Stimulants as weight loss drugs

[MrCloud]

Before the raise of glp1 people used to run other compounds to lose weight. Personally i dont even care about eating on extended release methylphenidate, thats why i even stopped taking it. There is also the famous eca stack with ephedrine. Medicine like mysimba or adipex. Considering that glp1 give kind of fast tolerance and get expensive quick shouldnt more "simple" options like stimulants be considered ?

 

[Biggerisbetternl]

Every drug has its pro's and cons. From what I understand the sides from stims are a main drawback. GLP-1 drugs are actually designed for weight loss and should give users less negative sides. Besides that the stims like ephedrine you mention are banned or illegal in most countries so not much safer in that regard either. Caffeine is a stim too that can aid with weight loss, and is probably the one of the few I would recommend if you have to go that route.

 

[Ghoul]

Pharma GLPs don’t create any tolerance.

You (like many, including some doctors) don’t understand how these hormones work. They’re not diet pills.

 

[MrCloud]

Pharma GLPs don’t create any tolerance.

You (like many, including some doctors) don’t understand how these hormones work. They’re not diet pills.

Unfortunately you dont make much sense

Every drug has its pro's and cons. From what I understand the sides from stims are a main drawback. GLP-1 drugs are actually designed for weight loss and should give users less negative sides. Besides that the stims like ephedrine you mention are banned or illegal in most countries so not much safer in that regard either. Caffeine is a stim too that can aid with weight loss, and is probably the one of the few I would recommend if you have to go that route.

yeah ephedrine is banned because they used to make amphetamine out of it. In my country you can still find it otc in pharmacy for nasal congestion.

 

[frenexen]

Pharma GLPs don’t create any tolerance.

You (like many, including some doctors) don’t understand how these hormones work. They’re not diet pills.

They target GPCRs that undergo the same internalization as any other. To say they don't create any tolerance is just false.

Some are resistant sure, especially Orforglipron, but not immune.

 

[TudorG]

why are people looking at past shitty alternatives? just use reta. one of my mates has been on it for 2 years and while it's true he now takes 10mg a week it still works. And he is constantly sub 10% bodyfat.
Stimulants are shit for weight loss. You build tolerance fast on them. After a while I could eat even while on a high dose of stims. Stick to reta even if you take 10mg a week, is worth it!

 

[Country Club Hero]

Most of us here originally kept lean with the types of drugs you’re talking about. ECA, Clen, DNP, etc. Glps have only been prevalent in this game for 3-4 years now in general.

Stims are ok and work fine. But for overall, long term safety purposes, I think glp drugs are generally safer overall. But we still lack long term studies. I use glps to stay lean now and use mild stims for preworkout only.

I guess I agree with you but you seem to be coming from a closed mind not considering most of us are over 22 and been lifting more than a year or two so we have plenty of experience with stims over the years.

 

[SlamSumTest]

There’s no such thing as free lunch and everything has a cost.

My results on Reta have been amazing, to the point where getting lean/ripped finally became effortless…which concerns me.

I’m a bit suspicious of how GLP1s tamper and down regulate your dopamine pathways. While people are able to quit addictions, I do believe this does more harm than good for everyone else.

But, at the end of the day, all of these drugs must be used indefinitely to maintain the results achieved on it. Take that what you will, we don’t really know how tampering with our reward pathways can cause issues down the line (mostly psychological issues potentially if I had to guess).