LGOP528
Member
Will do. I am getting an mri soon so I will know a little more. Here is my old mri from 3 years ago.
MESO-Rx
Anabolic Steroids
Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic
- Thread starter Qingdao Sigma Chemicals
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Ghoul
Well-known Member
No need to fear random prions appearing from some external source when you can worry about the functional equivalent forming in your very own peptide vials:
Transmissible Proteins: Expanding the Prion Heresy - PMC
The once-heretical concept that a misfolded protein is the infectious agent responsible for prion diseases is now widely accepted. Recent exciting research has led not only to the end of the skepticism that proteins can transmit disease but also to ...
pmc.ncbi.nlm.nih.gov
I wonder if people think there's some scientific agency out there playing around with peptides the way the UGL community does, like a guardian angel, that would surely warn of the potential hazards of injecting our random concotions. And assuming, since there's no public campaign against it by the authorities, it must be safe.
Filter your peptides folks. It may not protect you completely, but it'll help reduce the risks.
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Damn @readalot ………you know you’re just trying to get as accurate as you can to make a voodoo doll!!
Hahahaha
readalot
Member
Just trying to help our dear brother/sister/other here with some harm reduction.
janoshik
Subscriber
Most of the peptides (in this field) are far too small to be physically capable of forming prions. The peptides(well, mostly proteins) have to be certain size to achieve 'structural flexibility' to switch like that, must have the hydrophobic areas that could subsequently be exposed and be unstable enough that interaction with 'turned brethren' would overcome the barrier to enter a different state. But not too unstable otherwise it wouldn't pass to start with.No need to fear random prions appearing from some external source when you can worry about the functional equivalent forming in your very own peptide vials:
View attachment 310646
View attachment 310651
Transmissible Proteins: Expanding the Prion Heresy - PMC
The once-heretical concept that a misfolded protein is the infectious agent responsible for prion diseases is now widely accepted. Recent exciting research has led not only to the end of the skepticism that proteins can transmit disease but also to ...
I wonder if people think there's some scientific agency out there playing around with peptides the way the UGL community does, like a guardian angel, that would surely warn of the potential hazards of injecting our random concotions. And assuming, since there's no public campaign against it by the authorities, it must be safe.
At least that's my amateur take on it.
I just enjoy learning about these.
It's insanely interesting field of study.
MissedArmDay66
New Member
@Ghoul did you ever find any syringes with stoppers with low risk of leeching into peptides for your idea of pulling entire vial into syringe and filtering per dose?
Dang-1
Member
I’ve spent another 10 min QSC post scrolling for damn relevant info again to no avail. Gave up and message them for the list and sales again on WhatsApp. I do wish this thread was more useful but oh well.
Could have saved yourself some time and grabbed it off Telegram. Takes like 3-4 seconds
Where else would they discuss all these other topics? It's not like there are dedicated forum sections for homebrewing, general steroid discussion, lab testing, blood work etc... oh wait actually there is.
dontletheoldmanin
Member
I already have it and use it for that reason lol.
Sicsemptyran
New Member
readalot
Member
I AM a jerk for being on this forum. You got me there.
I've made my piece with prions but don't use u-hCG anymore haha. Can't really say I am a fan of peptides. Maybe I am missing out. Will most likely try GH soon or stare at the $450 vial in the fridge for a while like I did with the stanozolol for a couple of years. I take my time.
AnTabolic73
Well-known Member
But is there a prion section?!
Well yeah, the QSC thread of course...
UncleBuns
Well-known Member
I wish I could lay off the u-HCG. I've tried for many years to rid myself of obsessive thoughts about lady pee, but I always fail. I have finally found peace with my desires and come to accept who I am. If injecting lady pee quiets the demons, then so it shall be.
Ghoul
Well-known Member
I hope my insatiable curiosity never comes off as disregarding the infinitely greater knowledge you have in this area.
As I understand it, only a subset of proteins can become infectious brain damaging prions. It requires several elements,
-----------
1. Must be able to cross the blood brain barrier.
2. They must be able to take on an amyloid configuration.
3. Have the ability to self replicate by acting as a "template" to modify existing natural cellular proteins.
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I'll use my favorite peptide, Semaglutide to illustrate.
GLP-1 has more research behind it. so I'll use it for reference. but the same charachteristics apply to close analogs like Sema.
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1. GLP-1 easily crosses the blood brain barrier.
2. GLP-1 forms amyloid fibrils as the result of simply being reconstituted in a solution with the wrong PH, unless Polysorbate 80(or similar) is included as an excipient!
"Protein or peptide aggregation into amyloid fibrils is a widespread phenomenon that plays a critical role not only in many neurodegenerative diseases but also in the stability of protein- and peptide-based biopharmaceuticals."
3. Whether GLP-1 fibrils can replicate, and what would make it happen, is unknown.
So we have 2 of the 3 factors constituting a potential prion disease present in UGL Sema, and the 3rd is an unknown.
It's been demonstrated that aggregates, including fibrils, can be significantly reduced, and their future development slowed, by filtering at .10um or larger. Unexpectedly, smaller pore sizes cause more fibrils to form.
No good can come from injecting amyloids into our bodies regardless whether they can replicate or not, especially if they can cross the blood brain barrier. So in my opinion, filtering the larger aggregates out of peptides will reduce the amount of that harmful gunk, and reduce the chances of some mutated form turning out to be something much worse years later.
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Black Beard
Member
@Qingdao Sigma Chemicals
Hey Tracy, it's been 3 weeks since my order was in customs (12/14/2024). Would i be getting a reship at 4 weeks? This sucks.
(Says "delivered to local carrier" since 12/19/2024 with zero movement)
Hey Tracy, it's been 3 weeks since my order was in customs (12/14/2024). Would i be getting a reship at 4 weeks? This sucks.
(Says "delivered to local carrier" since 12/19/2024 with zero movement)
bigforyouben
Member
Reship is 30 days after last tracking update. If it makes you feel any better my package that was stuck since 12/19 started moving a couple days ago.
You have to take the holidays into consideration.
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