Serious hormonal issues... anavar and its interaction with progesterone

[Spokeonawheel]

My wife has been having serious problems with her health related to hormonal issues.

Her progesterone is nearly bottomed out, extremely low. Like less than .1 (sorry can't remember the rest of range) Her testosterone was on the very low end of normal. Estrogen at a healthy high level.

The crashed progesterone led to A LOT of bleeding. 30 day, extremely heavy period? I guess you'd still call it a period. 5 day break... and then right back to the problems.

She'd seen a couple doctors, had an appt with her gyno which was gonna be like a month away. At some they prescribed her some bullshit progesterone cream. Did a bunch of bloodwork....low iron, very low hemoglobin.

Eventually, she got so weak and it was so ridiculous she went to the ER. Exams done, ultrasound done. The hormonal imbalances had caused endometrial hyperplasia... thickening of the uterine wall. All these problems.... results of hormonal imbalances.

We are still working on these issues, but She's doing much better now.

She's 42. Relatively young for menopausal problems. And her estro is still nice and high.

What we want to know is if past anavar usage could have played a part in any of this mess? She's ran maybe 3 or 4 total cycles over the past 2 years or so. The most recent being an 8 week cycle of 10 mg daily anavar. The most recent cycle ended in October 2020. She seemed to tolerate everything pretty well... no major sides, maybe missing 1 period per cycle, 2 at most, then back to normal.

What effect does anavar have on progesterone?

I'd assume it raises progesterone due to the cessation of periods. I've been researching, but haven't found much, if anything.

If anyone has any insight, or bloodwork results that may shine some light on this we'd love to hear it.

Thanks ladies and gentleman.

 

[TheIncomparableMrHarrow]

I don’t have any bloodwork to help you out here but my wife has done 3-4 var cycles. The highest she has ever gone to was 20mgs. She hasnt gone past 15mgs since. In fact she is currently ramping down her var from 15mgs to 10mgs this past week of her current cycle. Everything seems to be or has been good during her previous runs.

Side affects were possibly a bit of acne but nothing to bad on maybe one run and back pumps when she went as high as 20mgs. Besides her first cycle, her cycle lengths are typically at least 8 weeks and have gone as long as 9 and 1/2 weeks. During every single cycle she is scheduled to have at least two periods. She has always missed a maximum of one period. She has also used birth control pills during the entire time. Her blood markers all seem to be good and she has had no major medical concerns that we have had to worry about.

I don’t know if this helps at all but has been her experiences thus far.

I also don’t want to get too personal here either and I apologize if this offends you at all. It is not my intention just a bit curious. What are her low progesterone symptoms? Would they be the same as a male’s in regards to length of time to climax? I know it is generally a common occurrence of the onset of acne when it is too high.

 

[Jet Labs]

I've known plenty of ladies over the years who've ran var only cycles and I've never heard of such a reaction especially one so extreme. Could possibly be something else and the var is just exasperating the condition?

 

[TheIncomparableMrHarrow]

To avoid any confusion regarding my last post: bloodwork has come back good but I don’t have the actual bloodwork paperwork to post. She generally only gets bloodwork done on a yearly basis unless there are other issues.

 

[Spokeonawheel]

@TheIncomparableMrHarrow

Her symptoms of low progesterone was an absolute shit ton of blood loss from well... you know.

Low progesterone in females triggers, well, there periods. Progesterone that never recovers just causes all sorts of problems.

Appreciate the response tho.

 

[Spokeonawheel]

I've known plenty of ladies over the years who've ran var only cycles and I've never heard of such a reaction especially one so extreme. Could possibly be something else and the var is just exasperating the condition?

I suspect exactly the same. I don't think it was the anavar. Her last cycle was 5 months ago.

I do wonder if it could have been just enough extra hormonal weirdness that it might have tipped over a balance that was already compromised. I guess that was inevitable either way.

 

[Jet Labs]

I suspect exactly the same. I don't think it was the anavar. Her last cycle was 5 months ago.

I do wonder if it could have been just enough extra hormonal weirdness that it might have tipped over a balance that was already compromised. I guess that was inevitable either way.

Yah bro I can't see var and such a low dose of it causing such harsh health issues. I'd be getting here tested head to toe for anything and everything else just to be safe and keep her off gear period.

 

[Millard]

I suspect exactly the same. I don't think it was the anavar. Her last cycle was 5 months ago.

What did the doctor say about the anavar affecting it?

 

[Spokeonawheel]

@Millard

She didn't bring it up. Probably embarrassed. Or wasn't even thinking about it being any sort of real source of the issue. More something we have wondered about since.

Here's the thing about bringing up AAS use with a doctor....

Some will be somewhat knowledgeable and non judgmental. Others can be a shitshow and utterly clueless. All docs aren't created equal and very few really understand much in this regard unless they are specialized in some related field.

The first doctor I brought up my AAS usage with told me steroids would shrink my penis. It was at this point that I knew they have absolutely no fucking clue what they are talking about.

If she ends up seeing any type of endocrinologist, she's gonna need to bring it up. Especially, if we haven't sorted this by then.

 

[Spokeonawheel]

As far as her gear use. That was her choice. I even asked her to find her own source. I didn't want to be the guy putting his chic on gear to turn her into his science experiment.

But, she's reasonable. She's not real concerned about continuing gear usage. She just wants to be healthy and feel better

 

[Bumble]

My wife has been having serious problems with her health related to hormonal issues.

Her progesterone is nearly bottomed out, extremely low. Like less than .1 (sorry can't remember the rest of range) Her testosterone was on the very low end of normal. Estrogen at a healthy high level.

The crashed progesterone led to A LOT of bleeding. 30 day, extremely heavy period? I guess you'd still call it a period. 5 day break... and then right back to the problems.

She'd seen a couple doctors, had an appt with her gyno which was gonna be like a month away. At some they prescribed her some bullshit progesterone cream. Did a bunch of bloodwork....low iron, very low hemoglobin.

Eventually, she got so weak and it was so ridiculous she went to the ER. Exams done, ultrasound done. The hormonal imbalances had caused endometrial hyperplasia... thickening of the uterine wall. All these problems.... results of hormonal imbalances.

We are still working on these issues, but She's doing much better now.

She's 42. Relatively young for menopausal problems. And her estro is still nice and high.

What we want to know is if past anavar usage could have played a part in any of this mess? She's ran maybe 3 or 4 total cycles over the past 2 years or so. The most recent being an 8 week cycle of 10 mg daily anavar. The most recent cycle ended in October 2020. She seemed to tolerate everything pretty well... no major sides, maybe missing 1 period per cycle, 2 at most, then back to normal.

What effect does anavar have on progesterone?

I'd assume it raises progesterone due to the cessation of periods. I've been researching, but haven't found much, if anything.

If anyone has any insight, or bloodwork results that may shine some light on this we'd love to hear it.

Thanks ladies and gentleman.

I would think the answer to this lies in her past medical history, with little, or no, connection to Anavar.

There's a tendency, that's nearly universal in my experience, that people tend to tunnel vision on the latest/newest medication or treatment (for good or for bad) to explain what's going on. It happens to all of us, medical or not, here and there.. especially when looking at ourselves or loved ones. (Objectivity is lost.)

Women without this bleeding issue require iron shots, many times, and transfusions, in some cases, much later in life. If she is having issues to the point of going to the ER, fuck her gyno/endo if she can't be seen next day...find another one.

 

[Spokeonawheel]

@Bumble

Seems pretty spot on.

She did have some past history 20 years ago that could be a contributing factor. Far more likely than the var as a culprit...Or it's just bad luck.

She did get 2 iron I fusions. Hemoglobin was 2 points away from needing blood.

Other doc appointments a few days away.

I think we all fear that we may damage ourselves in some way with this lifestyle. We know we are taking risks. The more cautious among us seek to moderate and limit risk. But it always there. None of us want the moment to come when some doc comes to inform you that something serious has gone wrong. And you say to yourself... "Holy shit. I have fucked myself up. This is my fault."

I seriously doubt this is her situation. But that fear is there. I have it myself. It can color your perception.

Thanks for all responses guys.

 

[Bumble]

@Bumble

Seems pretty spot on.

She did have some past history 20 years ago that could be a contributing factor. Far more likely than the var as a culprit...Or it's just bad luck.

She did get 2 iron I fusions. Hemoglobin was 2 points away from needing blood.

Other doc appointments a few days away.

I think we all fear that we may damage ourselves in some way with this lifestyle. We know we are taking risks. The more cautious among us seek to moderate and limit risk. But it always there. None of us want the moment to come when some doc comes to inform you that something serious has gone wrong. And you say to yourself... "Holy shit. I have fucked myself up. This is my fault."

I seriously doubt this is her situation. But that fear is there. I have it myself. It can color your perception.

Thanks for all responses guys.

"You're a good man, Charlie Brown."

I'm sure due diligence has been accomplished - over and over, and ongoing, in every area.

Get her treatment. Keep her safe. Good luck.

Tongue in cheek, not to be taken as anything other than what it is....I'd feel safer giving my one of my daughters anavar, than ibuprophen...or Adderall...or Xanax...or Zoloft.

 

[arrade]

My wife has been having serious problems with her health related to hormonal issues.

Her progesterone is nearly bottomed out, extremely low. Like less than .1 (sorry can't remember the rest of range) Her testosterone was on the very low end of normal. Estrogen at a healthy high level.

The crashed progesterone led to A LOT of bleeding. 30 day, extremely heavy period? I guess you'd still call it a period. 5 day break... and then right back to the problems.

She'd seen a couple doctors, had an appt with her gyno which was gonna be like a month away. At some they prescribed her some bullshit progesterone cream. Did a bunch of bloodwork....low iron, very low hemoglobin.

Eventually, she got so weak and it was so ridiculous she went to the ER. Exams done, ultrasound done. The hormonal imbalances had caused endometrial hyperplasia... thickening of the uterine wall. All these problems.... results of hormonal imbalances.

We are still working on these issues, but She's doing much better now.

She's 42. Relatively young for menopausal problems. And her estro is still nice and high.

What we want to know is if past anavar usage could have played a part in any of this mess? She's ran maybe 3 or 4 total cycles over the past 2 years or so. The most recent being an 8 week cycle of 10 mg daily anavar. The most recent cycle ended in October 2020. She seemed to tolerate everything pretty well... no major sides, maybe missing 1 period per cycle, 2 at most, then back to normal.

What effect does anavar have on progesterone?

I'd assume it raises progesterone due to the cessation of periods. I've been researching, but haven't found much, if anything.

If anyone has any insight, or bloodwork results that may shine some light on this we'd love to hear it.

Thanks ladies and gentleman.

Winstrol in high doses is a potent lower of progesterone and caused similar issues to this in rats
(I’m on mobile so I don’t have the study but google winstrol and progesterone )

I was actually looking up if anavar effected progesterone

Red clover is a phyto progesterone and estrogen I think, I’m using it right now cuz winny might have crashed my prog

There is a product caused progest-E
That is supposed to be a bio identical supplement

Dr Ray Peat and his forum has research on the needs of progesterone

Dr. Peat's Progest E Oil Complex, 34 ml

Kenogen Progest E Oil Complex by Dr Ray Peat is a natural bioidentical progesterone oil. Original Dr. Peat's Progest E, the best progesterone there is! Free Shipping option

www.longnaturalhealth.com

@Spokeonawheel

 

[arrade]

Some studies showcasing winstrol affecting progesterone

High, not low-dose of stanozolol (Anabolic – androgenic steroid) impedes embryo implantation by attenuating endometrial receptivity in the mouse, Mus musculus

The present investigation is aimed at evaluating the efficacy of one of the anabolic –androgenic steroids, stanozolol (ST), on establishment and maint…

www.sciencedirect.com

Winstrol binds to progesterone receptor

“Binding of stanozolol to both cell types could be partially displaced by progesterone, indicating that stanozolol binds to the progesterone receptor.“

The differential effects of stanozolol on human skin and synovial fibroblasts in vitro: DNA synthesis and receptor binding - PubMed

The anabolic steroid stanozolol stimulates the production of prostaglandin E2 (PGE2) and the matrix metalloproteinases collagenase and stromelysin in human skin fibroblasts but not in rheumatoid synovial fibroblasts. The basis for these differential responses was investigated at the levels of...

pubmed.ncbi.nlm.nih.gov

Winstrol and anavar aren’t the same drug. But both being somewhat similar I wouldn’t be surprised if anavar May have had some influence in the current issue (total guess tho)

Id recommend finding a way to increase your wife’s natural progesterone production and levels
Maybe progesterone based drugs would help, but I’m thinking of progesterone pre cursors or phyto progesterones

 

[Spokeonawheel]

Thanks for reply. She is currently on a bunch of progesterone and sees endo today.

 

[Jc420]

Some studies showcasing winstrol affecting progesterone

High, not low-dose of stanozolol (Anabolic – androgenic steroid) impedes embryo implantation by attenuating endometrial receptivity in the mouse, Mus musculus

The present investigation is aimed at evaluating the efficacy of one of the anabolic –androgenic steroids, stanozolol (ST), on establishment and maint…

www.sciencedirect.com

Winstrol binds to progesterone receptor

“Binding of stanozolol to both cell types could be partially displaced by progesterone, indicating that stanozolol binds to the progesterone receptor.“

The differential effects of stanozolol on human skin and synovial fibroblasts in vitro: DNA synthesis and receptor binding - PubMed

The anabolic steroid stanozolol stimulates the production of prostaglandin E2 (PGE2) and the matrix metalloproteinases collagenase and stromelysin in human skin fibroblasts but not in rheumatoid synovial fibroblasts. The basis for these differential responses was investigated at the levels of...

pubmed.ncbi.nlm.nih.gov

Winstrol and anavar aren’t the same drug. But both being somewhat similar I wouldn’t be surprised if anavar May have had some influence in the current issue (total guess tho)

Id recommend finding a way to increase your wife’s natural progesterone production and levels
Maybe progesterone based drugs would help, but I’m thinking of progesterone pre cursors or phyto progesterones

Anavar is commonly faked with Winstrol.