Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Stealth500]

Have you checked both tracking numbers? There’s 2 numbers associated with each number

no tracking, as in 2 weeks after payment still haven't been given a tracking number.

I hit the lottery with the new staff. I imagine they didn't have a merry christmas or a happy new year.

Just a test run to see how it goes, what carrier it lands with. The following one will be a real order..

 

[Juiced_lizard]

no tracking, as in 2 weeks after payment still haven't been given a tracking number.

I hit the lottery with the new staff. I imagine they didn't have a merry christmas or a happy new year.

Just a test run to see how it goes, what carrier it lands with. The following one will be a real order..

Have you asked for tracking? I’ve gotten plenty of orders without receiving tracking.

 

[Stealth500]

Have you asked for tracking? I’ve gotten plenty of orders without receiving tracking.

yeah, literally at the end of every back and forth message specified that it was a necessity just to make absolutely sure they didn't miss it.

 

[AlmightyAlpha]

Two of my 5 packs are getting delivered this week but those two were never in customs. Three are still stuck possible reship.
And I just got tracking for my Christmas order.

 

[Stealth500]

they'll get it


Lori

 

[Ghoul]

Question, has anyone had gyno sides from the GH here? I’ve been running GH from a different source for years but can’t come close to the price here. Wondering if it’s common with these kits or what’s up lol?

Also why am I still a “ new member “ wtf I’ve been a member for years..

TLDR: QSC GH is working more effectively than the other brand:

(likely due to higher purity, different impurity profile, freshness so less degradation, fewer aggregates, etc all triggering less of an immune response)

Post in thread 'Hgh gyno flares up'

Tuesday at 7:22 PM

Gynocomastia is associated with high levels of GH.

https://academic.oup.com/jes/article/6/Supplement_1/A492/6787497

When growth hormone therapy loses effectiveness, endocrinologists test for growth hormone antibodies, a sign of immunogenicity, ie, developing an immunity to GH.

If antibodies are detected, the usual approach to overcoming immunity is to try a different brand.



So it sounds like if gyno is flaring up right after switching brand or batches, that's a clue you've developed antibodies neutralizing GH, and after the switch, it started working like it...

• Ghoul

• 

One of QSCs big advantages in peptides is simply their high volume of sales, which means faster stock turnover, and fresher product. Better to buy fish from a busy shop, than a quiet, dusty place with few customers.

 

[readalot]

TLDR: QSC GH is working more effectively than the other brand

Not sure why, but something about it caused me to get gyno / a flair up. A QSC 24iu kit to be exact.

Not sure why, but something about it caused me to get gyno / a flair up. A QSC 24iu kit to be exact.

Weirdest thing is I have used Qsc HGH for two years, being 99% of the hgh I’ve used and never had an issue. But something about this one kit?

My read was his issue seemed to be batch specific from scanning the thread.

 

[readalot]

Then....

I started gh again 3 days ago and have no symptoms.. Qsc 36iu kit. Nips are fine, not sore, glands, not inflamed. I did take another 6 mg aromasin in yesterday.

Oddly I am also seemingly fuller with this kit also - same dosing, no other changes. Been 3 days without the ralox To assess and no flair up, but I’ll prob take a small dose for the next week or so to be sure.

 

[Ghoul]

My read was his issue seemed to be batch specific from scanning the thread.

Since gyno is closely associated with higher levels of GH, when using xx mg of two brands/batches, and one is inducing gyno but the other isn't, that's pretty strong evidence one is effectively delivering more GH.

Overdosing is never more than ~20% so that's unlikely the cause of dramatic gyno.

Immunogenicity against GH develops in a pretty high proportion of users, it's just not well documented because clinically it rarely rises to "significant" level. Significant being defined as very slow of no growth in children, or a similar lack of response in IGF when treating adults. Some lesser amount of effectiveness loss is likely quite common. (see inhibition in the chart above)

So while gyno might be caused by some unique mechanism(some odd impurity for instance), I think this is one of those "if you hear galloping think 'horse' not 'unicorn' " situations.

For those using GH long term, a GH antibody test every 6 months or so is probably a good idea. The added complexity for UGL vs pharma however is batch to batch variance. So unfortunately a UGL brand that works well, with low immunogenicity, may completely change on the next batch if the UGL changes something, while pharma is going to be extremely consistent.

If I was using a UGL GH and had no antibodies develop while on it, I'd buy a long term supply and store it in a cryofreezer.

 

[Middus]

Since gyno is closely associated with higher levels of GH, when using xx mg of two brands/batches, and one is inducing gyno but the other isn't, that's pretty strong evidence one is effectively delivering more GH.

Overdosing is never more than ~20% so that's unlikely the cause of dramatic gyno.

Immunogenicity against GH develops in a pretty high proportion of users, it's just not well documented because clinically it rarely rises to "significant" level. Significant being defined as very slow of no growth in children, or a similar lack of response in IGF when treating adults. Some lesser amount of effectiveness loss is likely quite common. (see inhibition in the chart above)

So while gyno might be caused by some unique mechanism(some odd impurity for instance), I think this is one of those "if you hear galloping think 'horse' not 'unicorn' " situations.

Gyno is caused by the particular individuals response to GH. All the other 'causes' per the injected HGH would be indirect.

 

[AlmightyAlpha]

Gyno is caused by the particular individuals response to GH. All the other 'causes' per the injected HGH would be indirect.

I'm glad I got my glands removed years ago. Now all I do is monitor bloodwork

 

[Ghoul]

Then....

Since immunogenicity doesn't develop instantly, it's entirely possible he's developing it to the QSC batch now too. It started strong, gyno flared, and after a short while xx% of gh is now being inhibited, effectively lowering the dose.

Two other relevant factors:

~He stopped, then restarted using it. A "drug holiday" can trigger a stronger immune response when restarting vs "continuous exposure" to a peptide/protein. **

~Immune response is highly individual. He may just have a strong immune reaction to gh of all types.

Of course this is all hypothesis, and not only do we not have antibody test results, but usually, we don't have all the facts of what he's using, how he's using it, etc.

**on another note, I strongly suspect this is happening with GLPs. As the European Medicine Agency points out, the impact of immunogenicity (development of ADAs, Anti-drug Antibodies) is often not fully understood until some time, often years, after a peptide/protein therapeutic hits the market:

https://e-b-f.eu/wp-content/uploads/2018/12/FW201809-02.-Meenu-Wadhwa-NIBSC.pdf

 

[Evac513]

@Qingdao Sigma Chemicals the pricelist posted yesterday on telegram says 50 shipping to USA but the rep is trying to charge me 65 shipping? Which is it?

 

[HUGE McBIGLARGE]

I know I asked this the other day, but it’s like 10 pages back now. So sorry for asking again.

But does QSC take bitcoin payments via lightning?

 

[mok4315]

**on another note, I strongly suspect this is happening with GLPs. As the European Medicine Agency points out, the impact of immunogenicity (development of ADAs, Anti-drug Antibodies) is often not fully understood until some time, often years, after a peptide/protein therapeutic hits the market:

That’s pretty bleak. Imagine losing 100, 200 pounds, maintaining for a few years at a lowish dose, then it stops working and you slowly regain all that weight. That’s some Flowers For Algernon shit right there.

 

[Ghoul]

That’s pretty bleak. Imagine losing 100, 200 pounds, maintaining for a few years at a lowish dose, then it stops working and you slowly regain all that weight. That’s some Flowers For Algernon shit right there.

Not a phenomenon observed in 10,000+ participants in the pharma trials, including the multi year extended phases. No loss of efficacy with continuous exposure.

However, "it stopped working" is a common theme among non-pharma users.

It's important to understand that immunogenicity isn't usually binary, ie, it happens or it doesn't. It's often there but just kept in check. With x dose, diluted to x ratio, at x frequency, without interruption, it doesn't rise to a level where it compromised efficacy.

So you take one dose, the immunogenic reaction peaks at, using an arbitrary scale of 1-10, 5. A week later it's dropped to 3. You take another dose (another "exposure event") it peaks at 5, drops to 3 by the next weekly dose, and back up to 5 and so on, remaining at a stable level.

Now you take a "drug holiday", an extended break from use, immunogenicity drops to 0, but in the absence of exposure to the peptide your immune system builds up a nice supply of "memory T-cells", a "rapid response team" for future "invasions".

You take another dose after long break. immunogenicity response jumps to 8 and the drug is much more rapidly cleared from your system. A week later it's down to 5, and with the next dose it's back to 8, rapidly neutralizing the peptide, so the only way to get the same effect as previously is to increase the dose.

And there are other factors. We know from the trials there isn't a problem with 1 "exposure event" per week, but microdose and now you've got 7 exposure events, giving your immune system daily practice on ridding itself of this "infection". And ironically, small doses are often worse in terms of creating immune responses than larger ones.

So that's why screwing around with what's proven effective long term is so risky. In some individuals, this unwanted "enhanced immune response" can last for years. or even a lifetime.

 

[Ateam2023]

Question, has anyone had gyno sides from the GH here? I’ve been running GH from a different source for years but can’t come close to the price here. Wondering if it’s common with these kits or what’s up lol?

Also why am I still a “ new member “ wtf I’ve been a member for years..

you've only posted 33 messages, lmao

 

[Justaguy99]

Any of you ever have a sudden change in aromatization?
Same cycle.
Same batch of gear.

Suddenly need hcg to keep e2 up.
Not concerned but if BF% is same any ideas what would equate to needing to add hcg.

Test/Primo
70/30

 

[Grey Spartan]

Any of you ever have a sudden change in aromatization?
Same cycle.
Same batch of gear.

Suddenly need hcg to keep e2 up.
Not concerned but if BF% is same any ideas what would equate to needing to add hcg.

Test/Primo
70/30

If I was to take a guess I would say a loss of visceral fat or just plain old adaptation.

 

[Ateam2023]

Androgens inhibit gyno. Estrogens, GH, IGF-1 , Prolactin and progesterone all cause gyno growth. GH itself can cause gyno and it also increases IGF and might also increase prolactin so there you go.

Not very common with GH but may happen.