Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic

[Ghoul]

Has it ever been characterized what the other 3% was? I was assuming it was other soluble peptides, if so, filtering wouldn't do anything. (as any filter that would pass tirz would also pass the impurity)

The impurities easily form into aggregates, and those are effectively filtered out once they're above .2um. Since the largest aggregates cause the strongest immune reactions, filtering is an effective way to deal with them.

 

[mok4315]

Aggregates form most easily from degraded peptide/protein. "Degraded" peptide including denatured (unfolded and not in its proper shape), peptide broken into fragments, or impurities (chains of random amino acids) left from the manufacturing process.

I've recently been reading about the way peptide aggregates tend to remain where they're injected in sub-q injection. The sit there attracting the attention of the immune system causing inflammation and pain.

I’ve been on the aggregate bandwagon since you’ve been beating this drum, but I gotta admit it’s a whole new thing seeing the evidence in person. His reaction definitely lasted close to 5 days, so it makes sense that the aggregates stuck around.
Man, glad I started filtering everything (in large part because of you), and I’ll teach him how to do it too.

 

[bigtom343]

#freeTracy

 

[TTK]

Ahhhh sonofabitch!

Haven't needed to order anything for many months. Haven't been on here either.

Sent in an order for peptides a few days ago, didn't hear back, thought I'd check this thread to see what their CNY plan was and BOOM!

Hopes and dreams destroyed.

I was really looking forward to trying PT141

 

[Middus]

My tracking says shipment info received and that’s all. Does that mean it shipped or label was only created?

How long has this been? and is it a USPS number?

 

[Ghoul]

I’ve been on the aggregate bandwagon since you’ve been beating this drum, but I gotta admit it’s a whole new thing seeing the evidence in person. His reaction definitely lasted close to 5 days, so it makes sense that the aggregates stuck around.
Man, glad I started filtering everything (in large part because of you), and I’ll teach him how to do it too.

It moved from theory to reality with me once I started using Tesamorelin, so prone to aggregation even the pharma version is known to cause painful site reactions with nearly every (daily) injection.

The first time I filtered a vial the pain disappeared, a huge eye opener. BUT, with each subsequent injection the pain progressively got worse.

Realizing aggregates must be reforming over time, I moved to the next level, loading a 3ml syringe with the entire vial contents and filtering right into an insulin syringe just before injecting.

It's how I use all my peptides now, and, in some cases, they've become so much more effective, I've had to lower the dose. I suspect it's due to less immunogenicity, so less of the drug is neutralized.




Next I plan to eliminate backfilling and the needle on the 3ml syringe by direct coupling the filter right onto a zero deadspace syringe and attach a zero deadspace 31g needle.

 

[Middus]

No, it was QSC tirz. Just realized you were talking about SSA Funny how they both tested at 97%.

QSC tirz has been known to cause ISR in some people. They've never been able to use it and had to switch brands

 

[craigdt]

Ahhhh sonofabitch!

Haven't needed to order anything for many months. Haven't been on here either.

Sent in an order for peptides a few days ago, didn't hear back, thought I'd check this thread to see what their CNY plan was and BOOM!

Hopes and dreams destroyed.

I was really looking forward to trying PT141

Yeah, sucks.

I just sent them an email asking about how they package their raw powders (cuz I ask dumb questions like that) and it bounced back.

Did some digging and realized what happened.

Bummer. They were my favorite supplier. Need to find a new Primo source

 

[Justaguy99]

I most definitely took pt141 and not my bpc
Not the night I had planned.
Note to self - stay off phone when doing shit.

 

[AlexDavis43]

Need to find a new Primo source

There are plenty.

 

[SpaceForce]

From last year...not sure if it's the same every year, but might help estimate the expiration date of this thread.

20th feb, end of CNY holidays

 

[SpaceForce]

While searching for the CNY end date for my last post I saw this response from QSC. If anyone still thinks this was an exit scam, he did a terrible job at pulling in orders.

 

[SWFL-239]

The impurities easily form into aggregates, and those are effectively filtered out once they're above .2um. Since the largest aggregates cause the strongest immune reactions, filtering is an effective way to deal with them.

How do you go about it just filter a vial or 2 at a time or for GH if I’m using a kit a month just reconstitute the whole thing, filter it and backload 60 slin pins


Never-mind scrolled down a few more post pics and everything.

 

[Ghoul]

How do you go about it just filter a vial or 2 at a time or for GH if I’m using a kit a month just reconstitute the whole thing, filter it and backload 60 slin pins

Aggregates form over time. The less time between reconstitution and use the better. Or the less time between filtering and use is better.

Since you're using a vial every 3 days, I'd reconstitute however many vials would fit into a 10ml syringe. Draw them all into the syringe, remove needle and attach filter, reattach needle.

Then backfill an insulin syringe just before you use it. Once you do it a few times it only takes seconds. Then whatever aggregates grow in syringe are filtered out and there's not enough time for new ones to form in the insulin syringe,

If that's too much work, just filter a few vials at a time (draw into syringe, attach filter, inject back into vial) and use however you normally would, or backfill a bunch of insulin syringes in advance from the filtered syringe,

 

[FastBun]

Aggregates form over time. The less time between reconstitution and use the better. Or the less time between filtering and use is better.

Since you're using a vial every 3 days, I'd reconstitute however many vials would fit into a 10ml syringe. Draw them all into the syringe, remove needle and attach filter, reattach needle.

Then backfill an insulin syringe just before you use it. Once you do it a few times it only takes seconds. Then whatever aggregates grow in syringe are filtered out and there's not enough time for new ones to form in the insulin syringe,

If that's too much work, just filter a few vials at a time (draw into syringe, attach filter, inject back into vial) and use however you normally would, or backfill a bunch of insulin syringes in advance from the filtered syringe,

Where is best place and filter you recommend???

 

[MissedArmDay66]

Realizing aggregates must be reforming over time, I moved to the next level, loading a 3ml syringe with the entire vial contents and filtering right into an insulin syringe just before injecting.

Were you able to source a syringe with a stopper that minimizes leaching while the reconned peptide is sitting in it for the duration of time it takes to get through the vial?

 

[mok4315]

Where is best place and filter you recommend???

Sterile 0.2 μm PES Syringe Filters

Hydrophilic PES syringe filters with single or double-layer membrane. Pore sizes of 0.2μm. Diameter of 13mm/25mm/33mm with Luer lock. Sterile individually packed.

shop.cobetter.com

Or these:

(75/Pk) PALL Acrodisc 13mm 0.2um Supor Membrane Syringe Filters 4602 | eBay

Find many great new & used options and get the best deals for (75/Pk) PALL Acrodisc 13mm 0.2um Supor Membrane Syringe Filters 4602 at the best online prices at eBay! Free shipping for many products!

www.ebay.com

Edit to say both for peptides.

 

[throwawaybb21]

How long has this been? and is it a USPS number?

12/31. YunExpress

 

[0x33]

Where is best place and filter you recommend???

I'd suggest this hydrophilic PVDF filter as it has the lowest protein binding Amazon.com

 

[MissedArmDay66]

Where is best place and filter you recommend???