I skipped sema went straight to tirz, never went over 2.5mg for months and couldn’t gain when I wanted on that dose. Dropped to 1mg and was able to have some appetite but still was hard to get enough calories. Super effective for cutting though. Messed with reta for a month started and stayed at 2mg/week and no appetite, nausea occasionally and gnarly reflux symptoms. Dropped that and off them all together now for 2 weeks and still low appetite so force feeding myself on a schedule to maintain my calories. But yeah I have no idea how folks get to those mega doses I’m miserable even at starter doses and don’t seem to build a tolerance.
Why would you expect a hormone, and that's what GLP is, an energy homeostasis regulating hormone, to have the same impact on everyone?
It's not a diet pill.
Would you expect 200mg/week Test to have the same impact on someone who's 800 natural vs some hypogonadal guy at 300?
You don't need a GLP. You make enough. You're not insensitive to it. So even a small dose is having a major impact. The people on "megadoses" have a deficit of GLP, which is why they aren't puking their guts out all day on 10x the dose you take. That's the reason responses are all over the map. Hyper responders are the ones who need it the least.
Do you know how bariatric surgery induces weight loss? A smaller stomach pushes food into the intestine faster, Intestinal hypertrophy releases....wait for it...GLP. It reduces appetite of course, and often puts diabetes into remission.
Now that guys who struggle to put on weight are using GLPs to make cutting even easier, it makes the question of who the real lazy fucks in this scenario are a lot more interesting.
For all the crybabies without the "willpower" to eat enough on a bulk, read on. Despite not being able to muster the strength to just open their mouths, put the food in, and chew, there's hope for you weak willed pussies:
Avexitide
The cheat in a syringe your mother's wish they had when they couldn't get your scrawny assess to eat anything.
It's an anti-GLP.
It blocks GLP receptors.
The perfect antidote for the guys above who just can't manage to eat another bite without puking because their biology...er, I mean abundant "willpower" won't allow it.
It's intended for those who bariatric surgery was too successful. And now the abundance of naturally produced GLP is a problem, causing hypoglycemia. and even too low of an appetite.
- Pivotal Phase 3 LUCIDITY trial will evaluate FDA-agreed upon primary outcome of reduction in hypoglycemia events and designed to align as closely as possible with previous Phase 2 trial designs - Amylyx expects first study participant dosed in LUCIDITY in Q1 2025 and topline results in 2026 -...
www.amylyx.com
It's time to let it go. You haven't been thin your entire life because you were born with some innate moral superiority. The 120 pound stringbean in dirty jeans at the gas station isn't skinny in a world of abundant food because he's overflowing with willpower and self control. He just has a high level of GLP. for whatever reason, just like you. And now we have a way to increase, and decrease that hormone at will.
Sorry, your natural state of low appetite doesn't make you special any more. You'll have to find another way to distinguish yourself.