Exactly, stops you from going to pee thus helps me massively to sleep through cause i pee like a horse normally, not every 20-30 minutes but just drink a lot and with a SGTL2 in play you will just urinate more frequently in general
MESO-Rx
Anabolic Steroids
Repurposed drugs
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bananafeet
Member
You know that continuously peeing could mean your kidneys are not shutting off because you're not hitting the proper sleep stages. I had that issue before I started CPAP machine.
Might be unrelated....
Yep good point but they are fine, i just pee a lot and have a small bladder unfortunately. Prostate is also good togo
I've only ever been on tirzepatide while on mirtazapine, but it works just fine for me on a low dose of tirzepatide. That's interesting that you've noticed a difference. Is it quite a marked one?
bananafeet
Member
Yes. Hunger is still there and the stomach doesn't get totally stopped.
But it's still early days. I'll leave a comment when I spend a month at 3mg per week (previous highest dose of sema).
I think it would probably counter the effects of GLP1 more than GIP. But that's just me bro sciencing. Be good if other people give it a whirl.
bananafeet
Member
Great lecture on PMDD. I find that any video over 6 years old in YouTube is great. The older the better.
Everything turned to shit on YouTube recently.
View: https://youtu.be/-5ras3wcbAc
I know this is female specific, but the neurology carries over.
Everything turned to shit on YouTube recently.
View: https://youtu.be/-5ras3wcbAc
I know this is female specific, but the neurology carries over.
bananafeet
Member
View: https://youtu.be/2Nydy3PeRdE
It seems MAOI's can be used to lower blood pressure. I wonder if it has any benefit for bodybuilders who have mood disorders/hypertension AND high blood pressure.
I am looking into these two compounds:
Phenelzine
Tranylcypromine
There are less sexual dysfunction with this class of drugs which is relevant to me because I still get some sexual dysfunction on sertraline. Mirtazapine helps but any dose of sertraline north of 50mg is touch and go.
The atypical antidepressants or antidepressants that have less sexual side effects usually don't work too well in more severe cases of depression.
Caveat: I have not personally used these drugs, but I have researched them extensively.
Phenelzine is notorious for causing sexual dysfunction, if you search through user experience reports on forums, Reddit, etc. Of course, the people who don't experience SD don't complain about it on the internet, but it is reported significantly more than tranylcypromine.
Tranylcypromine seems more like a mixed bag, like any other antidepressant.
Talking of hypertension, you need to be aware of the risk of hypertensive crisis if you consume tyramine rich foods, such as cured meats and aged cheese. So you have to be aware of your diet. A workaround to this is to take nortriptyline, which eliminates the risk, according to Dr Gillman.
Also, you absolutely cannot take sertraline or any other SSRI while on an MAOI, or it will cause potentially fatal serotonin toxicity.
If you want to know more, Kenny G is the world leading expert on them. He knows what he is talking about and debunks many myths and untruths about them on his website
PsychoTropical Research by Dr Ken Gillman
Critical independent evaluations in psycho-pharmacology - Expert commentary on Monoamine Oxidase Inhibitors and Serotonin toxicity
www.psychotropical.com
bananafeet
Member
Yeah copy. Guess I'll give Vortioxetine a spin first then. Thanks for the info bro.Caveat: I have not personally used these drugs, but I have researched them extensively.
Phenelzine is notorious for causing sexual dysfunction, if you search through user experience reports on forums, Reddit, etc. Of course, the people who don't experience SD don't complain about it on the internet, but it is reported significantly more than tranylcypromine.
Tranylcypromine seems more like a mixed bag, like any other antidepressant.
Talking of hypertension, you need to be aware of the risk of hypertensive crisis if you consume tyramine rich foods, such as cured meats and aged cheese. So you have to be aware of your diet. A workaround to this is to take nortriptyline, which eliminates the risk, according to Dr Gillman.
Also, you absolutely cannot take sertraline or any other SSRI while on an MAOI, or it will cause potentially fatal serotonin toxicity.
If you want to know more, Kenny G is the world leading expert on them. He knows what he is talking about and debunks many myths and untruths about them on his website
PsychoTropical Research by Dr Ken Gillman
Critical independent evaluations in psycho-pharmacology - Expert commentary on Monoamine Oxidase Inhibitors and Serotonin toxicity
That bloke gives some great info on dopamine. Seems like the discussion around depression isn't complete without it. Anti depressants are actually anti anxiety meds due to the dopamine issue.
gainslol
Member
Zolpidem (Ambien) has an interesting use.
It's a sleeping pill but it has this paradox where sometimes it can wake some people up from a coma.
View: https://medium.com/beingwell/the-strange-paradox-of-how-a-sleeping-pill-can-awaken-you-from-a-coma-b01263c537d4
It's a sleeping pill but it has this paradox where sometimes it can wake some people up from a coma.
View: https://medium.com/beingwell/the-strange-paradox-of-how-a-sleeping-pill-can-awaken-you-from-a-coma-b01263c537d4
gainslol
Member
There's also Cimetidine the old heart burn medication, it can remove stubborn warts and reduce the pain of shingles.
And Sumatriptan, the migraine drug, for sexual function. In some people it causes spontaneous ejaculation though, you may want to skip it during family gatherings.
And Sumatriptan, the migraine drug, for sexual function. In some people it causes spontaneous ejaculation though, you may want to skip it during family gatherings.
Although he's an expert on MAOIs, there are some things he doesn't really know what he's talking about. For some reason he really has a hate hard-on for mirtazapine. He thinks it's just an antihistamine and is unaware of its noradrenergic potency and serotonin receptors blocking properties
One other MAOI worth considering is selegiline. If you take it in a high enough dose orally, or sublingually, it becomes a full MAO-A and MAO-B inhibitor, and there are very few reports of sexual dysfunction. If you take a low dose <10 mg, it is a selective MAO-B inhibitor which can increase dopaminergic transmission modestly while avoiding the need for dietary restrictions or SSRI contraindications. This could be enough to give you a little dopamine lift
The other dopaminergic option is bupropion which, again, modestly increases transmission. Not just dopamine, but noradrenaline as well. I am prescribed it myself in conjunction with mirtazapine, and I do notice the mood lifting and motivation increasing effects of it
Interesting. I'm definitely going to look into sumatriptan to see if it has any evidence of improving delayed orgasm/anorgasmia
bananafeet
Member
I watched pretty much all his videos. He's a fellow aussie. Well he lives in my state at least but was obviously raised in Britain.
He gives the entire history of these drugs. I think he has a bit of a skewed view on things which he admits because he was given basically the most hopeless and treatment resistant cases.
The drug you mentioned buproprion I have on hand, I haven't taken it because it can false positive on drug tests as amphetamines. It's probably impossible to get prescribed off label because in Australia it's only indicated for smoking cessation. The interesting thing about buproprion is that its used with a SNRI to get the full range of catecholamine/neurotransmitters increased and is called "Californian Rocket Fuel" which is obviously a head nod to hydrazine the first antidepressant which was a rocket fuel.
Anyway I will keep the MAOIs as a last option. I have noticed at 25mg of sertraline and 60mg of mirtazapine my sexual dysfunction is pretty much gone. I don't like taking that much mirtazapine so I will lower it and see what happens. A final point on Sertraline is that it appears to be the only dopaminergic SSRI, which is probably why it's so popular and doesn't have the "parkinson like" side effects the others do.
This dopamine issue is probably why I like tren and cabergoline. I also wonder if masteron is dopaminergic because I do like that steroid too.
This guy also states that Selegiline is basically not worth the trouble and that's why it's not popular.
It's interesting that all these medications are basically out of production or in limited production but still available from India.
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