I mean abundant "willpower" won't allow it.

It's intended for those who bariatric surgery was too successful. And now the abundance of naturally produced GLP is a problem, causing hypoglycemia. and even too low of an appetite.

Amylyx Pharmaceuticals Announces Pivotal Phase 3 LUCIDITY Trial Design for GLP-1 Receptor Antagonist (Avexitide) in Post-Bariatric Hypoglycemia

- Pivotal Phase 3 LUCIDITY trial will evaluate FDA-agreed upon primary outcome of reduction in hypoglycemia events and designed to align as closely as possible with previous Phase 2 trial designs - Amylyx expects first study participant dosed in LUCIDITY in Q1 2025 and topline results in 2026 -...

www.amylyx.com

It's time to let it go. You haven't been thin your entire life because you were born with some innate moral superiority. The 120 pound stringbean in dirty jeans at the gas station isn't skinny in a world of abundant food because he's overflowing with willpower and self control. He just has a high level of GLP. for whatever reason, just like you. And now we have a way to increase, and decrease that hormone at will.

Sorry, your natural state of low appetite doesn't make you special any more. You'll have to find another way to distinguish yourself.

Despite the sass this was a super informative post and I appreciate it.

 

[Ghoul]

No one here was talking about having issues with bulking.
Why are you posting random things from 2017-2020 referring to people who have problems with bulking when no one here even mention it?

Trying to help you not feel so "sickened" by people using GLPs to lose weight.

Right? Those were your words?

A guy who pumps his ass full of premature death to sooth his muscle dysmophia sitting on his throne in judgement over others injecting GLPs to improve
their health.

That's what makes me sick. Knuckle dragging hypocrites without the slightest drop of self awareness.

 

[Rippidy Dippidy]

Trying to help you not feel so "sickened" by people using GLPs to lose weight.

Right? Those were your words?

A guy who pumps his ass full of premature death to sooth his muscle dysmophia sitting on his throne in judgement over others injecting GLPs to improve
their health.

That's what makes me sick. Hypocrites without the slightest drop of self awareness.

If you actually read what i said, It's people who take these drugs while doing absolutely nothing in their lifestyle other then sticking themselves with a pen to lose weight is what makes me sick.
They'll stick themselves with a pen, sit on the couch and open a bag of Dorito's. I said that pretty damn clearly.
Then you went off on a tangent quoting guys from 2017 about how they have issues eating too much to simply get a point across that you know what another drug does with the reverse effect of a GLP agonist.
Which was simply plugged in to show that you have additional knowledge off topic for absolutely no reason other then to show you're "smart" to get some weird sense of validation from random strangers on the internet.

 

[Middus]

A female complaining about a drug holds as much weight as a polyester towel.

On the contrary, the reports of side effects from women may seem more valuable in this case as they tend to have worse sides in regards to GLP.

 

[Middus]

If you actually read what i said, It's people who take these drugs while doing absolutely nothing in their lifestyle other then sticking themselves with a pen to lose weight is what makes me sick.
They'll stick themselves with a pen, sit on the couch and open a bag of Dorito's. I said that pretty damn clearly.

Yeah bro, no one does that. It is very difficult to out eat glp-1s that is working.
You are simply forcing your experience on others. lol. Because 1mg of Sema knocks you out doesn't mean that is how it affects everyone, else they would not have stepped up to 2.4 in clinical trials. Now they've just wrapped up safety tests on 7.2mg.There must have been something they noticed that helped them to convince the FDA beyond: "some people eat their away out of treatment"

 

[Rippidy Dippidy]

Yeah bro, no one does that. It is very difficult to out eat glp that is working.
You are simply forcing your experience on others. lol. Because 1mg of Sema knocks you out doesn't mean that is how it affects everyone, else they would not have stepped up to 2.4 in clinical trials. Now they've just wrapped up safety tests on 7.2mg.There must have been something they noticed that helped them to convince the FDA beyond.."some people eat their away out or treatment"

You can 100% out eat a GLP agonist. Most the people that come to me for "info" on it their first question is roughly "can i eat whatever i want and still lose weight" because they don't actually want to put in any work. which again is what I'm sick of.
Zero will power to do anything for themselves other than making excuses why they're fat.

 

[SpicyMeatball]

But yeah I have no idea how folks get to those mega doses I’m miserable even at starter doses and don’t seem to build a tolerance.

Is it that hard to comprehend that different bodies react differently and therefore need different dosages to achieve similar effects?

 

[Middus]

You can 100% out eat a GLP agonist. Most the people that come to me for "info" on it their first question is roughly "can i eat whatever i want and still lose weight" because they don't actually want to put in any work. which again is what I'm sick of.
Zero will power to do anything for themselves other than making excuses why they're fat.

I said out eat a GLP-1 that is 'working'
Again this is all about your mindset and ideology. It is quite normally human to want to eat your cake and have it. If DNP wasn't so toxic and forced people to eat a certain way, almost anyone would want to eat what they want and take DNP. What is the selling point of SLU and BAM?
Researchers try create exercise mimetics for obese 60-70 year olds too old to get in decent cardio and resistance, gym bros hop on it trying to simulate work-outs with less input.
Researchers look into mitochondrial uncouplers (shit like DNP) like BAM-15 for the same reasons, peeps too old and too fat to get the best gains out of exercise, body builders on a cut want to use it as an easy way out.
It's not unique to fat people. All human beings would literally and figuratively love to eat their cakes and still have it. Its human nature not fatso nature

 

[Jeffholio5]

Is it that hard to comprehend that different bodies react differently and therefore need different dosages to achieve similar effects?

I just got schooled by @Ghoul but yeah I guess I was under the wrong impression about how much variety there is to peoples glp receptor responses. Tbf though I’m a former/pseudo current fatty so I assumed I’d fall into the category that would require more medication but I guess I’m just lucky I get the intended effect from it.

 

[Middus]

Same thing goes for myostatin inhibitors. I mean you have gear to help you build muscle. WTF do you need something nature created to normalise muscle size? and if you want bigger muscles, why not just take gear and build your way to huge gains my hitting the weights?

 

[Rippidy Dippidy]

I said out eat a GLP-1 that is 'working'
Again this is all about your mindset and ideology. It is quite normally human to want to eat your cake and have it. If DNP wasn't so toxic and forced people to eat a certain way, almost anyone would want to eat what they want and take DNP. What is the selling point of SLU and BAM?
Researchers try create exercise mimetics for obese 60-70 year olds too old to get in decent cardio and resistance, gym bros hop on it trying to simulate work-outs with less input.
Researchers look into mitochondrial uncouplers (shit like DNP) like BAM-15 for the same reasons, peeps too old and too fat to get the best gains out of exercise, body builders on a cut want to use it as an easy way out.
It's not unique to fat people. All human beings would literally and figuratively love to eat their cakes and still have it. Its human nature not fatso nature

Of course a GLP that is WORKING they're going to lose weight, because in order to achieve the sense of a GLP working it would need to be successfully helping them lose weight...
If a GLP is WORKING and their appetite is suppressed but they still choose to eat a chocolate bar and GAIN weight the next day, it is now considered a GLP that is NOT working...
Not exactly sure why you're saying it's my mindset, this is a very simple understanding.

 

[Middus]

I just got schooled by @Ghoul but yeah I guess I was under the wrong impression about how much variety there is to peoples glp receptor responses. Tbf though I’m a former/pseudo current fatty so I assumed I’d fall into the category that would require more medication but I guess I’m just lucky I get the intended effect from it.

Bruh, I was a 365lbs fatty and playing Rugby and Soccer. My Lipids and bloodwork used to surprise Docs, especially the ones that had all the answers before calling for tests. My BP was barely pushing over 145 systolic. Hr was 65. I just knew it was not sustainable for my body to keep up and looked for a way out. Te funny thing is that because of some previous actions i sought, GLP1s offer zero appetite suppression for me. But still work.. lol

 

[Middus]

Of course a GLP that is WORKING they're going to lose weight, because in order to achieve the sense of a GLP working it would need to be successfully helping them lose weight...
If a GLP is WORKING and their appetite is suppressed but they still choose to eat a chocolate bar and GAIN weight the next day, it is now considered a GLP that is NOT working...
Not exactly sure why you're saying it's my mindset, this is a very simple understanding.

This is just ideology. You despise fat folks that's all. Your understanding of how GLPs work is even shoddy, especially with your Women and Sides comment.. especially regarding GLP1s. Anyway, I need to go and be useful somewhere else. I doubt this has been productive for anyone.

 

[Rippidy Dippidy]

Bruh, I was a 365lbs fatty and playing Rugby and Soccer. By Lipids and bloodwork used to surprise Docs, especially the ones that had all the answers before calling for tests. My BP was barely pushing over 145 systolic. Hr was 65. I just knew it was not sustainable for my body to keep up and looked for a way out. Te funny thing is that because of some previous actions i sought, GLP1s offer zero appetite suppression for me. But still work.. lol

I would love to argue that you THINK it had no appetite suppression in them when in fact that's the soul reason why you lost the weight.
Something you didn't even notice.

 

[Rippidy Dippidy]

This is just ideology. You despise fat folks that's all. Your understanding of how GLPs work is even shoddy, especially with your Women and Sides comment.. especially regarding GLP1s. Anyway, I need to go and be useful somewhere else. I doubt this has been productive for anyone.

You just said GLP agonist didn't suppress any appetite whatsoever which is simply stating you ate the exact same amount of calories day in and day out YET you still lost weight AND IM THE ONE WHO DOESNT UNDERSTAND GLP 1 AGONISTS ? LOL bro go to bed

 

[Rippidy Dippidy]

This is just ideology. You despise fat folks that's all. Your understanding of how GLPs work is even shoddy, especially with your Women and Sides comment.. especially regarding GLP1s. Anyway, I need to go and be useful somewhere else. I doubt this has been productive for anyone.

I don't mind fat folks at all, I love helping people that want the help.. not people who want a magical pill to take all their problems away while not even TRYING to diet or go for a walk. That's what i hate. Has absolutely nothing to do with "fat" people. That's just the people who often WANT to do nothing.
Hence the reason why they're fat.
I've helped multiple people lose their goal weight, gave them the blue print and what they need with NO drugs. That way they can lose the weight on the drop of a dime any time they want.
A handful of people had the will power to do it and the other 90% blew it off like it was too hard and choose their taste buds over their health.

 

[Benf15harp]

Gawwwdd damn! @Benf15harp I know you love wet box here you go.

Damn that’s one of those you’d have slap a few times before going to work on that thang lol

 

[SpicyMeatball]

I don't mind fat folks at all, I love helping people that want the help.. not people who want a magical pill to take all their problems away while not even TRYING to diet or go for a walk. That's what i hate. Has absolutely nothing to do with "fat" people. That's just the people who often WANT to do nothing.
Hence the reason why they're fat.
I've helped multiple people lose their goal weight, gave them the blue print and what they need with NO drugs. That way they can lose the weight on the drop of a dime any time they want.
A handful of people had the will power to do it and the other 90% blew it off like it was too hard and choose their taste buds over their health.

I don’t know what people have against drugs as “shortcuts”. I fucking love drugs. Modern medicine is a damn miracle, we live 25 years longer on average today than 80 years ago, back when people worked their asses off, didn’t eat processed foods, and didn’t have model medicine. Glp1s are going to bump that average up another 5-10 years at least. Drugs are good. Take em. Live a better, longer life than they did without em.

 

[Rippidy Dippidy]

I don’t know what people have against shortcuts. I fucking love drugs. Modern medicine is a damn miracle, we live 25 years
longer on average today than 80 years ago, back when people worked their asses off, didn’t eat processed foods, and didn’t have model medicine. Drugs are good. Take em. Live a better, longer life than they did without em.

I’m not against short cuts, I also use Sema etc to lose weight (appetite suppression). But what I don’t do is say I’m gonna build 50lbs of muscle and become a bodybuilder, then roll into GNC for protein isolate, drink it everyday, then sit on my couch doing nothing expecting to build muscle.