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[Trenbolonetax]

I have a question for y'all looking into SLU-pp-332: how are you arriving at your proposed dosages? I ask because all of the data is based on intraperitoneal administration, yet you are talking in terms of oral administration. Is there any empirical evidence that oral bioavailability matches or exceeds intraperitoneal bioavailability?

Moreover, the mice were dosed at 50mg/kg which approximates to 4mg/kg for humans based on ratio of surface area constants for mice (3) and humans (37). This would mean for a 100kg human the dose for intraperitoneal administration is ~400mg.

But if we assume oral bioavailability is 1/4 to 1/5 that of intraperitoneal administration, oral delivery of SLU-PP-332 would require 1.6-2.0g.

So... why not look at intramuscular administration to more closely match intraperitoneal administration, and maybe consider holding it in solution matching the solution used in animal testing?

I haven’t found any injectable version of SLUPP and don’t want to make my own.

Agree with you on oral dose needing to likely be higher. Folks allegedly saw benefits with mcg amount. I did the math on HED and that’s why I’m at 75mg daily so quickly. Cuz it made no sense to me to dose so low.

However, I don’t actually enjoy trailblazing like this, so I doubt I’ll go much above 100mg per day until a bunch of other folks do and report back lol

 

[rockyraccoon]

I haven’t found any injectable version of SLUPP and don’t want to make my own.

Agree with you on oral dose needing to likely be higher. Folks allegedly saw benefits with mcg amount. I did the math on HED and that’s why I’m at 75mg daily so quickly. Cuz it made no sense to me to dose so low.

However, I don’t actually enjoy trailblazing like this, so I doubt I’ll go much above 100mg per day until a bunch of other folks do and report back lol

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function - PubMed

ERR agonists maintain oxidative metabolism, which confers cardiac protection against pressure overload-induced HF in vivo. Our results provide direct pharmacologic evidence supporting the further development of ERR agonists as novel HF therapeutics.

pubmed.ncbi.nlm.nih.gov

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney - PubMed

A gradual decline in renal function occurs even in healthy aging individuals. In addition to aging, per se, concurrent metabolic syndrome and hypertension, which are common in the aging population, can induce mitochondrial dysfunction and inflammation, which collectively contribute to...

pubmed.ncbi.nlm.nih.gov

I'm hooked on all things mitochondria for some reason now. I believe this compound will shine at higher dosages.

 

[Trenbolonetax]

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function - PubMed

ERR agonists maintain oxidative metabolism, which confers cardiac protection against pressure overload-induced HF in vivo. Our results provide direct pharmacologic evidence supporting the further development of ERR agonists as novel HF therapeutics.

pubmed.ncbi.nlm.nih.gov

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney - PubMed

A gradual decline in renal function occurs even in healthy aging individuals. In addition to aging, per se, concurrent metabolic syndrome and hypertension, which are common in the aging population, can induce mitochondrial dysfunction and inflammation, which collectively contribute to...

pubmed.ncbi.nlm.nih.gov

I'm hooked on all things mitochondria for some reason now. I believe this compound will shine at higher dosages.

I'm on the same warpath you are re: mitochondria.

Reason for my fasted cycling, mots-c, SLUPP, carb restriction, etc.

I agree with you re: this compound shining at higher doses. I just don't want to be the first one there. I already took the standard 1.5mg "high dose" and blew it way out of the water without realizing there are at least a few other folks doing 10's of mgs per day.

 

[rockyraccoon]

I'm on the same warpath you are re: mitochondria.

Reason for my fasted cycling, mots-c, SLUPP, carb restriction, etc.

I agree with you re: this compound shining at higher doses. I just don't want to be the first one there. I already took the standard 1.5mg "high dose" and blew it way out of the water without realizing there are at least a few other folks doing 10's of mgs per day.

lol things quickly go hardcore for me too. SS-31 50mg/go just feels good, bro.

 

[narta]

Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function - PubMed

ERR agonists maintain oxidative metabolism, which confers cardiac protection against pressure overload-induced HF in vivo. Our results provide direct pharmacologic evidence supporting the further development of ERR agonists as novel HF therapeutics.

pubmed.ncbi.nlm.nih.gov

Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney - PubMed

A gradual decline in renal function occurs even in healthy aging individuals. In addition to aging, per se, concurrent metabolic syndrome and hypertension, which are common in the aging population, can induce mitochondrial dysfunction and inflammation, which collectively contribute to...

pubmed.ncbi.nlm.nih.gov

I'm hooked on all things mitochondria for some reason now. I believe this compound will shine at higher dosages.

 

[Trenbolonetax]

lol things quickly go hardcore for me too. SS-31 50mg/go just feels good, bro.

I have yet to try SS-31. Should I? Just say the word and I'm pulling the trigger next promo lol. I routinely do 30mg of mots-c daily, more recently it has been 10mg though.

 

[rockyraccoon]

I have yet to try SS-31. Should I? Just say the word and I'm pulling the trigger next promo lol. I routinely do 30mg of mots-c daily, more recently it has been 10mg though.

All I know is that SS-31 is rebuilding the block for the extra nitrous shots (MOTS-C). Forgive my crude understanding, but promo kits are definitely worth it.

 

[bubba618]

I haven’t found any injectable version of SLUPP and don’t want to make my own.

Agree with you on oral dose needing to likely be higher. Folks allegedly saw benefits with mcg amount. I did the math on HED and that’s why I’m at 75mg daily so quickly. Cuz it made no sense to me to dose so low.

However, I don’t actually enjoy trailblazing like this, so I doubt I’ll go much above 100mg per day until a bunch of other folks do and report back lol

More than likely a saline suspension would suffice, but I don't have any details of the animal testing to corroborate my guess.

I'm with you on conservative dosing at this early stage of the game while still approaching HED calculations.

 

[DugPrime]

I'm on the same warpath you are re: mitochondria.

Reason for my fasted cycling, mots-c, SLUPP, carb restriction, etc.

I agree with you re: this compound shining at higher doses. I just don't want to be the first one there. I already took the standard 1.5mg "high dose" and blew it way out of the water without realizing there are at least a few other folks doing 10's of mgs per day.

From what I've read in that study, SLU was effective in rats at a dose of 50mg/kg. If you convert that for humans using HED, it’d come out to about 8.1mg/kg. So tell me—are you just rich, or am I broke?

 

[Trenbolonetax]

From what I've read in studies, SLU was effective in rats at a dose of 50mg/kg. If you convert that for humans using HED, it’d come out to about 8.1mg/kg. So tell me—are you just rich, or am I broke?

I ordered raws brother! I'm not rich, nor broke. I'm a resourceful muthafucka.

I'm only doing about 75mg per day currently. Likely will end up around 100mg per day until other test subjects aka people, push higher. I'm not a big fan of trailblazing.

 

[Trenbolonetax]

All I know is that SS-31 is rebuilding the block for the extra nitrous shots (MOTS-C). Forgive my crude understanding, but promo kits are definitely worth it.

That was my understanding as well, from memory. One is repair one is while one is super charging.

 

[bubba618]

That was my understanding as well, from memory. One is repair one is while one is super charging.

Might consider the combination of Humanin, SS-31, MOTS-c, CoQ10, PQQ and magnesium for a couple of cycles per year for mitochondrial health. I also add some 5-MTHF due to a genetic problem with methylation (MTHFR mutation.)

My focus on mitochondrial health traces back to a bout with colon cancer a number of years back and a deep dive into the metabolic theory of cancer. I'll be running a version of this panel once or twice per year going forward.

 

[Trenbolonetax]

Might consider the combination of Humanin, SS-31, MOTS-c, CoQ10, PQQ and magnesium for a couple of cycles per year for mitochondrial health. I also add some 5-MTHF due to a genetic problem with methylation (MTHFR mutation.)

My focus on mitochondrial health traces back to a bout with colon cancer a number of years back and a deep dive into the metabolic theory of cancer. I'll be running a version of this panel once or twice per year going forward.

Definitely will look into it - thanks man.

My understanding from reading awhile ago was use the SS-31 prior to using MOTS-C, but I'm not sure how much truth there is to that?

 

[Sampei]

What the fuck are you all talking about with these little names of slu sli pipiripi and bla bla bla.

THERE IS ONLY ONE ANSWER to all your questions: UP THE TREN.
period.

 

[bubba618]

From what I've read in that study, SLU was effective in rats at a dose of 50mg/kg. If you convert that for humans using HED, it’d come out to about 8.1mg/kg. So tell me—are you just rich, or am I broke?

Um, if you're using the standard HED calculation using body surface area constants for mice and humans, the calculation would be 50mg/kg for mice * 3 (Km for mice)/37 (Km for humans) yielding 4.05mg/kg for humans unless I made a mistake somewhere (always possible.)

 

[Trenbolonetax]

Um, if you're using the standard HED calculation using body surface area constants for mice and humans, the calculation would be 50mg/kg for mice * 3 (Km for mice)/37 (Km for humans) yielding 4.05mg/kg for humans unless I made a mistake somewhere (always possible.)

My calculation was right inline with yours.

 

[bubba618]

Definitely will look into it - thanks man.

My understanding from reading awhile ago was use the SS-31 prior to using MOTS-C, but I'm not sure how much truth there is to that?

Running SS-31 for at least a couple weeks prior to starting MOTS-c is supposed to prime the cell and maximize the efficacy of the MOTS-c. I haven't noticed a difference either way, so I just run them concurrently for convenience's sake.

 

[Trenbolonetax]

Running SS-31 for at least a couple weeks prior to starting MOTS-c is supposed to prime the cell and maximize the efficacy of the MOTS-c. I haven't noticed a difference either way, so I just run them concurrently for convenience's sake.

I appreciate the real world feedback. Often times the theory doesn't pan out in practical application.

 

[Trenbolonetax]

What the fuck are you all talking about with these little names of slu sli pipiripi and bla bla bla.

THERE IS ONLY ONE ANSWER to all your questions: UP THE TREN.
period.

I would do this, alongside the SLUPP SLUPP, if it wasn't for wanting to preserve a bit of fertility. Don't tempt me with a good time, bro!

 

[Droc]

I just started today. Had 150mg this morning, raw powder dumped into pre workout. Need to look at some dosing. Are you? Any suggestions on dose?

I've heard anything less than 150 is kinda pointless, never tried it yet