beachathlete
Member
@Ghoul - apologies if you covered this a few pages back - this would seem to insinuate that TB500/BPC157 mixes aren't providing the intended effect or are there potential exceptions?
MESO-Rx
Anabolic Steroids
Qingdao Sigma Chemical Co., Ltd (International, US, EU, Canada and Australia domestic
- Thread starter Qingdao Sigma Chemicals
- Start date
What about compounders selling BPC mixes?
IronJohnDoe
Member
If by Tracy you mean the Korean actress that he uses as an avatar then yes she should be single.
If by Tracy you mean the China man behind QSC I have no frigging idea.
Ghoul
Member
There are no exceptions without a full study of the aggregation resulting from the interaction two peptides in a single container. Only experiments in preventing problems haven been done so far, "Coating" peptides in a kind of polymer that dissolves in the body has shown promise in preventing these molecules from sticking together.
FDA started expressing concern over BPC in 2023.
Then in October the FDA declined to remove BPC the "high risk" list of bulk drugs used by compounding pharmacies specifically because nothing whatsoever has been done by the manufacturers, petitioning the FDA for approval, to measure or control aggregation and immunogenicity risk, explicitly mentioning how they found it to often be carelessly combined with other substances, which increases risk exponentially vs being used as a single compound.
It's safer to keep them separate. Not necessarily "safe" (or dangerous), but definitely a lesser risk than mixing them for no reason than mere convenience. Even if someone insists on a single injection. at least storing them in separate vials will help:
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sinistral
Member
Am I correct to say from this that aggregates can form both before and after reconstitution?
Astartes
Member
Update: Interestingly, all orders I placed (4) between Dec15th and Dec 31st have now been received. Even those that did not come with a tracking code prior to sudden exit.
As previously stated QSC was an international seller. I am highly skeptical that they shut down due to US law enforcement or burned shipping lanes.
(Which they may have had due to recent seizures, or it could have …. more likely… occurred as a result of a full pressure campaign in general by customs and DEA)
Too much of a network to simply close all operations. No, this is a sudden and quick departure that coincided with CNY but was unrelated to it.
My gut, and this is simply my own thought process is that this is more likely pressure on Chinese Pharma to close gaps in grey market consumption to prevent sanctions, tariffs, or consequences to their white market.
Some of that pressure may have resulted from the new administration in US, but I am betting this is as much internally driven as externally driven.
For whatever reason, QSCs primary suppliers for Raws were burned first and they thought they count continue operating on peptides… then it was a quick exit.
Personally, I hope Tracy got out.
However, don’t think he pulled an exit scam, I think his ops got netted and we are unlikely to get the actual story due to CN being opaque.
To what degree they were compromised or operating with or without party authority, will most likely remain unknown.
(As always… I will batch test to determine quality, but expect it will likely come up positive)
As previously stated QSC was an international seller. I am highly skeptical that they shut down due to US law enforcement or burned shipping lanes.
(Which they may have had due to recent seizures, or it could have …. more likely… occurred as a result of a full pressure campaign in general by customs and DEA)
Too much of a network to simply close all operations. No, this is a sudden and quick departure that coincided with CNY but was unrelated to it.
My gut, and this is simply my own thought process is that this is more likely pressure on Chinese Pharma to close gaps in grey market consumption to prevent sanctions, tariffs, or consequences to their white market.
Some of that pressure may have resulted from the new administration in US, but I am betting this is as much internally driven as externally driven.
For whatever reason, QSCs primary suppliers for Raws were burned first and they thought they count continue operating on peptides… then it was a quick exit.
Personally, I hope Tracy got out.
However, don’t think he pulled an exit scam, I think his ops got netted and we are unlikely to get the actual story due to CN being opaque.
To what degree they were compromised or operating with or without party authority, will most likely remain unknown.
(As always… I will batch test to determine quality, but expect it will likely come up positive)
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Therapeutic Proteins DOES NOT ALWAYS EQUAL Peptides.
Some protein therapies are actually immune modulating antibodies. Their job is to be immunogenic, Sometimes to a devastating effect.
EPO too for example, it's not just a simple hormone (they're never simple though) like HGH. Epo is a cytokine. Cytokines by their very nature affect the immune system.
But yes, aggregates are an issue.
Ghoul
Member
Correct. Though once lyophilized there's no more aggregation until reconstitution. The nature of Jano testing means "related" aggregates like growth hormone dimer are identified, but others are just unspecified "impurities". Also, since reconstituted peptides are filtered prior to analysis, larger aggregates won't be detected at all. They can be through Size Exclusion Chromatography, which he offers. But in my opinion, it wouldn't make much of a difference, since they can form long after reconstitution, and filtering gets rid of both aggregates from manufacturing and "grown" later anyway.
So for the end user the results just reveal the quality of the product, but changes nothing in regards to filtering.
This is an eye opener on the topic from the POV of protein drug developer consultant giving a presentation at a pharma school.
Protein based drugs are still a relatively recent technology, and every week there's another advance made in detecting aggregates, tweaking manufacturing to prevent them, packaging companies are formulating new types of glass and plastics to prevent them from happening, and of course the basic research of quantifying their risk goes on.
But what everyone involved in producing and regulating protein drugs seems to intuitively understand, what motivates all this effort and billions in expense to get a handle on this, is that eventually, there's going to be another catastrophic event, and unlike the relatively few it devastated in the past, it could be millions the next time.
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Swolemates365
Subscriber
It’s good to see everyone getting packs still. Just need Tracy to re ship these seized now! We know your lurking Tracy!!
Garganzola
Member
Plot twist Tracy was Luigi
TurboJet
Member
Well 300 more pages till we hit 4k!
Anyone get us packs when ordered the week of 1/5 to 1/8 before the pause? Not sure why us would have issues post CNY.
Garganzola
Member
i think one guy did, i am still waiting for my order that was shipped on 1st of January.
mok4315
Member
I imagine the US “warehouses” were shipping out product until shortly after they too lost comms with QSC. Maybe they figured that if they weren’t getting paid, might as well keep the drugs. Or maybe they’re just laying low until QSC comes back online. I recall one or two guys getting their packs.
Astartes
Member
Yah. That is the pits. Hate it for those caught up in that.
Trailmixed
Member
Damn man, all these people on the “GLOW” protocol (GHK-Cu/BPC/TB-500) without knowing anything about aggregate formation. I guess no surprise with the lack of knowledge on the subject.
Trailmixed
Member
Got my CN tracking number on 12/30, have checked daily since then on LZ and USPS, and still nothing on it. Trying to deny the fact that I’m fucked lol
mok4315
Member
That’s what they get for trusting a mentally unstable narcissist. I truly hope SRY is no longer using her as a US warehouse.
Ghoul
Member
The rule is that biologics, which includes proteins, should never be mixed together in the same syringe. AAS are small molecule drugs and aren't nearly as likely to be incompatible,
The next time you have a few immunizations due, ask the nurse to draw them all into one syringe so you only have to endure a single injection and see what she says.
Tbaz192
Member
I had an order that never updated the tracking, just showed up at my door.
Said label being created, the whole time.
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