Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Cheburek1]

Is TestU 350mg/ml still available for EU?

Also any updated price list?

@Qingdao Sigma Chemicals

 

[vanguardx6]

Anyone else getting some insane pip from their injectable gw50150? Stings so bad going in & leaves a bad knot. About to toss a full kit

 

[godsgifttoearth]

Anyone else getting some insane pip from their injectable gw50150? Stings so bad going in & leaves a bad knot. About to toss a full kit

why would you want to inject it in the first place?

 

[vanguardx6]

why would you want to inject it in the first place?

Cheap as fuck promo, beter bio availibility

 

[gettingbig]

Anyone else getting some insane pip from their injectable gw50150? Stings so bad going in & leaves a bad knot. About to toss a full kit

Why throw it away? Reconstitute and run it thru a filter first

 

[BalticSea]

Is TestU 350mg/ml still available for EU?

Also any updated price list?

@Qingdao Sigma Chemicals

Yes. I ordered some vials.

 

[watchtymeflyyy]

Hello everyone

Holidays in china (national day holidays) from 1st to 7th october.
During this period you can place your orders and will be shipped after 7th october.

Domestic orders not affected and we will announce domestic promo soon, now usa domestic deliveries are way much faster than before since the relocation and you must have noticed that.

US Domestic promo I hope!

 

[BigJ89]

Yes, subq. It gives me energy and improves my mood. I have an overall elevated feeling of well being. When I went to Europe for a month, I didn’t take any peptides or test with me, and I was dragging the last week. It was so great to get home and get back to my regime.

With just being 35, your levels may already be good but it doesn’t hurt to try. I just turned 49, and had done a lot of damage with alcohol and eating like shit and not taking care of myself for about 6-7 years, so there’s a bit of repair to be done.

You got your NAD+ from this source QSC? That’s awesome bud. Once again I appreciate the help

 

[Cheburek1]

Yes. I ordered some vials.

I have only tried 250mg/ml and it was good, how is 350mg/ml version?

 

[nightprowler7]

Anyone else getting some insane pip from their injectable gw50150? Stings so bad going in & leaves a bad knot. About to toss a full kit

Try checking the ph?

 

[egonormical1010]

For those bored souls interested in my WhatsApp, just know, it has been restored. It was an accident and unrelated to Q

 

[Grey Spartan]

For those bored souls interested in my WhatsApp, just know, it has been restored. It was an accident and unrelated to Q

Nice.

 

[BalticSea]

I have only tried 250mg/ml and it was good, how is 350mg/ml version?

I still didn't use it. I buy them for bridging in the winter season.

 

[Ecstasy]

Yes it is. Use 3mL of BAC to reconstitute, and I strongly suggest you filter the contents into a sterile 3ml vial.

Thanks! Is it causing people some problems?

 

[Ghoul]

Thanks! Is it causing people some problems?

"Cloudy" after 1ml doesn't mean it's just hard to dissolve. It's a sign of protein aggregation. When peptides "clump up", they can trigger an immune response.

Pharma Tesa is already known to cause injection site reactions from this "allergic reaction", but aggregates make it worse, and beyond the discomfort, there's a risk of developing antibodies which cause your immune system attack the drug, reducing or even eliminating it's effectiveness. (aka Immunogenicity)

Filtering removes the largest protein aggregates, reducing PIP, and lowering the risk of immunizing yourself against the peptide's effects.

 

[Ecstasy]

"Cloudy" after 1ml doesn't mean it's just hard to dissolve. It's a sign of protein aggregation. When peptides "clump up", they can trigger an immune response.

Pharma Tesa is already known to cause injection site reactions from this "allergic reaction", but aggregates make it worse, and beyond the discomfort, there's a risk of developing antibodies which cause your immune system attack the drug, reducing or even eliminating it's effectiveness. (aka Immunogenicity)

Filtering removes the largest protein aggregates, reducing PIP, and lowering the risk of immunizing yourself against the peptide's effects.

I appreciate the thorough response! Bought some sterile vials and syringe filters. Is it a good idea to filter most of the peptides into new vials or is it just a big thing with Tesamorelin? Thanks!

 

[2old2getswol]

I appreciate the thorough response! Bought some sterile vials and syringe filters. Is it a good idea to filter most of the peptides into new vials or is it just a big thing with Tesamorelin? Thanks!

I’ve not filtered Reta, Tirz, Sema, Cagri, HCG or HGH from QSC and have not experienced any issues so take that for what you will.

 

[Ghoul]

I’ve not filtered Reta, Tirz, Sema, Cagri, HCG or HGH from QSC and have not experienced any issues so take that for what you will.

Of course observational anecdotes have value, so I'm not suggesting what you're saying is useless, however you have no idea how much immunogenicity your peptides are inducing. It's not as if you could typically feel the effects of aggregation and the immune response unless it was really bad.

 

[Ghoul]

I appreciate the thorough response! Bought some sterile vials and syringe filters. Is it a good idea to filter most of the peptides into new vials or is it just a big thing with Tesamorelin? Thanks!

I'm filtering all my peptides now, based on what I've learned. This is an increasing concern with commercial pharma producers as peptides become more widespread therapeutics. Most of the aggregation appears to happen in the final product container once it's in the hands of the user.

I ended up going down this rabbit hole for a few reasons, and a "cloudy" batch of PIP inducing Tesa was one.

The TLDR version is that all protein based therapeutics are susceptible to this aggregation process. Visible particles are the final stage. It's a concern because, at the least, aggregates don't work the way the peptide is intended. It's an altered version of the original product. Depending on various factors, those altered products can cause negative reactions as the immune system responds, maybe something you can feel, maybe not. Finally, aggregates can "train" the immune system to attack the original, unmodified peptide creating "tolerance" and reducing the effect you're seeking. This is referred to as "immunogenicity".

It impossible for end users to filter out all aggregates, especially the smaller ones like dimer. But the common .2um filters will eliminate the largest aggregates, without filtering out even the longest peptides. .1um may be even better. Only "Size Exclusion Chromatography" can eliminate all aggregates leaving behind pure peptide.

Here's a rough diagram showing the concept of proteins subject to various stresses like temp cycling (freeze thaw) contamination(especially silicone from stoppers and syringes), and agitation causing shear stress, all leading to aggregates forming, which then trigger an immune response.



This shows the approximately
aggregate size, with 100um being "visible", aka "cloudy solution", and the smallest aggregates 1um. Often, the larger the aggregate the worse the reaction and greater possibility of immunogenicity developing.

One final thing, developing immunity to a peptide does not typically seem to be anywhere near as long as immunity from something like a vaccine, but still best to be avoided or you could be pointlessly injecting a peptide with diminished or no effects at all.

 

[sushak]

What are the losses encountered when filtering though? Doesn't the filter hold back a lot of the solution? Even .25 ml held up absorbed into the filter would be significant no? Have you measured the before/after volume after filtering say a 2ml reconstitution solution?