Retatrutide

[gotgrowth]

Looking to start retatrutide a source I’m looking to buy from had 10,15 and 20mg. But his 10mg came in at 97 percent purity while his 15 and 20 came in at 99

My question if i start at 2mg a week will the 15mg last once reconstituted for 8 weeks ish ?

 

[Ghoul]

Anybody who is saying tirz is better than reta hasn't seen any of the reta phase 3 data.

I've read it all. Other than higher potential maximum weight loss at the highest dose, and worse insulin sensitivity and glucose control than Tirz, what's the "clear superiority" of it?

Other than for those who have a ton of weight to lose, and need the extra loss that Tirz is insufficient for.

 

[egruberman]

Anybody who is saying tirz is better than reta hasn't seen any of the reta phase 3 data.

Since you weren't kind enough to post the actual data

The Phase 3 TRIUMPH clinical program is ongoing and expected to conclude in 2026 with a couple thousand participants. Thus far:

24.2% mean weight reduction after 48 weeks (Tirz is 22.5 over 72 weeks)

Greater liver fat reduction over Tirz (82% reduction in 24 weeks with max dose) plus normalization of liver fat after 48 weeks for 85% of participants.

Reduction in triglycerides by 40%

Lowered apoC-III, which improves lipid metabolism, triglycerides specifically.

Interestingly, tirzepatide showed slightly greater reductions in HbA1c (2.4% vs. 2.02%) but that may be within the margin of error.

What seems most significant is the weight reduction and liver fat reduction over tirzepatide. Of note is the fact that these trials are run on folks with obesity, and a large portion on people with established ASCVD. Applicability to body builders is going to vary.

 

[Here2Learn]

I have responded a lot better to Reta than I had Sema or Tirz. Sema had the best inflammation decrease by a lot but had the most sides for me even with mitigation strategies. Tirz was better for sides, less help with inflammation but I didn’t lose much of anything on it. Reta has even less inflammation reduction but sides are great and I am losing, slowly but losing. I am on 4mg Reta and the appetite suppression is different, not overpowering like Sema but more like I get hungry then get full faster. I actually prefer that because otherwise I struggled to get enough calories in a day.

I personally believe there is not one best GLP but which one your body responds to the best.

Once I am in a place of maintenance I would love to move to .25mg of Sema and see if it works for me. I had the best inflammation reduction there without sides. We shall see when that time comes.

 

[Rakusa]

I have responded a lot better to Reta than I had Sema or Tirz. Sema had the best inflammation decrease by a lot but had the most sides for me even with mitigation strategies. Tirz was better for sides, less help with inflammation but I didn’t lose much of anything on it. Reta has even less inflammation reduction but sides are great and I am losing, slowly but losing. I am on 4mg Reta and the appetite suppression is different, not overpowering like Sema but more like I get hungry then get full faster. I actually prefer that because otherwise I struggled to get enough calories in a day.

I personally believe there is not one best GLP but which one your body responds to the best.

Once I am in a place of maintenance I would love to move to .25mg of Sema and see if it works for me. I had the best inflammation reduction there without sides. We shall see when that time comes.

thanks for your comment, but how do you observe different inflammation levels and the impact of said drugs on inflammation?

 

[Here2Learn]

thanks for your comment, but how do you observe different inflammation levels and the impact of said drugs on inflammation?

The fact that when I started Sema three days later my face was half the size. I mean that seriously too, I just don’t want to post pictures of my face but it was shocking.

As for on-going, my calves will get hard like completely flexed muscle all the time. It is just the inflammation and when it is down the calf has movement to it. Yesterday I was 3lbs lighter than I am today. I ate under 1,200 calories in those same 24 hours. Today is dose day and I will drop by tomorrow. Actually debating dosing every 6 days to just help with inflammation.

 

[zpped]

The only reason to choose something other than reta right now is if you can't afford it or have a bad reaction. It has so many more benefits. But it's not like you should throw out your tirz supply to switch.

People complain that it doesn't shut down their appetite are completely missing the point. The purpose is to lose weight not stop eating. Reta is a fine tuned evolution that improves upon the previous versions.

 

[NotHuman]

Since you weren't kind enough to post the actual data

The Phase 3 TRIUMPH clinical program is ongoing and expected to conclude in 2026 with a couple thousand participants. Thus far:

24.2% mean weight reduction after 48 weeks (Tirz is 22.5 over 72 weeks)

Greater liver fat reduction over Tirz (82% reduction in 24 weeks with max dose) plus normalization of liver fat after 48 weeks for 85% of participants.

Reduction in triglycerides by 40%

Lowered apoC-III, which improves lipid metabolism, triglycerides specifically.

Interestingly, tirzepatide showed slightly greater reductions in HbA1c (2.4% vs. 2.02%) but that may be within the margin of error.

What seems most significant is the weight reduction and liver fat reduction over tirzepatide. Of note is the fact that these trials are run on folks with obesity, and a large portion on people with established ASCVD. Applicability to body builders is going to vary.

Interesting regarding the triglycerides. I usually see them in the 70s when fasted.

However I had them pulled after 3 weeks on 2.5mg of Reta per week AFTER eating a large chicken/bacon/ranch sandwich from Jersey Mike’s and they were 62. I asked myself how that was possible since they should have been through the roof after a large meal. Now I understand why.

 

[keenpen]

The purpose is to lose weight not stop eating.

2 ways to lose weight. 1) eat less or 2) boost metabolism? Is there a 3rd way?

For someone in maintenance on the baby dose of tirz (5mg), but doesn't like to be hungry, would reta make sense to try?

It sounds like I need to grab a kit and give it a spin to see how it's different in the feelz department.

 

[egruberman]

2 ways to lose weight. 1) eat less or 2) boost metabolism? Is there a 3rd way?

There is one way to lose weight and that is to achieve a net negative energy balance, I.e. a "caloric deficit". Achieving this can be more or less complex for many people. There's no universal answer.

How one achieves that caloric deficit is the crux of the matter. Appetite regulation is a complex and powerful thing. Various kinds of expenditure have different results depending on the intensity.

 

[zpped]

2 ways to lose weight. 1) eat less or 2) boost metabolism? Is there a 3rd way?

For someone in maintenance on the baby dose of tirz (5mg), but doesn't like to be hungry, would reta make sense to try?

It sounds like I need to grab a kit and give it a spin to see how it's different in the feelz department.

eating less doesn't require you to never be hungry. impulse control and satiety works just as well and is likely healthier in the long run.

reta also induces a mild ketogenic state even while eating carbs.

Here's a nice writeup on one the the things that is unique to reta from RunningFNP who is a NP that's been in the reta phase 3 trial.

 

[Anonymous35]

I've read it all. Other than higher potential maximum weight loss at the highest dose, and worse insulin sensitivity and glucose control than Tirz, what's the "clear superiority" of it?

Other than for those who have a ton of weight to lose, and need the extra loss that Tirz is insufficient for.

Use both lmao

 

[Anonymous35]

eating less doesn't require you to never be hungry. impulse control and satiety works just as well and is likely healthier in the long run.

reta also induces a mild ketogenic state even while eating carbs.

Here's a nice writeup on one the the things that is unique to reta from RunningFNP who is a NP that's been in the reta phase 3 trial.

Yeah sure but the will power doesn’t last forever
On tirze/ reta i’m now abailble to maintain single digit bodyfat or 10% all the time
I don’t have any craving anymore
And no nausia i’m just feeling full all the time but not stuff

 

[zpped]

Yeah sure but the will power doesn’t last forever
On tirze/ reta i’m now abailble to maintain single digit bodyfat or 10% all the time
I don’t have any craving anymore
And no nausia i’m just feeling full all the time but not stuff

Dude you didn't understand what I was saying at all. Definitely wasn't talking about will power.

 

[keenpen]

eating less doesn't require you to never be hungry. impulse control and satiety works just as well and is likely healthier in the long run.

reta also induces a mild ketogenic state even while eating carbs.

Here's a nice writeup on one the the things that is unique to reta from RunningFNP who is a NP that's been in the reta phase 3 trial.

I put that PDF into notebooklm and had it create a podcast. After not understanding the PDF, I listened to the podcast and holy crap, I get it.

Give this a listen. It's pretty good.

 

[Anonymous35]

Dude you didn't understand what I was saying at all. Definitely wasn't talking about will power.

Will power to follow a diet is always there
But if you don’t want to eat in a firts place is gonna be easier

 

[Rakusa]

Alright, so I am considering a water fast for like 5 days to potentially remove cancerous cells, but I am also on 2mg of reta per week, considering moving up to 4 next week. What would be the interaction with reta and fasting? Is it a big no no, because of the glucagon pathway? No glycogen = higher blood sugar? Are there any risks involved?

 

[Trenbolonetax]

Alright, so I am considering a water fast for like 5 days to potentially remove cancerous cells, but I am also on 2mg of reta per week, considering moving up to 4 next week. What would be the interaction with reta and fasting? Is it a big no no, because of the glucagon pathway? No glycogen = higher blood sugar? Are there any risks involved?

I wouldn't be concerned one bit. I would ensure you're hydrating properly (electrolytes) because reta + fasting will make it more difficult to hold onto electrolytes initially due to drop in fasting insulin + no food = limited insulin and a big flush of water out.

Your blood sugar should remain more stable due to the reta. It will help push you further into a state of ketosis quicker, too. Which will help ameliorate some of the negative feels of jumping straight into a water fast.

If you've never fasted before and are jumping straight into this from a higher carb / SAD (standard american diet), you will probably feel kinda shitty since your body isn't well fat adapted and thus has trouble relying on fat + ketones as primary energy source.

As far as the biggest risk goes? Transient episodes of "low" blood sugar as your body is not used to this. I say "low" because when I was deep in ketosis I would routinely check my blood sugar 1hr ish post workout / post cycle and find myself in the 50's but I didn't get any of the physiologic side effects from this BG reading due to having forced my body to adapt to fat + ketones as main source of fuel.

 

[Trenbolonetax]

eating less doesn't require you to never be hungry. impulse control and satiety works just as well and is likely healthier in the long run.

reta also induces a mild ketogenic state even while eating carbs.

Here's a nice writeup on one the the things that is unique to reta from RunningFNP who is a NP that's been in the reta phase 3 trial.

Cool little summary by this dude. Thanks for posting.

Anecdotally, I can confirm that reta helps push further into a ketogenic state (further elevated BHB and quicker elevations in BHB with cessation of carbs e.g., carb cycling).

 

[deadbeef]

It will help push you further into a state of ketosis quicker, too.

I would think that this combined with fasting the concern would be ketoacidosis.

 

[gixxiepoo]

do y'all prefer one shot a week or microdosing every day?